KEGG ORTHOLOGY: K07834

ORTHOLOGY: K07834

Entry

K07834                      KO

Symbol

RALA

Name

Ras-related protein Ral-A

Pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04072

Phospholipase D signaling pathway

map05132

Salmonella infection

map05200

Pathways in cancer

map05210

Colorectal cancer

map05212

Pancreatic cancer

Disease

H02535

Neurodevelopmental disorder with dysmorphic facies

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07834  RALA; Ras-related protein Ral-A
   04015 Rap1 signaling pathway
    K07834  RALA; Ras-related protein Ral-A
   04072 Phospholipase D signaling pathway
    K07834  RALA; Ras-related protein Ral-A
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07834  RALA; Ras-related protein Ral-A
  09162 Cancer: specific types
   05210 Colorectal cancer
    K07834  RALA; Ras-related protein Ral-A
   05212 Pancreatic cancer
    K07834  RALA; Ras-related protein Ral-A
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K07834  RALA; Ras-related protein Ral-A
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07834  RALA; Ras-related protein Ral-A
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K07834  RALA; Ras-related protein Ral-A
Membrane trafficking [BR:ko04131]
Exocytosis
  Tethering complex
   Exocyst complex assembly proteins
    K07834  RALA; Ras-related protein Ral-A
GTP-binding proteins [BR:ko04031]
Small (monomeric) G-proteins
  Ras Family
   Ral
    K07834  RALA; Ras-related protein Ral-A

Genes

HSA:	5898(RALA)

PTR:	737424(RALA)

PPS:	100984239(RALA)

GGO:	101135135 101149508(RALA)

PON:	100441438(RALA)

PPYG:

129040786(RALA)

NLE:	100603441(RALA)

HMH:	116479044(RALA)

SSYN:

129490006(RALA)

MCC:	703440(RALA)

MCF:	102124292(RALA)

MTHB:

126950131

MNI:	105497757(RALA)

CSAB:

103226186(RALA)

CATY:

105597017(RALA)

PANU:

100997883(RALA)

TGE:	112620933(RALA)

MLEU:

105534009(RALA)

RRO:	104663117(RALA)

RBB:	108526577(RALA)

TFN:	117073171(RALA)

PTEH:

111552249(RALA)

CANG:

105513593(RALA)

CJC:	100398374(RALA)

SBQ:	101045370(RALA)

CIMI:

108287637(RALA)

ANAN:

105731695(RALA)

CSYR:

103257210(RALA)

MMUR:

105864404(RALA)

LCAT:

123647769(RALA)

PCOQ:

105818508(RALA)

OGA:	100944758(RALA)

MMU:	56044(Rala)

MCAL:

110308275(Rala)

MPAH:

110333717(Rala)

RNO:	81757(Rala)

MCOC:

116081427(Rala)

ANU:	117714072(Rala)

ASYL:

127664817(Rala)

MUN:	110545330(Rala)

CGE:	100769446 100769632(Rala)

MAUA:

101833843(Rala)

PROB:

127229591(Rala)

PLEU:

114685433(Rala)

MORG:

121432722(Rala)

MFOT:

126501587

AAMP:

119817559(Rala)

NGI:	103736746(Rala)

HGL:	101706563(Rala)

CPOC:

100718312(Rala)

CCAN:

109701457(Rala)

DORD:

105998338(Rala)

DSP:	122120863(Rala)

PLOP:

125346686(Rala)

NCAR:

124991187

MMMA:

107146193(Rala)

ITI:	101975833(Rala)

OCU:	100354283 100355907

OPI:	101523024(RALA)

TUP:	102481337(RALA)

GVR:

103596226

CFA:	475875(RALA)

CLUD:

112661306(RALA)

VVP:	112925806(RALA)

VLG:	121471412(RALA)

NPO:	129494120(RALA)

AML:	100484672(RALA)

UMR:	103674594(RALA)

UAH:	113258228(RALA)

UAR:	123789432(RALA)

ELK:

111157020

LLV:

125080707

MPUF:

101677806(RALA)

MLK:	131829133(RALA)

NVS:	122904631(RALA)

ORO:	101364360(RALA)

EJU:	114213686(RALA)

ZCA:	113911639(RALA) 113924333

MLX:	118024553(RALA)

NSU:	110592595(RALA)

