KEGG   ORTHOLOGY: K05363
Entry
K05363                      KO                                     
Symbol
murM
Name
serine/alanine adding enzyme [EC:2.3.2.10]
Pathway
map00550  Peptidoglycan biosynthesis
map01100  Metabolic pathways
Reaction
R08779  L-alanyl-tRNA:undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    K05363  murM; serine/alanine adding enzyme
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01011 Peptidoglycan biosynthesis and degradation proteins
    K05363  murM; serine/alanine adding enzyme
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.10  UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase
     K05363  murM; serine/alanine adding enzyme
Peptidoglycan biosynthesis and degradation proteins [BR:ko01011]
 Precursor biosynthesis
  Amino acid ligase
   K05363  murM; serine/alanine adding enzyme
Other DBs
COG: COG2348
GO: 0047206
Genes
AMH: I633_14530
AMAA: amad1_14030
AMAD: I636_13635
AMAI: I635_14005
BACO: OXB_0272
GMO: NCTC11323_00057(femB_1)
GSA: FOC50_04790
GHA: NCTC10459_01694(femX)
PLN: Plano_2272 Plano_2278
PKU: AUO94_04290 AUO94_04295 AUO94_04375
PRT: AUC31_15470 AUC31_15485 AUC31_15490 AUC31_15495
PLL: I858_011440 I858_011445 I858_011520
PANA: BBH88_07570 BBH88_07575
PDG: BCM40_03825 BCM40_03870 BCM40_03895
PHC: BBI08_08615 BBI08_08640 BBI08_08685
PPLA: BBI15_07090 BBI15_07095 BBI15_07100 BBI15_07115
PFAE: AJGP001_13170 AJGP001_13250
PLX: CW734_13135 CW734_13140 CW734_13145 CW734_13160
PMAT: BBI11_12575
PDEC: H1Q58_11865
PGQ: FK545_02085 FK545_02090 FK545_02320 FK545_02325
PLAY: DNR44_008505
SPOR: SporoP33_05385
SPOP: SporoP37_05875
SURE: SporoP32a_05895
SPOS: DV702_09585
LLK: LLKF_2319(murM)
LLX: NCDO2118_2181(murM)
LLM: llmg_2352(murM)
LLC: LACR_2372
LLR: llh_12055
LLN: LLNZ_12160
LLI: uc509_2051(murM)
LLW: kw2_2131(murM)
LGR: LCGT_0589
LGV: LCGL_0608
LPET: lgb_00592(femX)
LFO: LMK00_02910
LPK: LACPI_0939
LRN: CMV25_01205
LCAR: BHS00_06325
LPAA: BHS01_06840
SPY: SPy_0616(murM) SPy_1205
SPZ: M5005_Spy0511(murM) M5005_Spy0920
SPYM: M1GAS476_0565(murM) M1GAS476_0975
SPYA: A20_0553c(murM) A20_0956c(murM)
SPM: spyM18_0683(femB) spyM18_1156
SPG: SpyM3_0435(murM.1) SpyM3_0846(murM.2)
SPS: SPs1046 SPs1420
SPH: MGAS10270_Spy0505(murM) MGAS10270_Spy1034
SPI: MGAS10750_Spy0530(murM) MGAS10750_Spy1069
SPJ: MGAS2096_Spy0523(murM) MGAS2096_Spy0979
SPK: MGAS9429_Spy0501(murM) MGAS9429_Spy1022
SPF: SpyM50878(murM) SpyM51352(murM)
SPA: M6_Spy0532 M6_Spy0909
SPB: M28_Spy0490(murM) M28_Spy0892
