KEGG ORTHOLOGY: K05745

ORTHOLOGY: K05745

Entry

K05745                      KO

Symbol

DIAPH3, DRF3

Name

diaphanous 3

Pathway

map04810

Regulation of actin cytoskeleton

map04820

Cytoskeleton in muscle cells

Disease

H02339

Auditory neuropathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04820 Cytoskeleton in muscle cells
    K05745  DIAPH3, DRF3; diaphanous 3
   04810 Regulation of actin cytoskeleton
    K05745  DIAPH3, DRF3; diaphanous 3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K05745  DIAPH3, DRF3; diaphanous 3
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Formins
     K05745  DIAPH3, DRF3; diaphanous 3

Genes

HSA:	81624(DIAPH3)

PTR:	452752(DIAPH3)

PPS:	100989070(DIAPH3)

GGO:	101144182(DIAPH3)

PON:	100174272(DIAPH3)

PPYG:

129011597(DIAPH3)

NLE:	100605042(DIAPH3)

HMH:	116467328(DIAPH3)

SSYN:

129463541(DIAPH3)

MCC:	695990(DIAPH3)

MCF:	101867517(DIAPH3)

MTHB:

126940555

MNI:	105485577(DIAPH3)

CSAB:

103214511(DIAPH3)

CATY:

105587361(DIAPH3)

PANU:

101019959(DIAPH3)

TGE:	112611023(DIAPH3)

MLEU:

105547338(DIAPH3)

RRO:	104666498(DIAPH3)

RBB:	108542482(DIAPH3)

TFN:	117063720(DIAPH3)

PTEH:

111529324(DIAPH3)

CANG:

105512717(DIAPH3)

CJC:	100411113(DIAPH3)

SBQ:	101035360(DIAPH3)

CIMI:

108311368(DIAPH3)

ANAN:

105727117

CSYR:

103261692(DIAPH3)

MMUR:

105863051(DIAPH3)

LCAT:

123648907(DIAPH3)

PCOQ:

105818829(DIAPH3)

OGA:	100959122(DIAPH3)

MMU:	56419(Diaph3)

MCAL:

110309434(Diaph3)

MPAH:

110325031(Diaph3)

RNO:	290396(Diaph3)

MCOC:

116084471(Diaph3)

ANU:	117705879(Diaph3)

ASYL:

127691235(Diaph3)

MUN:	110566932(Diaph3)

CGE:	100772633(Diaph3)

MAUA:

101825735(Diaph3)

PROB:

127230142(Diaph3)

PLEU:

114699723(Diaph3)

MORG:

121458429(Diaph3)

MFOT:

126511989

AAMP:

119800173(Diaph3)

NGI:	103725611(Diaph3)

HGL:	101709465(Diaph3)

CPOC:

100733267(Diaph3)

CCAN:

109682369

DORD:

105981686(Diaph3)

DSP:	122112863(Diaph3)

PLOP:

125348220(Diaph3)

NCAR:

124984916

MMMA:

107142573(Diaph3)

ITI:	101973679(Diaph3)

OCU:

100344823

OPI:	101528194(DIAPH3)

TUP:	102470921(DIAPH3)

GVR:	103610543(DIAPH3)

CFA:	485474(DIAPH3)

CLUD:

112678793(DIAPH3)

VVP:	112928075(DIAPH3)

VLG:	121476995(DIAPH3)

NPO:	129516681(DIAPH3)

AML:	100475459(DIAPH3)

UMR:	103677666(DIAPH3)

UAH:	113251398(DIAPH3)

UAR:	123801086(DIAPH3)

ELK:

111146997

LLV:

125094672

MPUF:

101676288(DIAPH3)

MNP:	132002527(DIAPH3)

MLK:	131813743(DIAPH3)

NVS:	122907135(DIAPH3)

ORO:	101385345(DIAPH3)

EJU:	114211148(DIAPH3)

ZCA:	113920931(DIAPH3)

MLX:	118009353(DIAPH3)

NSU:	110587604(DIAPH3)

LWW:	102737507(DIAPH3)

FCA:	101095543(DIAPH3)

PYU:	121037877(DIAPH3)

PCOO:

112860280(DIAPH3)

PBG:	122483300(DIAPH3)

PVIV:

125172814(DIAPH3)

LRUF:

124512885

LGF:	123598315(DIAPH3)

AJU:

106974520

PTG:	102960808(DIAPH3)

PPAD:

109247149(DIAPH3)

PUC:

125933838

PLEZ:

122213307(DIAPH3)

HHV:	120241900(DIAPH3)

BTA:	525628(DIAPH3)

BOM:	102266973(DIAPH3)

BIU:	109566663(DIAPH3)

BBUB:

102391982(DIAPH3)

BBIS:

104998601(DIAPH3)

CHX:	102168917(DIAPH3)

OAS:	101105168(DIAPH3)

BTAX:

128057559(DIAPH3)

CSUM:

138088987(DIAPH3)

ODA:	120883153(DIAPH3)

CCAD:

122447524(DIAPH3)

MREE:

136144164(DIAPH3)

OVR:	110137536(DIAPH3)

MBEZ:

129556209(DIAPH3)

SSC:	100737986(DIAPH3)

CFR:	102508133(DIAPH3)

CBAI:

105083453(DIAPH3)

CDK:	105086641(DIAPH3)

VPC:	102535564(DIAPH3)

BMUS:

118884305(DIAPH3)

LVE:

103071630

OOR:	101277713(DIAPH3)

LALB:

132508558(DIAPH3)

DLE:	111167859(DIAPH3)

PCAD:

102990952(DIAPH3)

PSIU:

116743205(DIAPH3)

PPHC:

136137794(DIAPH3)

NASI:

112414652(DIAPH3)

ECB:	100051814(DIAPH3)

EPZ:	103551341(DIAPH3)

EAI:	106834142(DIAPH3)

MYB:	102260421(DIAPH3)

MYD:	102768119(DIAPH3)

MMYO:

118650929(DIAPH3)

MLF:	102435332(DIAPH3)

MDT:	132228422(DIAPH3)

MYUM:

139006591(DIAPH3)

PKL:	118729304(DIAPH3)

EFUS:

103289633(DIAPH3)

MNA:	107545203(DIAPH3)

DRO:	112310979(DIAPH3)

SHON:

118981844(DIAPH3)

AJM:	119038267(DIAPH3)

PDIC:

114508754(DIAPH3)

PHAS:

123818893(DIAPH3)

MMF:	118622524(DIAPH3)

PPAM:

129080902(DIAPH3)

HAI:	109389936(DIAPH3)

RFQ:	117021776(DIAPH3)

PALE:

102893093(DIAPH3)

PGIG:

120614359(DIAPH3)

PVP:	105306123(DIAPH3)

RAY:	107514613(DIAPH3)

MJV:	108400668(DIAPH3)

TOD:	119259971(DIAPH3)

SARA:

101556052(DIAPH3)

SFUM:

130019212(DIAPH3)

SETR:

126016171(DIAPH3)

LAV:	100660202(DIAPH3)

TMU:

101356583

ETF:	101655992(DIAPH3)

DNM:	101412221(DIAPH3)

MDO:	100011744(DIAPH3)

GAS:	123242672(DIAPH3)

SHR:	100914294(DIAPH3)

AFZ:

127553287

PCW:	110221692(DIAPH3)

TVP:	118846518(DIAPH3)

PBRV:

138146624(DIAPH3)

OAA:	100078701(DIAPH3)

TACU:

119920970(DIAPH3)

GGA:	418824(DIAPH3)

PCOC:

116243324(DIAPH3)

MGP:	100551247(DIAPH3)

CJO:	107308095(DIAPH3)

TPAI:

128092120(DIAPH3)

LMUT:

125687527(DIAPH3)

NMEL:

110408747(DIAPH3)

APLA:

101792363(DIAPH3)

ACYG:

106041793(DIAPH3)

CATA:

118251373(DIAPH3)

AFUL:

116502344(DIAPH3)

TGU:	100229149(DIAPH3)

LSR:	110470851(DIAPH3)

SCAN:

103812253(DIAPH3)

PMOA:

120505795(DIAPH3)

OTC:	121337291(DIAPH3)

PRUF:

121353276(DIAPH3)

ATRC:

139600309(DIAPH3)

GFR:	102042315(DIAPH3)

FAB:	101818686(DIAPH3)

OMA:	130257492(DIAPH3)

PHI:	102113353(DIAPH3)

PMAJ:

107206319(DIAPH3)

CCAE:

111933154(DIAPH3)

CCW:	104693133(DIAPH3)

CBRC:

103615126(DIAPH3)

