KEGG   ORTHOLOGY: K05363
Entry
K05363                      KO                                     
Symbol
murM
Name
serine/alanine adding enzyme [EC:2.3.2.10]
Pathway
map00550  Peptidoglycan biosynthesis
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    K05363  murM; serine/alanine adding enzyme
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01011 Peptidoglycan biosynthesis and degradation proteins
    K05363  murM; serine/alanine adding enzyme
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.10  UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase
     K05363  murM; serine/alanine adding enzyme
Peptidoglycan biosynthesis and degradation proteins [BR:ko01011]
 Precursor biosynthesis
  Amino acid ligase
   K05363  murM; serine/alanine adding enzyme
Other DBs
RN: R08779
COG: COG2348
GO: 0047206
Genes
AMH: I633_14530
AMAA: amad1_14030
AMAD: I636_13635
AMAI: I635_14005
RSB: RS694_17635
MBRY: B1812_18800
BACO: OXB_0272
GMO: NCTC11323_00057(femB_1)
GSA: FOC50_04790
GHA: NCTC10459_01694(femX)
LLK: LLKF_2319(murM)
LLX: NCDO2118_2181(murM)
LLM: llmg_2352(murM)
LLC: LACR_2372
LLR: llh_12055
LLI: uc509_2051(murM)
LLW: kw2_2131(murM)
LGR: LCGT_0589
LGV: LCGL_0608
LPET: lgb_00592(femX)
SPY: SPy_0616(murM) SPy_1205
SPYA: A20_0553c(murM) A20_0956c(murM)
SPG: SpyM3_0435(murM.1) SpyM3_0846(murM.2)
SPF: SpyM50878(murM) SpyM51352(murM)
SOZ: Spy49_0518c(murM.1) Spy49_0951c(murM2)
SPN: SP_0615(fibA)
SPD: SPD_0535(murM_fibA)
SPR: spr0540(murM)
SPW: SPCG_0575(murM)
SJJ: SPJ_0566
SNV: SPNINV200_05420(murM)
SPX: SPG_0558
SNT: SPT_0640
SND: MYY_0664
SPNN: T308_02900
SNE: SPN23F05540(murM)
SPV: SPH_0708
SPP: SPP_0629
SNI: INV104_05130(murM)
SNP: SPAP_0601
SNX: SPNOXC05610(murM)
SNU: SPNA45_01491(murM)
SPNE: SPN034156_16110(murM)
SPNU: SPN034183_05640(murM)
SPNM: SPN994038_05520(murM)
SPNO: SPN994039_05530(murM)
SAG: SAG0509(fibA) SAG0510
SGC: A964_0540(murM) A964_0541(murM)
SAGP: V193_02835
SAGC: DN94_02835
SMU: SMU_717(murM)
SMC: SmuNN2025_1280(murM)
SMJ: SMULJ23_1281(murM)
SMUA: SMUFR_0625(murM)
STC: str1155(murM)
STL: stu1155(murM)
STE: STER_1112
STN: STND_1074
STU: STH8232_1341(murM)
STW: Y1U_C0774
STHE: T303_06625
SSA: SSA_0862(murM)
SSUI: T15_0381(murM)
SGO: SGO_1623(murM)
SEZ: Sez_1015(murM) Sez_1319(murM)
SUB: SUB0607(murM)
SDS: SDEG_0637(murM) SDEG_0947
SDA: GGS_0612(murM) GGS_0917(murM)
SDC: SDSE_0678(murM) SDSE_0983
SGG: SGGBAA2069_c15300(murM)
SGT: SGGB_1503(murM)
SMB: smi_1584(fibA)
SOR: SOR_1963(murM)
STK: STP_0096 STP_0414(murM)
STB: SGPB_1404(murM)
SCF: Spaf_1436
SSR: SALIVB_1141(femX)
STF: Ssal_01216(murM)