STG: MGAS15252_0537(murM) MGAS15252_0917
STX: MGAS1882_0534(murM) MGAS1882_0912
SOZ: Spy49_0518c(murM.1) Spy49_0951c(murM2)
STZ: SPYALAB49_000543
SPYH: L897_02755 L897_04550
SPN: SP_0615(fibA)
SPD: SPD_0535(murM_fibA)
SPR: spr0540(murM)
SPW: SPCG_0575(murM)
SJJ: SPJ_0566
SNV: SPNINV200_05420(murM)
SPX: SPG_0558
SNT: SPT_0640
SND: MYY_0664
SPNN: T308_02900
SNE: SPN23F05540(murM)
SPV: SPH_0708
SNC: HMPREF0837_10904
SNM: SP70585_0676
SPP: SPP_0629
SNI: INV104_05130(murM)
SPNG: HMPREF1038_00636
SNB: SP670_0673
SNP: SPAP_0601
SNX: SPNOXC05610(murM)
SNU: SPNA45_01491(murM)
SPNE: SPN034156_16110(murM)
SPNU: SPN034183_05640(murM)
SPNM: SPN994038_05520(murM)
SPNO: SPN994039_05530(murM)
SAG: SAG0509(fibA) SAG0510
SAN: gbs0555 gbs0556
SAK: SAK_0659 SAK_0660
SGC: A964_0540(murM) A964_0541(murM)
SAGS: SaSA20_0494 SaSA20_0495
SAGL: GBS222_0486
SAGM: BSA_5970 BSA_5980
SAGI: MSA_6120 MSA_6130
SAGR: SAIL_6260 SAIL_6280
SAGP: V193_02835
SAGC: DN94_02835
SAGT: GBSCOH1_0492 GBSCOH1_0493
SAGE: EN72_02930 EN72_02935
SAGG: EN73_03005 EN73_03010
SAGN: W903_0686 W903_0687
SAGJ: ID870_06720 ID870_06725
SMU: SMU_717(murM)
SMC: SmuNN2025_1280(murM)
SMUT: SMUGS5_03160
SMJ: SMULJ23_1281(murM)
SMUA: SMUFR_0625(murM)
STC: str1155(murM)
STL: stu1155(murM)
STE: STER_1112
STN: STND_1074
STU: STH8232_1341(murM)
STW: Y1U_C0774
STHE: T303_06625
STHS: AVT04_09070
SSA: SSA_0862(murM)
SSK: SSUD12_0367
SSUI: T15_0381(murM)
SGO: SGO_1623(murM)
SEZ: Sez_1015(murM) Sez_1319(murM)
SEQ: SZO_06490 SZO_09500
SEZO: SeseC_01341 SeseC_01704
SEQU: Q426_02530 Q426_04025
SEU: SEQ_1178 SEQ_1501
SUB: SUB0607(murM)
SDS: SDEG_0637(murM) SDEG_0947
SDG: SDE12394_03425 SDE12394_05320
SDA: GGS_0612(murM) GGS_0917(murM)
SDC: SDSE_0678(murM) SDSE_0983
SDQ: SDSE167_0691(murM) SDSE167_1051
SGA: GALLO_1508
SGG: SGGBAA2069_c15300(murM)
SGT: SGGB_1503(murM)
SMB: smi_1584(fibA)
SGW: D7D53_09215
STOY: STYK_15260(murM)
SOR: SOR_1963(murM)
STK: STP_0096 STP_0414(murM)
STB: SGPB_1404(murM)
SCP: HMPREF0833_10855
SCF: Spaf_1436
SSR: SALIVB_1141(femX)
STF: Ssal_01216(murM)
STJ: SALIVA_0993(murM)
STRS: SSAL8618_04945
SSAH: HSISS4_00840(murM)
STD: SPPN_03240
SMN: SMA_1515
SIF: Sinf_1329
SIE: SCIM_0530(murM)
SIB: SIR_1111(murM)
SIU: SII_1132(murM)
SANG: SAIN_0586(murM)
SANC: SANR_0598(murM)
SANS: DK43_07235
SCG: SCI_0623(murM)
SCON: SCRE_0603(murM)
SCOS: SCR2_0603(murM)
SOI: I872_02755
SIK: K710_0130 K710_1338
SIQ: DQ08_00640 DQ08_06195
SIO: DW64_00640 DW64_06190
SIZ: SI82_00740 SI82_06345
SLU: KE3_1458
