KEGG ORTHOLOGY: K05251

ORTHOLOGY: K05251

Entry

K05251                      KO

Symbol

TSHB

Name

thyrotropin subunit beta

Pathway

map04024

cAMP signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04081

Hormone signaling

map04918

Thyroid hormone synthesis

map04923

Regulation of lipolysis in adipocytes

map05320

Autoimmune thyroid disease

Disease

H00250

Congenital nongoitrous hypothyroidism (CHNG)

H01699

Isolated TSH deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K05251  TSHB; thyrotropin subunit beta
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K05251  TSHB; thyrotropin subunit beta
   04081 Hormone signaling
    K05251  TSHB; thyrotropin subunit beta
09150 Organismal Systems
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K05251  TSHB; thyrotropin subunit beta
   04918 Thyroid hormone synthesis
    K05251  TSHB; thyrotropin subunit beta
09160 Human Diseases
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K05251  TSHB; thyrotropin subunit beta
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05251  TSHB; thyrotropin subunit beta
Cytokines and neuropeptides [BR:ko04052]
Neuropeptides
  GPCR binding
   K05251  TSHB; thyrotropin subunit beta

Genes

HSA:	7252(TSHB)

PTR:	748248(TSHB)

PPS:	100967932(TSHB)

GGO:	101149441(TSHB)

PON:	100443696(TSHB)

PPYG:

129019779(TSHB)

NLE:	100593224(TSHB)

HMH:	116469564(TSHB)

SSYN:

134734659(TSHB)

MCC:	709374(TSHB)

MCF:	102135350(TSHB)

MTHB:

126930833

MNI:	105479142(TSHB)

CSAB:

103224162(TSHB)

CATY:

105596339(TSHB)

PANU:

100997620(TSHB)

TGE:	112607784(TSHB)

MLEU:

105554361(TSHB)

RRO:	104669072(TSHB)

RBB:	108528124(TSHB)

TFN:	117075647(TSHB)

PTEH:

111549640(TSHB)

CANG:

105505308(TSHB)

CJC:	100385359(TSHB)

SBQ:	101038043(TSHB)

CIMI:

108301156(TSHB)

ANAN:

105727010(TSHB)

CSYR:

103259233(TSHB)

MMUR:

105878705(TSHB)

LCAT:

123635085(TSHB)

PCOQ:

105810584(TSHB)

OGA:	100946847(TSHB)

MMU:	22094(Tshb)

MCAL:

110291669(Tshb)

MPAH:

110320677(Tshb)

RNO:	25653(Tshb)

MCOC:

116094220(Tshb)

ANU:	117707795(Tshb)

ASYL:

127682157(Tshb)

MUN:	110562999(Tshb)

CGE:	100751072(Tshb)

MAUA:

101830447(Tshb)

PROB:

127232740(Tshb)

PLEU:

114698552(Tshb)

MORG:

121437809(Tshb)

MFOT:

126510835

AAMP:

119801437(Tshb)

NGI:	103734942(Tshb)

HGL:	101720907(Tshb)

CPOC:

100721947(Tshb)

CCAN:

109682241(Tshb)

DORD:

105991889(Tshb)

DSP:	122118330(Tshb)

DMER:

138816575(Tshb)

PLOP:

125355732(Tshb)

NCAR:

124965259

MMMA:

107156185(Tshb)

ITI:	101977209(Tshb)

OCU:	100302414(TSHB)

OPI:	101527959(TSHB)

OCZ:	121168806(TSHB)

TUP:	102501103(TSHB)

GVR:	103589326(TSHB)

CFA:	403973(TSHB)

CLUD:

112664158(TSHB)

VVP:	112916831(TSHB)

VLG:	121490462(TSHB)

NPO:	129501188(TSHB)

AML:	100469951(TSHB)

UMR:	103669418(TSHB)

UAH:	113244442(TSHB)

UAR:	123794929(TSHB)

ELK:

111143605

LLV:

125099052

MPUF:

