KEGG ORTHOLOGY: K05230

ORTHOLOGY: K05230

Entry

K05230                      KO

Symbol

DEFA

Name

defensin, alpha

Pathway

map04621

NOD-like receptor signaling pathway

map05150

Staphylococcus aureus infection

map05202

Transcriptional misregulation in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K05230  DEFA; defensin, alpha
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K05230  DEFA; defensin, alpha
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K05230  DEFA; defensin, alpha

Other DBs

TC:

1.C.19.1

Genes

HSA:	1667(DEFA1) 1668(DEFA3) 1669(DEFA4) 1670(DEFA5) 1671(DEFA6) 728358(DEFA1B)

PTR:	107973256 463971(DEFA4) 463972(DEFA5) 619353(DEFA7) 619354(DEFA6) 742808(DEFA1)

PPS:	100978165(DEFA4) 100978828(DEFA6) 100991118 100991783 112438857 117981563 129395845 129395846 129395848 129395849

GGO:	101150241(DEFA4) 101150606(DEFA6) 101151457 101152910 115935617

PON:	100432023(DEFA5) 100461256(DEFA6) 100461630(DEFA4) 100462118 112134649 112134667(DEFA1)

PPYG:

129042622 129042629 129042766(DEFA4) 129042784 129043039 129043040 129043041 129043054(DEFA6)

NLE:	100579628(DEFA4) 100593470(DEFA6) 100594140(DEFA5) 100595156 105740503 115830447 115833882 115834728

HMH:	116472391 116472392 116472393 116472394(DEFA6) 116473839

SSYN:

129487816(DEFA6) 129489328 129491135 129491143 129491148 129491156 129491159 129491166

MCC:	114680386 574121(RTD1C) 574122(RTD1A) 574123(RTD1B) 574196(MNP1A) 574197(MNP2) 574309 574310 574311(DEFA4) 717000(DEFA6)

MCF:	102115299(DEFA6) 102115676 102116444 102117659 102118641 102125546 102125912 102126703 135964514 135964515 135964591

MTHB:

126961091 126961092 126961094 126961099 126961112 126961113

MNI:	105464161 105464162 105464163 105464164 105468980 105468981 112424497

CSAB:

103215301 103215303 103215304(DEFA1) 103247085 103247087

CATY:

105574565 105574566 105574567 105574568 105594204(DEFA6) 105594205(DEFA4) 105594206 105594208(DEFA5) 105594209 105594210

PANU:

100126731(DEFA1) 100126732(DEFA1) 100196939(BTDC) 100196940(BTDA) 100196941(BTDB) 101016209 101016942 101018347

TGE:	112617671 112618085 112618091 112629713 112630368(DEFA6) 112630485(DEFA1) 112630559 112630579(DEFA4)

MLEU:

105550685 105550687 105550690 105550691 105550692 105550693 105550694 105550695 105550696 105550697 105550698 105550699 105550700 105550701(DEFA6)

RRO:	104666848 104674078 104675524 104678684 104679032 104679033 104679035 115899676 115899677 115899678

RBB:	108516716 108516722 108516723 108520649 108524614 108525723

TFN:	117063645 117063667 117072102 117072191 117072277 117072318

PTEH:

111534252 111545997 111547373 116418870

CANG:

105503422 105504420 105525759 105525760 105525761(DEFA1B) 105525764(DEFA6) 105525766

CJC:	100386936 100407125 100415641(DEFA4)

SBQ:	101046624 101047148 101049999 101050964 104650356 104650357

CIMI:

108293116 108293123 108293124 108293125 108298912 108298913

ANAN:

105720681(DEFA4) 105720721(DEFA5) 135271790

CSYR:

103267627

MMUR:

105881499 105881500

LCAT:

123626562 123626563

PCOQ:

105811620 105811621 105811622

OGA:	100956062 105888387 105888389 105888390

MMU:

100038927(Defa30) 100041688(Defa35) 100041759(Defa41) 100041787(Defa40) 100041811(Defa27) 100041890(Defa32) 100041895(Defa37) 100041952(Defa34) 100294660(Defa2) 100503970 100505096(Defa33) 100862126(Defa36) 13216(Defa1) 13218(Defa29) 13219(Defa-rs10) 13221(Defa-rs12) 13222(Defa-rs2) 13223(Defa-rs4) 13226(Defa31) 13236(Defa25) 13237(Defa3) 13238(Defa4) 13239(Defa5) 13240(Defa6) 23855(Defa17) 382000(Defa39) 382059(Defa22) 497114(Defa23) 503491(Defa24) 626682(Defa28) 626708(Defa26) 634825(Defa38) 66298(Defa21) 665927(Defa42) 665956(Defa43) 68009(Defa20)

MCAL:

110287647 110287648 110288025 110288689 110288772 110288820 110289029 110289030 110289223 110300373 110300489

MPAH:

110314840 110314841 110314843 110314844 110314845 110315646 110315647 110315648 110336973 110337137

RNO:	286958(Np4) 286995(Defa5) 290856(Defa24) 498658(Defa9) 498659(RatNP-3b) 613220(Defal1) 613223(Defa6) 613224(Defa8) 613225(Defa11)

MCOC:

116071207 116104743 116104745

ANU:	117721697 117721698 117721701 117721968

ASYL:

127668607 127668792 127668815 127668973

MUN:	110541339 110544542 110544853 110566878 132653464 132653465 132653466 132653467 132653468 132653469 132653471 132653472 132653473 132653474

CGE:	100755370 100757016 100757305 100768088 107977597 113831044

MAUA:

101842644 106022692 121135116 121135118 121135145 121135148 121135153 121135154 121135156 121138219 121138220 121138611 121138612

PROB:

127220235 127220475

PLEU:

114688881 114688882 114688883 114688885 114688886 114689198 114701851 114701852 114701864 114701865 114701866 114701867 114701868 119089186 119089187

MORG:

121462147 121462148 121462150 121462152 121462211 121462363

MFOT:

126498569 126498576 126498692 126498713 126498736 126498808 126498809 126498811

AAMP:

119811644 119811645(Defa5) 119812499 119812548

NGI:	103728340 103745282 103745290

HGL:	101713941 106008121

CPOC:

100192401(Gncp-1b) 100712792

CCAN:

109674521 109678543 109678544 109678545 109702618

DORD:

105991559 105991560 105991583 106001835

DSP:	122125246 122125283 122125290 122125291 122125292 122125293 122125294 122125297 122125300

PLOP:

125339519

NCAR:

124979430 124981864 124981931

MMMA:

107158186 125613246

OCU:	100009115(MCP-1) 100009134 100009135 100009136 103346080

OPI:

101519055

TUP:	102494162 102494573 102498707(Defensin-5) 102499971(Defensin-7)

GVR:	103610195 103610197

ECB:	100306983(DEFA11) 100306984(DEFA12) 100306988(DEFA16) 100306992(DEFA20) 100306994(DEFA22) 100306998(DEFA26) 100307002(DEFA1) 100307018(DEFA31L) 100307022(DEFA35L) 100307023(DEFA36L) 100307027(DEFA5L) 100307028(DEFA5)

EPZ:

103557224

EAI:	106841381 106841382 106841383 106841384 106841385 106841386 106841423 106841424 123281436 123281439 123281440 123281441

MYB:

102242625

MDT:	132226821 132228795 132228796 132228797

MYUM:

139005870

PKL:	118704469(DEFA5)

DRO:	112321303 112321304

PHAS:

123807450 123807643 123807671 123807678 123807680 123807710

MMF:	118622919 118622986

HAI:	109378345 109386808

RFQ:	117021613 117021662 117021671

PGIG:

TOD:

SETR:

LAV:

TMU:

ETF:

MDO:	100619794(DEFA6)

GAS:	123233470 123233471

SHR:

105749056

AFZ:	127548531 127548533

PCW:	110207186(DEFA6)

TVP:

118841552

PBRV:

138176537

OAA:	103168722 114807316 114807392

ASN:

112551917

» show all

Reference

PMID:15372083

Authors

Lehrer RI

Title

Primate defensins.