SIG: N596_04265
SIP: N597_06110
SPAT: A0O21_02760
STRA: ATM98_03930
SSOB: DK181_03430
SEQI: A6J79_07615
SKI: D7D50_06405
SPEI: EHW89_02750
SRAT: FY406_06920
SPLR: C0J00_06920
SVB: NCTC12167_01073(murM)
SMEN: SAMEA4412692_0952(murM)
SFER: NCTC12278_00174(murM) NCTC12278_01321(femX)
SCAI: NCTC12191_01576(murM) NCTC12191_02000(femX)
SPSU: NCTC13786_00865(murM_1) NCTC13786_00965(murM_2) NCTC13786_01918(murM_3)
SCHJ: DDV21_008035
SPOC: NCTC10925_00256(femX) NCTC10925_00366(murM_1) NCTC10925_01239(murM_2)
SLAT: J4854_07435
SAUP: NCTC3168_01369(murM)
SURN: NCTC13766_01447(murM)
SACO: SAME_01700(murM)
SVF: NCTC3166_01379(murM)
SRUM: GPZ88_01515
SACY: O6R09_06440
SMIE: NCTC11169_00546(murM)
SRUN: LPB404_07195
SPAM: SP4011_16620(fibA)
SDID: N1495_00550 N1495_06555
SZG: J5M87_06430
SDEN: SM121_05235
SLIN: SM123_04005
SNID: AAFQ93_02045 AAFQ93_03695
SSUV: PXH68_02825
FPEN: KIW23_03760 KIW23_06815
LSN: LSA_00260
LROS: LROSL1_1092
OOE: OEOE_1444
OEN: DSM07_03035
OSI: DLJ48_01415
LME: LEUM_1773
LMM: MI1_07685
LMK: LMES_1540
LCI: LCK_01455
LKI: LKI_07255
LEC: LGMK_04890
LCN: C270_01475
LGS: LEGAS_0406
LGE: C269_01960
LLF: BCR17_05370
LGC: A9176_03910
LSU: A6B45_08485
LPSE: FGL85_03835
LKN: FGL74_03335
WKO: WKK_02350
WCE: WS08_1006
WTR: KHQ32_05625
WCT: WS74_1072
WCI: WS105_1068
WCB: AO080_04420 AO080_09985
WJO: FOL01_1588
WPA: CO680_00890
WCF: C6P13_02120
WSO: WSWS_00295 WSWS_01363(murM)
WHE: EFA59_07215
WDI: H9L19_02390
WVR: IE337_01505
WCO: G7084_02380
WEI: EQG49_04135
EFA: EF2658
EFL: EF62_2819(murM)
EFI: OG1RF_12030(fibA)
EFD: EFD32_2218(murM)
EFS: EFS1_2129
EFN: DENG_02594(murM)
EFQ: DR75_1359
ESS: ATZ33_07540
ERX: ATZ35_16095
MPS: MPTP_1602
MPX: MPD5_0449
VHY: G7082_03765
CIU: G4D55_16050
FSA: C5Q98_07305
EUU: ADJ67_01780
PBQ: C3V37_07730
APR: Apre_0286
AVG: I6H45_04225
AOB: I6H46_07520
EUC: EC1_13930
FRO: AALO17_10780
BULL: JOS54_03215
AMUO: KWG62_09260
ERB: A4V01_18985
GOC: CXX93_07025
AUM: AURMO_00310
LEU: Leucomu_05180
LEB: G7066_09835
LVI: G7068_03835
ART: Arth_0771
ARR: ARUE_c09440
ARM: ART_3681
ARE: AL755_04505
AAQ: AOC05_01375
ARW: MB46_00885
ARU: ASPU41_09360
ARQ: BWQ92_06145
ARN: CGK93_05130
ARTP: E5206_18910
APOA: J0916_01120
AOD: Q8Z05_11825
ARTU: E7Y32_02315
ARTZ: FCN77_04335
ARTC: KY499_08700
ARI: UM93_16200
AAU: AAur_0993
PUE: FV140_05115
SATK: SA2016_1068
CCYC: SCMU_08430
SPUE: AB5L97_04340
SERJ: SGUI_1444
ORN: DV701_14665 DV701_14675
SERW: FY030_01845
AHE: Arch_0164
ARCA: HC352_00785 HC352_02060 HC352_02065 HC352_02070