101694582(TSHB)

MNP:	132000667(TSHB)

MLK:	131810102(TSHB)

NVS:	122900364(TSHB)

ORO:	101385992(TSHB)

EJU:	114207848(TSHB)

ZCA:	113911985(TSHB)

MLX:	118000530(TSHB)

NSU:	110580517(TSHB)

LWW:	102744995(TSHB)

FCA:	554350(TSHB)

PYU:	121027745(TSHB)

PCOO:

112848756(TSHB)

PBG:	122479637(TSHB)

PVIV:

125172765(TSHB)

LGF:	123598510(TSHB)

AJU:

106969661

PTG:	102951543(TSHB)

PPAD:

109272111(TSHB)

PUC:

125912212

PLEZ:

122227258(TSHB)

HHV:	120243089(TSHB)

BTA:	281552(TSHB)

BOM:	102287977(TSHB)

BIU:	109555886(TSHB)

BBUB:

102400331(TSHB)

BBIS:

104981576(TSHB)

CHX:	102185966(TSHB)

OAS:	101104284(TSHB)

BTAX:

128045676(TSHB)

CSUM:

138074376(TSHB)

ODA:	120856037(TSHB)

CCAD:

122435876(TSHB)

MREE:

136162737(TSHB)

OVR:	110124968(TSHB)

MBEZ:

129541493(TSHB)

SSC:	397658(TSHB)

CFR:	102511444(TSHB)

CBAI:

105079529(TSHB)

CDK:	105089625(TSHB)

VPC:	102535863(TSHB)

BACU:

103002421(TSHB)

BMUS:

118905449(TSHB)

LVE:	103084958(TSHB)

OOR:	101277384(TSHB)

LALB:

132516011(TSHB)

GMF:	115859788(TSHB)

DDP:	132422148(TSHB)

DLE:	111179992(TSHB)

PCAD:

102990145(TSHB)

PSIU:

116762615(TSHB)

PPHC:

136126627(TSHB)

NASI:

112413059(TSHB)

ECB:	100034188(TSHB)

EPZ:	103547739(TSHB)

EAI:	106835710(TSHB)

MYB:	102247015(TSHB)

MYD:	102761777(TSHB)

MMYO:

118673750(TSHB)

MLF:	102428488(TSHB)

MDT:	132220414(TSHB)

MYUM:

138995644(TSHB)

PKL:	118727200(TSHB)

EFUS:

103291216(TSHB)

MNA:	107545279(TSHB)

DRO:	112314072(TSHB)

SHON:

118981967(TSHB)

AJM:	119041738(TSHB)

PDIC:

114489183(TSHB)

PHAS:

123804754(TSHB)

MMF:	118619356 118637853(TSHB)

PPAM:

129063692(TSHB)

HAI:	109392811(TSHB)

RFQ:	117014998(TSHB)

PALE:

102887106(TSHB)

PGIG:

120584959(TSHB)

PVP:	105296493(TSHB)

RAY:	107499811(TSHB)

MJV:	108398053(TSHB)

TOD:	119236624(TSHB)

SARA:

101548067(TSHB)

SFUM:

130046218(TSHB)

SETR:

125997604(TSHB)

LAV:	100660279(TSHB)

TMU:

101342176

ETF:	101656953(TSHB)

DNM:	101443520(TSHB)

MDO:	503501(TSHB)

GAS:	123246726(TSHB) 123255757

SHR:	100927019(TSHB)

AFZ:

127562304

PCW:	110216823(TSHB)

TVP:	118858349(TSHB)

PBRV:

138162162(TSHB)

MLAO:

141490065(TSHB)

OAA:	100074530(TSHB)

TACU:

119930401(TSHB)

GGA:	395937(TSHB)

PCOC:

116236902(TSHB)

MGP:	100546526(TSHB)

CJO:	107324819(TSHB)

TPAI:

128088217(TSHB)

LMUT:

125684082(TSHB)

NMEL:

110388251(TSHB)

APLA:

101804542(TSHB)

ACYG:

106041291(TSHB)

CATA:

118255337(TSHB)

AFUL:

116498883(TSHB)

TGU:	100220136(TSHB)

LSR:	110473073(TSHB)

PMOA:

120497633(TSHB)

OTC:	121345676(TSHB)

PRUF:

121349779(TSHB)

ATRC:

139601334(TSHB)

GFR:	102040289(TSHB)

FAB:	101818412(TSHB)

OMA:	130263702(TSHB)

PHI:	102111041(TSHB)

PMAJ:

107214721(TSHB)

CCAE:

111939730(TSHB)

CCW:	104692414(TSHB)

CBRC:

103625275(TSHB)

ACOE:

138098958(TSHB)

ETL:	114064421(TSHB)

ZAB:	102062496(TSHB)

ZLE:	135458133(TSHB)

ACHL:

103802493

SVG:	106851066(TSHB)

MMEA:

130578875(TSHB)

HRT:	120762755(TSHB)

SATI:

136371733(TSHB)

CCIC:

134054142(TSHB)

FPG:	101920577(TSHB)

FCH:	102055291(TSHB)

CCRI:

104156792(TSHB)

NNT:	104410855(TSHB)

SHAB:

115602211(TSHB)

ACUN:

113488772(TSHB)

TALA:

104360089(TSHB)

ACHC:

115334935(TSHB)

HALD:

104322959(TSHB)

HLE:	104838631(TSHB)

AGEN:

126052491

HHAR:

128154183(TSHB)

GCL:

127026308

CSTI:

104552220(TSHB)

LDI:	104342416(TSHB)

MNB:	103770146(TSHB)

DPUB:

104296293(TSHB)

PPUS:

135191392(TSHB)

AVIT:

104275048(TSHB)

BRHI:

104498882(TSHB)

EGZ:	104126777(TSHB)

NNI:	104010336(TSHB)

PCRI:

104027272(TSHB)

PCAO:

104042921(TSHB)

PADL:

103923539(TSHB)

AFOR:

103893548(TSHB)

FGA:	104074675(TSHB)

CBOR:

142093395(TSHB)

GSTE:

104257875(TSHB)

CBOY:

140662718(TSHB)

MAME:

142419199(TSHB)

CLV:	102098073(TSHB)

CNIC:

135997169(TSHB)

MUI:	104535516(TSHB)

PGUU:

104460753 104464938

PLET:

104624952(TSHB)

EHS:	104512265(TSHB)

CMAC:

104482257(TSHB)

CUCA:

104067102(TSHB)

TEO:	104379075(TSHB)

BREG:

104631444(TSHB)

OHA:	104333519(TSHB)

ACAR:

104521577(TSHB)

CPEA:

104392578(TSHB)

CVF:	104289500(TSHB)

RTD:	128900287(TSHB)

CRID:

134525445(TSHB)

LMIC:

141733731(TSHB)

AAM:	106485256(TSHB)

AROW:

112971629(TSHB)

NPD:	112951510(TSHB)

TGT:	104581246(TSHB)

DNE:	112993693(TSHB)

SCAM:

104142283(TSHB)

ASN:	102380596(TSHB)

AMJ:	102568447(TSHB)

CPOO:

109317708(TSHB)

GGN:	109295430(TSHB)

PSS:	102449915(TSHB)

CIZ:	142002035(TSHB)

CMY:	102944542(TSHB)

CCAY:

125625160(TSHB)

DCC:	119846306(TSHB)

CPIC:

101951522(TSHB)

TST:	117875728(TSHB)

CABI:

116826035(TSHB)

MRV:	120402892(TSHB)

ACS:	100552987(tshb)

ASAO:

132773335(TSHB)

PVT:	110072381(TSHB)

SUND:

121929667(TSHB)

PBI:	103057906(TSHB)

PMUR:

107284060(TSHB)

CTIG:

120314145(TSHB)

TSR:	106539291(TSHB)

PGUT:

117663782(TSHB)

PCAE:

139314283(TSHB)

APRI:

131196043(TSHB)

PTEX:

113444334(TSHB)

NSS:	113416972(TSHB)

VKO:	123032197(TSHB)

PMUA:

114599405(TSHB)

PRAF:

128416219(TSHB)

ZVI:	118089082(TSHB)

HCG:	128324718(TSHB)

GJA:	107111993(TSHB)

STOW:

125433603(TSHB)

EMC:	129330502(TSHB)

XLA:	100381085(tshb.S) 108707690(tshb.L)

XTR:	100496349(tshb)

NPR:	108799084(TSHB)

RTEM:

120928613(TSHB)

ACAT:

141129967(TSHB)

PADS:

140340963(TSHB)

BBUF:

120994935(TSHB)

BGAR:

122933231

DTC:	141063210(TSHB)

PWL:	138302008(TSHB)

MUO:	115481338(TSHB)

GSH:	117347286(TSHB)

DRE:	100001596 353223(tshba)

SRX:	107708057 107709218 107729736 107746338

SANH:

107666041 107673498 107685836 107696970

SGH:	107554217 107596801

CCAR:

109066636 109091211 109104673(tshba)

CAUA:

113088913 113094052

CGIB:

127944559 127959912

PTET:

122328605 122329296 122347410(tshba)

LROH:

127154740 127166581(tshba)

GRF:	141291231 141347224(tshba)

OMC:	131532584 131543051(tshba)

PPRM:

120473960 120493495(tshba)

RKG:	130084357 130104001(tshba)

MAMB:

125260140 125273237(tshba)

CIDE:

127504970 127514057

CERY:

137009572 137010663(tshba)

MASI:

127418956 127445970

TROS:

130557028(tshba) 130571769

TDW:	130409544 130424825(tshba)

MANU:

129431192 129450764(tshba)

PDAB:

135770050(tshba) 135775157

IPU:	108271948(tshba)

IFU:	128614687(tshba)

PHYP:

113531113

SMEO:

124389515(tshba)

TFD:	113643122(tshba)

TVC:	132844543(tshba)

CGAR:

128526989(tshba)

NGRA:

132884429(tshba)

TRN:	134316266(tshba)

AMEX:

103029304(tshba) 125806743

CMAO:

118808420(tshba) 118822373

EEE:

113583091

CHAR:

105906383 105908275(tshba)

SPIL:

134086953 134092260

ASAD:

121707153(tshba) 121713690

TRU:	101067051 101071898

TFS:	130517226 130523891(tshba)

TNG:	GSTEN00033886G001

LCO:	104918371 104933253

NCC:	104941458 104941542 104955409

TBEN:

117471673 117489329(tshba) 117494279

CGOB:

115008420 115010792 115028448

PGEO:

117442256 117447197(tshba)

GACU:

117539574(tshba) 117545996 117549301

EMAC:

134863100 134863444 134882185(tshba)

ELY:	117257074(tshba) 117257945 117258978

EFO:	125890469(tshba) 125892416 125902461(fshb)

PLEP:

121944248(fshb) 121946440 121951446(tshba)

SLUC:

116043388(fshb) 116051618(tshba) 116062135

ECRA:

117944071(tshba) 117944921(fshb) 117948175

ESP:	116687732 116687891 116692926

PFLV:

114554622(tshb) 114556838 114558367

GAT:	100174866(fsh-beta) 120829849 120834840(tshba)

PPUG:

119194329 119223164 119229945(tshba)

AFB:	129099323 129102414(fshb) 129106040(tshba)

CLUM:

117725258 117730607(tshba) 117733465

PSWI:

130192763 130199390 130208578(tshba)

CANA:

137783096 137796830(tshba) 137799866

CVE:	137873969(tshba) 137882155 137889087

MSAM:

119886481(tshba) 119905435

SCHU:

122880226(fshb) 122882444 122884719(tshba)

CUD:	121505371(tshba) 121512857 121517179

SPUL:

138587954 138605916(tshba)

LMIX:

132978224(tshba) 132980218 132989169

HTC:	141787567 141794796(tshba) 141798814

ALAT:

119017925 119021647(tshba) 119023089

ASTR:

137592289 137595663(tshba)

MZE:

101469720

ONL:	100534562 112843248

OAU:	116317784(tshba)

OLA:	101171658 105354380 105356452(fshb)

OML:	112145255(tshba) 112160446(fshb)

CSAI:

133419849 133449293(tshba)

XMA:	102216862 102231810

XCO:	114135739 114153699

XHE:	116710762 116718307 116722142

PRET:

103464691 103467433

PFOR:

103134583 103149701(fshb)

PLAI:

106937917 106938306 106963070

PMEI:

106911816(fshb) 106925136 106925557

GAF:	122829565 122833497(tshba) 122845908

PPRL:

129364353 129372363 129372886(tshba) 129373556

CVG:	107087029 107101308

CTUL:

119773598 119778977(tshba)

GMU:	124856796(tshba) 124865862 124867252

NFU:

107385053

KMR:	108231646(tshba)

ALIM:

106517672 106533422

NWH:	119412449(tshba) 119417262 119430234(fshb)

AOCE:

111568011(tshba)

EJA:	138197529(tshba) 138208011

BFRE:

138616624(tshba) 138633554

MCEP:

125005371 125007228(tshba) 125011936

CSEM:

103386559

POV:	109635365(tshb)

SSEN:

122767811(tshba) 122772590 122777694

SSOE:

131459719 131460936(tshba)

HHIP:

117759199(fshb) 117761065(tshba) 117764984

HSP:	118101946(tshba) 118104447(fshb) 118110730

PPLT:

128438523(fshb) 128441944 128460146(tshba)

SMAU:

118302391 118309536(tshba) 118316721

LCF:	108873578(tshba) 108877929

SDU:	111219370 111224431

SLAL:

111662363

XGL:	120783080(tshba) 120803513

HCQ:

109506967

SSCV:

125967423(fshb) 125976753(tshba)

SBIA:

133498423 133507728(tshba)

PEE:	133408610(tshba) 133414769

PTAO:

133471748 133483684(tshba)

BPEC:

110164942

ENY:	140362471 140365598(tshba) 140381539

MALB:

109951766

BSPL:

114851795 114855051(tshba) 114858681

SJO:	128355740(tshba) 128357105

SSCO:

133977693(tshba) 133983736

TTY:	137181199(tshba)

GMH:	115540138 115559203

SASA:

100136355(tshb) 106572976

STRU:

115166445

OTW:	112221229 112254205(tshba)

OMY:	100136289(tshba) 110494700 110531299

OGO:	124003659 124020999(tshba) 124032424

ONE:	115122494 115145372

OKI:	109882835 109890149 109899110

OKE:	118388252 118399736(tshba) 127913051

OMM:	135503872 135527976 135542267

OCLA:

139371377 139395954 139414224 139417636

SALP:

111970633 112069024

SNH:	120024344 120065667

SFON:

129815947 129829340 129851413

CCLU:

121575822 121578717(tshba) 123483451

ELS:	105007569 114840475

OEP:	134018510 134018511 134018513 134028358(tshba)

SFM:	108918388(tshb) 108939147

PKI:

111857073

AANG:

118207825 118210728(tshba)

AROT:

135234975 135238303(tshba)

CCOG:

133110512(tshba) 133138966

LOC:	102690058(tshb)

PSPA:

121299532 121299747

ARUT:

117430019 117962742

PSEX:

120526917(tshba)

LCM:	102362870 102363810(TSHB)

CMK:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

PMRN:

Reference

PMID:1320763

Authors

Dumont JE, Lamy F, Roger P, Maenhaut C

Title

Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors.

Journal

Physiol Rev 72:667-97 (1992)
DOI:10.1152/physrev.1992.72.3.667

LinkDB

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