KEGG   ORTHOLOGY: K06030
Entry
K06030                      KO                                     
Symbol
MFN2, FZO1
Name
mitofusin 2 [EC:3.6.5.-]
Pathway
map04137  Mitophagy - animal
map04214  Apoptosis - fly
map04621  NOD-like receptor signaling pathway
map05012  Parkinson disease
map05022  Pathways of neurodegeneration - multiple diseases
Disease
H00264  Charcot-Marie-Tooth disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K06030  MFN2, FZO1; mitofusin 2
  09143 Cell growth and death
   04214 Apoptosis - fly
    K06030  MFN2, FZO1; mitofusin 2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K06030  MFN2, FZO1; mitofusin 2
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K06030  MFN2, FZO1; mitofusin 2
   05022 Pathways of neurodegeneration - multiple diseases
    K06030  MFN2, FZO1; mitofusin 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06030  MFN2, FZO1; mitofusin 2
   03029 Mitochondrial biogenesis
    K06030  MFN2, FZO1; mitofusin 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.5  Acting on GTP to facilitate cellular and subcellular movement
    3.6.5.-
     K06030  MFN2, FZO1; mitofusin 2
Membrane trafficking [BR:ko04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    K06030  MFN2, FZO1; mitofusin 2
  Other autophagy associated proteins
   ER-mitochondria tethering complex
    K06030  MFN2, FZO1; mitofusin 2
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    K06030  MFN2, FZO1; mitofusin 2
Other DBs
COG: COG0699
TC: 1.N.6.1.1 1.N.6.1.2 1.R.1.1.1
Genes
HSA: 9927(MFN2)
PTR: 457958(MFN2)
PPS: 100973903(MFN2)
PON: 100172672(MFN2)
NLE: 100599174(MFN2)
MCC: 100427191(MFN2)
MCF: 101926564(MFN2)
MTHB: 126953005
CSAB: 103225593(MFN2)
CATY: 105580849(MFN2)
PANU: 101024137(MFN2)
TGE: 112619023(MFN2)
RRO: 104668934(MFN2)
RBB: 108539352(MFN2)
TFN: 117093304(MFN2)
PTEH: 111526293(MFN2)
CANG: 105507377
CJC: 100412019(MFN2)
SBQ: 101041459(MFN2)
CSYR: 103249716(MFN2)
MMUR: 105882711(MFN2)
LCAT: 123634464(MFN2)
PCOQ: 105824956(MFN2)
OGA: 100962687(MFN2)
MMU: 170731(Mfn2)
MCAL: 110292135(Mfn2)
MPAH: 110322845(Mfn2)
RNO: 64476(Mfn2)
MCOC: 116097001(Mfn2)
MUN: 110555747(Mfn2)
CGE: 100763273(Mfn2)
MAUA: 101840032(Mfn2)
PLEU: 114685518(Mfn2)
MFOT: 126508210
AAMP: 119816725(Mfn2)
NGI: 103747475(Mfn2)
HGL: 101715674(Mfn2)
CPOC: 100714032(Mfn2)
CCAN: 109683965(Mfn2)
DORD: 105997460(Mfn2)
DSP: 122121408(Mfn2)
NCAR: 124978147