APHO: JTE88_00775
TPY: CQ11_04900
TPYO: X956_02825
TBW: NCTC13354_00579(femX)
TBER: QPC17_01840
BAST: BAST_1252
GVG: HMPREF0421_20446
GVH: HMPREF9231_1109
RRS: RoseRS_3975
RCA: Rcas_1415
HAU: Haur_0083
SBE: RAAC3_TM7C01G0351
MMA: MM_2112
MMAZ: MmTuc01_2165
MEQ: MSWHS_0743
MSW: MSSIT_3014
MHOR: MSHOH_0633 MSHOH_3235
AG: AAG21689(femX)
 » show all
Reference
PMID:10759563
  Authors
Filipe SR, Tomasz A
  Title
Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes.
  Journal
Proc Natl Acad Sci U S A 97:4891-6 (2000)
DOI:10.1073/pnas.080067697
  Sequence
[spr:spr0540]
LinkDB

KEGG   ENZYME: 2.3.2.10
Entry
EC 2.3.2.10                 Enzyme                                 
Name
UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase;
alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase;
UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase;
uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase;
L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase;
L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
Sysname
L-alanyl-tRNAAla:UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase
Reaction(IUBMB)
L-alanyl-tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine = tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine [RN:R04613]
Reaction(KEGG)
R04613;
(other) R08779
Substrate
L-alanyl-tRNA(Ala) [CPD:C00886];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine
Product
tRNA(Ala) [CPD:C01635];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine
Comment
Also acts on L-seryl-tRNASer.
History
EC 2.3.2.10 created 1972, modified 2013
Pathway
ec00550  Peptidoglycan biosynthesis
Orthology
K05363  serine/alanine adding enzyme
Genes
AMH: I633_14530
AMAA: amad1_14030
AMAD: I636_13635
AMAI: I635_14005
BACO: OXB_0272
GMO: NCTC11323_00057(femB_1)
GSA: FOC50_04790
GHA: NCTC10459_01694(femX)
PLN: Plano_2272 Plano_2278
PKU: AUO94_04290 AUO94_04295 AUO94_04375
PRT: AUC31_15470 AUC31_15485 AUC31_15490 AUC31_15495
PLL: I858_011440 I858_011445 I858_011520
PANA: BBH88_07570 BBH88_07575
PDG: BCM40_03825 BCM40_03870 BCM40_03895
PHC: BBI08_08615 BBI08_08640 BBI08_08685
PPLA: BBI15_07090 BBI15_07095 BBI15_07100 BBI15_07115
PFAE: AJGP001_13170 AJGP001_13250
PLX: CW734_13135 CW734_13140 CW734_13145 CW734_13160
PMAT: BBI11_12575
PDEC: H1Q58_11865
PGQ: FK545_02085 FK545_02090 FK545_02320 FK545_02325
PLAY: DNR44_008505
SPOR: SporoP33_05385
SPOP: SporoP37_05875
SURE: SporoP32a_05895
SPOS: DV702_09585
LLK: LLKF_2319(murM)
LLX: NCDO2118_2181(murM)