STJ: SALIVA_0993(murM)
SSAH: HSISS4_00840(murM)
SMN: SMA_1515
SIF: Sinf_1329
SIE: SCIM_0530(murM)
SIB: SIR_1111(murM)
SIU: SII_1132(murM)
SANG: SAIN_0586(murM)
SANC: SANR_0598(murM)
SANS: DK43_07235
SCG: SCI_0623(murM)
SCON: SCRE_0603(murM)
SCOS: SCR2_0603(murM)
SLU: KE3_1458
SVB: NCTC12167_01073(murM)
SMEN: SAMEA4412692_0952(murM)
SFER: NCTC12278_00174(murM) NCTC12278_01321(femX)
SCAI: NCTC12191_01576(murM) NCTC12191_02000(femX)
SPSU: NCTC13786_00865(murM_1) NCTC13786_00965(murM_2) NCTC13786_01918(murM_3)
SPOC: NCTC10925_00256(femX) NCTC10925_00366(murM_1) NCTC10925_01239(murM_2)
SAUP: NCTC3168_01369(murM)
SURN: NCTC13766_01447(murM)
SACO: SAME_01700(murM)
SVF: NCTC3166_01379(murM)
LSN: LSA_00260
OOE: OEOE_1444
LME: LEUM_1773
LMM: MI1_07685
LMK: LMES_1540
LCI: LCK_01455
LKI: LKI_07255
WKO: WKK_02350
WCE: WS08_1006
WCT: WS74_1072
EFA: EF2658
EFL: EF62_2819(murM)
EFI: OG1RF_12030(fibA)
EFD: EFD32_2218(murM)
EFS: EFS1_2129
EFN: DENG_02594(murM)
EFQ: DR75_1359
MPS: MPTP_1602
MPX: MPD5_0449
APR: Apre_0286
EUC: EC1_13930
CCYC: SCMU_08430
ART: Arth_0771
ARM: ART_3681
AAGI: NCTC2676_1_00491(femX_1)
AAU: AAur_0993
JDE: Jden_1393
SERJ: SGUI_1444
AHE: Arch_0164
TPYO: X956_02825
TBW: NCTC13354_00579(femX)
BAST: BAST_1252
RCA: Rcas_1415
HAU: Haur_0083
MBAS: ALGA_4324
IAL: IALB_2475
SAAL: L336_0183
WBA: UR17_C0001G0243(femAB)
MMA: MM_2112
AG: AAG21689(femX)
 » show all
Reference
  Authors
Filipe SR, Tomasz A
  Title
Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes.
  Journal
Proc Natl Acad Sci U S A 97:4891-6 (2000)
DOI:10.1073/pnas.080067697
  Sequence
[spr:spr0540]
LinkDB

KEGG   ENZYME: 2.3.2.10
Entry
EC 2.3.2.10                 Enzyme                                 
Name
UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase;
alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase;
UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase;
uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase;
L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase;
L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
Sysname
L-alanyl-tRNAAla:UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase
Reaction(IUBMB)
L-alanyl-tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine = tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine [RN:R04613]
Reaction(KEGG)
R04613;
(other) R08779
Substrate
L-alanyl-tRNA(Ala) [CPD:C00886];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine
Product
tRNA(Ala) [CPD:C01635];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine
Comment
Also acts on L-seryl-tRNASer.
