KEGG   ORTHOLOGY: K04741
Entry
K04741                      KO                                     
Symbol
CASP12
Name
caspase 12 [EC:3.4.22.-]
Pathway
map04141  Protein processing in endoplasmic reticulum
map04210  Apoptosis
map04621  NOD-like receptor signaling pathway
map05010  Alzheimer disease
map05014  Amyotrophic lateral sclerosis
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05161  Hepatitis B
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04741  CASP12; caspase 12
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04741  CASP12; caspase 12
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K04741  CASP12; caspase 12
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    K04741  CASP12; caspase 12
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04741  CASP12; caspase 12
   05014 Amyotrophic lateral sclerosis
    K04741  CASP12; caspase 12
   05020 Prion disease
    K04741  CASP12; caspase 12
   05022 Pathways of neurodegeneration - multiple diseases
    K04741  CASP12; caspase 12
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04741  CASP12; caspase 12
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C14: caspase family
   K04741  CASP12; caspase 12
Genes
HSA: 100506742(CASP12)
PTR: 466766(CASP12)
PPS: 100991705
GGO: 101137790
PON: 100436165 100938140
NLE: 100587073
HMH: 116476195
MCC: 724039(CASP12)
MCF: 102115795
MTHB: 126935004
MNI: 105493692
CSAB: 103248368
CATY: 105588760
PANU: 101005329
TGE: 112605952
MLEU: 105534151(CASP4)
RRO: 104665278
RBB: 108513174
PTEH: 111540056
CANG: 105501186
CSYR: 103267234
MMUR: 105862473
LCAT: 123641788
OGA: 100954053
MMU: 12364(Casp12)
MCAL: 110302047
MPAH: 110327565
RNO: 156117(Casp12)
MCOC: 116073421
ANU: 117699648
MUN: 110552937
CGE: 100759746(Casp4)
MAUA: 101828435
PROB: 127216920
PLEU: 114686852
HGL: 101725565
OCU: 103350677
TUP: 102489486
CFA: 479458(CASP12)
CLUD: 112671425
VVP: 112925944
VLG: 121499341
NPO: 129497876
AML: 100465168
UMR: 103662441
UAH: 113259719
UAR: 123792512
ELK: 111153889
LLV: 125078536
MPUF: 101670985
MNP: 132028961
MLK: 131834806
NVS: 122912245
ORO: 101382304
EJU: 114211415
ZCA: 118355935
MLX: 118013166
NSU: 110586231
LWW: 102743671
FCA: 100135767(CASP12)
PYU: 121020796
PCOO: 112865165
PBG: 122482900
LRUF: 124504970
PTG: 102968230
PPAD: 109258466
PUC: 125910552
AJU: 106976502
HHV: 120246764
CCAD: 122449999
BACU: 103011794(CASP12)
LVE: 103079424
OOR: 101272972
NASI: 112415739
ECB: 100069290
EPZ: 103559836
EAI: 106837654
MYB: 102240773
MYD: 102773959
MMYO: 118664384
MLF: 102431309
PKL: 118712750
EFUS: 103303784
MNA: 107532383
DRO: 112314270
SHON: 119000401
AJM: 119060799
PDIC: 114499895
PHAS: 123818526
MMF: 118628924
PPAM: 129086067
HAI: 109377699
RFQ: 117029875
PALE: 102894880
PGIG: 120599677
PVP: 105297472
RAY: 107504291
SARA: 105942814
TMU: 101352646
ETF: 101653369
DNM: 101417090
AFZ: 127554934
PCW: 110214950
MMER: 123543279
 » show all
Reference
  Authors
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J
  Title
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.
  Journal
Nature 403:98-103 (2000)
DOI:10.1038/47513
Reference
  Authors
Fischer H, Koenig U, Eckhart L, Tschachler E
  Title
Human caspase 12 has acquired deleterious mutations.
  Journal
Biochem Biophys Res Commun 293:722-6 (2002)
DOI:10.1016/S0006-291X(02)00289-9
  Sequence
[hsa:100506742]
LinkDB

DBGET integrated database retrieval system