LLM: llmg_2352(murM)
LLC: LACR_2372
LLR: llh_12055
LLN: LLNZ_12160
LLI: uc509_2051(murM)
LLW: kw2_2131(murM)
LGR: LCGT_0589
LGV: LCGL_0608
LPET: lgb_00592(femX)
LFO: LMK00_02910
LPK: LACPI_0939
LRN: CMV25_01205
LCAR: BHS00_06325
LPAA: BHS01_06840
SPY: SPy_0616(murM) SPy_1205
SPZ: M5005_Spy0511(murM) M5005_Spy0920
SPYM: M1GAS476_0565(murM) M1GAS476_0975
SPYA: A20_0553c(murM) A20_0956c(murM)
SPM: spyM18_0683(femB) spyM18_1156
SPG: SpyM3_0435(murM.1) SpyM3_0846(murM.2)
SPS: SPs1046 SPs1420
SPH: MGAS10270_Spy0505(murM) MGAS10270_Spy1034
SPI: MGAS10750_Spy0530(murM) MGAS10750_Spy1069
SPJ: MGAS2096_Spy0523(murM) MGAS2096_Spy0979
SPK: MGAS9429_Spy0501(murM) MGAS9429_Spy1022
SPF: SpyM50878(murM) SpyM51352(murM)
SPA: M6_Spy0532 M6_Spy0909
SPB: M28_Spy0490(murM) M28_Spy0892
STG: MGAS15252_0537(murM) MGAS15252_0917
STX: MGAS1882_0534(murM) MGAS1882_0912
SOZ: Spy49_0518c(murM.1) Spy49_0951c(murM2)
STZ: SPYALAB49_000543
SPYH: L897_02755 L897_04550
SPN: SP_0615(fibA)
SPD: SPD_0535(murM_fibA)
SPR: spr0540(murM)
SPW: SPCG_0575(murM)
SJJ: SPJ_0566
SNV: SPNINV200_05420(murM)
SPX: SPG_0558
SNT: SPT_0640
SND: MYY_0664
SPNN: T308_02900
SNE: SPN23F05540(murM)
SPV: SPH_0708
SNC: HMPREF0837_10904
SNM: SP70585_0676
SPP: SPP_0629
SNI: INV104_05130(murM)
SPNG: HMPREF1038_00636
SNB: SP670_0673
SNP: SPAP_0601
SNX: SPNOXC05610(murM)
SNU: SPNA45_01491(murM)
SPNE: SPN034156_16110(murM)
SPNU: SPN034183_05640(murM)
SPNM: SPN994038_05520(murM)
SPNO: SPN994039_05530(murM)
SAG: SAG0509(fibA) SAG0510
SAN: gbs0555 gbs0556
SAK: SAK_0659 SAK_0660
SGC: A964_0540(murM) A964_0541(murM)
SAGS: SaSA20_0494 SaSA20_0495
SAGL: GBS222_0486
SAGM: BSA_5970 BSA_5980
SAGI: MSA_6120 MSA_6130
SAGR: SAIL_6260 SAIL_6280
SAGP: V193_02835
SAGC: DN94_02835
SAGT: GBSCOH1_0492 GBSCOH1_0493
SAGE: EN72_02930 EN72_02935
SAGG: EN73_03005 EN73_03010
SAGN: W903_0686 W903_0687
SAGJ: ID870_06720 ID870_06725
SMU: SMU_717(murM)
SMC: SmuNN2025_1280(murM)
SMUT: SMUGS5_03160
SMJ: SMULJ23_1281(murM)
SMUA: SMUFR_0625(murM)
STC: str1155(murM)
STL: stu1155(murM)
STE: STER_1112
STN: STND_1074
STU: STH8232_1341(murM)
STW: Y1U_C0774
STHE: T303_06625
STHS: AVT04_09070
SSA: SSA_0862(murM)
SSK: SSUD12_0367
SSUI: T15_0381(murM)
SGO: SGO_1623(murM)
SEZ: Sez_1015(murM) Sez_1319(murM)
SEQ: SZO_06490 SZO_09500
SEZO: SeseC_01341 SeseC_01704
SEQU: Q426_02530 Q426_04025
SEU: SEQ_1178 SEQ_1501
SUB: SUB0607(murM)
SDS: SDEG_0637(murM) SDEG_0947
SDG: SDE12394_03425 SDE12394_05320
SDA: GGS_0612(murM) GGS_0917(murM)