OCU: 100350119
OPI: 101523963(MFN2)
TUP: 102474328(MFN2)
GVR: 103605139(MFN2)
CFA: 487439(MFN2)
CLUD: 112678123(MFN2)
VVP: 112929755(MFN2)
VLG: 121497172(MFN2)
AML: 100470367(MFN2)
UMR: 103666645(MFN2)
UAH: 113270495(MFN2)
UAR: 123779618(MFN2)
ELK: 111154723
LLV: 125098037
MPUF: 101691353(MFN2)
ORO: 101369854(MFN2)
EJU: 114213159(MFN2)
ZCA: 113934218(MFN2)
MLX: 118019997(MFN2)
NSU: 110575133(MFN2)
LWW: 102729614
FCA: 101101068(MFN2)
PYU: 121021287(MFN2)
PBG: 122479938(MFN2)
LRUF: 124514778
PTG: 102972369(MFN2)
PPAD: 109274124(MFN2)
AJU: 106989449(MFN2)
HHV: 120226656(MFN2)
BTA: 534574(MFN2)
BOM: 102264443(MFN2)
BIU: 109570412(MFN2)
BBUB: 102398468(MFN2)
BBIS: 104995829(MFN2)
CHX: 102181325(MFN2)
OAS: 101110526(MFN2)
ODA: 120880233(MFN2)
CCAD: 122451947(MFN2)
SSC: 100512354(MFN2)
CFR: 102504460(MFN2)
CBAI: 105070960(MFN2)
CDK: 105107041(MFN2)
VPC: 102534440(MFN2)
BACU: 103019535(MFN2)
LVE: 103081252(MFN2)
OOR: 101289484(MFN2)
DLE: 111187123(MFN2)
PCAD: 102984012(MFN2)
PSIU: 116755350(MFN2)
ECB: 100055966(MFN2)
EPZ: 103552179(MFN2)
EAI: 106836664(MFN2)
MYB: 102246147(MFN2)
MYD: 102763805(MFN2)
MMYO: 118675233(MFN2)
MLF: 102423766(MFN2)
MNA: 107531559(MFN2)
PKL: 118731958(MFN2)
HAI: 109381283(MFN2)
DRO: 112299118(MFN2)
SHON: 118986339(MFN2)
AJM: 119064110(MFN2)
PDIC: 114496756(MFN2)
PHAS: 123831753(MFN2)
MMF: 118626257(MFN2)
RFQ: 117026917(MFN2)
PALE: 102881288(MFN2)
PGIG: 120585808(MFN2)
PVP: 105294358(MFN2)
RAY: 107507537 107513128(MFN2)
MJV: 108385721(MFN2)
TOD: 119235254(MFN2)
SARA: 101551291(MFN2)
LAV: 100657545(MFN2)
TMU: 101360670
ETF: 101661936(MFN2)
DNM: 101423208(MFN2)
MDO: 100013425(MFN2)
GAS: 123240313(MFN2)
SHR: 100915154(MFN2)
PCW: 110198989(MFN2)
OAA: 100089939(MFN2)
GGA: 419484(MFN2)
PCOC: 116242531(MFN2)
MGP: 100542450(MFN2)
CJO: 107323369(MFN2)
NMEL: 110408535(MFN2)
APLA: 101791051(MFN2)
ACYG: 106040209(MFN2)
AFUL: 116497541(MFN2)
TGU: 100230233(MFN2)
LSR: 110479718(MFN2)
SCAN: 103820843(MFN2)
PMOA: 120496747(MFN2)
OTC: 121343963(MFN2)
PRUF: 121358389(MFN2)
GFR: 102032568(MFN2)
FAB: 101815947(MFN2)
PHI: 102110409(MFN2)
PMAJ: 107213712(MFN2)
CCAE: 111938718(MFN2)
CCW: 104693246(MFN2)
CBRC: 103616125(MFN2)
ETL: 114056909(MFN2)
ZAB: 102072262(MFN2)
ACHL: 103802563(MFN2)
FPG: 101921025(MFN2)
FCH: 102053459(MFN2)
CLV: 102088591(MFN2)
EGZ: 104133089(MFN2)
NNI: 104009006(MFN2)
PLET: 104623419(MFN2)
PCRI: 104024579(MFN2)
PCAO: 104039739(MFN2)