History
EC 2.3.2.10 created 1972, modified 2013
Pathway
ec00550  Peptidoglycan biosynthesis
Orthology
K05363  serine/alanine adding enzyme
Genes
AMHI633_14530
AMAAamad1_14030
AMADI636_13635
AMAII635_14005
RSBRS694_17635
MBRYB1812_18800
BACOOXB_0272
GMONCTC11323_00057(femB_1)
GSAFOC50_04790
GHANCTC10459_01694(femX)
PLNPlano_2272 Plano_2278
PKUAUO94_04290 AUO94_04295 AUO94_04375
PRTAUC31_15470 AUC31_15485 AUC31_15490 AUC31_15495
PLLI858_011440 I858_011445 I858_011520
PANABBH88_07570 BBH88_07575
PDGBCM40_03825 BCM40_03870 BCM40_03895
PHCBBI08_08615 BBI08_08640 BBI08_08685
PPLABBI15_07090 BBI15_07095 BBI15_07100 BBI15_07115
PFAEAJGP001_13170 AJGP001_13250
PLXCW734_13135 CW734_13140 CW734_13145 CW734_13160
PMATBBI11_12575
PDECH1Q58_11865
PGQFK545_02085 FK545_02090 FK545_02320 FK545_02325
SPORSporoP33_05385
SPOPSporoP37_05875
SURESporoP32a_05895
SPOSDV702_09585
PLAYDNR44_008505
LLKLLKF_2319(murM)
LLXNCDO2118_2181(murM)
LLMllmg_2352(murM)
LLCLACR_2372
LLRllh_12055
LLNLLNZ_12160
LLIuc509_2051(murM)
LLWkw2_2131(murM)
LGRLCGT_0589
LGVLCGL_0608
LPKLACPI_0939
LRNCMV25_01205
LCARBHS00_06325
LPAABHS01_06840
LPETlgb_00592(femX)
SPYSPy_0616(murM) SPy_1205
SPZM5005_Spy0511(murM) M5005_Spy0920
SPYMM1GAS476_0565(murM) M1GAS476_0975
SPYAA20_0553c(murM) A20_0956c(murM)
SPMspyM18_0683(femB) spyM18_1156
SPGSpyM3_0435(murM.1) SpyM3_0846(murM.2)
SPSSPs1046 SPs1420
SPHMGAS10270_Spy0505(murM) MGAS10270_Spy1034
SPIMGAS10750_Spy0530(murM) MGAS10750_Spy1069
SPJMGAS2096_Spy0523(murM) MGAS2096_Spy0979
SPKMGAS9429_Spy0501(murM) MGAS9429_Spy1022
SPFSpyM50878(murM) SpyM51352(murM)
SPAM6_Spy0532 M6_Spy0909
SPBM28_Spy0490(murM) M28_Spy0892
STGMGAS15252_0537(murM) MGAS15252_0917
STXMGAS1882_0534(murM) MGAS1882_0912
SOZSpy49_0518c(murM.1) Spy49_0951c(murM2)
STZSPYALAB49_000543
SPYHL897_02755 L897_04550
SPNSP_0615(fibA)
SPDSPD_0535(murM_fibA)
SPRspr0540(murM)
SPWSPCG_0575(murM)
SJJSPJ_0566
SNVSPNINV200_05420(murM)
SPXSPG_0558
SNTSPT_0640
SNDMYY_0664
SPNNT308_02900
SNESPN23F05540(murM)
SPVSPH_0708
SNCHMPREF0837_10904
SNMSP70585_0676
SPPSPP_0629
SNIINV104_05130(murM)
SPNGHMPREF1038_00636
SNBSP670_0673
SNPSPAP_0601
SNXSPNOXC05610(murM)
SNUSPNA45_01491(murM)
SPNESPN034156_16110(murM)
SPNUSPN034183_05640(murM)
SPNMSPN994038_05520(murM)
SPNOSPN994039_05530(murM)
SAGSAG0509(fibA) SAG0510
SANgbs0555 gbs0556
SAKSAK_0659 SAK_0660
SGCA964_0540(murM) A964_0541(murM)
SAGSSaSA20_0494 SaSA20_0495
SAGLGBS222_0486
SAGMBSA_5970 BSA_5980
SAGIMSA_6120 MSA_6130
