KEGG   ORTHOLOGY: K06645
Entry
K06645                      KO                                     
Symbol
CDC25A
Name
M-phase inducer phosphatase 1 [EC:3.1.3.48]
Pathway
map04110  Cell cycle
map04218  Cellular senescence
map04914  Progesterone-mediated oocyte maturation
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06645  CDC25A; M-phase inducer phosphatase 1
   04218 Cellular senescence
    K06645  CDC25A; M-phase inducer phosphatase 1
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K06645  CDC25A; M-phase inducer phosphatase 1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K06645  CDC25A; M-phase inducer phosphatase 1
   05207 Chemical carcinogenesis - receptor activation
    K06645  CDC25A; M-phase inducer phosphatase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K06645  CDC25A; M-phase inducer phosphatase 1
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06645  CDC25A; M-phase inducer phosphatase 1
   03400 DNA repair and recombination proteins
    K06645  CDC25A; M-phase inducer phosphatase 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K06645  CDC25A; M-phase inducer phosphatase 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein tyrosine phosphatases (PTPs)
  Class III PTPs
   CDC25s
    K06645  CDC25A; M-phase inducer phosphatase 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     K06645  CDC25A; M-phase inducer phosphatase 1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K06645  CDC25A; M-phase inducer phosphatase 1
Other DBs
GO: 0004725
Genes
HSA: 993(CDC25A)
PTR: 460341(CDC25A)
PPS: 100985899(CDC25A)
GGO: 101142222(CDC25A)
PON: 100460228(CDC25A)
PPYG: 129033384(CDC25A)
NLE: 100588003(CDC25A)
HMH: 116473518(CDC25A)
SSYN: 129482558(CDC25A)
MCC: 710858(CDC25A)
MCF: 102137696(CDC25A)
MTHB: 126948666
MNI: 105480393(CDC25A)
CSAB: 103228635(CDC25A)
CATY: 105573640(CDC25A)
PANU: 101017438(CDC25A)
TGE: 112618658(CDC25A)
MLEU: 105540400(CDC25A)
RRO: 104671299(CDC25A)
RBB: 108517663(CDC25A)
TFN: 117080687(CDC25A)
PTEH: 111555493(CDC25A)
CANG: 105509746(CDC25A)
CJC: 100408832(CDC25A)
SBQ: 101041208(CDC25A)
CIMI: 108305295(CDC25A)
ANAN: 105731887(CDC25A)
CSYR: 103251011(CDC25A)
MMUR: 105874913(CDC25A)
LCAT: 123623323(CDC25A)
PCOQ: 105811317(CDC25A)
OGA: 100942877(CDC25A)
MMU: 12530(Cdc25a)
MCAL: 110301556(Cdc25a)
MPAH: 110327415(Cdc25a)
RNO: 171102(Cdc25a)
MCOC: 116072801(Cdc25a)
ANU: 117693812(Cdc25a)
MUN: 110565748(Cdc25a)
CGE: 100767961(Cdc25a)
MAUA: 101826345(Cdc25a)
PROB: 127236150(Cdc25a)
PLEU: 114705236(Cdc25a)
MORG: 121464398(Cdc25a)
MFOT: 126499932
AAMP: 119810533(Cdc25a)
NGI: 103750230(Cdc25a)
HGL: 101699133(Cdc25a)
CPOC: 100721008(Cdc25a)
CCAN: 109699005(Cdc25a)
DORD: 105994612(Cdc25a)
DSP: 122095677(Cdc25a)
PLOP: 125342401(Cdc25a)
NCAR: 124969415
MMMA: 107145391(Cdc25a)
OCU: 100354280
OPI: 101519009(CDC25A)
TUP: 102482369(CDC25A)