SDC: SDSE_0678(murM) SDSE_0983
SDQ: SDSE167_0691(murM) SDSE167_1051
SGA: GALLO_1508
SGG: SGGBAA2069_c15300(murM)
SGT: SGGB_1503(murM)
SMB: smi_1584(fibA)
SGW: D7D53_09215
STOY: STYK_15260(murM)
SOR: SOR_1963(murM)
STK: STP_0096 STP_0414(murM)
STB: SGPB_1404(murM)
SCP: HMPREF0833_10855
SCF: Spaf_1436
SSR: SALIVB_1141(femX)
STF: Ssal_01216(murM)
STJ: SALIVA_0993(murM)
STRS: SSAL8618_04945
SSAH: HSISS4_00840(murM)
STD: SPPN_03240
SMN: SMA_1515
SIF: Sinf_1329
SIE: SCIM_0530(murM)
SIB: SIR_1111(murM)
SIU: SII_1132(murM)
SANG: SAIN_0586(murM)
SANC: SANR_0598(murM)
SANS: DK43_07235
SCG: SCI_0623(murM)
SCON: SCRE_0603(murM)
SCOS: SCR2_0603(murM)
SOI: I872_02755
SIK: K710_0130 K710_1338
SIQ: DQ08_00640 DQ08_06195
SIO: DW64_00640 DW64_06190
SIZ: SI82_00740 SI82_06345
SLU: KE3_1458
SIG: N596_04265
SIP: N597_06110
SPAT: A0O21_02760
STRA: ATM98_03930
SSOB: DK181_03430
SEQI: A6J79_07615
SKI: D7D50_06405
SPEI: EHW89_02750
SRAT: FY406_06920
SPLR: C0J00_06920
SVB: NCTC12167_01073(murM)
SMEN: SAMEA4412692_0952(murM)
SFER: NCTC12278_00174(murM) NCTC12278_01321(femX)
SCAI: NCTC12191_01576(murM) NCTC12191_02000(femX)
SPSU: NCTC13786_00865(murM_1) NCTC13786_00965(murM_2) NCTC13786_01918(murM_3)
SCHJ: DDV21_008035
SPOC: NCTC10925_00256(femX) NCTC10925_00366(murM_1) NCTC10925_01239(murM_2)
SLAT: J4854_07435
SAUP: NCTC3168_01369(murM)
SURN: NCTC13766_01447(murM)
SACO: SAME_01700(murM)
SVF: NCTC3166_01379(murM)
SRUM: GPZ88_01515
SACY: O6R09_06440
SMIE: NCTC11169_00546(murM)
SRUN: LPB404_07195
SPAM: SP4011_16620(fibA)
SDID: N1495_00550 N1495_06555
SZG: J5M87_06430
SDEN: SM121_05235
SLIN: SM123_04005
SNID: AAFQ93_02045 AAFQ93_03695
SSUV: PXH68_02825
FPEN: KIW23_03760 KIW23_06815
LSN: LSA_00260
LROS: LROSL1_1092
OOE: OEOE_1444
OEN: DSM07_03035
OSI: DLJ48_01415
LME: LEUM_1773
LMM: MI1_07685
LMK: LMES_1540
LCI: LCK_01455
LKI: LKI_07255
LEC: LGMK_04890
LCN: C270_01475
LGS: LEGAS_0406
LGE: C269_01960
LLF: BCR17_05370
LGC: A9176_03910
LSU: A6B45_08485
LPSE: FGL85_03835
LKN: FGL74_03335
WKO: WKK_02350
WCE: WS08_1006
WTR: KHQ32_05625
WCT: WS74_1072
WCI: WS105_1068
WCB: AO080_04420 AO080_09985
WJO: FOL01_1588
WPA: CO680_00890
WCF: C6P13_02120
WSO: WSWS_00295 WSWS_01363(murM)
WHE: EFA59_07215
WDI: H9L19_02390
WVR: IE337_01505
WCO: G7084_02380
WEI: EQG49_04135
EFA: EF2658
EFL: EF62_2819(murM)
EFI: OG1RF_12030(fibA)
EFD: EFD32_2218(murM)
EFS: EFS1_2129
EFN: DENG_02594(murM)
EFQ: DR75_1359
ESS: ATZ33_07540
ERX: ATZ35_16095
MPS: MPTP_1602
MPX: MPD5_0449
VHY: G7082_03765