SAGRSAIL_6260 SAIL_6280
SAGPV193_02835
SAGCDN94_02835
SAGTGBSCOH1_0492 GBSCOH1_0493
SAGEEN72_02930 EN72_02935
SAGGEN73_03005 EN73_03010
SAGNW903_0686 W903_0687
SMUSMU_717(murM)
SMCSmuNN2025_1280(murM)
SMUTSMUGS5_03160
SMJSMULJ23_1281(murM)
SMUASMUFR_0625(murM)
STCstr1155(murM)
STLstu1155(murM)
STESTER_1112
STNSTND_1074
STUSTH8232_1341(murM)
STWY1U_C0774
STHET303_06625
STHSAVT04_09070
SSASSA_0862(murM)
SSKSSUD12_0367
SSUIT15_0381(murM)
SGOSGO_1623(murM)
SEZSez_1015(murM) Sez_1319(murM)
SEQSZO_06490 SZO_09500
SEZOSeseC_01341 SeseC_01704
SEQUQ426_02530 Q426_04025
SEUSEQ_1178 SEQ_1501
SUBSUB0607(murM)
SDSSDEG_0637(murM) SDEG_0947
SDGSDE12394_03425 SDE12394_05320
SDAGGS_0612(murM) GGS_0917(murM)
SDCSDSE_0678(murM) SDSE_0983
SDQSDSE167_0691(murM) SDSE167_1051
SGAGALLO_1508
SGGSGGBAA2069_c15300(murM)
SGTSGGB_1503(murM)
SMBsmi_1584(fibA)
SORSOR_1963(murM)
STKSTP_0096 STP_0414(murM)
STBSGPB_1404(murM)
SCPHMPREF0833_10855
SCFSpaf_1436
SSRSALIVB_1141(femX)
STFSsal_01216(murM)
STJSALIVA_0993(murM)
STRSSSAL8618_04945
SSAHHSISS4_00840(murM)
STDSPPN_03240
SMNSMA_1515
SIFSinf_1329
SIESCIM_0530(murM)
SIBSIR_1111(murM)
SIUSII_1132(murM)
SANGSAIN_0586(murM)
SANCSANR_0598(murM)
SANSDK43_07235
SCGSCI_0623(murM)
SCONSCRE_0603(murM)
SCOSSCR2_0603(murM)
SOII872_02755
SIKK710_0130 K710_1338
SIQDQ08_00640 DQ08_06195
SIODW64_00640 DW64_06190
SIZSI82_00740 SI82_06345
SLUKE3_1458
SIGN596_04265
SIPN597_06110
SPATA0O21_02760
STRAATM98_03930
SSOBDK181_03430
SEQIA6J79_07615
SKID7D50_06405
SPEIEHW89_02750
SRATFY406_06920
SGWD7D53_09215
SPLRC0J00_06920
SVBNCTC12167_01073(murM)
SMENSAMEA4412692_0952(murM)
SFERNCTC12278_00174(murM) NCTC12278_01321(femX)
SCAINCTC12191_01576(murM) NCTC12191_02000(femX)
SPSUNCTC13786_00865(murM_1) NCTC13786_00965(murM_2) NCTC13786_01918(murM_3)
SCHJDDV21_008035
SPOCNCTC10925_00256(femX) NCTC10925_00366(murM_1) NCTC10925_01239(murM_2)
SLATJ4854_07435
SAUPNCTC3168_01369(murM)
SURNNCTC13766_01447(murM)
SACOSAME_01700(murM)
SVFNCTC3166_01379(murM)
FPENKIW23_03760 KIW23_06815
LSNLSA_00260
LROSLROSL1_1092
OOEOEOE_1444
OENDSM07_03035
OSIDLJ48_01415
LMELEUM_1773
LMMMI1_07685
LMKLMES_1540
LCILCK_01455
LKILKI_07255
LECLGMK_04890
LCNC270_01475
LGSLEGAS_0406
LGEC269_01960
LLFBCR17_05370
LGCA9176_03910
LSUA6B45_08485
LPSEFGL85_03835
WKOWKK_02350
WCEWS08_1006
WCTWS74_1072
WCIWS105_1068
WCBAO080_04420 AO080_09985
WJOFOL01_1588
WPACO680_00890
WCFC6P13_02120
WSOWSWS_00295 WSWS_01363(murM)
WHEEFA59_07215
WDIH9L19_02390
WVRIE337_01505
WCOG7084_02380
