KEGG ORTHOLOGY: K06622

ORTHOLOGY: K06622

Entry

K06622                      KO

Symbol

CDKN2C, P18, INK4C

Name

cyclin-dependent kinase inhibitor 2C

Pathway

map01522

Endocrine resistance

map04110

Cell cycle

map04934

Cushing syndrome

map05166

Human T-cell leukemia virus 1 infection

map05202

Transcriptional misregulation in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C

Other DBs

GO:

0004861

Genes

HSA:	1031(CDKN2C)

PTR:	469319(CDKN2C)

PPS:	100992391(CDKN2C)

GGO:	101125732(CDKN2C)

PON:	100459088(CDKN2C)

PPYG:

129015494(CDKN2C)

NLE:	100606274(CDKN2C)

HMH:	116473141(CDKN2C)

SSYN:

129469021(CDKN2C)

MCC:	711877(CDKN2C)

MCF:	102132965(CDKN2C)

MTHB:

126961765

MNI:	105495030(CDKN2C)

CSAB:

103224834(CDKN2C)

CATY:

105571660(CDKN2C)

PANU:

100998894(CDKN2C)

TGE:	112626379(CDKN2C)

MLEU:

105534841(CDKN2C)

RRO:	104672737(CDKN2C)

RBB:	108531808(CDKN2C)

TFN:	117092609(CDKN2C)

PTEH:

111524037(CDKN2C)

CANG:

105500653(CDKN2C)

CJC:	100395956(CDKN2C)

SBQ:	101041782(CDKN2C)

CIMI:

108318024(CDKN2C)

ANAN:

105705126(CDKN2C)

CSYR:

103253579(CDKN2C)

MMUR:

105877534(CDKN2C)

LCAT:

123635667(CDKN2C)

ERUF:

138389518(CDKN2C)

PCOQ:

105806281(CDKN2C)

OGA:	100947399(CDKN2C)

MMU:	12580(Cdkn2c)

MCAL:

110292857(Cdkn2c)

MPAH:

110323411(Cdkn2c)

RNO:	54238(Cdkn2c)

MCOC:

116096405(Cdkn2c)

ANU:	117708327(Cdkn2c)

ASYL:

127681073(Cdkn2c)

MUN:	110563557(Cdkn2c)

CGE:	100774733(Cdkn2c)

MAUA:

101828904(Cdkn2c)

PROB:

127225157(Cdkn2c)

PLEU:

114706541(Cdkn2c)

PMAV:

102922455(Cdkn2c)

MORG:

121447806(Cdkn2c)

MFOT:

126497939

AAMP:

119817951(Cdkn2c)

CNL:	130883299(Cdkn2c)

NGI:	103733571(Cdkn2c)

HGL:	101721834(Cdkn2c)

CPOC:

100727634(Cdkn2c)

CCAN:

109700012(Cdkn2c)

DORD:

105990024(Cdkn2c)

DSP:	122110174(Cdkn2c)

DMER:

138803354(Cdkn2c)

PLOP:

125355142(Cdkn2c)

NCAR:

124988066

MMMA:

107141779(Cdkn2c)

ITI:	101975692(Cdkn2c)

OCU:

100358955

OPI:	101517996(CDKN2C)

OCZ:	121155289(CDKN2C)

TUP:	102484147(CDKN2C)

GVR:	103600891(CDKN2C)

CFA:	475359(CDKN2C)

CLUD:

112642487(CDKN2C)

VVP:	112914731(CDKN2C)

VLG:	121481677(CDKN2C)

NPO:	129520495(CDKN2C)

AML:	100470950(CDKN2C)

UMR:	103670732(CDKN2C)

UAH:	113254692(CDKN2C)

UAR:	123793712(CDKN2C)

ELK:

111143151

LLV:

125098666

MPUF:

101673844(CDKN2C)

MNP:	132000854(CDKN2C)

MLK:	131809759(CDKN2C)

NVS:	122899958(CDKN2C)

ORO:	101379422(CDKN2C)

EJU:	114212009(CDKN2C)

ZCA:	113916997(CDKN2C)

MLX:	118019429(CDKN2C)

NSU:	110575042(CDKN2C)

LWW:	102746757(CDKN2C)