ACUN: 113487794(MFN2)
TALA: 104364188(MFN2)
PADL: 103917991(MFN2)
AFOR: 103907437(MFN2)
ACHC: 115343147(MFN2)
HALD: 104321845(MFN2)
HLE: 104837878(MFN2)
AGEN: 126050433
GCL: 127024698
CCRI: 104155118(MFN2)
CSTI: 104550212(MFN2)
EHS: 104515210(MFN2)
CMAC: 104479921(MFN2)
MUI: 104545988(MFN2)
FGA: 104077836(MFN2)
GSTE: 104250980(MFN2)
LDI: 104340385(MFN2)
MNB: 103778743(MFN2)
OHA: 104332630(MFN2)
NNT: 104399660(MFN2)
DPUB: 104305833(MFN2)
PGUU: 104461842(MFN2)
ACAR: 104518224(MFN2)
CPEA: 104395431(MFN2)
AVIT: 104278995
CVF: 104290445(MFN2)
CUCA: 104060560(MFN2)
TEO: 104372549(MFN2)
BRHI: 104490039(MFN2)
AAM: 106482467(MFN2)
AROW: 112970127(MFN2)
NPD: 112959575(MFN2)
TGT: 104570934(MFN2)
DNE: 112980602(MFN2)
SCAM: 104141854(MFN2)
ASN: 102374370(MFN2)
AMJ: 102572527(MFN2)
CPOO: 109314263(MFN2)
GGN: 109293662(MFN2)
PSS: 102447012(MFN2)
CMY: 102944655(MFN2)
CPIC: 101943561(MFN2)
TST: 117867884(MFN2)
CABI: 116821904(MFN2)
MRV: 120387937(MFN2)
ACS: 100557065(mfn2)
PVT: 110073212(MFN2)
SUND: 121936124(MFN2)
PBI: 103066015(MFN2)
PMUR: 107295427(MFN2)
CTIG: 120313280(MFN2)
TSR: 106544402(MFN2)
PGUT: 117666891(MFN2)
VKO: 123031024(MFN2)
PMUA: 114602877(MFN2)
ZVI: 118086311(MFN2)
GJA: 107111574(MFN2)
STOW: 125445775(MFN2)
XLA: 108697551(mfn2.S) 431918(mfn2.L)
XTR: 549268(mfn2)
NPR: 108798426(MFN2)
RTEM: 120915685(MFN2)
BBUF: 120999910(MFN2)
BGAR: 122928801(MFN2)
DRE: 567448(mfn2)
CCAR: 109059212
CAUA: 113107824
PPRM: 120477734(mfn2)
MAMB: 125280285(mfn2)
IPU: 108265739(mfn2)
PHYP: 113533622(mfn2)
SMEO: 124399536(mfn2)
TFD: 113656019(mfn2)
AMEX: 103030025(mfn2)
EEE: 113578194(mfn2)
LCO: 104932314(mfn2)
CGOB: 115019720(mfn2)
ELY: 117258271(mfn2)
EFO: 125891986(mfn2)
PLEP: 121946519(mfn2)
SLUC: 116050870(mfn2)
ECRA: 117948142(mfn2)
ESP: 116692635
PFLV: 114558679(mfn2)
GAT: 120829200(mfn2)
PPUG: 119204597 119223709(mfn2)
MSAM: 119904959(mfn2)
CUD: 121517325(mfn2)
ALAT: 119022817(mfn2)
MZE: 101476877(mfn2)
ONL: 100696586(mfn2)
OAU: 116320558(mfn2)
OLA: 101170481(mfn2)
OML: 112140849(mfn2)
XMA: 102236418(mfn2)
XCO: 114141901(mfn2)
XHE: 116720990(mfn2)
PRET: 103466977(mfn2)
PFOR: 103154228(mfn2)
PLAI: 106960225(mfn2)
PMEI: 106928337(mfn2)
CVG: 107098915(mfn2)
CTUL: 119789410(mfn2)
GMU: 124869298(mfn2)
NFU: 107390565(mfn2)
KMR: 108249436(mfn2)
ALIM: 106530038(mfn2)
NWH: 119416856(mfn2)
AOCE: 111588283
MCEP: 125022949(mfn2)
CSEM: 103384844(mfn2)
POV: 109630874(mfn2)
