KEGG ORTHOLOGY: K05611

ORTHOLOGY: K05611

Entry

K05611                      KO

Symbol

UCHL1

Name

ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12]

Pathway

map05012

Parkinson disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00057

Parkinson disease

H00266

Hereditary spastic paraplegia

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
   05022 Pathways of neurodegeneration - multiple diseases
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C12: ubiquitin C-terminal hydrolase family
   K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1
Ubiquitin system [BR:ko04121]
Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UCH
    K05611  UCHL1; ubiquitin carboxyl-terminal hydrolase L1

Other DBs

GO:

0004843

Genes

HSA:	7345(UCHL1)

PTR:	461185(UCHL1)

PPS:	100978798(UCHL1)

GGO:	101150793(UCHL1)

PON:	100440914(UCHL1)

PPYG:

129035443(UCHL1)

NLE:	100588568(UCHL1)

HMH:	116456565(UCHL1)

SSYN:

129464933(UCHL1)

MCC:	701579(UCHL1)

MCF:	102133043(UCHL1)

MTHB:

126954454

MNI:	105487716(UCHL1)

CSAB:

103246177(UCHL1)

CATY:

105584822(UCHL1)

PANU:

101014623(UCHL1)

TGE:	112624447(UCHL1)

MLEU:

105545175(UCHL1)

RRO:	104679224(UCHL1)

RBB:	108516888(UCHL1)

TFN:	117085311(UCHL1)

PTEH:

111550901(UCHL1)

CANG:

105516763(UCHL1)

CJC:	100409098(UCHL1)

SBQ:	101052104(UCHL1)

CIMI:

108290144(UCHL1)

ANAN:

105732748(UCHL1) 135268904

CSYR:

103275631(UCHL1)

MMUR:

105872232(UCHL1)

LCAT:

123624121(UCHL1)

PCOQ:

105813709(UCHL1) 105814707

OGA:	100943608(UCHL1)

MMU:	22223(Uchl1)

MCAL:

110294542(Uchl1)

MPAH:

110330551(Uchl1)

RNO:	29545(Uchl1)

MCOC:

116071098(Uchl1)

ANU:	117713035(Uchl1)

MUN:	110547740(Uchl1)

CGE:	100766373(Uchl1)

MAUA:

101824441(Uchl1)

PROB:

127232273(Uchl1)

PLEU:

114702031(Uchl1)

MORG:

121460939(Uchl1)

MFOT:

126506440

AAMP:

119800351(Uchl1)

NGI:	103729235(Uchl1)

HGL:	101702892(Uchl1)

CPOC:

100714582(Uchl1)

CCAN:

109690785(Uchl1)

DORD:

105980218(Uchl1)

DSP:	122106691(Uchl1)

PLOP:

125364579(Uchl1)

NCAR:

124994651

MMMA:

107139207(Uchl1)

OCU:

100357806

OPI:	101517628(UCHL1)

TUP:	102478017(UCHL1)

GVR:	103587125(UCHL1)

CFA:	479098(UCHL1)

CLUD:

112653500(UCHL1)

VVP:	112919659(UCHL1) 112924918

VLG:	121471571 121487267 121488669(UCHL1)

NPO:	129510393(UCHL1)

AML:	100484886(UCHL1)

UMR:	103672780(UCHL1)

UAH:	113262438(UCHL1)

UAR:	123804046(UCHL1)

ELK:

111148969

LLV:	125080796 125093667

MPUF:

101671160(UCHL1)

MNP:	132005650(UCHL1)

MLK:	131824616(UCHL1)

NVS:	122890205(UCHL1)

ORO:	101379197(UCHL1)

EJU:	114197558(UCHL1)

ZCA:	113924700(UCHL1) 113935072

MLX:	118010580(UCHL1)

NSU:	110590867(UCHL1)

LWW:	102739984(UCHL1)

FCA:	101093604(UCHL1)

PYU:	121036500(UCHL1)

PCOO:

112858138(UCHL1)

PBG:	122478948(UCHL1)

PVIV:

125164956(UCHL1)

LRUF:

124520675

PTG:	102949487(UCHL1)

PPAD:

109245853(UCHL1)

AJU:

106977844

HHV:	120228550(UCHL1) 120232264

BTA:	514394(UCHL1)

