KEGG   ORTHOLOGY: K05824
Entry
K05824                      KO                                     
Symbol
LYS12
Name
homoisocitrate dehydrogenase [EC:1.1.1.87]
Pathway
map00300  Lysine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Reaction
R01934  (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
R01936  (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
R04862  (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K05824  LYS12; homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.87  homoisocitrate dehydrogenase
     K05824  LYS12; homoisocitrate dehydrogenase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K05824
Other DBs
COG: COG0473
GO: 0047046
Genes
SCE: YIL094C(LYS12)
SEUB: DI49_2692
SPAO: SPAR_I00750
AGO: AGOS_ADL214C
ERC: Ecym_3326
KLA: KLLA0_E08339g
KMX: KLMA_80130(LYS12)
LTH: KLTH0G10384g
VPO: Kpol_1003p39
ZRO: ZYRO0A01914g
CGR: 2888168(LYS12)
NCS: NCAS_0B06250(NCAS0B06250)
NDI: NDAI_0B03550(NDAI0B03550)
TPF: TPHA_0C03410(TPHA0C03410)
TBL: TBLA_0B05940(TBLA0B05940)
TGB: HG536_0A02300
TDL: TDEL_0G02180(TDEL0G02180)
KAF: KAFR_0J01360(KAFR0J01360)
KNG: KNAG_0A05420(KNAG0A05420)
ZMK: HG535_0D02020
SLUD: SCDLUD_002757
DHA: DEHA2C16852g
PIC: PICST_50442(LYS12)
PGU: PGUG_03875 PGUG_03876
SPAA: SPAPADRAFT_59913
LEL: PVL30_000182(LYS12)
LBG: 92206101(LODBEIA_P09050)
CAL: CAALFM_CR01400WA(LYS12)
CTP: CTRG_00945
COT: CORT_0A02990
CDU: CD36_26410
CTEN: 18246588(LYS12)
CLUS: A9F13_04g01914
CAUR: CJI96_0003344
ASAU: 88173017(PUMCH_001952)
PPA: PAS_chr2-2_0168
PKZ: C5L36_0C04140
BNN: FOA43_004130(LYS12)
BBRX: BRETT_002820(LYS12)
OPA: HPODL_04851
YLI: 2910431(YALI2_D00210g)
SLB: AWJ20_5129(LYS12)
NCR: NCU02954(lys-7)
NTE: NEUTE1DRAFT119171(NEUTE1DRAFT_119171)
SMP: 10809532(SMAC4_00496)
PAN: PODANSg09901
PBEL: QC761_106340(LYS12)
PPSD: QC762_106340(LYS12)
PPSP: QC763_106340(LYS12)
PPSA: QC764_106340(LYS12)
TTT: THITE_2122134
MTM: MYCTH_2295290
CTHR: CTHT_0055150
RTHE: 98128361(VTJ83DRAFT_695)
MGR: MGG_01566
PPEI: PpBr36_01084
PGRI: PgNI_03934
TMN: UCRPA7_5672
SSCK: SPSK_09424
FGR: FGSG_01392
FPU: FPSE_08564
FPOA: FPOAC1_001498(LYS12)
FVN: FVRRES_01700
FVR: FVEG_09468
FOX: FOXG_11323
FFC: NCS54_00044400
FKR: NCS57_00042600
FMU: J7337_000493(LYS12)
TRE: TRIREDRAFT_23184
TRR: M419DRAFT_138813
TATV: 25781406(TrAtP1_013057)
TASP: 36619307(LYS12)
MAW: 19246186(LYS12_1)
MAJ: MAA_00573
MBRN: 26242772(lys12)
PCHM: VFPPC_01118
UVI: 66067130(UV8b_06353)
CMT: CCM_06018
AMUS: LMH87_005376
PLJ: 28891040(PLICBS_004644)
PTKZ: JDV02_009506(LYS12)
DCON: 63720525(DCS_07882)
VAL: VDBG_03889
VDA: VDAG_01116
CFJ: CFIO01_06688
CLUP: CLUP02_14367
CHIG: CH63R_06308
CDET: 87949305(CDEST_12805)
SAPO: SAPIO_CDS4368
ELA: UCREL1_9930
PFY: PFICI_15112
SSL: SS1G_02537
BFU: BCIN_06g02300
MBE: MBM_09266
PSCO: LY89DRAFT_614007
GLZ: GLAREA_06943
ANI: ANIA_05206
AFM: AFUA_6G07390
ACT: ACLA_081560
NFI: NFIA_053070
AOR: AO090005001561
ANG: An15g02490
AFV: AFLA_004390
ALUC: AKAW2_60443S(LYS12)
ACHE: ACHE_11370S(LYS12)
APUU: APUU_41359S(LYS12)
PCS: N7525_000423
PDP: PDIP_70630
POU: POX_b02757
PPSF: 300790111(PFLUO_LOCUS4292)
TMF: EYB26_007915
TRG: TRUGW13939_00840
CIM: CIMG_08027
CPW: 9690651(LYS12)
URE: UREG_02316
ABE: ARB_06194
TVE: TRV_01663