FCA:	101086582(CDKN2C)

PYU:	121027105(CDKN2C)

PCOO:

112848354(CDKN2C)

PBG:	122482154(CDKN2C)

PVIV:

125172647(CDKN2C)

LRUF:

124516229

LGF:	123597869(CDKN2C)

AJU:

106973704

PTG:	102961641(CDKN2C)

PPAD:

109266897(CDKN2C)

PUC:

125913467

PLEZ:

122227027(CDKN2C)

HHV:	120240620(CDKN2C)

BTA:	505691(CDKN2C)

BOM:	102272454(CDKN2C)

BIU:	109556313(CDKN2C)

BBUB:

102396473(CDKN2C)

BKE:	129655470(CDKN2C)

BBIS:

104984621(CDKN2C)

CHX:	102169723(CDKN2C)

OAS:	101109224(CDKN2C)

BTAX:

128044912(CDKN2C)

CSUM:

138074070(CDKN2C)

ODA:	120856165(CDKN2C)

CCAD:

122436995(CDKN2C) 122449984

MREE:

136152010(CDKN2C)

OVR:	110146397(CDKN2C)

MBEZ:

129541498(CDKN2C)

SSC:	100515210(CDKN2C)

CFR:	102507152(CDKN2C)

CBAI:

105066465(CDKN2C)

CDK:	105092949(CDKN2C)

VPC:	102545263(CDKN2C)

BACU:

103019317(CDKN2C)

BMUS:

118885651(CDKN2C)

LVE:	103075084(CDKN2C)

OOR:	101287647(CDKN2C)

LALB:

132516195(CDKN2C)

GMF:	115860392(CDKN2C)

DDP:	132420521(CDKN2C)

DLE:	111175798(CDKN2C)

PCAD:

102986788(CDKN2C)

PSIU:

116744327(CDKN2C)

PPHC:

136133040(CDKN2C)

NASI:

112395820(CDKN2C)

ECB:	100051195(CDKN2C)

EPZ:	103550643(CDKN2C)

EAI:	106826063(CDKN2C)

MYB:	102257630(CDKN2C)

MYD:	102756495(CDKN2C)

MMYO:

118676710(CDKN2C)

MLF:	102423668(CDKN2C)

MDT:	132231105(CDKN2C)

MYUM:

139003351(CDKN2C)

PKL:	118724553(CDKN2C)

EFUS:

103284032(CDKN2C)

MNA:	107538025(CDKN2C)

DRO:	112314586(CDKN2C)

SHON:

118985009(CDKN2C)

AJM:	119051808(CDKN2C)

PDIC:

114497779(CDKN2C)

PHAS:

123830717(CDKN2C)

MMF:	118626383(CDKN2C)

PPAM:

129069656(CDKN2C)

HAI:	109390269(CDKN2C)

RFQ:	117027694(CDKN2C)

PALE:

102878098(CDKN2C)

PGIG:

120620809(CDKN2C)

PVP:	105297173(CDKN2C)

RAY:	107497964(CDKN2C)

MJV:	108404720(CDKN2C)

TOD:	119236368(CDKN2C)

SARA:

101545934(CDKN2C)

SFUM:

130031106(CDKN2C)

SETR:

126011297(CDKN2C)

LAV:	100669475(CDKN2C)

TMU:

101341387

ETF:	101647907(CDKN2C)

DNM:	101418445(CDKN2C)

MDO:	100020812(CDKN2C)

GAS:	123245033(CDKN2C)

SHR:	100927420(CDKN2C)

AFZ:

127563336

PCW:	110209335(CDKN2C)

TVP:	118847990(CDKN2C)

PBRV:

138164995 138165358

OAA:	114805449(CDKN2C)

TACU:

119940429(CDKN2C)

GGA:	429104(CDKN2C)

PCOC:

116234552(CDKN2C)

MGP:	104912502(CDKN2C)

CJO:	107317588(CDKN2C)

TPAI:

128072321(CDKN2C)

LMUT:

125692802(CDKN2C)

NMEL:

110402276(CDKN2C)

APLA:

101794566(CDKN2C)

AACU:

137860216(CDKN2C)

ACYG:

106032943(CDKN2C)

CATA:

118243474(CDKN2C)

AFUL:

116492049(CDKN2C)

TGU:	100220326(CDKN2C)

LSR:	110470604(CDKN2C)

SCAN:

103815007(CDKN2C)

PMOA:

120503293(CDKN2C)

OTC:	121345112(CDKN2C)

PRUF:

121362252(CDKN2C)

GFR:	102034516(CDKN2C)

FAB:	101815473(CDKN2C)

OMA:	130256452(CDKN2C)

PHI:	102101327(CDKN2C)

PMAJ:

107208495(CDKN2C)

CCAE:

111943841(CDKN2C)

CCW:	104695210(CDKN2C)

CBRC:

103621890(CDKN2C)

ACOE:

138114198(CDKN2C)

ETL:	114062544(CDKN2C)

ZAB:	102074201(CDKN2C)

ZLE:	135451278(CDKN2C)

ACHL:

103811242(CDKN2C)

SVG:	106849794(CDKN2C)

MMEA:

130574077(CDKN2C)

HRT:	120756850(CDKN2C)

SATI:

136365155(CDKN2C)

CFAI:

136294748(CDKN2C)

CCIC:

134046733(CDKN2C)

FPG:	101916167(CDKN2C)

FCH:	102051318(CDKN2C)

CCRI:

104166408(CDKN2C)

SHAB:

115612195(CDKN2C)

ACUN:

113483155(CDKN2C)

TALA:

104359254(CDKN2C)

ACHC:

115349539(CDKN2C)

HLE:	104841030(CDKN2C)

AGEN:

126042217

HHAR:

128148392(CDKN2C)

BBUT:

142035207(CDKN2C)

GCL:

127019082

CSTI:

104560180(CDKN2C)

LDI:	104342928(CDKN2C)

MNB:	103775405(CDKN2C)

DPUB:

104307924(CDKN2C)

PPUS:

135177493(CDKN2C)

AVIT:

104269705

BRHI:

104488699(CDKN2C)

EGZ:	104131493(CDKN2C)

NNI:	104009364(CDKN2C)

PCRI:

104032352(CDKN2C)

PCAO:

104047454(CDKN2C)

PARX:

142059172(CDKN2C)

PADL:

103912449(CDKN2C)

AFOR:

103905616(CDKN2C)

CBOR:

142084801(CDKN2C)

CBOY:

140654504(CDKN2C)

MAME:

142412863(CDKN2C)

CLV:	102090072(CDKN2C)

CNIC:

136001834(CDKN2C)

MUI:	104543201(CDKN2C)

PGUU:

104470384(CDKN2C)

PLET:

104616067(CDKN2C)

EHS:	104516998(CDKN2C)

CUCA:

104060153(CDKN2C)

TEO:	104371418(CDKN2C)

BREG:

104639466(CDKN2C)

GAME:

129209645(CDKN2C)

OHA:	104334198(CDKN2C)

ACAR:

104520943(CDKN2C)

CPEA:

104394420(CDKN2C)

CVF:	104286254(CDKN2C)

RTD:	128914229(CDKN2C)

CRID:

134519247(CDKN2C)

LMIC:

141747792(CDKN2C)

NARQ:

141467933(CDKN2C)

AAM:	106491607(CDKN2C)

AROW:

112976009(CDKN2C)

NPD:	112959572(CDKN2C)

TGT:	104571032(CDKN2C)

DNE:	112986506(CDKN2C)

SCAM:

104149614(CDKN2C)

ASN:	102370721(CDKN2C)

AMJ:	102571103(CDKN2C)

CPOO:

109307003(CDKN2C)

GGN:	109305307(CDKN2C)

PSS:	102448899(CDKN2C)

CIZ:	142017782(CDKN2C)

CMY:	102940829(CDKN2C)

CCAY:

125641563(CDKN2C)

LKP:	140916301(CDKN2C)

NDS:	141992971(CDKN2C)

DCC:	119860742(CDKN2C)

CPIC:

101931916(CDKN2C)

TST:	117881167(CDKN2C)

EOB:	135882531(CDKN2C)

CABI:

116817308(CDKN2C)

MRV:	120370074(CDKN2C)

ACS:	100556777(cdkn2c)

