KEGG ORTHOLOGY: K06637

ORTHOLOGY: K06637

Entry

K06637                      KO

Symbol

BUB1B, BUBR1, MAD3L

Name

mitotic checkpoint serine/threonine-protein kinase BUB1 beta [EC:2.7.11.1]

Pathway

map04110

Cell cycle

map05166

Human T-cell leukemia virus 1 infection

Disease

H00020

Colorectal cancer

H01288

Mosaic variegated aneuploidy syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  BUB family
   K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Core SAC proteins
     K06637  BUB1B, BUBR1, MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Genes

HSA:	701(BUB1B)

PTR:	453324(BUB1B)

PPS:	100970272(BUB1B)

GGO:	101145178(BUB1B)

PON:	100455824(BUB1B)

PPYG:

129013936(BUB1B)

NLE:	100607252(BUB1B)

HMH:	116481691(BUB1B)

SSYN:

129482628(BUB1B)

MCC:	100423079(BUB1B)

MCF:	102133579(BUB1B)

MTHB:

126959800

MNI:	105493198(BUB1B)

CSAB:

103245845(BUB1B)

CATY:

105574259(BUB1B)

PANU:

101009307(BUB1B)

TGE:	112627536(BUB1B)

MLEU:

105546185(BUB1B)

RRO:	104659672(BUB1B)

RBB:	108526889(BUB1B)

TFN:	117070876(BUB1B)

PTEH:

111524256(BUB1B)

CANG:

105505030(BUB1B)

CJC:	100413586(BUB1B)

SBQ:	101052819(BUB1B)

CIMI:

108306103(BUB1B)

ANAN:

105724149(BUB1B)

CSYR:

103272334(BUB1B)

MMUR:

105872430(BUB1B)

LCAT:

123624096(BUB1B)

PCOQ:

105814453(BUB1B)

OGA:	100951988(BUB1B)

MMU:	12236(Bub1b)

MCAL:

110284043(Bub1b)

MPAH:

110318363(Bub1b)

RNO:	171576(Bub1b)

MCOC:

116090691(Bub1b)

ANU:	117703595(Bub1b)

ASYL:

127685736(Bub1b)

MUN:	110566837(Bub1b)

CGE:

100754771

MAUA:

101826222(Bub1b)

PROB:

127221651(Bub1b)

PLEU:

114705912(Bub1b)

MORG:

121465654(Bub1b)

MFOT:

126496628

AAMP:

119814778(Bub1b)

NGI:	103741499(Bub1b)

HGL:	101705847(Bub1b)

CPOC:

100728730(Bub1b)

CCAN:

109693520(Bub1b)

DORD:

105981017(Bub1b)

DSP:	122114453(Bub1b)

PLOP:

125340885(Bub1b)

NCAR:

124976879

MMMA:

107138234(Bub1b)

ITI:	101957181(Bub1b)

OCU:

100349688

OPI:	101530078(BUB1B)

TUP:	102493876(BUB1B)

GVR:	103591299(BUB1B)

CFA:	608350(BUB1B)

CLUD:

112676132(BUB1B)

VVP:	112919939(BUB1B)

VLG:	121484782(BUB1B)

NPO:	129504264(BUB1B)

AML:	100464546(BUB1B)

UMR:	103673467(BUB1B)

UAH:	113242041(BUB1B)

UAR:	123804219(BUB1B)

ELK:

111140380

LLV:

125105161

MPUF:

101671914(BUB1B)

MNP:	131999624(BUB1B)

MLK:	131836103(BUB1B)

NVS:	122893082(BUB1B)

ORO:	101373720(BUB1B)

EJU:	114221352(BUB1B)

ZCA:	113909993(BUB1B)

MLX:	118003216(BUB1B)

NSU:	110585553(BUB1B)

LWW:	102729306(BUB1B)

FCA:	101087670(BUB1B)

PYU:	121042064(BUB1B)

PCOO:

112855246(BUB1B)

PBG:	122468784(BUB1B)

PVIV:

125168743(BUB1B)

LRUF:

124508713

LGF:	123583175(BUB1B)

AJU:

106968546

PTG:	102972649(BUB1B)

PPAD:

109262594(BUB1B)

PUC:

125909842

PLEZ:

122222198(BUB1B)

HHV:	120232293(BUB1B)

BTA:	537027(BUB1B)

BOM:	102274816(BUB1B)

BIU:	109564922(BUB1B)

BBUB:

102416300(BUB1B)

BBIS:

104994400(BUB1B)

CHX:	102176047(BUB1B)

OAS:	101108313(BUB1B)

BTAX:

128054489(BUB1B)

CSUM:

138073831(BUB1B)

ODA:	120853220(BUB1B)

CCAD:

122443380(BUB1B)

MREE:

136171741(BUB1B)

OVR:	110124034(BUB1B)

MBEZ:

129562885(BUB1B)

SSC:	102164975(BUB1B)

CFR:	102521363(BUB1B)

CBAI:

105076892(BUB1B)

CDK:	105096887(BUB1B)

VPC:	102540454(BUB1B)

BACU:

103016990(BUB1B)

BMUS:

118889094(BUB1B)

LVE:	103079417(BUB1B)

OOR:	101282086(BUB1B)

LALB:

132519123(BUB1B)

DLE:	111181757(BUB1B)

PCAD:

102985069(BUB1B)

PSIU:

116749563(BUB1B)

NASI:

112391210(BUB1B)

ECB:	100629735(BUB1B)

EPZ:	103561630(BUB1B)

EAI:	106835169(BUB1B)

MYB:	102253751(BUB1B)

MYD:	102756936(BUB1B)

MMYO:

118649734(BUB1B)

MLF:	102442783(BUB1B)

MDT:	132239118(BUB1B)

MYUM:

139003353(BUB1B)

PKL:	118723689(BUB1B)

EFUS:

103287305(BUB1B)

MNA:	107543005(BUB1B)

DRO:	112311444(BUB1B)

SHON:

118993598(BUB1B)

AJM:	119061304(BUB1B)

PDIC:

114492836(BUB1B)

PHAS:

123808254(BUB1B)

MMF:	118634820(BUB1B)

PPAM:

129063039(BUB1B)

HAI:	109383975(BUB1B)

RFQ:	117024246(BUB1B)

PALE:

102896980(BUB1B)

PGIG:

120587191(BUB1B)

PVP:	105288626(BUB1B)

RAY:	107514461(BUB1B)

MJV:	108401648(BUB1B)

TOD:	119238482(BUB1B)

SARA:

101550683(BUB1B)

SFUM:

130041435(BUB1B)

SETR:

126024569(BUB1B)

LAV:	100668287(BUB1B)

TMU:

101346237

ETF:	101650270(BUB1B)

DNM:	101431286(BUB1B)

GAS:	123234086(BUB1B)

AFZ:

127549221

TVP:	118828919(BUB1B)

PBRV:

138175381(BUB1B)

OAA:	100084747(BUB1B)

GGA:	378922(BUB1B)

PCOC:

116237837(BUB1B)

MGP:

100543305

CJO:	107314246(BUB1B)

TPAI:

128086374(BUB1B)

LMUT:

125695190(BUB1B)

NMEL:

110401707(BUB1B)

APLA:

101790286(BUB1B)

ACYG:

106047065(BUB1B)

CATA:

118244678(BUB1B)

AFUL:

116490236(BUB1B)

TGU:	100232557(BUB1B)

LSR:	110485065(BUB1B)

SCAN:

103822308(BUB1B)

PMOA:

120500971(BUB1B)

OTC:

121335718

PRUF:

121354784(BUB1B) 121362752

ATRC:

139590448(BUB1B)

GFR:	102045196(BUB1B)

FAB:	101822055(BUB1B)

OMA:	130254471(BUB1B)

PHI:	102102959(BUB1B)

PMAJ:

107205325(BUB1B)

CCAE:

111930493(BUB1B)

CCW:	104692976(BUB1B)

CBRC:

103624747(BUB1B)

ACOE:

138111228

ETL:	114067937(BUB1B)

ZLE:	135448885(BUB1B)

ACHL:

103809294(BUB1B)

SVG:	106854804(BUB1B)

MMEA:

130586548(BUB1B)

HRT:	120753694(BUB1B)

SATI:

136362279(BUB1B)

CCIC:

134045397(BUB1B)

FPG:	101911948(BUB1B)

FCH:	102047575(BUB1B)

CCRI:

104169667(BUB1B)

NNT:	104406410(BUB1B)

SHAB:

115606938(BUB1B)

ACUN:

113481007(BUB1B)

TALA:

104358193(BUB1B)

ACHC:

115351999(BUB1B)

HALD:

104311084(BUB1B)

HLE:	104829883(BUB1B)

AGEN:

126047423

HHAR:

128153149(BUB1B)

GCL:

127016388

CSTI:

104556433(BUB1B)

LDI:	104340102(BUB1B)

MNB:	103776710(BUB1B)

DPUB:

104304439(BUB1B)

PPUS:

135186138(BUB1B)

AVIT:

104273403(BUB1B)

BRHI:

104497619(BUB1B)

EGZ:	104131362(BUB1B)

NNI:	104020527(BUB1B)

