KEGG ORTHOLOGY: K06519

ORTHOLOGY: K06519

Entry

K06519                      KO

Symbol

SLC3A2, MDU1, CD98

Name

solute carrier family 3, member 2

Pathway

map04150

mTOR signaling pathway

map04216

Ferroptosis

map04974

Protein digestion and absorption

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04150 mTOR signaling pathway
    K06519  SLC3A2, MDU1, CD98; solute carrier family 3, member 2
09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    K06519  SLC3A2, MDU1, CD98; solute carrier family 3, member 2
09150 Organismal Systems
  09154 Digestive system
   04974 Protein digestion and absorption
    K06519  SLC3A2, MDU1, CD98; solute carrier family 3, member 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K06519  SLC3A2, MDU1, CD98; solute carrier family 3, member 2
   04147 Exosome
    K06519  SLC3A2, MDU1, CD98; solute carrier family 3, member 2
   04090 CD molecules
    K06519  SLC3A2, MDU1, CD98; solute carrier family 3, member 2
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC3: Heavy subunits of the heteromeric amino acid transporters
   K06519  SLC3A2, MDU1, CD98; solute carrier family 3, member 2
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06519  SLC3A2, MDU1, CD98; solute carrier family 3, member 2
CD molecules [BR:ko04090]
Proteins
  K06519  CD98, SLC3A2; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

Other DBs

GO:	0005432 0015175

TC:

8.A.9.2

Genes

HSA:	6520(SLC3A2)

PTR:	451271(SLC3A2)

PPS:	100970046(SLC3A2)

GGO:	101128892(SLC3A2)

PON:	100172374(SLC3A2)

NLE:	100585864(SLC3A2)

HMH:	116468911(SLC3A2)

MCC:	722218(SLC3A2)

MCF:	101866986(SLC3A2)

MTHB:

126935461

MNI:	105469470(SLC3A2)

CSAB:

103233824(SLC3A2)

CATY:

105577530(SLC3A2)

PANU:

101002647(SLC3A2)

TGE:	112605736(SLC3A2)

MLEU:

105549064(SLC3A2)

RRO:	104672659(SLC3A2)

RBB:	108536131(SLC3A2)

TFN:	117081014(SLC3A2)

PTEH:

111522330(SLC3A2)

CANG:

105512246(SLC3A2)

CJC:	100395002(SLC3A2)

SBQ:	101035613(SLC3A2)

CIMI:

108286266(SLC3A2)

CSYR:

103255623(SLC3A2)

MMUR:

105878569(SLC3A2)

LCAT:

123641292(SLC3A2)

PCOQ:

105826694(SLC3A2)

OGA:	100942646(SLC3A2)

MMU:	17254(Slc3a2)

MCAL:

110285746(Slc3a2)

MPAH:

110317822(Slc3a2)

RNO:	50567(Slc3a2)

MCOC:

116103505(Slc3a2)

ANU:	117711845(Slc3a2)

MUN:	110557463(Slc3a2)

CGE:	100689315(Slc3a2)

MAUA:

101832315(Slc3a2)

PROB:

127228802(Slc3a2)

PLEU:

114683616(Slc3a2)

MORG:

121454339(Slc3a2)

MFOT:

126498462

AAMP:

119803876(Slc3a2) 119804212

NGI:	103737658(Slc3a2)

HGL:	101701746(Slc3a2)

CPOC:

100731455(Slc3a2)

CCAN:

109693842(Slc3a2)

DORD:

105995528(Slc3a2)

DSP:	122104976(Slc3a2)

PLOP:

125362108(Slc3a2)

NCAR:

124958488

MMMA:

107135939(Slc3a2)

OCU:	100009363(SLC3A2)

OPI:	101526843(SLC3A2)

TUP:	102471595(SLC3A2)

GVR:	103591104(SLC3A2)

CFA:	483777(SLC3A2)

CLUD:

112659375(SLC3A2)

VVP:	112924348(SLC3A2)

VLG:	121472059(SLC3A2)

NPO:	129503128(SLC3A2)

AML:	100465352(SLC3A2)

UMR:	103678209(SLC3A2)

UAH:	113246945(SLC3A2)

UAR:	123789799(SLC3A2)

ELK:

111149601

LLV:

125079091

MPUF:

101682175(SLC3A2)

MNP:	132019833(SLC3A2)

MLK:	131814279(SLC3A2)

NVS:	122913028(SLC3A2)

ORO:	101380055(SLC3A2)

EJU:	114220384(SLC3A2)

ZCA:	113915138(SLC3A2)

MLX:	118015965(SLC3A2)

NSU:	110575917(SLC3A2)

LWW:	102748323(SLC3A2)

FCA:	101093546(SLC3A2)

PYU:	121023806(SLC3A2)

PCOO:

112852154(SLC3A2)