WEIEQG49_04135
EFAEF2658
EFLEF62_2819(murM)
EFIOG1RF_12030(fibA)
EFDEFD32_2218(murM)
EFSEFS1_2129
EFNDENG_02594(murM)
EFQDR75_1359
ESSATZ33_07540
MPSMPTP_1602
MPXMPD5_0449
VHYG7082_03765
FSAC5Q98_07305
PBQC3V37_07730
EUUADJ67_01780
APRApre_0286
AVGI6H45_04225
AOBI6H46_07520
EUCEC1_13930
FROAALO17_10780
CIUG4D55_16050
BULLJOS54_03215
AMUOKWG62_09260
ERBA4V01_18985
CCYCSCMU_08430
GOCCXX93_07025
AUMAURMO_00310 AURMO_01777
LEULeucomu_05180
LEBG7066_02915 G7066_09835
LVIG7068_03835
AGGC1N71_10935
ARTArth_0771
ARRARUE_c09440
ARMART_3681
AREAL755_04505
AAQAOC05_01375
ARWMB46_00885
ARUASPU41_09360
ARQBWQ92_06145
ARNCGK93_05130
ARTHC3B78_03720
ARTPE5206_18910
AAGINCTC2676_1_00491(femX_1)
ARIUM93_16200
AAUAAur_0993
PUEFV140_05115
PSULAU252_06305
PSEYGU243_20260
KIIKocCE7_09855
KODHBK84_09800
SATKSA2016_1068
JDEJden_1393
XYLET495_05710
SERJSGUI_1444
SERWFY030_01845
ORNDV701_14665 DV701_14675
AHEArch_0164
ARCAHC352_00785 HC352_02060 HC352_02065 HC352_02070
APHOJTE88_00775
TPYCQ11_04900
TPYOX956_02825
TBWNCTC13354_00579(femX)
BASTBAST_1252
GVGHMPREF0421_20446
GVHHMPREF9231_1109
RRSRoseRS_3975
RCARcas_1415
HAUHaur_0083
ROLCA51_29440
MBASALGA_4324
RUNDR864_23705
IALIALB_2475
SAALL336_0183
SBERAAC3_TM7C01G0351
WBAUR17_C0001G0243(femAB)
MMAMM_2112
MMAZMmTuc01_2165
MEQMSWHS_0743
MSWMSSIT_3014
MHORMSHOH_0633 MSHOH_3235
 » show all
Reference
1  [PMID:4248527]
  Authors
Plapp R, Strominger JL
  Title
Biosynthesis of the peptidoglycan of bacterial cell walls. 18. Purification and properties of L-alanyl transfer ribonucleic acid-uridine diphosphate-N-acetylmuramyl-pentapeptide transferase from Lactobacillus viridescens.
  Journal
J Biol Chem 245:3675-82 (1970)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.10
IUBMB Enzyme Nomenclature: 2.3.2.10
ExPASy - ENZYME nomenclature database: 2.3.2.10
BRENDA, the Enzyme Database: 2.3.2.10
CAS: 37257-26-4
LinkDB

KEGG   REACTION: R08779
Entry
R08779                      Reaction                               
Name
L-alanyl-tRNA:undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase
Definition
L-Alanyl-tRNA + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <=> tRNA(Ala) + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
Equation
Reaction class
RC00055  C00886_C01635
RC00096  C05893_C17550
Enzyme
Pathway
rn00550  Peptidoglycan biosynthesis
rn01100  Metabolic pathways
Orthology
K05363  serine/alanine adding enzyme [EC:2.3.2.10]
LinkDB

DBGET integrated database retrieval system