GVR: 103591612(CDC25A)
CFA: 484780(CDC25A)
CLUD: 112665734(CDC25A)
VVP: 112912171(CDC25A)
VLG: 121494228(CDC25A)
NPO: 129522597(CDC25A)
AML: 100477247(CDC25A)
UMR: 103675112(CDC25A)
UAH: 113256823(CDC25A)
UAR: 123779966(CDC25A)
ELK: 111144080
LLV: 125080840
MPUF: 101680806(CDC25A)
MNP: 132011276(CDC25A)
MLK: 131823881(CDC25A)
NVS: 122909467(CDC25A)
ORO: 101369809(CDC25A)
EJU: 114225128(CDC25A)
ZCA: 113918722(CDC25A)
MLX: 118005263(CDC25A)
NSU: 110577660(CDC25A)
LWW: 102747860(CDC25A)
FCA: 101098445(CDC25A)
PYU: 121011146(CDC25A)
PCOO: 112852660(CDC25A)
PBG: 122487215(CDC25A)
PVIV: 125158956(CDC25A)
LRUF: 124523955
PTG: 102957057(CDC25A)
PPAD: 109247747(CDC25A)
PUC: 125930666
AJU: 106979176
HHV: 120229362(CDC25A)
BTA: 520188(CDC25A)
BOM: 102285046(CDC25A)
BIU: 109576463(CDC25A)
BBUB: 102415490(CDC25A)
BBIS: 105004673(CDC25A)
CHX: 102181731(CDC25A)
OAS: 101113178(CDC25A)
BTAX: 128054910(CDC25A)
ODA: 120868201(CDC25A)
CCAD: 122424249(CDC25A)
MBEZ: 129547792(CDC25A)
SSC: 100737380(CDC25A)
CFR: 102509600(CDC25A)
CBAI: 105083373(CDC25A)
CDK: 105103857(CDC25A)
VPC: 102532416(CDC25A)
BACU: 103016547(CDC25A)
BMUS: 118904114(CDC25A)
LVE: 103085456(CDC25A)
OOR: 101282274(CDC25A)
DLE: 111174440(CDC25A)
PCAD: 102992519(CDC25A)
PSIU: 116762728(CDC25A)
NASI: 112403815(CDC25A)
ECB: 100064223(CDC25A)
EPZ: 103567910(CDC25A)
EAI: 106821782(CDC25A)
MYD: 102760761(CDC25A)
MMYO: 118668522(CDC25A)
PKL: 118715710(CDC25A)
EFUS: 103300851(CDC25A)
MNA: 107529418(CDC25A)
DRO: 112309765(CDC25A)
SHON: 118976202(CDC25A)
AJM: 119038075(CDC25A)
PDIC: 114501673(CDC25A)
PHAS: 123830798(CDC25A)
MMF: 118633065(CDC25A)
PPAM: 129087811(CDC25A)
HAI: 109375294(CDC25A)
RFQ: 117037274(CDC25A)
PALE: 102897196(CDC25A)
PGIG: 120582298(CDC25A)
PVP: 105302354(CDC25A)
RAY: 107513304(CDC25A)
MJV: 108402658(CDC25A)
TOD: 119259478(CDC25A)
SARA: 101550787(CDC25A)
SETR: 126014058(CDC25A)
LAV: 100659991(CDC25A)
TMU: 101346532
ETF: 101640269(CDC25A)
DNM: 101423936(CDC25A)
MDO: 100018150(CDC25A)
GAS: 123230824(CDC25A)
SHR: 100924467(CDC25A)
PCW: 110217106(CDC25A)
TVP: 118831405(CDC25A)
OAA: 100085311(CDC25A)
GGA: 420375(CDC25A)
PCOC: 116238507(CDC25A)
MGP: 100546502(CDC25A)
CJO: 107308656(CDC25A)
TPAI: 128086415(CDC25A)
LMUT: 125696397(CDC25A)
NMEL: 110390717(CDC25A)
APLA: 101800901(CDC25A)
ACYG: 106046801(CDC25A)
CATA: 118251873(CDC25A)
AFUL: 116486619(CDC25A)
TGU: 100231363(CDC25A)
SCAN: 103813021(CDC25A)
PMOA: 120510615(CDC25A)
OTC: 121337999(CDC25A)
PRUF: 121357168(CDC25A)
GFR: 102040683(CDC25A)
FAB: 101816817(CDC25A)
OMA: 130250370(CDC25A)
PHI: 102104005(CDC25A)
PMAJ: 107201060(CDC25A)
CCAE: 111925581(CDC25A)
CCW: 104686374(CDC25A)
CBRC: 103617977(CDC25A)
ETL: 114069284(CDC25A)
ZAB: 102067880(CDC25A)
ZLE: 135443496(CDC25A)
ACHL: 103806323(CDC25A)
SVG: 106862796(CDC25A)
MMEA: 130574572(CDC25A)
HRT: 120763061(CDC25A)
FPG: 101911899(CDC25A)