CIU: G4D55_16050
FSA: C5Q98_07305
EUU: ADJ67_01780
PBQ: C3V37_07730
APR: Apre_0286
AVG: I6H45_04225
AOB: I6H46_07520
EUC: EC1_13930
FRO: AALO17_10780
BULL: JOS54_03215
AMUO: KWG62_09260
ERB: A4V01_18985
GOC: CXX93_07025
AUM: AURMO_00310
LEU: Leucomu_05180
LEB: G7066_09835
LVI: G7068_03835
ART: Arth_0771
ARR: ARUE_c09440
ARM: ART_3681
ARE: AL755_04505
AAQ: AOC05_01375
ARW: MB46_00885
ARU: ASPU41_09360
ARQ: BWQ92_06145
ARN: CGK93_05130
ARTP: E5206_18910
APOA: J0916_01120
AOD: Q8Z05_11825
ARTU: E7Y32_02315
ARTZ: FCN77_04335
ARTC: KY499_08700
ARI: UM93_16200
AAU: AAur_0993
PUE: FV140_05115
SATK: SA2016_1068
CCYC: SCMU_08430
SPUE: AB5L97_04340
SERJ: SGUI_1444
ORN: DV701_14665 DV701_14675
SERW: FY030_01845
AHE: Arch_0164
ARCA: HC352_00785 HC352_02060 HC352_02065 HC352_02070
APHO: JTE88_00775
TPY: CQ11_04900
TPYO: X956_02825
TBW: NCTC13354_00579(femX)
TBER: QPC17_01840
BAST: BAST_1252
GVG: HMPREF0421_20446
GVH: HMPREF9231_1109
RRS: RoseRS_3975
RCA: Rcas_1415
HAU: Haur_0083
SBE: RAAC3_TM7C01G0351
MMA: MM_2112
MMAZ: MmTuc01_2165
MEQ: MSWHS_0743
MSW: MSSIT_3014
MHOR: MSHOH_0633 MSHOH_3235
 » show all
Reference
1  [PMID:4248527]
  Authors
Plapp R, Strominger JL
  Title
Biosynthesis of the peptidoglycan of bacterial cell walls. 18. Purification and properties of L-alanyl transfer ribonucleic acid-uridine diphosphate-N-acetylmuramyl-pentapeptide transferase from Lactobacillus viridescens.
  Journal
J Biol Chem 245:3675-82 (1970)
  Sequence
[ag:AAG21689]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.10
IUBMB Enzyme Nomenclature: 2.3.2.10
ExPASy - ENZYME nomenclature database: 2.3.2.10
BRENDA, the Enzyme Database: 2.3.2.10
CAS: 37257-26-4
LinkDB

KEGG   REACTION: R08779
Entry
R08779                      Reaction                               
Name
L-alanyl-tRNA:undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase
Definition
L-Alanyl-tRNA + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> tRNA(Ala) + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
Equation
C00886 + C05893 <=> C01635 + C17550
Reaction class
RC00055  C00886_C01635
RC00096  C05893_C17550
Enzyme
2.3.2.10
Pathway
rn00550  Peptidoglycan biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.10
     R08779  L-Alanyl-tRNA + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> tRNA(Ala) + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
Orthology
K05363  serine/alanine adding enzyme [EC:2.3.2.10]
LinkDB

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