LWW:	102733284(RALA)

FCA:	101091003(RALA)

PCOO:

112866929(RALA)

PBG:	122487712(RALA)

PVIV:

125160399(RALA)

LRUF:

124523651

LGF:	123606250(RALA)

AJU:

106974372

PTG:	102961464(RALA)

PPAD:

109268019(RALA)

PUC:

125930748

PLEZ:

122205935(RALA)

HHV:	120235587(RALA)

BTA:	538477(RALA)

BOM:	102278480(RALA)

BIU:	109557564(RALA)

BBUB:

102400111(RALA)

BBIS:

104980401(RALA)

CHX:	102189928(RALA)

OAS:	101121767(RALA)

BTAX:

128046606(RALA)

CSUM:

138079961(RALA)

ODA:	120877262(RALA)

CCAD:

122438558(RALA)

MREE:

136170709(RALA)

OVR:	110132183(RALA)

MBEZ:

129552583(RALA)

SSC:	100622254(RALA)

CFR:	102518761(RALA)

CBAI:

105062834(RALA)

CDK:	105088273(RALA)

VPC:	102542835(RALA)

BACU:

103013487(RALA)

BMUS:

118900736(RALA)

LVE:	103072770(RALA)

OOR:	101274228(RALA)

LALB:

132524846(RALA)

DLE:	111184488(RALA)

PCAD:

102987577(RALA)

PSIU:

116759480(RALA)

NASI:

112403276(RALA)

ECB:	100051360(RALA)

EPZ:	103563476(RALA)

EAI:	106841046(RALA)

MYB:	102254804(RALA)

MYD:	102753958(RALA)

MMYO:

118665967(RALA)

MLF:	102432493(RALA)

MDT:	132211146(RALA)

MYUM:

139016536(RALA)

PKL:	118714448(RALA)

EFUS:

103293905(RALA)

MNA:	107532781(RALA)

DRO:	112302767(RALA)

SHON:

118994012(RALA) 119001847

AJM:	119055899(RALA) 119059209

PDIC:

114507682(RALA) 114510122

PHAS:

123806644 123811958(RALA)

MMF:	118620141(RALA)

PPAM:

129063346(RALA)

HAI:	109388814(RALA)

RFQ:	117012416(RALA)

PALE:

102898811(RALA)

PGIG:

120591838(RALA)

PVP:	105303207(RALA)

RAY:	107512715(RALA)

MJV:	108393225(RALA)

TOD:	119241738(RALA)

SARA:

101550569 101556703(RALA)

SFUM:

130022649(RALA) 130036901

SETR:

126020426(RALA)

LAV:	100662460(RALA)

TMU:

101354107

ETF:	101657728(RALA)

DNM:	101439293(RALA)

MDO:	100011023(RALA)

GAS:	123230641(RALA)

SHR:	100922286(RALA)

AFZ:

127550041

PCW:	110192961(RALA)

TVP:	118831515(RALA) 118833551

PBRV:

138158257(RALA) 138169898

OAA:	100075904(RALA)

TACU:

119926907(RALA)

GGA:	420765(RALA)

PCOC:

116232792(RALA)

MGP:	100540796(RALA)

CJO:	107309860(RALA)

TPAI:

128088453(RALA)

LMUT:

125696054(RALA)

NMEL:

110393806(RALA)

APLA:

101795827(RALA)

ACYG:

106042885(RALA)

CATA:

118250876(RALA)

AFUL:

116485950(RALA)

TGU:	100190004(RALA)

LSR:	110479475(RALA)

SCAN:

103823803(RALA)

PMOA:

120504988(RALA)

OTC:	121333735(RALA)

PRUF:

121352996(RALA)

ATRC:

139591298(RALA)

GFR:	102042646(RALA)

FAB:	101815706(RALA)

OMA:	130249510(RALA)

PHI:	102103214(RALA)

PMAJ:

107200682(RALA)

CCAE:

111923675(RALA)

CCW:	104688903(RALA)

CBRC:

103615748(RALA)

ACOE:

138106709(RALA)

ETL:	114068672(RALA)

ZAB:	102070005(RALA)

ZLE:	135444009(RALA)

ACHL:

103797279(RALA)

SVG:	106857416(RALA)

MMEA:

130576592(RALA)

HRT:	120754895(RALA)

SATI:

136363611(RALA)