FCH: 102054923(CDC25A)
CLV: 102084553(CDC25A)
EGZ: 104121808(CDC25A)
NNI: 104019237(CDC25A)
PCRI: 104024426(CDC25A)
PLET: 104614013(CDC25A)
EHS: 104510285(CDC25A)
PCAO: 104048283
ACUN: 113476811(CDC25A)
TALA: 104363385(CDC25A)
PADL: 103916196(CDC25A)
AFOR: 103903477(CDC25A)
ACHC: 115338979(CDC25A)
HALD: 104321484(CDC25A)
HLE: 104828423(CDC25A)
AGEN: 126037607
GCL: 127013312
CCRI: 104160309(CDC25A)
CSTI: 104550080(CDC25A)
CMAC: 104484842(CDC25A)
BREG: 104638872(CDC25A)
FGA: 104069742(CDC25A)
GSTE: 104261162(CDC25A)
LDI: 104349517(CDC25A)
MNB: 103781153
OHA: 104326595
NNT: 104406434(CDC25A)
SHAB: 115610972(CDC25A)
DPUB: 104299212(CDC25A)
PGUU: 104468492(CDC25A)
ACAR: 104517797(CDC25A)
CPEA: 104398438(CDC25A)
AVIT: 104278370
CVF: 104287040(CDC25A)
RTD: 128904788(CDC25A)
CUCA: 104061607(CDC25A)
TEO: 104372529(CDC25A)
BRHI: 104495683
AAM: 106499367
AROW: 112977410(CDC25A)
NPD: 112951558(CDC25A)
TGT: 104579029
DNE: 112993598(CDC25A)
SCAM: 104150100(CDC25A)
ASN: 102384816(CDC25A)
AMJ: 102569214(CDC25A)
CPOO: 109305787(CDC25A)
GGN: 109291133(CDC25A)
PSS: 102458852(CDC25A)
CMY: 102931776(CDC25A)
CCAY: 125632997(CDC25A)
DCC: 119852038(CDC25A)
CPIC: 101944298(CDC25A)
TST: 117871895(CDC25A)
CABI: 116828404(CDC25A)
MRV: 120399640(CDC25A)
ACS: 100558641(cdc25a) 103280245
ASAO: 132779713(CDC25A)
PVT: 110082540(CDC25A)
SUND: 121935243(CDC25A)
PBI: 103059140(CDC25A)
CTIG: 120319681(CDC25A)
TSR: 106549893(CDC25A)
PGUT: 117673238
APRI: 131198945(CDC25A)
PTEX: 113451206(CDC25A)
VKO: 123017889(CDC25A)
PMUA: 114607182(CDC25A)
PRAF: 128423865(CDC25A)
ZVI: 118092194
HCG: 128330758(CDC25A)
GJA: 107124887(CDC25A)
STOW: 125440879(CDC25A)
EMC: 129337525(CDC25A)
XLA: 398141(cdc25a.L) 734734(cdc25a.S)
XTR: 733851(cdc25a)
NPR: 108800705
RTEM: 120941712(CDC25A)
BBUF: 121000768(CDC25A)
BGAR: 122938084(CDC25A)
MUO: 115459789 115465821(CDC25A)
GSH: 117354430(CDC25A)
TPRE: 106651124
LBD: 127281810
HHAL: 106685042
PCLA: 123752145
VDE: 111245511
VJA: 111260799
GAE: 121382917
HRF: 124136630
HRJ: 124264152
CRG: 105344441
CVN: 111132091
RPHI: 132721060
XEN: 124445013
RES: 135695928
 » show all
Reference
PMID:1836978
  Authors
Galaktionov K, Beach D
  Title
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.
  Journal
Cell 67:1181-94 (1991)
DOI:10.1016/0092-8674(91)90294-9
  Sequence
[hsa:993]
Reference
  Authors
Karlsson-Rosenthal C, Millar JB
  Title
Cdc25: mechanisms of checkpoint inhibition and recovery.
  Journal
Trends Cell Biol 16:285-92 (2006)
DOI:10.1016/j.tcb.2006.04.002
Reference
  Authors
Hong HY, Choi J, Cho YW, Kim BC
  Title
Cdc25A promotes cell survival by stimulating NF-kappaB activity through IkappaB-alpha phosphorylation and destabilization.
  Journal
Biochem Biophys Res Commun 420:293-6 (2012)
DOI:10.1016/j.bbrc.2012.02.152
  Sequence
[hsa:993]
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