PCRI:

104029641(BUB1B)

PCAO:

104044327(BUB1B)

PADL:

103925168(BUB1B)

AFOR:

103902637(BUB1B)

FGA:	104073480(BUB1B)

GSTE:

104260411(BUB1B)

CBOY:

140653375(BUB1B)

CLV:	102096269(BUB1B)

MUI:	104537097(BUB1B)

PGUU:

104471149

PLET:

104626414(BUB1B)

EHS:	104502536(BUB1B)

CMAC:

104485762(BUB1B)

CUCA:

104064494(BUB1B)

TEO:	104375572(BUB1B)

BREG:

104636631(BUB1B)

OHA:	104326702(BUB1B)

ACAR:

104528161(BUB1B)

CPEA:

104385137(BUB1B)

CVF:	104293012(BUB1B)

RTD:	128908470(BUB1B)

CRID:

134514422(BUB1B)

AAM:	106486730(BUB1B)

AROW:

112969663(BUB1B)

NPD:	112952072(BUB1B)

TGT:	104580071(BUB1B)

DNE:	112989500(BUB1B)

SCAM:

104141483(BUB1B)

ASN:	102376270(BUB1B)

AMJ:	102573314(BUB1B)

CPOO:

109321486(BUB1B)

GGN:	109298734(BUB1B)

PSS:	102459964(BUB1B)

CMY:	102930824(BUB1B)

CCAY:

125637718(BUB1B)

DCC:	119857259(BUB1B)

CPIC:

101953667(BUB1B)

TST:	117876712(BUB1B)

CABI:

116837812(BUB1B)

MRV:	120405246(BUB1B)

ACS:	100551949(bub1b)

ASAO:

132765903(BUB1B)

SUND:

121933170(BUB1B)

CTIG:

120307665(BUB1B)

PGUT:

117665696(BUB1B)

APRI:

131187651(BUB1B)

PTEX:

113439213(BUB1B)

NSS:	113409954(BUB1B)

VKO:	123026926(BUB1B)

PMUA:

114593681(BUB1B)

PRAF:

128410658(BUB1B)

ZVI:	118083023(BUB1B)

HCG:	128341098(BUB1B)

GJA:	107119644(BUB1B)

STOW:

125427357(BUB1B)

EMC:	129324341(BUB1B)

XLA:	378923(bub1b.L)

XTR:	100125106(bub1b)

NPR:	108789285(BUB1B)

RTEM:

120920731(BUB1B)

BBUF:

120981831(BUB1B)

BGAR:

122922150(BUB1B)

PWL:	138260270(BUB1B)

MUO:	115477089(BUB1B)

GSH:	117364155(BUB1B)

DRE:	567006(bub1bb)

SRX:

107726582

SANH:

107663167 107678768(bub1b)

CCAR:

109055584(bub1bb)

CAUA:

113117807

CGIB:

127976532

PTET:

122334441(bub1bb)

LROH:

127179941(bub1bb)

OMC:	131522900(bub1bb)

PPRM:

120473274(bub1bb)

RKG:	130085692(bub1bb)

MAMB:

125269269(bub1bb)

CIDE:

127499001

CERY:

137006969(bub1bb)

MASI:

127410720 127455212

MANU:

129418054(bub1bb)

PDAB:

135736724(bub1bb)

IPU:	108269626(bub1bb)

IFU:	128612761(bub1bb)

PHYP:

113538618(bub1b)

SMEO:

124390353(bub1bb)

TFD:	113659722(bub1bb)

TVC:	132852773(bub1bb)

CGAR:

128535457(bub1bb)

NGRA:

132894322(bub1bb)

TRN:	134325470(bub1bb)

AMEX:

103035444(bub1bb)

CMAO:

118823657(bub1bb)

EEE:	113571360(bub1b)

CHAR:

105908340(bub1bb) 105909562(bub1ba)

SPIL:

134097716(bub1ba)

TRU:	101076711(bub1b)

TFS:	130513175(bub1bb)

LCO:	104924801(bub1b)

NCC:	104953742(bub1b)

TBEN:

117480770(bub1bb)

CGOB:

115027344(bub1b)

PGEO:

117467544(bub1bb)

GACU:

117549893(bub1bb)

EMAC:

134881543(bub1bb)

ELY:	117266778(bub1bb)

EFO:	125900707(bub1bb)

PLEP:

121953801(bub1bb)

SLUC:

116035522(bub1bb)

ECRA:

117935840(bub1bb)

ESP:	116670004(bub1b)

PFLV:

114546479(bub1b)

GAT:	120832559(bub1bb)

PPUG:

119227751(bub1bb)

