KEGG ORTHOLOGY: K08063

ORTHOLOGY: K08063

Entry

K08063                      KO

Symbol

RFXAP

Name

regulatory factor X-associated protein

Pathway

map04612

Antigen processing and presentation

map05152

Tuberculosis

map05340

Primary immunodeficiency

Disease

H00985

MHC class II deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    K08063  RFXAP; regulatory factor X-associated protein
09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K08063  RFXAP; regulatory factor X-associated protein
  09163 Immune disease
   05340 Primary immunodeficiency
    K08063  RFXAP; regulatory factor X-associated protein

Genes

HSA:	5994(RFXAP)

PTR:	100610983(RFXAP)

PPS:	100984854(RFXAP)

GGO:	101138043(RFXAP)

PON:	100450280(RFXAP)

PPYG:

129011463(RFXAP)

NLE:	100582394(RFXAP)

HMH:	116467079(RFXAP)

SSYN:

129463821(RFXAP)

MCC:	694441(RFXAP)

MCF:	102138204(RFXAP)

MTHB:

126940314

MNI:	105486041(RFXAP)

CSAB:

103214283(RFXAP)

CATY:

105587865(RFXAP)

PANU:

101004422(RFXAP)

TGE:	112610875(RFXAP)

MLEU:

105548797(RFXAP)

RRO:	104677939(RFXAP)

RBB:	108516591(RFXAP)

TFN:	117097323(RFXAP)

PTEH:

111540491(RFXAP)

CANG:

105512540(RFXAP)

CJC:	100393775(RFXAP)

SBQ:	101027776(RFXAP)

CIMI:

108310787

ANAN:

105726212(RFXAP)

MMUR:

105862082(RFXAP)

LCAT:

123649092

PCOQ:

105810125(RFXAP)

OGA:	100944066(RFXAP)

MMU:	170767(Rfxap)

MCAL:

110291319(Rfxap)

MPAH:

110320546(Rfxap)

RNO:	499617(Rfxap)

MCOC:

116092874(Rfxap)

ANU:	117707613(Rfxap)

ASYL:

127683344(Rfxap)

MUN:	110554912(Rfxap)

CGE:	100774659(Rfxap)

MAUA:

101823038

PROB:

127216334(Rfxap)

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103752221(Rfxap)

HGL:	101719989(Rfxap)

CPOC:

100717309(Rfxap)

CCAN:

109699608(Rfxap)

DORD:

105997133(Rfxap)

DSP:

122112884

DMER:

138814316(Rfxap)

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

TUP:	102484630(RFXAP)

GVR:	103606841(RFXAP)

CFA:	607367(RFXAP)

CLUD:

112670174

VVP:	112918543(RFXAP)

VLG:

121497710

NPO:	129504517(RFXAP)

AML:	100475849(RFXAP)

UMR:

103664419

UAH:	113251009(RFXAP)

UAR:

123791799

ELK:

111158537

LLV:

125095617

MPUF:

101691297(RFXAP)

MNP:	132002961(RFXAP)

MLK:	131813818(RFXAP)

NVS:

122907026

ORO:	101375274(RFXAP)

EJU:	114209262(RFXAP)

ZCA:

113920434

MLX:	118009506(RFXAP)

NSU:

110570217

LWW:	102736882(RFXAP)

FCA:	101088294(RFXAP)

PYU:

121012650

PCOO:

112860842(RFXAP)

PBG:

122476973

PVIV:

125163493(RFXAP)

LRUF:

124508332

LGF:

123607414

AJU:

106973843

PTG:	102967387(RFXAP)

PPAD:

109265816(RFXAP)

PUC:

125934000

PLEZ:

122228876

HHV:

120246209

BTA:	540760(RFXAP)

BOM:	102280534(RFXAP)

BIU:	109566774(RFXAP)

BBUB:

102412691

CHX:	102185753(RFXAP)

OAS:	105612445(RFXAP)

BTAX:

128057741(RFXAP)

CSUM:

138089017(RFXAP)

ODA:

120883112

CCAD:

122447069

MREE:

136144384(RFXAP)

OVR:	110136329(RFXAP)

MBEZ:

129556325(RFXAP)

SSC:	100155648(RFXAP)

CFR:	102520757(RFXAP)

CBAI:

105066308(RFXAP)

CDK:	105100832(RFXAP)

VPC:	102529776(RFXAP)

BACU:

103020095(RFXAP)

BMUS:

118884400

LVE:	103077390(RFXAP)

OOR:	101287764(RFXAP)

LALB:

132509001(RFXAP)

GMF:	115866556(RFXAP)

DLE:	111175071(RFXAP)

PCAD:

102974203(RFXAP)

PSIU:

116743311(RFXAP) 116749884

PPHC:

136137506(RFXAP)

NASI:

112409269

EAI:

106844942

MYB:	102243528(RFXAP) 106725997

MYD:	102753562(RFXAP)

MMYO:

118650050

MLF:	102428345(RFXAP)

MDT:	132228235(RFXAP)

MYUM:

139006706(RFXAP)

PKL:

118728723

EFUS:

103303304(RFXAP)

MNA:	107525164(RFXAP)

DRO:	112313590(RFXAP)

SHON:

118994861

AJM:	119044404(RFXAP)

PDIC:

118497287

PHAS:

123818928

MMF:

118622493

PPAM:

129081143(RFXAP)

HAI:	109388472(RFXAP)

RFQ:	117021063(RFXAP)

PALE:

102898769(RFXAP)

PGIG:

120610613

PVP:	105293314(RFXAP)

RAY:

107503949

TOD:	119258530(RFXAP)

SARA:

101539233(RFXAP)

SFUM:

130018407(RFXAP)

SETR:

126015935(RFXAP)

LAV:	100658303(RFXAP)

TMU:

101345853

ETF:

101664682

DNM:	101432051(RFXAP)

MDO:	100027231(RFXAP)

GAS:

123241257

SHR:	100920977(RFXAP)

AFZ:

127555244

PCW:	110195160(RFXAP)

TVP:

118836670

PBRV:

138143434(RFXAP)

OAA:

100080809

GGA:	418899(RFXAP)

PCOC:

116244162(RFXAP)

CJO:	107306771(RFXAP)

TPAI:

128074839(RFXAP)

LMUT:

125694886

NMEL:

110402808(RFXAP)

APLA:

101800567

ACYG:

125185055(RFXAP)

CATA:

118246026(RFXAP)

AFUL:

116501334(RFXAP)

TGU:	101234225(RFXAP)

LSR:	110476700(RFXAP)

SCAN:

103812558(RFXAP)

PMOA:

120496306

OTC:

121337267

PRUF:

121353247

ATRC:

139600274(RFXAP)

FAB:	101806274(RFXAP)

OMA:	130253238(RFXAP)

PMAJ:

107209746(RFXAP)

CCW:

104689928

ACOE:

138117385(RFXAP)

ETL:	114060971(RFXAP)

ZLE:	135460219(RFXAP)

SVG:	106865352(RFXAP)

MMEA:

130578553(RFXAP)

HRT:	120748639(RFXAP)

SATI:

136375034(RFXAP)

CCIC:

134057877(RFXAP)

SHAB:

115604511(RFXAP)

TALA:

116959130

ACHC:

115353599

AGEN:

126048404

HHAR:

128153276(RFXAP)

GCL:

127029493

PPUS:

135188502(RFXAP)

CBOY:

140649549(RFXAP)

CNIC:

135994243(RFXAP)

CUCA:

128850913(RFXAP)

RTD:	128913404(RFXAP)

CRID:

134514729(RFXAP)

NPD:	112942882(RFXAP)

DNE:	112982142(RFXAP)

AMJ:	102570327(RFXAP)

CMY:

CCAY:

DCC:

CPIC:

TST:	117871030(RFXAP)

CABI:

116839744(RFXAP)

MRV:

120401683

ACS:	103278417(rfxap)

ASAO:

132772083(RFXAP)

PVT:	110074023(RFXAP)

SUND:

121926989

PBI:	103048639(RFXAP)

PMUR:

107287661(RFXAP)

CTIG:

120300827

TSR:	106545914(RFXAP)

PGUT:

117662136(RFXAP)

PCAE:

139316966(RFXAP)

APRI:

131200054(RFXAP)

PTEX:

113441745(RFXAP)

NSS:	113421489(RFXAP)

VKO:

123029553

PMUA:

114595806(RFXAP)

PRAF:

128412745(RFXAP)

ZVI:	118085782(RFXAP)

HCG:	128352040(RFXAP)

GJA:	107106040(RFXAP)

STOW:

125432056

EMC:	129325448(RFXAP)

XLA:	108709940(rfxap.S)

XTR:	100379771(rfxap)

NPR:	108785355(RFXAP)

RTEM:

120929140

ACAT:

141127107(RFXAP)

BBUF:

120996288

BGAR:

122931146

DTC:	141096543(RFXAP)

PWL:	138250540(RFXAP)

MUO:	115468582(RFXAP)

GSH:	117362855(RFXAP)

DRE:	100006212(rfxap)

SRX:	107728283 107728874 107734457(rfxap)

SANH:

107686162(rfxap) 107697413

SGH:	107578759 107589095

CCAR:

109097408 109097409 122144395

CAUA:

113054456 113110044

CGIB:

127966480 128021054

PTET:

122352839

LROH:

127172122(rfxap)

GRF:	141299290(rfxap)

OMC:	131548634(rfxap)

PPRM:

120482693

RKG:	130074093(rfxap)

MAMB:

125262767

CIDE:

127521532

CERY:

137028669(rfxap)

MASI:

127432946 127433679

TROS:

130546625(rfxap)

TDW:	130411515(rfxap)

MANU:

129446780(rfxap)

PDAB:

135741715(rfxap)

IPU:

108276696

IFU:	128620352(rfxap)

PHYP:

113543604(rfxap)

SMEO:

124393606

TFD:

113638030

TVC:	132863096(rfxap)

CGAR:

128545761(rfxap)