Journal

Nat Rev Microbiol 2:727-38 (2004)
DOI:10.1038/nrmicro976

LinkDB

ORTHOLOGY: K21100

Entry

K21100                      KO

Symbol

DEFB4

Name

beta-defensin 4

Pathway

map04621

NOD-like receptor signaling pathway

map04657

IL-17 signaling pathway

map05150

Staphylococcus aureus infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K21100  DEFB4; beta-defensin 4
   04657 IL-17 signaling pathway
    K21100  DEFB4; beta-defensin 4
09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K21100  DEFB4; beta-defensin 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K21100  DEFB4; beta-defensin 4
Transporters [BR:ko02000]
Other transporters
  Pores ion channels
   K21100  DEFB4; beta-defensin 4

Other DBs

GO:

0031731

TC:	1.C.85.1.2

Genes

HSA:	100289462(DEFB4B) 124906748 1673(DEFB4A)

PTR:	129388399 450193(DEFB4A)

PPS:	129395878 134730866

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	100169969(DEFB4) 114675435 114675439 114676064 114680396

MCF:	102124095 107130570 135964516

MTHB:

126961108 126961109

MNI:	105499844 112423340

CSAB:

103215308(DEFB4B)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

SBQ:

CIMI:

ANAN:

110567506 135271799(DEFB4B)

MMUR:

105869239 109729810

MMU:	116746(Defb6) 27358(Defb3) 56519(Defb4)

MCAL:

110287619 110287653 110300661

MPAH:

110336192 110337034 110337095

RNO:	641624(Defb5) 64389(Defb4)

MCOC:

116071202 116071203 116104742

ANU:	117721925 117721950

ASYL:

127668559 127668561 127668562 127668563 127668564 127668565 127668975

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

CFA:	100135059(DEFB4A)

LLV:

125094398

BTA:	100141457(DEFB10) 100297617(DEFB1) 132344036 132344087 281743(EBD) 286836(DEFB4A) 286837(TAP) 403090(LAP) 404107(DEFB13) 768320(DEFB7)

BBUB:

112578537 123332559 123332581

CHX:	100861169 100861170

OAS:	100505451(SBD2) 121818081

CSUM:

138078306 138078865

ODA:

120859931

CCAD:

122432323

SSC:	396819(DEFB1)

ECB:	100033989(DEFB4B)

GGA:	395840(AvBD2)

PCOC:

116235652

MGP:	678665(THP2)

CJO:

107312329

TPAI:

128085943

NMEL:

110396689

APLA:

101795872(BD2)

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

PHI:

PMAJ:

CCAE:

CBRC:

ACOE:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

CCIC:

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

CSTI:

MNB:

DPUB:

PPUS:

AVIT:

BRHI:

EGZ:

NNI:	104014755(DEFB4B)

PCRI:

PADL:

AFOR:

FGA:

GSTE:

CBOY:

CLV:

CNIC:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

CRID:

AROW:

NPD:

TGT:	104567381(DEFB4B)

DNE:

SCAM:

PSS:

CPIC:

TST:

CABI:

MRV:

Reference

PMID:9831658

Authors

Liu L, Wang L, Jia HP, Zhao C, Heng HH, Schutte BC, McCray PB Jr, Ganz T

Title

Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.

Journal

Gene 222:237-44 (1998)
DOI:10.1016/S0378-1119(98)00480-6

Sequence

[hsa:1673]

LinkDB

ORTHOLOGY: K23126

Entry

K23126                      KO

Symbol

DEFB103

Name

beta-defensin 103

Pathway

map04621

NOD-like receptor signaling pathway

map05150

Staphylococcus aureus infection

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K23126  DEFB103; beta-defensin 103
09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K23126  DEFB103; beta-defensin 103
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K23126  DEFB103; beta-defensin 103
Transporters [BR:ko02000]
Other transporters
  Pores ion channels
   K23126  DEFB103; beta-defensin 103

Other DBs