SSEN: 122777533(mfn2)
HHIP: 117765118(mfn2)
HSP: 118111046(mfn2)
LCF: 108900504
SDU: 111219020(mfn2)
SLAL: 111670657(mfn2)
XGL: 120803408(mfn2)
HCQ: 109528670(mfn2)
BPEC: 110156031
MALB: 109965274(mfn2)
BSPL: 114859097(mfn2)
SASA: 106572197(mfn2)
STRU: 115166092(mfn2)
OTW: 112233033(mfn2)
OMY: 110532171(mfn2)
OGO: 124031845(mfn2)
ONE: 115132053(mfn2)
SALP: 111966358(mfn2)
SNH: 120059402(mfn2)
CCLU: 121538236(mfn2)
ELS: 105013857(mfn2)
SFM: 108924939(mfn2)
PKI: 111859143(mfn2)
AANG: 118207810(mfn2)
LOC: 102686245(mfn2)
PSEX: 120531068(mfn2)
LCM: 102356846(MFN2)
CMK: 103181399 121851690(mfn2)
RTP: 109919457(mfn2)
BFO: 118430427
BBEL: 109472718
CIN: 100186475
SCLV: 120331645
SPU: 590207
APLC: 110982308
SKO: 102800824
DME: Dmel_CG3869(Marf) Dmel_CG4568(fzo)
DER: 6551379
DSE: 6612272
DSI: Dsimw501_GD16797(Dsim_GD16797) Dsimw501_GD28586(Dsim_GD28586)
DAN: 6502113
DSR: 110181561
DPO: 4815608
DPE: 6600034
DMN: 108156230
DWI: 6644538
DMO: Dmoj_GI15189(Dmoj_Marf) Dmoj_GI26396
DHE: 111602054
DVI: 6633239
CCAT: 101452505
BOD: 106615811
MDE: 101901601
SCAC: 106083566
LCQ: 111679253
LSQ: 119608951
HIS: 119653855
ACOZ: 120953831
AARA: 120898775
ASTE: 118507720
AALB: 109409560
CPII: 120429830
CNS: 116339459
BCOO: 119078063
AME: 410263
ACER: 107995837
ALAB: 122718289
BIM: 100746892
BBIF: 117211371
BVK: 117237417
BVAN: 117160988
BTER: 100646597
BPYO: 122573192
CCAL: 108625121
OBB: 114877724
MGEN: 117225297
NMEA: 116434944
CGIG: 122397104
SOC: 105202128
MPHA: 105834556
AEC: 105151679
ACEP: 105620404
PBAR: 105426270
VEM: 105565456
HST: 105190222
DQU: 106747777
CFO: 105253002
FEX: 115243953
LHU: 105671492
PGC: 109854036
OBO: 105275814
PCF: 106786974
PFUC: 122515235
VPS: 122636002
NVI: 100121959
CSOL: 105364545
TPRE: 106653039
MDL: 103574440
CGLO: 123274289
FAS: 105266639
DAM: 107043013
AGIF: 122848273
CINS: 118073287
LHT: 122512990
CCIN: 107272630
TCA: 658690
DPA: 109540118
SOY: 115887434
ATD: 109604288
CSET: 123314555
AGB: 108913171
LDC: 111510072
NVL: 108566432
APLN: 108743397
OTU: 111427303
BMOR: 101737843
BMAN: 114248923
MSEX: 115442561
BANY: 112054872
NIQ: 126769978
PMAC: 106718413
PPOT: 106104816
PXU: 106128427
PRAP: 111000195
PBX: 123708982
PNAP: 125049859
ZCE: 119834886
CCRC: 123690908
HAW: 110372680
HZE: 124631016
TNL: 113504448
SLIU: 111351690
OFU: 114352454
PXY: 105382934
CFEL: 113363340
API: 100166803
DNX: 107168084
RMD: 113555984
BTAB: 109042172
DCI: 103509414