NGRA:

132873329(rfxap)

TRN:	134332215(rfxap)

AMEX:

103039202

CMAO:

118824552

EEE:	113572180(rfxap)

CHAR:

105896329

SPIL:

134080157(rfxap)

TRU:	101075394(rfxap)

TFS:	130537962(rfxap)

TNG:	GSTEN00018868G001

LCO:	104928218(rfxap)

NCC:	104964550(rfxap)

TBEN:

117490436(rfxap)

CGOB:

115019327(rfxap)

PGEO:

117458522(rfxap)

GACU:

117535137(rfxap)

EMAC:

134872431(rfxap)

ELY:	117271275(rfxap)

EFO:

125898419

PLEP:

121963486

SLUC:

116037130

ECRA:

117955437(rfxap)

ESP:	116701152(rfxap)

PFLV:

114567182(rfxap)

GAT:

120822385

PPUG:

119215906(rfxap)

AFB:	129113463(rfxap)

CLUM:

117742489(rfxap)

PSWI:

130188574(rfxap)

CANA:

137802194(rfxap)

CVE:	137876430(rfxap)

MSAM:

119895178

SCHU:

122888169

CUD:

121518736

SPUL:

138602966(rfxap)

LMIX:

132987992(rfxap)

ALAT:

119031377

ASTR:

137606281(rfxap)

MZE:	101471661(rfxap)

ONL:	100704569(rfxap)

OAU:

116311904

OLA:	101167388(rfxap)

OML:

112139895

CSAI:

133459442 133459554

XMA:	102218213(rfxap)

XCO:	114153306(rfxap)

XHE:	116728703(rfxap)

PRET:

103475560(rfxap)

PFOR:

103140050 103140107(rfxap)

PLAI:

106951405(rfxap)

PMEI:

106922235(rfxap)

GAF:

122844505

PPRL:

129373607(rfxap)

CVG:	107088285(rfxap)

CTUL:

119779216

GMU:

124876473

NFU:	107391187(rfxap)

KMR:

108236909

ALIM:

106514161(rfxap)

NWH:

119420563

AOCE:

111566079(rfxap)

EJA:	138196338(rfxap)

BFRE:

138634029(rfxap)

MCEP:

125021382

CSEM:

103395221(rfxap) 103399480

POV:	109635807(rfxap)

SSEN:

122779557

SSOE:

131458242(rfxap)

HHIP:

117774126(rfxap)

HSP:

118122094

PPLT:

128457541(rfxap)

SMAU:

118300872

LCF:

108893716

SDU:	111217127(rfxap)

SLAL:

111662677(rfxap)

XGL:

120802587

HCQ:	109515632(rfxap)

SSCV:

125982575(rfxap)

SBIA:

133492160(rfxap)

PEE:	133416121(rfxap)

PTAO:

133467599(rfxap)

BPEC:

110158608(rfxap)

ENY:	140360602(rfxap)

MALB:

109971886(rfxap)

BSPL:

114869072(rfxap)

SJO:	128371351(rfxap)

SSCO:

133993712(rfxap)

GMH:	115547834(rfxap)

SASA:

106563855(rfxap) 106604035

STRU:

115153827 115204639

OTW:	112238481(rfxap) 112239533

OMY:	110510256 110533260

OGO:	123995231 124007444

ONE:	115123809 115125633

OKI:	109873981(rfxap) 109881529

OKE:	118362200 118384885(rfxap)

OMM:	135532878 135544029(rfxap) 135551097

OCLA:

139388601 139419378 139419380

SALP:

112072828 112076117

SNH:	120021647 120056819

CCLU:

121542048 121555391

ELS:	105029978(rfxap)

OEP:	134013774(rfxap)

SFM:	108936053(rfxap)

PKI:	111840452(rfxap)

AANG:

118236196(rfxap)

AROT:

135264066(rfxap)

CCOG:

133132212(rfxap)

LOC:	102690257(rfxap)

PSPA:

121321372

ARUT:

117406047 117406921

PSEX:

120524015

LCM:	102346053(RFXAP)

CMK:

103177191

CPLA:

122551070

HOC:	132816492(rfxap)

LERI:

129698013(rfxap)

HAKA:

140726912(rfxap)

PMRN:

LRJ:

BFO:

BBEL:

SPU:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

PCAN:

MYI:

PMAX:

LLON:

DGT:

Reference

PMID:9118943

Authors

Durand B, Sperisen P, Emery P, Barras E, Zufferey M, Mach B, Reith W

Title

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.

Journal

EMBO J 16:1045-55 (1997)
DOI:10.1093/emboj/16.5.1045

Sequence

[hsa:5994]

Reference

PMID:20024540

Authors

Bushway M, Cycon KA, Mulvaney K, Murphy SP

Title

Coordinate loss of MHC class II expression in the diffuse large B cell lymphoma cell line OCI-Ly2 is due to a novel mutation in RFX-AP.

Journal

Immunogenetics 62:109-16 (2010)
DOI:10.1007/s00251-009-0418-3

Sequence

[hsa:5994]

LinkDB

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