PBL: PAAG_06387
PBN: PADG_01286
AJE: HCAG_07785
BGH: BDBG_09367
PNO: SNOG_01047
PTE: PTT_19273
PTRR: 6350425(PtrM4_046160)
BZE: COCCADRAFT_8727
BSC: COCSADRAFT_35926
BOR: COCMIDRAFT_8810
AALT: CC77DRAFT_1025667
ADAC: 96085024(ACET3X_004702)
ARAB: EKO05_0003961
ZTR: MYCGRDRAFT_85715
PFJ: MYCFIDRAFT_201320
FFU: CLAFUR5_02121
CBET: CB0940_00163
BCOM: BAUCODRAFT_73623
NPA: UCRNP2_9220
TML: GSTUM_00011274001
SPO: 2542609(lys12)
SOM: SOMG_00247(lys12)
CNE: CND03850
CNB: CNBD2460
CNG: CNAG_01264
CGI: CGB_D6560C
CDEU: CNBG_0832
CDEC: 89987044(IAS62_000268)
CTEG: 91987438(I308_100580)
CBAS: 91980320(I312_100272)
CDEP: 91084477(L203_100261)
KMG: 30163107(I203_102099)
KNE: 92180149(IAR55_002891)
KDJ: 28968972(I303_105279)
KBI: 30210320(I302_106813)
KPIN: 30170717(I206_104809)
KSH: 87956978(IL334_004847)
KER: 91101839(V865_003035)
KSN: 43585495(CI109_103007)
KBO: 90014850(L199_003866)
KEP: 91094063(L201_003393)
TMS: TREMEDRAFT_37357
TASA: A1Q1_01965
CCAC: CcaHIS019_0111110(LYS12)
TVS: TRAVEDRAFT_163469
DSQ: DICSQDRAFT_103251
PCO: PHACADRAFT_249972
SHS: STEHIDRAFT_77028
HIR: HETIRDRAFT_311764
PSQ: PUNSTDRAFT_112210
ADL: AURDEDRAFT_110590
FME: FOMMEDRAFT_169234
GTR: GLOTRDRAFT_109763
RSX: RhiXN_00672
LBC: LACBIDRAFT_229977
CCI: CC1G_00055
ABP: AGABI1DRAFT113649(AGABI1DRAFT_113649)
ABV: AGABI2DRAFT191701(AGABI2DRAFT_191701)
PCUB: JR316_0004687
MRR: Moror_17619
MORE: E1B28_004546
SCM: SCHCO_02623734(SCHCODRAFT_02623734)
CPUT: CONPUDRAFT_64839
SLA: SERLADRAFT_460541
WSE: WALSEDRAFT_60334
WIC: J056_003089
UMA: UMAG_04873
PFP: PFL1_04288
SGRA: EX895_000301
MGL: MGL_3003
MRT: MRET_3610
MSYM: MSY001_1272
PTRC: PtA15_18A53
PSTR: Pst134EA_026693
MLR: MELLADRAFT_35949
RIE: OCT59_028299
ACAN: ACA1_255210
NGR: NAEGRDRAFT_79802
PFUW: KF707C_48470
PLAL: FXN65_23330
PCQ: PcP3B5_09520(hicd)
PMUI: G4G71_07730
PNT: G5B91_27755
PDR: H681_20765
PKC: PKB_4900(leub3)
PSET: THL1_4856
PTRL: OU419_23855
PSWO: SD196_22920
HPEG: EAO82_05040
HAES: LO767_13135
PDEN: F1C79_19295
HARR: HV822_11970
PNN: KEM63_14200
PPHA: BVH74_01680
AMAH: DLM_3455
AQS: DKK66_09785
VOX: LCH97_15160
AQL: BXU06_12520
MAER: DAI18_01190
RRS: RoseRS_1057
RCA: Rcas_3471
CAU: Caur_0331
CHL: Chy400_0356
CAG: Cagg_3600
HAU: Haur_3304
ATM: ANT_08240
PSUB: Pelsub_P2051
LEK: hrd7_27880(hicd)
CAP: CLDAP_04830
PMET: G4Y79_23070
DRA: DR_1674
DGE: Dgeo_1458
DDR: Deide_09240
DMR: Deima_1545
DGO: DGo_CA1124
DPD: Deipe_3811
DSW: QR90_06130
DCH: SY84_04075
DAB: AUC44_04755
DPU: SU48_06750
DEZ: DKM44_12070
DWU: DVJ83_05910
DFC: DFI_05685
DEIN: DAAJ005_11775
DGA: DEGR_21420
DPH: EHF33_11670
DRB: N0D28_12770
DAH: DAETH_21930
DAQU: M8445_09600
DTAE: LAJ19_09465
DMB: E5F05_11230
DSC: ABOD76_12915
DEID: HLB42_10275
TRA: Trad_2841
TTH: TT_C1012
TTJ: TTHA1378(TTHA1378)
TTS: Ththe16_1388
TTL: TtJL18_0670
TSC: TSC_c20650(icd2)
THC: TCCBUS3UF1_6370
TOS: Theos_0440
TAQ: TO73_0559
TPAR: AV541_03840
TBC: A0O31_01242
TANT: KNN15_01885
MRB: Mrub_2738
MRE: K649_08845
MTAI: Mtai_v1c23390
MSV: Mesil_1337
OPR: Ocepr_1387
MHD: Marky_1533
MEUZ: KRP56_05915
 » show all
Reference
PMID:4395693
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
  Sequence
[sce:YIL094C]
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