KEGG ORTHOLOGY: K07410

KEGG

ORTHOLOGY: K07410

Entry

K07410                      KO

Symbol

CYP1B1

Name

cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]

Pathway

Steroid hormone biosynthesis

Tryptophan metabolism

Metabolism of xenobiotics by cytochrome P450

Ovarian steroidogenesis

Chemical carcinogenesis - DNA adducts

MicroRNAs in cancer

Chemical carcinogenesis - receptor activation

Chemical carcinogenesis - reactive oxygen species

Reaction

melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

Disease

Anterior segment dysgenesis

Primary congenital glaucoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05204 Chemical carcinogenesis - DNA adducts
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05207 Chemical carcinogenesis - receptor activation
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP1 family
   K07410  CYP1B1; cytochrome P450 family 1 subfamily B1

Genes

HSA:	1545(CYP1B1)

PTR:	459163(CYP1B1)

PPS:	100989599(CYP1B1)

GGO:

PPYG:

NLE:

HMH:

SSYN:

MCC:	710385(CYP1B1)

MCF:	102146810(CYP1B1)

MTHB:

MNI:

CSAB:

103220462(CYP1B1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100395270(CYP1B1)

SBQ:

CIMI:

108293778(CYP1B1)

ANAN:

105733181(CYP1B1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13078(Cyp1b1)

MCAL:

MPAH:

RNO:	25426(Cyp1b1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:

CFA:	483038(CYP1B1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:	111158468 111158469

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101099873(CYP1B1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	511470(CYP1B1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100070088(CYP1B1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:	100079784(CYP1B1)

GGA:	421466(CYP1B1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106029463(CYP1B1)

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

FAB:

OMA:

PHI:

PMAJ:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

SVG:

MMEA:

HRT:

SATI:

136359346(CYP1B1)

FPG:

FCH:

SHAB:

ACUN:

TALA:

ACHC:

HLE:

AGEN:

GCL:

DPUB:

EGZ:

NNI:

PADL:

AFOR:

CLV:

CUCA:

CPEA:

RTD:

AAM:

AROW:

NPD:

DNE:

ASN:	102377626 102384287

AMJ:	102560255(CYP1B1)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108716653(cyp1b1.L) 108717803(cyp1b1.S)

XTR:	100490477(cyp1b1)

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	100150054(cyp1b1)

SRX:	107719205 107747251

SANH:

107665613 107676394

SGH:	107549156 107586077

CCAR:

109100547 109100558

CAUA:

113092372 113112441

CGIB:

127970242 128025950

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137020866(cyp1b1)

MASI:

127411871 127414411

TROS:

TDW:

MANU:

IPU:	100313516(cyp1b)

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

LCO:

NCC:	104946527 104949720

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

MSAM:

SCHU:

CUD:

ALAT:

ASTR:

137604207(cyp1b1)

MZE:

ONL:	100653403(cyp1b1)

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

MALB:

BSPL:

SJO:

SASA:

106576803 106604807

STRU:

115153034 115193979

OTW:	112252828 112252866

OMY:	100381269(cyp1b1) 110502297

OGO:

ONE:	115113365 115135284

OKI:	109889798 109899606

OKE:	118369530 118401769

SALP:

111952066 111978757

SNH:	120017899 120045592

CCLU:

121553509 121582677

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

121315656 121316728

ARUT:

117403234 117410677

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116939745 116943149 116948393

LRJ:	133339223 133347278 133352819

SCLV:

120340657 120340658

CRG:	105345597 117692595

CANU:

CVN:

OED:	125657726 125670494

MMER:

RPHI:

132723153 132751856 132757626

MAEA:

XEN:	124445177 124446641

Reference

Authors

Sutter TR, Tang YM, Hayes CL, Wo YY, Jabs EW, Li X, Yin H, Cody CW, Greenlee WF

Title

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

Journal

J Biol Chem 269:13092-9 (1994)
DOI:10.1016/S0021-9258(17)36803-5

Sequence

[hsa:1545]

LinkDB

DBGET integrated database retrieval system