PBG:	122483917(SLC3A2)

PVIV:

125176742(SLC3A2)

LRUF:

124505358

PTG:	102965141(SLC3A2)

PPAD:

109246609(SLC3A2)

PUC:

125931967

AJU:

106981745

HHV:	120249193(SLC3A2)

BTA:	507107(SLC3A2)

BOM:	102275454(SLC3A2)

BIU:	109554449(SLC3A2)

BBUB:

102412834(SLC3A2)

BBIS:

104998667(SLC3A2)

CHX:	102187568(SLC3A2)

OAS:	101116778(SLC3A2)

BTAX:

128068796(SLC3A2)

ODA:	120874591(SLC3A2)

CCAD:

122430855(SLC3A2)

MBEZ:

129548840(SLC3A2)

SSC:	100144589(SLC3A2)

CFR:	102507069(SLC3A2)

CBAI:

105070151(SLC3A2)

CDK:	105091514(SLC3A2)

VPC:	102534878(SLC3A2)

BACU:

103019552(SLC3A2)

BMUS:

118899226(SLC3A2)

LVE:	103071401(SLC3A2)

OOR:	101285311(SLC3A2)

DLE:	111183840(SLC3A2)

PCAD:

102982424(SLC3A2)

PSIU:

116757871(SLC3A2)

NASI:

112402288(SLC3A2)

ECB:	100064046(SLC3A2)

EPZ:	103558960(SLC3A2)

EAI:	106822075(SLC3A2)

MYB:	102263968(SLC3A2)

MYD:	102754570(SLC3A2)

MMYO:

118648994(SLC3A2)

MLF:	102442663(SLC3A2)

PKL:	118707230(SLC3A2)

EFUS:

103303725(SLC3A2)

MNA:	107539793(SLC3A2)

DRO:	112317101 112317268

SHON:

118991636(SLC3A2)

AJM:	119045479 119045511

PDIC:

114499141 114499411

PHAS:

123829231 123829284 123829286 123829287

MMF:	118628363(SLC3A2)

PPAM:

129068426 129068484 129068631

HAI:	109384305(SLC3A2)

RFQ:	117030501(SLC3A2)

PALE:

102886234(SLC3A2)

PGIG:

120600658(SLC3A2)

PVP:	105297822(SLC3A2)

RAY:	107501610(SLC3A2)

MJV:	108397052(SLC3A2)

TOD:	119250059(SLC3A2)

SARA:

101541489(SLC3A2)

SETR:

126017626(SLC3A2)

LAV:	100669507(SLC3A2)

TMU:

101360954

ETF:	101653913(SLC3A2)

DNM:	101434493(SLC3A2)

MDO:	100013019(SLC3A2)

GAS:	123251344(SLC3A2)

SHR:	100918928(SLC3A2)

AFZ:

127541817

PCW:	110195303(SLC3A2)

OAA:	100075569(SLC3A2)

PCOC:

116237754(SLC3A2)

TGU:	115492065(SLC3A2)

LSR:	110480564(SLC3A2)

PMOA:

120506075(SLC3A2)

OTC:

121336823

PRUF:

121360675(SLC3A2)

OMA:	130262744(SLC3A2)

PHI:	102112839(SLC3A2)

PMAJ:

107199248(SLC3A2)

SVG:	106864431(SLC3A2)

ACHC:

115347763(SLC3A2)

SHAB:

115602993(SLC3A2)

ASN:	102372110(SLC3A2)

AMJ:	102558098(SLC3A2)

PSS:	102453089(SLC3A2)

CMY:	102933524(SLC3A2)

CCAY:

125640624(SLC3A2)

DCC:	119859093(SLC3A2)

CPIC:

101937381(SLC3A2)

TST:	117880174(SLC3A2)

CABI:

116838828(SLC3A2)

MRV:	120409335(SLC3A2)

ACS:	100552621(slc3a2) 103282584

ASAO:

132764298(SLC3A2)

PVT:	110081016(SLC3A2)

SUND:

121916019(SLC3A2)

PBI:	103064247(SLC3A2) 112540950

PMUR:

107291637 107292430(SLC3A2)

CTIG:

120317091(SLC3A2)

TSR:

106541836

PGUT:

117670284(SLC3A2)

APRI:

131186816(SLC3A2)

PTEX:

113446628(SLC3A2)

NSS:	113426326(SLC3A2)

VKO:	123032685(SLC3A2)

PMUA:

114586822(SLC3A2) 114603412

PRAF:

128403302(SLC3A2) 128418220

ZVI:	118076517(SLC3A2)

HCG:	128332895 128337090(SLC3A2)

GJA:	107115207(SLC3A2)

STOW:

125441631(SLC3A2)

EMC:	129338676(SLC3A2)

XLA:	379133(slc3a2.L) 379938(slc3a2.S)

