KEGG   ORTHOLOGY: K08101
Entry
K08101                      KO                                     
Symbol
HY2
Name
phytochromobilin:ferredoxin oxidoreductase [EC:1.3.7.4]
Pathway
map00860  Porphyrin metabolism
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K08101  HY2; phytochromobilin:ferredoxin oxidoreductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.7  With an iron-sulfur protein as acceptor
    1.3.7.4  phytochromobilin:ferredoxin oxidoreductase
     K08101  HY2; phytochromobilin:ferredoxin oxidoreductase
Other DBs
RN: R03678
GO: 0050619
Genes
ATH: AT3G09150(HY2)
ALY: 9320783
CRB: 17892864
CSAT: 104745078 104749614 104764610
EUS: EUTSA_v10011657mg
BRP: 103859309 103870559
BNA: 106352983 106439211
BOE: 106295900 106331861
RSZ: 108860076 108863089
THJ: 104799118
CPAP: 110811856
CIT: 102609362
PVY: 116135627
MINC: 123205883
TCC: 18589938
GRA: 105783974
GAB: 108450615
GMX: 100791053
VRA: 106765267
VAR: 108338713
VUN: 114193684
CCAJ: 109795293
APRC: 113846963
LJA: Lj0g3v0050649.1(Lj0g3v0050649.1) Lj2g3v3337330.1(Lj2g3v3337330.1)
ADU: 107496238
AIP: 107609834
LANG: 109342143
FVE: 101309029
RCN: 112202176
PPER: 18778367
PMUM: 103326785
PAVI: 110761571
PDUL: 117624673
MDM: 103426911
ZJU: 107406401
MNT: 21385429
CSV: 101217650
CMO: 103492001
BHJ: 120071771
MCHA: 111021651
CMAX: 111485492
CMOS: 111461368
CPEP: 111779700
RCU: 8261167
JCU: 105647226
HBR: 110634414
MESC: 110610189
PEU: 105131030
JRE: 108994596
QSU: 111997816
QLO: 115981670
TWL: 120001734
VVI: 100267105
VRI: 117916930
SLY: 778324(AUREA)
SPEN: 107008239
SOT: 102604691
CANN: 107875610
NSY: 104250102
NTO: 104118127
NAU: 109228690
INI: 109160056
SIND: 105170921
EGT: 105958969
ECAD: 122599805
LSV: 111883501
CCAV: 112529391
DCR: 108193224
CSIN: 114263854
BVG: 104889193
SOE: 110796859
NNU: 104612006
MING: 122091181
TSS: 122671382
NCOL: 116246629
OSA: 4325761
DOSA: Os01t0949400-01(Os01g0949400)
OBR: 102708119
BDI: 100829998
ATS: 109784146
SBI: 8081332
ZMA: 542164
SITA: 101767227
SVS: 117857311
PHAI: 112893571
PDA: 103705671
EGU: 105047124
MUS: 103976148
DCT: 110105041
PEQ: 110018338
AOF: 109850042
ATR: 18433244
PPP: 112290529
 » show all
Reference
  Authors
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
  Title
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
  Journal
Plant Cell 13:965-78 (2001)
DOI:10.1105/tpc.13.4.965
Reference
  Authors
Kohchi T, Mukougawa K, Frankenberg N, Masuda M, Yokota A, Lagarias JC
  Title
The Arabidopsis HY2 gene encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase.
  Journal
Plant Cell 13:425-36 (2001)
DOI:10.1105/tpc.13.2.425
  Sequence
[ath:AT3G09150]
LinkDB

KEGG   ENZYME: 1.3.7.4
Entry
EC 1.3.7.4                  Enzyme                                 
Name
phytochromobilin:ferredoxin oxidoreductase;
HY2;
PPhi B synthase;
phytochromobilin synthase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With an iron-sulfur protein as acceptor
Sysname
(3Z)-phytochromobilin:ferredoxin oxidoreductase
Reaction(IUBMB)
(3Z)-phytochromobilin + 2 oxidized ferredoxin = biliverdin IXalpha + 2 reduced ferredoxin [RN:R03678]
Reaction(KEGG)
R03678
Substrate
(3Z)-phytochromobilin [CPD:C05913];
oxidized ferredoxin [CPD:C00139]
Product
biliverdin IXalpha;
reduced ferredoxin [CPD:C00138]
Comment
Catalyses the two-electron reduction of biliverdin IXalpha. Can use [2Fe-2S] ferredoxins from a number of sources as acceptor but not the [4Fe-4S] ferredoxin from Clostridium pasteurianum. The isomerization of (3Z)-phytochromobilin to (3E)-phytochromobilin is thought to occur prior to covalent attachment to apophytochrome in the plant cell cytoplasm. Flavodoxins can be used instead of ferredoxin.