AFB:	129103151(bub1bb)

CLUM:

117725352(bub1bb)

PSWI:

130201831(bub1bb)

CANA:

137787798(bub1bb)

CVE:	137880381(bub1bb)

MSAM:

119910356(bub1bb)

SCHU:

122861338(bub1bb)

CUD:	121526380(bub1bb)

SPUL:

138591676(bub1bb)

LMIX:

132993324(bub1bb)

ALAT:

119004427(bub1bb)

MZE:	101474622(bub1b)

ONL:	100706285(bub1b)

OAU:	116322284(bub1bb)

OLA:	100820727(bub1b)

OML:	112141506(bub1bb)

CSAI:

133462957(bub1bb)

XMA:	102231436(bub1b)

XCO:	114134078(bub1b)

XHE:	116708858(bub1b)

PRET:

103458557(bub1b)

PFOR:

103136084 103136085

PLAI:

106952303

PMEI:

106913923

GAF:	122845593(bub1bb)

PPRL:

129365124(bub1bb)

CVG:	107094351(bub1b)

CTUL:

119789541(bub1bb)

GMU:	124855407(bub1bb)

NFU:	107392480(bub1b)

KMR:	108234189(bub1bb)

ALIM:

106519848(bub1b)

NWH:	119427152(bub1bb)

AOCE:

111578032(bub1bb)

EJA:	138199786(bub1bb)

BFRE:

138636303(bub1bb)

MCEP:

125023289(bub1bb)

CSEM:

103389571(bub1b)

POV:	109628147(bub1b)

SSEN:

122765527(bub1bb)

SSOE:

131444828(bub1bb)

HHIP:

117756622(bub1bb)

HSP:	118116337(bub1bb)

PPLT:

128450484(bub1bb)

SMAU:

118286281(bub1bb)

LCF:	108892586(bub1bb)

SDU:	111225862(bub1b)

SLAL:

111652451(bub1b)

XGL:	120795511(bub1bb)

HCQ:	109516066(bub1b)

SSCV:

125980671(bub1bb)

SBIA:

133513185(bub1bb)

PEE:	133413122(bub1bb)

PTAO:

133487949(bub1bb)

BPEC:

110155400(bub1b)

ENY:	140370877(bub1bb)

MALB:

109968322(bub1b)

BSPL:

114848766(bub1bb)

SJO:	128375418(bub1bb)

SSCO:

134001155(bub1bb)

SASA:

106582108

STRU:

115172676

OTW:	112261851(bub1bb)

OMY:	110497980(bub1bb) 110529349

OGO:	123990534 124002004(bub1bb)

ONE:	115107541 115146274

OKI:	109894550 109900525

OKE:	118362423(bub1bb) 118398866

OMM:	135506195 135508275(bub1bb)

OCLA:

139375275 139415507

SALP:

111968788

SNH:	120024182 120059857(bub1bb)

CCLU:

121539225(bub1bb) 121544475

ELS:	105015642(bub1b)

SFM:	108919506(bub1b)

PKI:	111838880(bub1b)

AANG:

118207288(bub1bb)

AROT:

135250076(bub1bb)

CCOG:

133107776(bub1bb)

LOC:	102691087(bub1b)

PSPA:

121329501

ARUT:

117418591(bub1bb) 117422654

CPLA:

122553816(bub1bb)

HOC:	132817826(bub1bb)

BFO:

LPIC:

NLU:

MQU:

DMK:

PJA:

PCHN:

HAME:

PTRU:

HAZT:

PPOI:

DSV:

RSAN:

RMP:	119169842 119186856

VDE:

VJA:

DFR:

SDM:

HRF:

HRJ:

CRG:

PMAX:

AIRR:

MMER:

OSN:

NVE:

ATEN:

XEN:

MBR:	MONBRDRAFT_32082

» show all

Reference

PMID:14706340

Authors

Shin HJ, Baek KH, Jeon AH, Park MT, Lee SJ, Kang CM, Lee HS, Yoo SH, Chung DH, Sung YC, McKeon F, Lee CW

Title

Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.

Journal

Cancer Cell 4:483-97 (2003)
DOI:10.1016/S1535-6108(03)00302-7

Sequence

[hsa:701]

Reference

PMID:9618306

Authors

Donadelli R, Benatti L, Remuzzi A, Morigi M, Gullans SR, Benigni A, Remuzzi G, Noris M

Title

Identification of a novel gene--SSK1--in human endothelial cells exposed to shear stress.

Journal

Biochem Biophys Res Commun 246:881-7 (1998)
DOI:10.1006/bbrc.1998.8713

Sequence

[hsa:701]

LinkDB

DBGET integrated database retrieval system