CCIC:

134047147(RALA)

FPG:	101917513(RALA)

FCH:	102058517(RALA)

CCRI:

104165094(RALA)

NNT:	104409142(RALA)

SHAB:

115618823(RALA)

ACUN:

113477514(RALA)

TALA:

104362627(RALA)

ACHC:

115339402(RALA)

HALD:

104312768(RALA)

HLE:	104840665(RALA)

AGEN:

126045602

HHAR:

128145639(RALA)

CSTI:

104551512(RALA)

LDI:	104344723(RALA)

MNB:	103779571(RALA)

DPUB:

104304049(RALA)

PPUS:

135189310(RALA)

AVIT:

104268893(RALA)

BRHI:

104496636(RALA)

EGZ:	104128717(RALA)

NNI:	104012419(RALA)

PCRI:

104025679(RALA)

PCAO:

104040975(RALA)

PADL:

103914767(RALA)

AFOR:

103895242(RALA)

FGA:	104075723(RALA)

GSTE:

104252029

CLV:	102088192(RALA)

MUI:	104536450(RALA)

PGUU:

104459622(RALA)

PLET:

104618060(RALA)

EHS:	104504511(RALA)

CMAC:

104474939(RALA)

CUCA:

104065945(RALA)

TEO:	104384249(RALA)

BREG:

104642543(RALA)

OHA:	104337153(RALA)

ACAR:

104530886(RALA)

CPEA:

104392157(RALA)

CVF:	104282795(RALA)

RTD:	128905500(RALA)

CRID:

134511515(RALA)

AAM:	106495276(RALA)

AROW:

112973746(RALA)

NPD:	112943741(RALA)

TGT:	104568242(RALA)

DNE:	112996101(RALA)

SCAM:

104147058(RALA)

ASN:	102378520(RALA)

AMJ:	102564719(RALA)

CPOO:

109312777(RALA)

GGN:	109291870(RALA)

PSS:	102457367(RALA)

CMY:	102938684(RALA)

CCAY:

125631844(RALA)

DCC:	119850958(RALA)

CPIC:

101931829(RALA)

TST:	117872600(RALA)

CABI:

116832621(RALA)

MRV:	120398084(RALA)

ACS:	100555475(rala)

ASAO:

132778544(RALA)

PVT:	110076196(RALA)

SUND:

121934235(RALA)

PBI:	103050544 103050785

PMUR:

107284933(RALA)

CTIG:

120305247(RALA)

TSR:	106553852(RALA)

PGUT:

117664094(RALA)

APRI:

131198369(RALA)

PTEX:

113437331(RALA)

NSS:	113416772(RALA)

VKO:	123035735(RALA)

PMUA:

114606971(RALA)

PRAF:

128423831(RALA)

ZVI:	118091832(RALA)

HCG:	128330776(RALA)

GJA:	107125740(RALA)

STOW:

125440934(RALA)

EMC:	129337439(RALA)

XLA:	399386(rala.L)

XTR:	548669(rala)

NPR:	108789599(RALA)

RTEM:

120940406(RALA)

BBUF:

121001117(RALA)

BGAR:

122937933(RALA)

PWL:	138267009(RALA)

MUO:	115470621(RALA)

GSH:	117353837(RALA)

DRE:	393993(ralaa) 492355(ralab)

SRX:	107713672 107718103 107722561 107734325

SANH:

107653786 107655676 107688427 107689393

SGH:	107565693 107566919 107585502 107589833

CCAR:

109049141 109103059 109103060 122142216

CAUA:

113042231 113045850 113066329 113066344 113117106

CGIB:

127946550 128013192 128027800

PTET:

122329960(ralaa) 122359403(ralab)

LROH:

127156005(ralaa) 127180428(ralab)

OMC:	131521194(ralab) 131533186(ralaa)

PPRM:

120482334(ralab) 120492448(ralaa)

RKG:	130070918(ralab)

MAMB:

125250473(ralab) 125257917(ralaa)

CIDE:

127495244 127505704 127525753

CERY:

137002525(ralab) 137013884(ralaa)

MASI:

127431517 127434752 127440285 127442387

TROS:

130546856(ralaa) 130554625(ralab)

TDW:	130412952(ralaa) 130417752(ralab)

MANU:

129426658(ralaa) 129442323(ralab)