ASAO:

132773906(CDKN2C)

PVT:	110076178(CDKN2C)

SUND:

121929821

PBI:	103053459(CDKN2C)

PMUR:

107283071(CDKN2C)

CTIG:

120297350(CDKN2C)

TSR:	106541820(CDKN2C)

PGUT:

117664211(CDKN2C)

PCAE:

139314040(CDKN2C)

APRI:

131195918(CDKN2C)

PTEX:

113440711(CDKN2C)

NSS:	113411010(CDKN2C)

VKO:	123023617(CDKN2C)

PMUA:

114599020(CDKN2C)

PRAF:

128415788(CDKN2C)

ZVI:	118089498(CDKN2C)

HCG:	128322619(CDKN2C)

GJA:	107116289(CDKN2C)

STOW:

125433973(CDKN2C)

EMC:	129330727(CDKN2C)

XLA:	108714312(cdkn2c.L) 108715590(cdkn2c.S)

XTR:	100144705(cdkn2c)

NPR:	108783816(CDKN2C)

RTEM:

120945929(CDKN2C)

ACAT:

141103683(CDKN2C)

PADS:

140336486(CDKN2C)

DTC:	141076309(CDKN2C)

PWL:	138293458(CDKN2C)

MUO:	115473329(CDKN2C)

GSH:	117346035(CDKN2C)

DRE:	555797(cdkn2c)

SRX:	107707576 107743873

SANH:

107657864 107699560

SGH:	107548184 107550257 107599829

CCAR:

109058083(cdkn2c) 122145910

CAUA:

113069319 113069837 113107067

CGIB:

127962835 128018839

PTET:

122349869(cdkn2c)

LROH:

127169175(cdkn2c)

GRF:	141287469(cdkn2c)

OMC:	131545921(cdkn2c)

PPRM:

120481797(cdkn2c)

RKG:	130091613(cdkn2c)

MAMB:

125279238(cdkn2c)

CIDE:

127518017

CERY:

137026294(cdkn2c)

MASI:

127415262 127424047

TROS:

130568068(cdkn2c)

TDW:	130439846(cdkn2c)

MANU:

129413399(cdkn2c)

PDAB:

135730506(cdkn2c)

IPU:

108265004

IFU:	128607975(cdkn2c)

PHYP:

113527280(cdkn2c)

SMEO:

124399466(cdkn2c)

TFD:	113655749(cdkn2c)

TVC:	132853545(cdkn2c)

CGAR:

128529970(cdkn2c)

NGRA:

132893216(cdkn2c)

TRN:	134317693(cdkn2c)

AMEX:

103024048(cdkn2c)

CMAO:

118812951(cdkn2c)

EEE:	113572097(cdkn2c)

CHAR:

105895128(cdkn2c)

SPIL:

134101838(cdkn2c)

ASAD:

121678468(cdkn2c)

TFS:	130528309(cdkn2c)

TNG:	GSTEN00028829G001

LCO:	104925255(cdkn2c)

TBEN:

117497777(cdkn2c)

CGOB:

115007221(cdkn2c)

PGEO:

117444852(cdkn2c)

GACU:

117551473

EMAC:

134869064(cdkn2c)

ELY:	117254351(cdkn2c)

EFO:	125896447(cdkn2c)

PLEP:

121941274(cdkn2c)

SLUC:

116055178(cdkn2c)

ECRA:

117951065(cdkn2c)

ESP:	116694896(cdkn2c)

PFLV:

114561874(cdkn2c)

GAT:	120824355(cdkn2c)

PPUG:

119216572(cdkn2c)

AFB:	129094843(cdkn2c)

CLUM:

117729802(cdkn2c)

PSWI:

130194234(cdkn2c)

CANA:

137794556(cdkn2c)

CVE:	137870101(cdkn2c)

MSAM:

119900727(cdkn2c)

SCHU:

122877506(cdkn2c)

EARM:

139287324(cdkn2c)

CUD:	121512527(cdkn2c)

SPUL:

138607883(cdkn2c)

LMIX:

132962738(cdkn2c)

HTC:	141789438(cdkn2c)

ALAT:

119028048(cdkn2c)

ASTR:

137599356(cdkn2c)

PKLU:

139203145(cdkn2c)

MZE:	101484144 112430374

ONL:	100695802 109194384

OAU:	116323168 116333313

OLA:	101163481(cdkn2c)

OML:	112150567(cdkn2c)

CSAI:

133458399(cdkn2c)

XMA:	102230397(cdkn2c)

XCO:	114151621(cdkn2c)

XHE:	116726524(cdkn2c)

PRET:

103464068(cdkn2c) 103464190

PFOR:

103138468(cdkn2c)

PLAI:

106951078(cdkn2c)

PMEI:

106931443(cdkn2c)

GAF:	122838439(cdkn2c)

PPRL:

129379538(cdkn2c)

CVG:

107084055

CTUL:

119779621 119780881(cdkn2c)

GMU:	124874205(cdkn2c)

NFU:	107393153(cdkn2c)

ALIM:

106530509

NWH:	119407838(cdkn2c)

AOCE:

111571419(cdkn2c)

EJA:	138198800(cdkn2c)

BFRE:

138621189(cdkn2c)

MCEP:

125009532(cdkn2c)

CSEM:

103397432(cdkn2c)

SSEN:

122780476(cdkn2c)

SSOE:

131465239(cdkn2c)

HHIP:

117760254(cdkn2c)

HSP:	118121158(cdkn2c)

PPLT:

128448344(cdkn2c)

SMAU:

118317645(cdkn2c)

LCF:

108881373

SDU:	111239825(cdkn2c)

SLAL:

111651876

XGL:	120791168(cdkn2c)

HCQ:	109531898(cdkn2c)

SSCV:

125972295(cdkn2c)

SBIA:

133503065(cdkn2c)

PEE:	133405884(cdkn2c)

PTAO:

133481240(cdkn2c)

BPEC:

110160228(cdkn2c)

ENY:	140353495(cdkn2c)

MALB:

109967446(cdkn2c)

BSPL:

114853933(cdkn2c)

SJO:	128362226(cdkn2c)

SSCO:

133985059(cdkn2c)

SASA:

106584328 106613897

STRU:

115158388(cdkn2c)

OTW:	112251012(cdkn2c)

OMY:	110521563 110524431

OGO:	123996826(cdkn2c)

ONE:	115108427(cdkn2c)

OKI:	109902619(cdkn2c)

OKE:	118391050(cdkn2c)

OMM:	135511735 135556415

OCLA:

139407629 139410183

SALP:

111976075

SNH:	120054857(cdkn2c)

SFON:

129855272

CCLU:

121533408(cdkn2c) 121539892

ELS:	105026377(cdkn2c)

OEP:	134010881(cdkn2c)

SFM:	108919037(cdkn2c)

PKI:	111848953(cdkn2c)

AANG:

118224762(cdkn2c)

AROT:

135253706(cdkn2c)

CCOG:

133127223(cdkn2c)

LOC:	102689618(cdkn2c)

PSPA:

121326434 121330500

ARUT:

117412162 117417006

PSEX:

120537961(cdkn2c)

LCM:	102367385(CDKN2C)

RTP:	109914995(cdkn2c)

CPLA:

122554350(cdkn2c)

CPUN:

140479904(cdkn2c)

HOC:	132819088(cdkn2c)

SCAU:

119964596(cdkn2c)

LERI:

HAKA:

BFO:

BBEL:

SPU:

LPIC:

LVG:

APLC:

ARUN:

AAMU:

SKO:

PFLL:

NVI:

BROR:

HRF:

HRJ:

HASI:

HCRA:

Reference

PMID:17654117

Authors

Canepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF

Title

INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.

Journal

IUBMB Life 59:419-26 (2007)
DOI:10.1080/15216540701488358

Reference

PMID:12077144

Authors

Blais A, Monte D, Pouliot F, Labrie C

Title

Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1.

Journal

J Biol Chem 277:31679-93 (2002)
DOI:10.1074/jbc.M204554200

Sequence

[hsa:1031]

Reference

PMID:8001816

Authors

Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y

Title

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

Journal

Genes Dev 8:2939-52 (1994)
DOI:10.1101/gad.8.24.2939

Sequence

[hsa:1031]

LinkDB

DBGET integrated database retrieval system