KEGG ORTHOLOGY: K08101

ORTHOLOGY: K08101

Entry

K08101                      KO

Symbol

HY2

Name

phytochromobilin:ferredoxin oxidoreductase [EC:1.3.7.4]

Pathway

map00860

Porphyrin metabolism

map01110

Biosynthesis of secondary metabolites

Reaction

R03678

(3Z)-phytochromobilin:ferredoxin oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K08101  HY2; phytochromobilin:ferredoxin oxidoreductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.4  phytochromobilin:ferredoxin oxidoreductase
     K08101  HY2; phytochromobilin:ferredoxin oxidoreductase

Other DBs

GO:

0050619

Genes

ATH:	AT3G09150(HY2)

ALY:

9320783

CRB:

17892864

CSAT:

104745078 104749614 104764610

EUS:	EUTSA_v10011657mg

BRP:	103859309 103870559

BNA:	106352983 106439211 125587929

BOE:	106295900 106331861

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10015899mg

PVY:

MINC:

TCC:

GRA:

GHI:	107939449 107945135

GAB:

108450615

HSYR:

120117492 120143576

DZI:	111302716 111303932

EGR:

104421483

GMX:

100791053

GSJ:	114385397 114403479

PVU:	PHAVU_008G284200g

VRA:

VAR:

VUN:

CCAJ:

APRC:

MTR:

TPRA:

CAM:	101503524 101506703 101510774 105851316

PSAT:

VVO:

LJA:

ADU:

AIP:

AHF:	112701760 112766749

LANG:

109342143

PCIN:

129317400 129318213 129318261

QSA:	O6P43_013988

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:	103929552 103934579

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:	7467396 7478520

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:	778324(AUREA)

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107761635 107823317

NSY:

NTO:

NAU:

INI:

ITR:	116003618 116004293

SIND:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:	110878838 110930825

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110689478 110704564 110734512

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119270459 119278613

TAES:

123059393 123066605 123075631

TUA:

LPER:

LRD:

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	122041944 122046470

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_151708(HY2-2) SELMODRAFT_83654(HY2-1)

PPP:

112290529

» show all

Reference

PMID:11283349

Authors

Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.

Title

Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.

Journal

Plant Cell 13:965-78 (2001)
DOI:10.1105/tpc.13.4.965

Reference

PMID:11226195

Authors

Kohchi T, Mukougawa K, Frankenberg N, Masuda M, Yokota A, Lagarias JC

Title

The Arabidopsis HY2 gene encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase.

Journal

Plant Cell 13:425-36 (2001)
DOI:10.1105/tpc.13.2.425

Sequence

[ath:AT3G09150]

LinkDB

ENZYME: 1.3.7.4

Entry

EC 1.3.7.4                  Enzyme

Name

phytochromobilin:ferredoxin oxidoreductase;
HY2;
PPhi B synthase;
phytochromobilin synthase

Class

Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor

Sysname

(3Z)-phytochromobilin:ferredoxin oxidoreductase

Reaction(IUBMB)

(3Z)-phytochromobilin + 2 oxidized ferredoxin = biliverdin IXalpha + 2 reduced ferredoxin [RN:R03678]

Reaction(KEGG)

R03678

Substrate

(3Z)-phytochromobilin [CPD:C05913];
oxidized ferredoxin [CPD:C00139]

Product

biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]

Comment

Catalyses the two-electron reduction of biliverdin IXalpha. Can use [2Fe-2S] ferredoxins from a number of sources as acceptor but not the [4Fe-4S] ferredoxin from Clostridium pasteurianum. The isomerization of (3Z)-phytochromobilin to (3E)-phytochromobilin is thought to occur prior to covalent attachment to apophytochrome in the plant cell cytoplasm. Flavodoxins can be used instead of ferredoxin.

History

EC 1.3.7.4 created 2002

Pathway

ec00860

Porphyrin metabolism

ec01110

Biosynthesis of secondary metabolites

Orthology

K08101

phytochromobilin:ferredoxin oxidoreductase

Genes

ATH:	AT3G09150(HY2)

ALY:

9320783

CRB:

17892864

CSAT:

104745078 104749614 104764610

EUS:	EUTSA_v10011657mg

BRP:	103859309 103870559

BNA:	106352983 106439211 125587929

BOE:	106295900 106331861

RSZ:

108863089

THJ:

104799118

CPAP:

110811856

CIT:

102609362

CIC:	CICLE_v10015899mg

PVY:

116135627

MINC:

123205883

TCC:

18589938

GRA:

105783974

GHI:	107939449 107945135

GAB:

108450615

HSYR:

120117492 120143576

DZI:	111302716 111303932

EGR:

104421483

GMX:

100791053

GSJ:	114385397 114403479

PVU:	PHAVU_008G284200g

VRA:

106765267

VAR:

108338713

VUN:

114193684

CCAJ:

109795293

APRC:

113846963

MTR:

11434871

TPRA:

123881987 123919836

CAM:	101503524 101506703 101510774 105851316

PSAT:

127117521

VVO:

131617749

LJA:

130732929

ADU:

107496238

AIP:

107609834

AHF:	112701760 112766749

LANG:

109342143

PCIN:

129317400 129318213 129318261

QSA:	O6P43_013988

FVE:

101309029

RCN:

112202176

PPER:

18778367

PMUM:

103326785

PAVI:

110761571

PDUL:

117624673

MDM:

103426911

MSYL:

126615439

PXB:	103929552 103934579

ZJU:

107406401

MNT:

21385429

CSAV:

115721362

CSV:

101217650

CMO:

103492001

BHJ:

120071771

MCHA:

111021651

CMAX:

111485492

CMOS:

111461368

CPEP:

111779700

RCU:

8261167

MEAN:

126686737

JCU:

105647226

HBR:

110634414

MESC:

110610189

POP:	7467396 7478520

PEU:

105131030

PALZ:

118032978 118035177

JRE:

108994596

CILL:

122292677

CAVE:

132164719 132183158

QSU:

111997816

QLO:

115981670

TWL:

120001734

VVI:

100267105

VRI:

117916930

SLY:	778324(AUREA)

SPEN:

107008239

SOT:

102604691

SSTN:

125863480

SDUL:

129887656

CANN:

107875610

LBB:

132626409

NTA:	107761635 107823317

NSY:

104250102

NTO:

104118127

NAU:

109228690

INI:

109160056

ITR:	116003618 116004293

SIND:

105170921

EGT:

105958969

SSPL:

121749680 121750085

SMIL:

131006824

SHIS:

125215257

APAN:

127260061

HAN:	110878838 110930825

ECAD:

122599805

LSV:

111883501

CCAV:

112529391

DCR:

108193224

CSIN:

114263854

RVL:

131314522

AEW:

130770127

BVG:

104889193

SOE:

110796859

CQI:	110689478 110704564 110734512

ATRI:

130815023

MOF:

131148975

NNU:

104612006

MING:

122091181

TSS:

122671382

PSOM:

113308909 113321152

OSA:

4325761

OBR:

102708119

OGL:

127756402

BDI:

100829998

ATS:

109784146

TDC:	119270459 119278613

TAES:

123059393 123066605 123075631

TUA:

125546046

LPER:

127345746

LRD:

124661795

SBI:

8081332

ZMA:

542164

MFLO:

136454010

SITA:

101767227

SVS:

117857311

PVIR:

120672659 120709242

PHAI:

112893571

PDA:

103705671

EGU:

105047124

MUS:

103976148

ZOF:	122041944 122046470

DCT:

110105041

PEQ:

110018338

AOF:

109850042

MSIN:

131226777

NCOL:

116246629

ATR:

18433244

SMO:	SELMODRAFT_151708(HY2-2) SELMODRAFT_83654(HY2-1)

PPP:

112290529

» show all

Reference

1 [PMID:11283349]

Authors

Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.

Title

Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.

Journal

Plant Cell 13:965-78 (2001)
DOI:10.1105/tpc.13.4.965

Reference

2 [PMID:11500553]

Authors

McDowell MT, Lagarias JC.

Title

Purification and biochemical properties of phytochromobilin synthase from etiolated oat seedlings.

Journal

Plant Physiol 126:1546-54 (2001)
DOI:10.1104/pp.126.4.1546

Reference

3 [PMID:8215388]

Authors

Terry MJ, Wahleithner JA, Lagarias JC.

Title

Biosynthesis of the plant photoreceptor phytochrome.

Journal

Arch Biochem Biophys 306:1-15 (1993)
DOI:10.1006/abbi.1993.1473

Other DBs

ExplorEnz - The Enzyme Database:

1.3.7.4

IUBMB Enzyme Nomenclature:

1.3.7.4

ExPASy - ENZYME nomenclature database:

1.3.7.4

BRENDA, the Enzyme Database:

1.3.7.4

CAS:	138263-99-7

LinkDB

REACTION: R03678

Entry

R03678                      Reaction

Name

(3Z)-phytochromobilin:ferredoxin oxidoreductase

Definition

(3Z)-Phytochromobilin + 2 Oxidized ferredoxin <=> Biliverdin + 2 Reduced ferredoxin

Equation

C05913 + 2 C00139 <=> C00500 + 2 C00138

Reaction class

RC01574

C00500_C05913

Enzyme

1.3.7.4

Pathway

rn00860

Porphyrin metabolism

rn01110

Biosynthesis of secondary metabolites

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.4
     R03678  (3Z)-Phytochromobilin + 2 Oxidized ferredoxin <=> Biliverdin + 2 Reduced ferredoxin

Orthology

K08101

phytochromobilin:ferredoxin oxidoreductase [EC:1.3.7.4]

Other DBs

RHEA:

16380

LinkDB

DBGET integrated database retrieval system