PDAB:

135766773(ralab) 135785403(ralaa)

IPU:	108268083(ralaa) 108280580(ralab)

IFU:	128614509(ralaa) 128623840(ralab)

PHYP:

113526890 113543101

SMEO:

124384028(ralaa) 124402913(ralab)

TFD:	113640287(ralab) 113644312(ralaa)

TVC:	132845569(ralaa) 132848275(ralab)

CGAR:

128512850 128520834(ralaa)

NGRA:

132871469(ralab) 132887099(ralaa)

TRN:	134302898(ralab) 134309831(ralaa)

AMEX:

103038832(ralab) 103042957(ralaa)

CMAO:

118796823(ralab) 118816310(ralaa)

EEE:	113572010 113574769

CHAR:

105900592

SPIL:

134064093

TRU:

101063846

TFS:	130513716(ralaa)

TNG:	GSTEN00025528G001

LCO:	104933802(rala)

NCC:	104942387(rala)

TBEN:

117498728(ralaa)

CGOB:

115025295(rala)

PGEO:

117465597(ralaa)

GACU:

117544735(ralaa)

EMAC:

134858037(ralaa)

ELY:	117264651(ralaa)

EFO:	125881682(ralaa)

PLEP:

121960491(ralaa)

SLUC:

116048589(ralaa)

ECRA:

117937842(ralaa)

ESP:	116672060(rala)

PFLV:

114548942

GAT:	120811334(ralaa)

PPUG:

119198392(ralaa)

AFB:	129110458(ralaa)

CLUM:

117749646(ralaa)

PSWI:

130205924(ralaa)

CANA:

137788584(ralaa)

CVE:	137875036(ralaa)

MSAM:

119912105(ralaa)

SCHU:

122866319(ralaa)

CUD:	121527003(ralaa)

SPUL:

138595716(ralaa)

LMIX:

132993927(ralaa)

ALAT:

119008495(ralaa)

ASTR:

137587547(ralaa)

MZE:

101477841

ONL:

100697392

OAU:	116310342(ralaa)

OLA:

101167252

OML:	112151583(ralaa)

CSAI:

133423680(ralaa)

XMA:

102226410

XCO:

114136396

XHE:	116711381(rala)

PRET:

103456795(rala)

PFOR:

103147563

PLAI:

106936522

PMEI:

106912886

GAF:	122823988(ralaa)

PPRL:

129352074(ralaa)

CVG:

107099411

CTUL:

119798441(ralaa)

GMU:	124857849(ralaa)

NFU:	107382592(rala)

KMR:	108230441(ralaa)

ALIM:

106515570(rala)

NWH:	119426574(ralaa)

AOCE:

111569283(ralaa)

EJA:	138204432(ralaa)

BFRE:

138619789(ralaa)

MCEP:

124995818(ralaa)

CSEM:

103377373

POV:

109629648

SSEN:

122765991(ralaa)

SSOE:

131470687(ralaa)

HHIP:

117753686(ralaa)

HSP:	118098309(ralaa)

PPLT:

128425463(ralaa)

SMAU:

118287138(ralaa)

LCF:	108900002(ralaa)

SDU:	111224344(rala)

SLAL:

111673639(rala)

XGL:	120789612(ralaa)

HCQ:

109524708

SSCV:

125986171(ralaa)

SBIA:

133492464(ralaa)

PEE:	133396402(ralaa)

PTAO:

133470232(ralaa)

BPEC:

110165508

ENY:	140364781(ralaa)

MALB:

109961462

BSPL:

114853079(ralaa)

SJO:	128382062(ralaa)

SSCO:

134002212(ralaa)

GMH:	115536951 115549201

SASA:

106590204 106597431(rala)

STRU:

115170183(rala) 115195716

OTW:	112227265 112245199

OMY:	110489872(ralaa) 110509119

OGO:	124039732 124042171

ONE:	115121616(rala) 115130316

OKI:	109872128(rala) 109899429

OKE:	118372623 118394363

OMM:	135538706 135558345

OCLA:

139367128 139375805

SALP:

111953626 112070872

SNH:	120020061 120051108(ralaa)

CCLU:

121569935 121580576

ELS:	105008548 105025131

OEP:	134034730(ralaa)

SFM:	108937745 108942425

PKI:	111859546(rala)

AANG:

118225683(ralaa) 118234476

AROT:

135252605(ralaa) 135260698

CCOG:

133126168 133137429

LOC:	102690746(rala)

PSPA:

121312775 121314234

ARUT:

117394449 117400380

PSEX:

120529530

LCM:	102350198(RALA)

CMK:

103181544

RTP:	109920565(ralaa)

CPLA:

122549313

HOC:

132811850

LERI:

129696192(ralaa)

PMRN:

116938696 116940881 116945522

LRJ:	133344907 133345956

BFO:

BBEL:

CIN:

SPU:

LPIC:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG2849(Rala)

DER:

6550874

DSI:	Dsimw501_GD16321(Dsim_GD16321)

DYA:	Dyak_GE16885

DSR:

110184378

DPO:	4814818 6896984

DPE:	6588009 6599332

DMN:	108155991 108156252 108163458

DWI:

6648714

DGR:

6566005

DMO:	Dmoj_GI14784

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:	108369142 108377804 108382031

AOQ:

129237086

ALUD:

128857143

TDA:	119671791 119671804

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135957608(Rala)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

109428515 109430093 115256340

ASUA:

134207667

CQU:	CpipJ_CPIJ012257

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139102140(Rala)

TLN:	139825380(Rala)

HST:

DQU:

CFO:

FEX:

PMEC:

138939765(Rala)

LHU:	105676150(Rala)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124212168(Rala)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138125560(Rala)

DPA:

109535135

ESIM:

136410007(Rala)

EFOR:

136348602(Rala)

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:	108558917 108563229

DCOR:

135804130(Rala)

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_205708

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137933628(Rala)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106692562(Rala)

NLU:

120354235

HVI:

124366895

MQU:	129004060 129004062

PHU:	Phum_PHUM256760

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

139692319(Rala)

FCD:	110845022 110848580

DPX:	DAPPUDRAFT_303962

DMK:

116918237

DPZ:

124342270

AFRA:

136026275

PVM:	113821621(Rala)

PJA:	122247651 122263074

PCHN:

125039960

HAME:

121863059

PCLA:

123760363(Rala)

CQD:	128699225(Rala)

PTRU:

123503103

ESN:

126980567

MNZ:

135201141

MRJ:	136849899(Rala)

PORN:

139765714(Rala)

HAZT:

108672884

EAF:

111708009

LSM:	121119541(Rala)

TCF:

131881046

PPOI:

119096602 119096736

ISC:	115318710 121833969

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107359965 107368913

DPTE:

113789600 113794112 113797998

DFR:	124494151 124494927 124498304

CSCU:

111618409

CVS:	136988258(Rala)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106464274 106470857 106470858 106474797

PMEO:

129597169

CEL:	CELE_Y53G8AR.3(ral-1)

CBR:	CBG_15686(Cbr-ral-1)

CRQ:	GCK72_011374

NAI:	NECAME_10030

BMY:	BM_BM6769(Bma-ral-1)

LOA:	LOAG_09362

TSP:

Tsp_01642

HRO:	HELRODRAFT_69267

LGI:	LOTGIDRAFT_193895

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:	124265773 124267622

HASI:

HCRA:

CRG:

CANU:

CVN:	111112216 111112915

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

OVI:	T265_00011 T265_02188

LLON:

135500660

NVE:

5517905

EPA:	110250332 110254771

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:	100206789 124813196

HSY:	130621674 130621675

RES:

135682345

TAD:	TRIADDRAFT_22031

AQU:	100636028 100636281

SSCK:

SPSK_06763

RIE:	OCT59_011197

MBR:	MONBRDRAFT_35711

SRE:	PTSG_00801

EIV:	EIN_135230

ACAN:

ACA1_054190

» show all

Reference

PMID:12888294

Authors

Feig LA

Title

Ral-GTPases: approaching their 15 minutes of fame.

Journal

Trends Cell Biol 13:419-25 (2003)
DOI:10.1016/S0962-8924(03)00152-1

Reference

PMID:18756269

Authors

Cascone I, Selimoglu R, Ozdemir C, Del Nery E, Yeaman C, White M, Camonis J

Title

Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.

Journal

EMBO J 27:2375-87 (2008)
DOI:10.1038/emboj.2008.166

Sequence

[hsa:5898]

LinkDB

DBGET integrated database retrieval system