KEGG ORTHOLOGY: K07410

ORTHOLOGY: K07410

Entry

K07410                      KO

Symbol

CYP1B1

Name

cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]

Pathway

map00140

Steroid hormone biosynthesis

map00380

Tryptophan metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map04913

Ovarian steroidogenesis

map05204

Chemical carcinogenesis - DNA adducts

map05206

MicroRNAs in cancer

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

Reaction

R03088

R03090

R03629

melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase

R07079

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07080

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07081

benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07085

benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R07087

9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)

R09416

R09418

R09442

Disease

H01159

Anterior segment dysgenesis

H01203

Primary congenital glaucoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05204 Chemical carcinogenesis - DNA adducts
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05207 Chemical carcinogenesis - receptor activation
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP1 family
   K07410  CYP1B1; cytochrome P450 family 1 subfamily B1

Genes

HSA:	1545(CYP1B1)

PTR:	459163(CYP1B1)

PPS:	100989599(CYP1B1)

GGO:

PPYG:

NLE:

HMH:

SSYN:

MCC:	710385(CYP1B1)

MCF:	102146810(CYP1B1)

MTHB:

126933548

MNI:

105464862

CSAB:

103220462(CYP1B1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100395270(CYP1B1)

SBQ:

101049264

CIMI:

108293778(CYP1B1)

ANAN:

105733181(CYP1B1)

CSYR:

103271895

MMUR:

105884508

LCAT:

123636812

ERUF:

138399839(CYP1B1)

PCOQ:

105818018

OGA:

100949593

MMU:	13078(Cyp1b1)

MCAL:

110312728

MPAH:

110335735

RNO:	25426(Cyp1b1)

MCOC:

116079592

ANU:	117716952(Cyp1b1)

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

PMAV:

102906854(Cyp1b1)

MORG:

MFOT:

AAMP:

CNL:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138829207(Cyp1b1)

PLOP:

125356549

NCAR:

124962692

SVUL:

306644018(CYP1B1)

MMMA:

107137344

ITI:

101970101

SCIL:

308632640(CYP1B1)

MAVE:

308273886(CYP1B1)

OCU:

OPI:

OCZ:

TUP:

GVR:

CFA:	483038(CYP1B1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:	111158468 111158469

LLV:

MPUF:

MNP:

MLK:

NVS:

MMAQ:

308349611(CYP1B1)

ORO:

EJU:

ZCA:

MLX:

MANO:

NSU:

LWW:

FCA:	101099873(CYP1B1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

CCRU:

144231710(CYP1B1)

BTA:	511470(CYP1B1)

BOM:	102283377(CYP1B1)

BIU:

BJV:

BBUB:

BKE:

BBIS:

CHX:

OAS:

OCAN:

138437037(CYP1B1)

BTAX:

128056850

CSUM:

138091753(CYP1B1)

ODA:

120851684

CCAD:

122441577

MREE:

136164458(CYP1B1)

OVR:	110127528(CYP1B1)

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:	115854110(CYP1B1)

DDP:	132434974(CYP1B1)

SCOO:

307195852(CYP1B1)

PCRS:

137205270(CYP1B1)

DLE:

111174870

PCAD:

102981351

PSIU:

116764271

PPHC:

136133942(CYP1B1)

NASI:

112405151

HAMP:

307064357(CYP1B1)

ECB:	100070088(CYP1B1)

EPZ:	103548412(CYP1B1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139019830(CYP1B1)

PKL:

118717247

EFUS:

103305457

POTS:

308257035(CYP1B1)

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

RHII:

308505707(CYP1B1)

PALE:

PGIG:

PVP:

RAY:

MJV:	108387118(CYP1B1)

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138177408(CYP1B1)

OAA:	100079784(CYP1B1)

TACU:

119927335

GGA:	421466(CYP1B1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

AACU:

137853733(CYP1B1)

OJA:

118164603

BCLA:

308456946(CYP1B1)

ACYG:

106029463(CYP1B1)

ABRC:

308191868(CYP1B1)

CATA:

118256369

AFUL:

116488292

TGU:

100230258

LSR:	110469414(CYP1B1)

VMC:

128804816

VCHA:

128785172

AIB:	137471191(CYP1B1)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139591286(CYP1B1)

MATE:

118685740

MAEN:

136555282(CYP1B1)

FAB:

OMA:

PHI:

PMAJ:

CCW:

CBRC:

ACOE:

138108008(CYP1B1)

ETL:

ZAB:

ZLE:

SVG:

MMEA:

HRT:

SATI:

136359346(CYP1B1)

CFAI:

136286713(CYP1B1)

CCIC:

SHAB:

POCC:

FPG:

FCH:

FRS:

ACUN:

ANOC:

141956377(CYP1B1)

SURA:

141941134(CYP1B1)

TALA:

ACHC:

HLE:

AGEN:

HHAR:

BBUT:

142038082(CYP1B1)

GCL:

DPUB:

PPUS:

IIN:

EGZ:

NNI:

PARX:

142055384(CYP1B1)

PADL:

103922881

AFOR:

103902731

CBOR:

142081422(CYP1B1)

CBOY:

140650155(CYP1B1)

MAME:

142407776(CYP1B1)

CLV:

102085752

CNIC:

135986649

NMAY:

308039419(CYP1B1)

CUCA:

104057920

PCUR:

138717495(CYP1B1)

GAME:

129204198

CEUR:

306716380(CYP1B1)

CPEA:

104394945

RTD:

128907848

CRID:

134512924

LMIC:

141740725(CYP1B1)

NARQ:

141479637(CYP1B1)

AAM:

AROW:

NPD:

DNE:

ASN:	102377626 102384287

AMJ:	102560255(CYP1B1)

CPOO:

109319889

GGN:

109304747

PSS:	102451045(CYP1B1)

CIZ:	142010980(CYP1B1)

CMY:

114019062

CCAY:

125633811

LKP:	140909339(CYP1B1)

NDS:	141984540(CYP1B1)

DCC:

CPIC:

TST:

EOB:

CABI:

116822556(CYP1B1)

MRV:

120400195

EMQ:	137162735(CYP1B1)

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139321493(CYP1B1)

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108716653(cyp1b1.L) 108717803(cyp1b1.S)

XTR:	100490477(cyp1b1)

RTEM:

ACAT:

BBUF:

BGAR:

DTC:	141063468(CYP1B1)

PWL:	138295874(CYP1B1)

MUO:	115465046(CYP1B1)

GSH:

117357799

DRE:	100150054(cyp1b1)

DAES:

130239742

SRX:	107719205 107747251

SANH:

107665613 107676394

SGH:	107549156 107586077

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141325187(cyp1b1)

OMC:

131551981

PPRM:

120468625

RKG:

130106379

SCEP:

307149450(cyp1b1)

MAMB:

125277247

CIDE:

127525467

CERY:

137020866(cyp1b1)

MASI:

127411871 127414411

TROS:

130559519

TDW:

130432018

MANU:

129416488(cyp1b1)

PDAB:

135786596(cyp1b1)

IPU:	100313516(cyp1b)

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:	101073188(cyp1b1)

TFS:

130534129

NCC:	104946527 104949720

TBEN:

117475682

CGOB:

115020443

PGEO:

117459262(cyp1b1)

GACU:

117551219

EMAC:

134859020

ELY:	117248681(cyp1b1)

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

CANA:

137779969(cyp1b1)

CVE:	137884560(cyp1b1)

MSAM:

119916912

SCHU:

122884819

EARM:

139293916(cyp1b1)

CUD:

121510615

SPUL:

138588382(cyp1b1)

LMIX:

132975891

HTC:	141795067(cyp1b1)

ALAT:

119034148

ASTR:

137604207(cyp1b1)

PKLU:

139210686(cyp1b1)

LCO:

104921916

MZE:	101487279(cyp1b1)

ONL:	100653403(cyp1b1)

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

103477101(cyp1b1)

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

LTU:	140313338(cyp1b1)

MCEP:

125019270

AOCE:

111586556

EJA:	138195616(cyp1b1)

BFRE:

138615974(cyp1b1)

LCF:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125978233(cyp1b1)

SBIA:

133509672

PEE:

133409881

PTAO:

133486069

ENY:	140351295(cyp1b1)

MALB:

BSPL:

SJO:

SSCO:

TTY:	137196706(cyp1b1)

GMH:

115560135

SASA:

106576803 106604807

STRU:

115153034 115193979

OTW:	112252828 112252866

OMY:	100381269(cyp1b1) 110502297

OGO:

124041418

ONE:	115113365 115135284

OKI:	109889798 109899606

OKE:	118369530 118401769

OMM:

135510857

OCLA:

139381441 139410025

SALP:

111952066 111978757

SNH:	120017899 120045592

SFON:

CCLU:

ELS:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

CPUN:

140457475(cyp1b1)

HOC:

132831043

SCAU:

119967059

LERI:

129697626

HAKA:

140733119(cyp1b1)

PMRN:

116939745 116943149 116948393

LRJ:	133339223 133347278 133352819

SCLV:

120340657 120340658

CLEP:

143450679

LVG:	121426207 121432016

PFLL:

139138587 139151585 139151586 139152303

BARL:

143287771 143293641

CRG:	105345597 117692595

CANU:

128187749

CVN:

111133558

OED:	125657726 125670494

MMER:

123544838

RPHI:

132723153 132751856 132757626

MAEA:

128228812

MCAZ:

138020014 138021464 138021673 138021977

MFOO:

137976349 137976401 137994054 137994282 137994309

» show all

Reference

PMID:8175734

Authors

Sutter TR, Tang YM, Hayes CL, Wo YY, Jabs EW, Li X, Yin H, Cody CW, Greenlee WF

Title

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

Journal

J Biol Chem 269:13092-9 (1994)
DOI:10.1016/S0021-9258(17)36803-5

Sequence

[hsa:1545]

LinkDB

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