BOM:	102282378(UCHL1)

BIU:	109560420(UCHL1)

BBUB:

102414729(UCHL1)

BBIS:

105002305(UCHL1)

CHX:	102178714(UCHL1)

OAS:	101117250(UCHL1)

BTAX:

128049637(UCHL1)

ODA:	120862070(UCHL1)

CCAD:

122422247(UCHL1)

MBEZ:

129562074(UCHL1)

SSC:	396637(UCHL1)

CFR:	102514352(UCHL1)

CBAI:

105074936(UCHL1)

CDK:	105089356(UCHL1)

VPC:	102545316(UCHL1)

BACU:

103007566(UCHL1)

BMUS:

118896027(UCHL1) 118901744

LVE:	103069363(UCHL1)

OOR:	101283487(UCHL1)

DLE:	111170307(UCHL1)

PCAD:

102992459(UCHL1)

PSIU:

116754378(UCHL1)

NASI:

112390666(UCHL1)

ECB:	100033838(UCHL1)

EPZ:	103566718(UCHL1)

EAI:	106841278(UCHL1)

MYB:	102262310(UCHL1)

MYD:	102769091(UCHL1)

MMYO:

118668091(UCHL1)

MLF:	102438806(UCHL1)

MDT:	132219889(UCHL1)

PKL:	118707451(UCHL1)

EFUS:

103284927(UCHL1)

MNA:	107532405(UCHL1)

DRO:	112316770(UCHL1)

SHON:

118999616(UCHL1)

AJM:	119043898(UCHL1)

PDIC:

114492393(UCHL1)

PHAS:

123815802(UCHL1)

MMF:	118617787 118622804 118638061(UCHL1)

PPAM:

129077648(UCHL1)

HAI:	109381761(UCHL1)

RFQ:	117021900(UCHL1)

PALE:

102881932(UCHL1)

PGIG:

120588005(UCHL1)

PVP:	105293880(UCHL1)

RAY:	107518760(UCHL1)

MJV:	108391552(UCHL1)

TOD:	119261064(UCHL1)

SARA:

101555197(UCHL1)

LAV:	100662483(UCHL1)

TMU:

101353430

ETF:	101659726(UCHL1) 101660477

DNM:	101432163(UCHL1)

MDO:	100015629(UCHL1)

GAS:	123251973(UCHL1)

SHR:	100918150(UCHL1)

AFZ:

127539985

PCW:	110211607(UCHL1)

TVP:	118853784(UCHL1)

OAA:	114815493(UCHL1)

GGA:	770302(UCHL1)

PCOC:

116225875(UCHL1)

MGP:	100549618(UCHL1)

CJO:	107313792(UCHL1)

TPAI:

128080409(UCHL1)

LMUT:

125692456(UCHL1)

NMEL:

110399164(UCHL1)

APLA:

101799480(UCHL1)

ACYG:

106048055(UCHL1)

CATA:

118251422(UCHL1)

AFUL:

116488722(UCHL1)

TGU:	751589(UCHL1)

LSR:	110475493(UCHL1)

SCAN:

103826167(UCHL1)

PMOA:

120497489(UCHL1)

OTC:	121335027(UCHL1)

PRUF:

121349072(UCHL1)

GFR:	102037972(UCHL1)

FAB:	101809666(UCHL1)

OMA:	130252806(UCHL1)

PHI:	102104928(UCHL1)

PMAJ:

107202745(UCHL1)

CCAE:

111945483(UCHL1)

CCW:	104690880(UCHL1)

CBRC:

103622526(UCHL1)

ETL:	114061161(UCHL1)

ZAB:	102063491(UCHL1)

ZLE:	135446494(UCHL1)

ACHL:

103799291

SVG:	106850055(UCHL1)

MMEA:

130576832(UCHL1)

HRT:	120752634(UCHL1)

SATI:

136360104(UCHL1)

FPG:	101924718(UCHL1)

FCH:	102047483(UCHL1)

CCRI:

104158059(UCHL1)

NNT:	104413876(UCHL1)

SHAB:

115611005(UCHL1)

ACUN:

113479207(UCHL1)

TALA:

104356523(UCHL1)

ACHC:

115350810(UCHL1)

HALD:

104311349(UCHL1)

HLE:	104836149(UCHL1)

AGEN:

126036316

GCL:

127015652

CSTI:

104551127(UCHL1)

LDI:	104341650(UCHL1)

MNB:	103771974(UCHL1)

DPUB:

104309417(UCHL1)

AVIT:

104269296(UCHL1)

BRHI:

104496597(UCHL1)

EGZ:	104128491(UCHL1)

NNI:	104020796(UCHL1)

PCRI:

104026130(UCHL1)

PCAO:

104050886(UCHL1)

PADL:

103924019(UCHL1)

AFOR:

103899655(UCHL1)

FGA:	104072964(UCHL1)

GSTE:

104251888(UCHL1)

CLV:	102083724(UCHL1)

MUI:	104546217(UCHL1)

PGUU:

104463311(UCHL1)

PLET:

104619740(UCHL1)

EHS:	104516140(UCHL1)

CMAC:

104474598(UCHL1)

CUCA:

104064278(UCHL1)

TEO:	104383667(UCHL1)

BREG:

104637862(UCHL1)

OHA:	104330346(UCHL1)

ACAR:

104524496(UCHL1)

CPEA:

104396317(UCHL1)

CVF:	104286412(UCHL1)

RTD:	128909927(UCHL1)

AAM:	106490166(UCHL1)

AROW:

112971786(UCHL1)

NPD:	112945850(UCHL1)

TGT:	104567040(UCHL1)

DNE:	112979509(UCHL1)

SCAM:

104143129(UCHL1)

ASN:	102372366(UCHL1)

AMJ:	102576186(UCHL1)

CPOO:

109322324(UCHL1)

GGN:	109304068(UCHL1)

PSS:	102451446(UCHL1)

CMY:	102945907(UCHL1)

CCAY:

125635988(UCHL1)

DCC:	119855289(UCHL1)

CPIC:

101941582(UCHL1)

TST:	117877715(UCHL1)

CABI:

116822775(UCHL1)

MRV:	120407113(UCHL1)

ACS:	100561831(uchl1)

ASAO:

132776607(UCHL1)

PVT:	110075251(UCHL1)

SUND:

121932056(UCHL1)

PBI:	103058291(UCHL1)

PMUR:

107283769 107294562

CTIG:

120299926(UCHL1)

PGUT:

117669963(UCHL1)

APRI:

131203515(UCHL1)

PTEX:

113435775(UCHL1)

NSS:	113417131(UCHL1)

VKO:	123017060(UCHL1)

PMUA:

114604170(UCHL1)

PRAF:

128421022(UCHL1)

ZVI:	118083659(UCHL1)

HCG:	128327863(UCHL1) 128339245

GJA:	107118479(UCHL1)

STOW:

125440290(UCHL1)

EMC:	129336835(UCHL1)

XLA:	108698136(uchl1.L) 735204(uchl1.S)

XTR:	496780(uchl1)

NPR:	108790863 108793718(UCHL1)

RTEM:

120923934(UCHL1) 120930242

BBUF:

120991779(UCHL1)

BGAR:

122935899(UCHL1)

MUO:	115462628(UCHL1)

GSH:	117361473(UCHL1)

DRE:	325119(uchl1)

SRX:	107709457 107750438

SANH:

107701450 107702299(uchl1)

SGH:	107548360 107562608

CCAR:

109049970 109071129 109092917

CAUA:

113044254 113107027 113107493

CGIB:

127948443 127958107

PTET:

122348488(uchl1)

LROH:

127172233(uchl1)

OMC:	131545610(uchl1)

PPRM:

120494116(uchl1)

RKG:	130089565(uchl1)

MAMB:

125272644(uchl1)

CIDE:

127519893

CERY:

137032075(uchl1)

MASI:

127443652 127444552

TROS:

130552714(uchl1)

TDW:	130407932(uchl1)

MANU:

129444677(uchl1)

IPU:

108260831

IFU:	128604461(uchl1)

PHYP:

113544228(uchl1)

SMEO:

124381148(uchl1)

TFD:	113660648(uchl1)

TVC:	132860836(uchl1)

TRN:	134326675(uchl1)

AMEX:

103023920(uchl1)