CLEC: 106660847
HHAL: 106688017
NLU: 111048616
FOC: 113206933
ZNE: 110831218
FCD: 110846703
PJA: 122267698
PCHN: 125039403
HAME: 121879968
PCLA: 123757129
PTRU: 123503783
HAZT: 108679755
EAF: 111716950
LSM: 121117670
PPOI: 119105725
DSV: 119446569
RSAN: 119389739
RMP: 119177036
VDE: 111252933
VJA: 111270271
DPTE: 113795218
DFR: 124497669
CSCU: 111631341
PTEP: 107457351
SDM: 118188748
CEL: CELE_ZK1248.14(fzo-1)
CBR: CBG_02514(Cbr-fzo-1)
BMY: BM_BM7647(Bma-fzo-1)
PCAN: 112557131
BGT: 106053535
GAE: 121390185
HRF: 124122499
MYI: 110450460
PMAX: 117344432
MMER: 123527416
OBI: 106881618
OSN: 115224764
SHX: MS3_00001582(MFN2)
EGL: EGR_03981
NVE: 5514215
EPA: 110251765
ATEN: 116289247
AMIL: 114970970
PDAM: 113681238
DGT: 114518303
HMG: 100205666
SCE: YBR179C(FZO1)
SEUB: DI49_1205
ERC: Ecym_7066
KMX: KLMA_10794(FZO1)
NCS: NCAS_0B01990(NCAS0B01990)
NDI: NDAI_0C05690(NDAI0C05690)
TPF: TPHA_0A01290(TPHA0A01290)
TBL: TBLA_0H03810(TBLA0H03810)
TDL: TDEL_0A05160(TDEL0A05160)
KAF: KAFR_0I00690(KAFR0I00690)
KNG: KNAG_0A03510(KNAG0A03510)
CAL: CAALFM_C404260CA(FZO1)
SLB: AWJ20_1158(FZO1)
NCR: NCU00436(uvs-5)
NTE: NEUTE1DRAFT82395(NEUTE1DRAFT_82395)
MGR: MGG_05209
SSCK: SPSK_05927
MAJ: MAA_05849
CMT: CCM_09450
BFU: BCIN_03g01740(Bcfzo1)
MBE: MBM_01833
ANI: AN6897.2
ANG: ANI_1_676124(An14g04870)
ALUC: AKAW2_41132A(FZO1)
ACHE: ACHE_51180A(FZO1)
APUU: APUU_12213A(FZO1)
ABE: ARB_03335
TVE: TRV_04155
SPO: SPBC1706.03(fzo1)
CNE: CNF03260
CNB: CNBF1520
TASA: A1Q1_04468
ABP: AGABI1DRAFT120610(AGABI1DRAFT_120610)
ABV: AGABI2DRAFT119324(AGABI2DRAFT_119324)
SCM: SCHCO_02676131(SCHCODRAFT_02676131)
MGL: MGL_1150
MRT: MRET_3000
 » show all
Reference
  Authors
Chen KH, Guo X, Ma D, Guo Y, Li Q, Yang D, Li P, Qiu X, Wen S, Xiao RP, Tang J
  Title
Dysregulation of HSG triggers vascular proliferative disorders.
  Journal
Nat Cell Biol 6:872-83 (2004)
DOI:10.1038/ncb1161
  Sequence
[hsa:9927]
Reference
  Authors
Chen Y, Dorn GW 2nd
  Title
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.
  Journal
Science 340:471-5 (2013)
DOI:10.1126/science.1231031
  Sequence
[hsa:9927]
Reference
PMID:9786948
  Authors
Hermann GJ, Thatcher JW, Mills JP, Hales KG, Fuller MT, Nunnari J, Shaw JM
  Title
Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p.
  Journal
J Cell Biol 143:359-73 (1998)
DOI:10.1083/jcb.143.2.359
  Sequence
[sce:YBR179C]
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