ACOE:

138107781(DIAPH3)

ETL:	114061944(DIAPH3)

ZAB:	102062660(DIAPH3)

ZLE:	135448123(DIAPH3)

SVG:	106865340(DIAPH3)

MMEA:

130577461(DIAPH3)

HRT:	120748568(DIAPH3)

SATI:

136357795(DIAPH3)

CCIC:

134057779(DIAPH3)

FPG:	101924112(DIAPH3)

FCH:	102050306(DIAPH3)

SHAB:

115604208(DIAPH3)

ACUN:

113481856(DIAPH3)

TALA:

104366779(DIAPH3)

ACHC:

115350734(DIAPH3)

HLE:	104836578(DIAPH3)

AGEN:

126045098

HHAR:

128141368(DIAPH3)

GCL:

127022255

CSTI:

104554503(DIAPH3)

DPUB:

104302614(DIAPH3)

PPUS:

135191764(DIAPH3)

AVIT:

104272099

BRHI:

104501131(DIAPH3)

EGZ:	104125594(DIAPH3)

NNI:	104012799(DIAPH3)

PCAO:

104050447

PADL:

103916243(DIAPH3)

AFOR:

103895917(DIAPH3)

FGA:	104077676(DIAPH3)

CBOY:

140646340(DIAPH3)

CLV:	102096480(DIAPH3)

CNIC:

135987164(DIAPH3)

CMAC:

104482397(DIAPH3)

CUCA:

104061848(DIAPH3)

OHA:	104328629(DIAPH3)

ACAR:

104523938(DIAPH3)

CPEA:

104391560(DIAPH3)

CVF:

104285682

RTD:	128912565(DIAPH3)

CRID:

134519453(DIAPH3)

AAM:	106491678(DIAPH3)

AROW:

112973539(DIAPH3)

NPD:	112943176(DIAPH3)

TGT:

104573022

DNE:	112989988(DIAPH3)

SCAM:

104142498(DIAPH3)

ASN:

102388353

AMJ:	106736897(DIAPH3)

CPOO:

109306465(DIAPH3)

GGN:	109303146(DIAPH3)

PSS:	102462391(DIAPH3)

CMY:	102931459(DIAPH3)

CCAY:

125637371(DIAPH3)

DCC:	119849167(DIAPH3)

CPIC:

101941848(DIAPH3)

TST:	117870909(DIAPH3)

CABI:

116830849

MRV:	120387247(DIAPH3)

ACS:	100555400(diaph3)

ASAO:

132771411(DIAPH3)

PVT:	110078403(DIAPH3)

SUND:

121927216(DIAPH3)

PBI:

103060828

PMUR:

107284437(DIAPH3)

CTIG:

120301972(DIAPH3)

PGUT:

117665117(DIAPH3)

APRI:

131199303(DIAPH3)

PTEX:

113439498(DIAPH3)

NSS:	113415891(DIAPH3)

VKO:	123032391(DIAPH3)

PMUA:

114596621(DIAPH3)

PRAF:

128412006(DIAPH3)

ZVI:	118085458(DIAPH3)

HCG:	128351464(DIAPH3)

GJA:	107122538(DIAPH3)

STOW:

125431796(DIAPH3)

EMC:	129325631(DIAPH3)

XLA:	108708510(diaph3.L)

XTR:	100145568(diaph3)

NPR:

108799904

RTEM:

120929668(DIAPH3)

ACAT:

141127612(DIAPH3)

BBUF:

120995893(DIAPH3)

BGAR:

122932031(DIAPH3)

DTC:	141094506(DIAPH3)

PWL:	138250427(DIAPH3)

MUO:	115468673(DIAPH3)

GSH:	117362851(DIAPH3)

SRX:	107741707 107747718

SANH:

107660248 107691273

SGH:	107556337 107581615

CCAR:

109098308 109107504

CAUA:

113055384 113110818

CGIB:

127968161 128022195

PTET:

122353506(diaph3) 122357424(diaph2)

LROH:

127173477(diaph3) 127176522(diaph2)

GRF:	141293420(diaph3)

OMC:	131549021(diaph3) 131553028(diaph2)

PPRM:

120480658(diaph3)

RKG:	130083579(diaph3)

MAMB:

125256191(diaph3)

CIDE:

127522490

CERY:

137021474(diaph3) 137021613(diaph2)

MASI:

127425897

TROS:

130563438(diaph2) 130571480(diaph3)

TDW:	130410501(diaph3) 130437762(diaph2)

MANU:

129427333(diaph3)

PDAB:

135718790(diaph3)

IPU:	108271281(diaph3)

IFU:	128611107(diaph2) 128613424(diaph3)

PHYP:

113534602

SMEO:

124391131(diaph3)

TFD:	113658966(diaph3)

TVC:	132850051(diaph3) 132856034(diaph2)

CGAR:

128531627(diaph2) 128543036(diaph3)

NGRA:

132890605(diaph2) 132899687(diaph3)

TRN:	134319385(diaph2) 134331784(diaph3)

AMEX:

103030262(diaph3)

CMAO:

118807099(diaph2) 118819166(diaph3)

CHAR:

105911673

SPIL:

134071480

TRU:	101075165(diaph3)

TFS:	130519559 130530979

LCO:

104926257

NCC:

104955806

TBEN:

117471727 117488419(diaph2)

CGOB:

115004518(diaph3) 115014467(diaph1)

PGEO:

117441035 117453322 117454403(diaph2)

GACU:

117541060(diaph2) 117548142 117555952

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116700867(diaph3)

PFLV:

114555081(diaph3) 114562351(diaph1)

GAT:

120835445

PPUG:

119195830 119210838

AFB:	129090571 129101429

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

ALAT:

ASTR:

MZE:

ONL:

OAU:

OLA:	101155017(diaph3)

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

103461982(diaph3)

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:	107381640(diaph3)

KMR:

ALIM:

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103378652(diaph3)

POV:	109624818(diaph3)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111238337(diaph3)

SLAL:

111668360

XGL:

120792858

HCQ:	109524634(diaph3)

SSCV:

125967184

SBIA:

133498362

PEE:	133399091 133407311

PTAO:

133472273 133485067

BPEC:

110173036(diaph3)

ENY:

140381587

MALB:

109964526(diaph3)

BSPL:

114852343

SJO:

128376055

SSCO:

133977789

GMH:	115558374(diaph3)

OMY:	110517047 110517682

OGO:

124018174

OMM:	135542890 135542910

OCLA:

139394558 139413972 139414026

ELS:

105020029

OEP:

134007848

SFM:	108918293(diaph3)

PKI:

AANG:

AROT:

CCOG:

LOC:	102689798(diaph1) 102697182(diaph3)

PSPA:

121327491

ARUT:

117405378 117406999

PSEX:

120523740

LCM:	102349641(DIAPH3)

CMK:

RTP:

CPLA:

HOC:

LERI:

HAKA:

PMRN:

LRJ:

BBEL:

LPIC:

AJJ:

ARUN:

AAMU:

AFIL:

PFLL:

ACER:

SOY:

AGRG:

CSET:

AGB:

LDC:

APLN:

PPYR:

SLIU:

CCRN:

DVT:

DCI:

HHAL:

106683242(dia)

HVI:

MQU:

FOC:

TPAL:

BROR:

IEL:

DMK:

AFRA:

PJA:

PCHN:

PCLA:

123758867(dia)

CQD:	128700318(dia)

MNZ:

135201657

MRJ:	136850250(dia)

HAZT:

108664668

LSM:	121120848(dia)

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

GOE:

DFR:

CVS:	136974227(dia)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PVUL:

BGT:

GAE:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

OSN:

LJP:

ATEN:

XEN:

HSY:

RES:

ACAN:

Reference

PMID:20624953

Authors

Schoen CJ, Emery SB, Thorne MC, Ammana HR, Sliwerska E, Arnett J, Hortsch M, Hannan F, Burmeister M, Lesperance MM

Title

Increased activity of Diaphanous homolog 3 (DIAPH3)/diaphanous causes hearing defects in humans with auditory neuropathy and in Drosophila.

Journal

Proc Natl Acad Sci U S A 107:13396-401 (2010)
DOI:10.1073/pnas.1003027107

Sequence

[hsa:81624] [rno:290396]

Reference

PMID:10678165

Authors

Tominaga T, Sahai E, Chardin P, McCormick F, Courtneidge SA, Alberts AS

Title

Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling.

Journal

Mol Cell 5:13-25 (2000)
DOI:10.1016/S1097-2765(00)80399-8

Sequence

[mmu:56419]

LinkDB

DBGET integrated database retrieval system