CMAO:

118816578(uchl1)

EEE:	113587695(uchl1)

CHAR:

105908418(uchl1)

TRU:	101069774(uchl1)

TFS:	130528004(uchl1)

TNG:	GSTEN00007218G001

LCO:	104934202(uchl1)

NCC:	104942986(uchl1)

TBEN:

117482332(uchl1)

CGOB:

115008129(uchl1)

PGEO:

117453804(uchl1)

GACU:

117556065(uchl1)

EMAC:

134864387(uchl1)

ELY:	117254634(uchl1)

EFO:	125885594(uchl1)

PLEP:

121942185(uchl1)

SLUC:

116034357(uchl1)

ECRA:

117935004(uchl1)

ESP:	116697966(uchl1)

PFLV:

114568703(uchl1)

GAT:	120825247(uchl1)

PPUG:

119218594(uchl1)

AFB:	129095961(uchl1)

CLUM:

117738852(uchl1)

PSWI:

130190085(uchl1)

MSAM:

119898828(uchl1)

SCHU:

122873648(uchl1)

CUD:	121507886(uchl1)

ALAT:

119027695(uchl1)

MZE:	101482896(uchl1)

ONL:	100534475(uchl1)

OAU:	116333710(uchl1)

OLA:	101155828(uchl1)

OML:	112137595(uchl1)

CSAI:

133451624(uchl1)

XMA:	102233947(uchl1)

XCO:	114145390(uchl1)

XHE:	116719902(uchl1)

PRET:

103459450(uchl1)

PFOR:

103136402(uchl1)

PLAI:

106964576(uchl1)

PMEI:

106904352(uchl1)

GAF:	122830403(uchl1)

PPRL:

129376955(uchl1)

CVG:	107090463(uchl1)

CTUL:

119774324(uchl1)

GMU:	124867843(uchl1)

NFU:

107395703

KMR:	108231227(uchl1)

ALIM:

106526179(uchl1)

NWH:	119423077(uchl1)

AOCE:

111583015(uchl1)

MCEP:

125004534(uchl1)

CSEM:

103383638(uchl1)

POV:	109638250(uchl1)

SSEN:

122770999(uchl1)

HHIP:

117771020(uchl1)

HSP:	118121229(uchl1)

PPLT:

128429714(uchl1)

SMAU:

118312615(uchl1)

LCF:

108893111

SDU:	111216625(uchl1)

SLAL:

111657345(uchl1)

XGL:	120799679(uchl1)

HCQ:	109511321(uchl1)

SSCV:

125968418

SBIA:

133506037(uchl1)

PEE:	133404022(uchl1)

PTAO:

133476709(uchl1)

BPEC:

110167608(uchl1)

MALB:

109955542(uchl1)

BSPL:

114853064(uchl1)

SJO:	128371661(uchl1)

SASA:

100196868(uchl1)

STRU:

115182783 115182785

OTW:

112240461

OMY:	110511064(uchl1) 118947011

OGO:	124020268 124021170

OKI:	109879252 116372964

OKE:	118396177 127918880 127920033

SNH:	120037631 120039268

CCLU:

121560666 123488665

ELS:	105007816(uchl1)

SFM:	108924328(uchl1) 108930794

PKI:	111833704 111853044(uchl1)

AANG:

118227775 118231308

LOC:	102690328(uchl1)

PSPA:

121324095 121329503

ARUT:

117408372 117420535

PSEX:

120527672(uchl1)

LCM:	102365585(UCHL1)

CMK:	103175870(uchl1)

RTP:	109929852(uchl1)

CPLA:

122550898(uchl1)

HOC:	132819557(uchl1)

LERI:

129698151(uchl1)

LRJ:

133339580

CPV:

cgd8_3200

CHO:	Chro.80372

» show all

Reference

PMID:12408865

Authors

Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr

Title

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.

Journal

Cell 111:209-18 (2002)
DOI:10.1016/S0092-8674(02)01012-7

Sequence

[hsa:7345]

Reference

PMID:2163617

Authors

Day IN, Hinks LJ, Thompson RJ

Title

The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase.

Journal

Biochem J 268:521-4 (1990)
DOI:10.1042/bj2680521

Sequence

[hsa:7345]

LinkDB

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