XTR:	493209(slc3a2)

NPR:	108794432(SLC3A2)

RTEM:

120917568 120917569

BBUF:

120981108(SLC3A2)

BGAR:

122920323(SLC3A2)

MUO:	115480070(SLC3A2)

GSH:	117365720(SLC3A2)

DRE:	399488(slc3a2b) 790938(zgc:158423) 796322(slc3a2a)

SRX:	107707044 107707057 107715370 107738018 107756163

SANH:

107669341 107683549 107683574 107700018 107702063

SGH:	107548235 107559405 107595329 107597055 107597056

CCAR:

109045996(slc3a2) 109046265 109092598 109093027

CAUA:

113038516 113052200 113078012 113095064 113105629 113105630

CGIB:

127942141 127962105 127962106 127985495 128017209

PTET:

122326237(slc3a2b) 122348144 122349556

LROH:

127152230(slc3a2b) 127167560(zgc:158423) 127167633

OMC:	131528814(slc3a2b) 131544236(zgc:158423) 131544781(slc3a2a)

PPRM:

120470108 120470356(zgc:158423) 120494695(slc3a2b)

RKG:	130073992(slc3a2b) 130103377 130103379(zgc:158423)

MAMB:

125253544(slc3a2b) 125265541 125265542

CIDE:

127504068 127516544 127516545

MASI:

127429067 127431186 127447142 127453764 127453768

TROS:

130549671 130549672 130570138(slc3a2b)

TDW:	130407771(slc3a2b) 130425948

MANU:

129424128(slc3a2b) 129439062 129439098

IPU:	108267557 108279203(slc3a2b)

IFU:	128610087 128622637(slc3a2b)

PHYP:

113540033 113541784(slc3a2)

SMEO:

124386741 124398038(slc3a2b)

TFD:	113635221 113662102(slc3a2b)

TVC:	132848655 132860076(slc3a2b)

AMEX:

103024422 103045737

CMAO:

118820641(slc3a2b) 118825465

EEE:	113579831 113586009

CHAR:

105894160 105911333(slc3a2b)

TRU:	101063061(slc3a2) 101070290

TFS:	130522411(slc3a2a) 130534708(si:dkey-202g17.3)

TNG:	GSTEN00024382G001

LCO:	104929379 104937562 104937690(slc3a2)

NCC:	104947723(slc3a2) 104948182

TBEN:

117470444 117487908(slc3a2a) 117496649

CGOB:

115017888 115023818(slc3a2) 115026991

PGEO:

117444136 117457722 117463421 117463737(slc3a2a)

GACU:

117551738(slc3a2a) 117552134 117557539

EMAC:

134875956(slc3a2a) 134879862(si:dkey-202g17.3) 134881657(slc3a2b)

ELY:	117246057 117246430 117259070 117267659

EFO:	125883921(slc3a2a) 125889262(si:dkey-202g17.3) 125901370

PLEP:

121943525 121962344(slc3a2a) 121965655

SLUC:

116039912(slc3a2a) 116047730 116053588

ECRA:

117934540(slc3a2a) 117940693 117942188

ESP:	116670553 116678554 116686561(slc3a2)

PFLV:

114545906(slc3a2) 114547268 114550207

GAT:	120815151 120820712 120822356(slc3a2a)

PPUG:

119215231 119223183(slc3a2a) 119227398

AFB:	129092584(si:dkey-202g17.3) 129093290(slc3a2a) 129103923

CLUM:

117725141 117741523 117747869(slc3a2a)

PSWI:

130201584 130211115(si:dkey-202g17.3) 130211689(slc3a2a)

MSAM:

119882305 119883488 119909777 119912192(slc3a2a)

SCHU:

122862324(slc3a2b) 122870498(slc3a2a) 122879633(si:dkey-202g17.3)

CUD:	121504696 121516099

ALAT:

119004298 119009805 119027055 119027057

MZE:	101484220 101486330(slc3a2)

ONL:	100705172(slc3a2) 100710813 102082501 109195675

OAU:	116314754 116317857(slc3a2a) 116317858 116335520

OLA:	101159121 101167257 101170465(slc3a2)

OML:	112149140 112149461 112156274(slc3a2a)

CSAI:

133420613(slc3a2a) 133442369(si:dkey-202g17.3) 133462070

XMA:	102223583 102232531(slc3a2)

XCO:	114155704 114157759(slc3a2)

XHE:	116707919 116709206 116732986(slc3a2)

PRET:

103458108 103474630 103480734(slc3a2)

PFOR:

103136278 103154076(slc3a2) 103156173

PLAI:

106947989(slc3a2) 106949990 106963252

PMEI:

106910135 106932845 106934218

GAF:	122820295(slc3a2a) 122833250(si:dkey-202g17.3) 122846610

PPRL:

129358779(si:dkey-202g17.3) 129373327(slc3a2a) 129377298

CVG:	107084125(slc3a2) 107094174 107096053

CTUL:

119776404(slc3a2a) 119787813 119792114

GMU:	124855833 124881390(slc3a2a) 124884618(si:dkey-202g17.3)

NFU:	107380294 107380955(slc3a2)

KMR:	108234876(slc3a2a) 108240952 108249617

ALIM:

106515409 106517950(slc3a2) 106534852

NWH:	119409686(slc3a2a) 119411250 119427880

AOCE:

111568660 111581275(slc3a2)

MCEP:

125013584 125022303(slc3a2a) 125024169

CSEM:

103378054 103382212 103385026(slc3a2)

POV:	109630296 109634936(slc3a2) 109647734

SSEN:

122767042(slc3a2a) 122773839(si:dkey-202g17.3) 122783139

HHIP:

117752254(slc3a2a) 117756146 117773189

HSP:	118102618(slc3a2a) 118106397(si:dkey-202g17.3) 118116302

SMAU:

118286619(slc3a2b) 118299753(si:dkey-202g17.3) 118301100(slc3a2a)

LCF:	108892379 108893206 108900826(si:dkey-202g17.3)

SDU:	111231297(slc3a2) 111237169 111238884

SLAL:

111652967 111653463(slc3a2) 111656005

XGL:	120791510 120795275 120797650(slc3a2a)

HCQ:	109507013(slc3a2) 109520255 109526434

SSCV:

125972430(si:dkey-202g17.3) 125980744 125987330

SBIA:

133494645(slc3a2a) 133501438 133504994(si:dkey-202g17.3)

PEE:	133397733(slc3a2a) 133401875 133405438(si:dkey-202g17.3)

PTAO:

133473020(slc3a2a) 133479631 133482101(si:dkey-202g17.3)

BPEC:

110153078 110154091 110159341(slc3a2)

MALB:

109951724 109965833(slc3a2)

BSPL:

114843272 114843284 114843289 114848252 114867784(si:dkey-202g17.3)

SJO:	128360267(si:dkey-202g17.3) 128375586 128383307(slc3a2a)

SASA:

100195278(4f2) 106563501(slc3a2) 106578137 106603161

STRU:

115154659 115162986 115194718 115204257

OTW:	112228802(slc3a2b) 112231343 112239582 112265079

OMY:	110500797 110507427 110509955 110533969

OGO:	123993064(si:dkey-202g17.3) 123993917 124006973 124014135

ONE:	115101314(slc3a2) 115124635 115135656 115137082

OKI:	109872800 109874015(slc3a2) 109897153 109905420

OKE:	118380292 118385133 118390347 118397130(si:dkey-202g17.3)

SALP:

111949910 111950241 111964164(slc3a2)

SNH:	120018671 120021345 120049448 120057230

CCLU:

121541825 121558220 121567054(si:dkey-202g17.3) 121579477

ELS:	105012097 105028069(slc3a2) 105029474

SFM:	108920214(slc3a2) 108925498

PKI:	111839520(slc3a2) 111849093

AANG:

118224299 118236522

PSPA:

121303756 121306235(slc3a2b) 121310137

ARUT:

117414525

PSEX:

120539371 120539372

LCM:	102352322 102363720(SLC3A2)

CMK:

103180805

CPLA:

122543775(slc3a2b)

HOC:	132836296(slc3a2b)

LERI:

129699650 129716017

PMRN:

116947695(SLC3A2)

LRJ:	133341466(SLC3A2)

CIN:

100180722

DME:	Dmel_CG2791(CD98hc)

DER:

6553572

DSE:

6614311

DSI:	Dsimw501_GD19444(Dsim_GD19444)

DYA:	Dyak_GE25755

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10226

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:	106619057 118679770

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ011854 CpipJ_CPIJ020244

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

FAS:

DAM:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:	115880195 115880234 115888978

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:

DNX:

AGS:

RMD:

BROR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

VDE:	111255576 111255585

VJA:	111261633 111263901

DPTE:

113795973

HRO:	HELRODRAFT_159582

» show all

Reference

PMID:19335336

Authors

Reynolds B, Roversi P, Laynes R, Kazi S, Boyd CA, Goberdhan DC

Title

Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties.

Journal

Biochem J 420:363-72 (2009)
DOI:10.1042/BJ20082198

Reference

PMID:3476959

Authors

Quackenbush E, Clabby M, Gottesdiener KM, Barbosa J, Jones NH, Strominger JL, Speck S, Leiden JM

Title

Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth.

Journal

Proc Natl Acad Sci U S A 84:6526-30 (1987)
DOI:10.1073/pnas.84.18.6526

Sequence

[hsa:6520]

LinkDB

DBGET integrated database retrieval system