History
EC 1.3.7.4 created 2002
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K08101  phytochromobilin:ferredoxin oxidoreductase
Genes
ATHAT3G09150(HY2)
ALY9320783
CRB17892864
CSAT104745078 104749614 104764610
EUSEUTSA_v10011657mg
BRP103859309 103870559
BNA106352983 106439211
BOE106295900 106331861
RSZ108860076 108863089
THJ104799118
CPAP110811856
CIT102609362
CICCICLE_v10015899mg
PVY116135627
MINC123205883
TCC18589938
GRA105783974
GHI107939449 107945135
GAB108450615
DZI111302716 111303932
EGR104421483 108960820
GMX100791053
GSJ114385397 114403479
PVUPHAVU_008G284200g
VRA106765267
VAR108338713
VUN114193684
CCAJ109795293
APRC113846963
MTRMTR_5g097080
CAM101503524 101506703 101510774 105851316
LJALj0g3v0050649.1(Lj0g3v0050649.1) Lj2g3v3337330.1(Lj2g3v3337330.1)
ADU107496238
AIP107609834
AHF112701760 112766749
LANG109342143
FVE101309029
RCN112202176
PPER18778367
PMUM103326785
PAVI110761571
PDUL117624673
MDM103426911
PXB103929552 103934579
ZJU107406401
MNT21385429
CSV101217650
CMO103492001
BHJ120071771
MCHA111021651
CMAX111485492
CMOS111461368
CPEP111779700
RCU8261167
JCU105647226
HBR110634414
MESC110610189
POP7467396 7478520
PEU105131030
PALZ118032978 118035177
JRE108994596
QSU111997816
QLO115981670
TWL120001734
VVI100267105
VRI117916930
SLY778324(AUREA)
SPEN107008239
SOT102604691
CANN107875610
NTA107761635 107823317
NSY104250102
NTO104118127
NAU109228690
INI109160056
ITR116003618 116004293
SIND105170921
EGT105958969
SSPL121749680 121750085
HAN110878838 110930825
ECAD122599805
LSV111883501
CCAV112529391
DCR108193224
CSIN114263854
BVG104889193
SOE110796859
CQI110689478 110704564 110734512
NNU104612006
MING122091181
TSS122671382
PSOM113308909 113321152
NCOL116246629
OSA4325761
DOSAOs01t0949400-01(Os01g0949400)
OBR102708119
BDI100829998
ATS109784146
TDC119270459 119278613
TAES123059393 123066605 123075631
SBI8081332
ZMA542164
SITA101767227
SVS117857311
PVIR120672659 120709242
PHAI112893571
PDA103705671
EGU105047124
MUS103976148
DCT110105041
PEQ110018338
AOF109850042
ATR18433244
SMOSELMODRAFT_151708(HY2-2) SELMODRAFT_83654(HY2-1)
PPP112290529
 » show all
Reference
1  [PMID:11283349]
  Authors
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
  Title
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
  Journal
Plant Cell 13:965-78 (2001)
DOI:10.1105/tpc.13.4.965
Reference
2  [PMID:11500553]
  Authors
McDowell MT, Lagarias JC.
  Title
Purification and biochemical properties of phytochromobilin synthase from etiolated oat seedlings.
  Journal
Plant Physiol 126:1546-54 (2001)
DOI:10.1104/pp.126.4.1546
Reference
3  [PMID:8215388]
  Authors
Terry MJ, Wahleithner JA, Lagarias JC.
  Title
Biosynthesis of the plant photoreceptor phytochrome.
  Journal
Arch Biochem Biophys 306:1-15 (1993)
DOI:10.1006/abbi.1993.1473
Other DBs
ExplorEnz - The Enzyme Database: 1.3.7.4
IUBMB Enzyme Nomenclature: 1.3.7.4
ExPASy - ENZYME nomenclature database: 1.3.7.4
BRENDA, the Enzyme Database: 1.3.7.4
CAS: 138263-99-7
LinkDB

KEGG   REACTION: R03678
Entry
R03678                      Reaction                               
Name
(3Z)-phytochromobilin:ferredoxin oxidoreductase
Definition
(3Z)-Phytochromobilin + 2 Oxidized ferredoxin <=> Biliverdin + 2 Reduced ferredoxin
Equation
C05913 + 2 C00139 <=> C00500 + 2 C00138
Reaction class
RC01574  C00500_C05913
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K08101  phytochromobilin:ferredoxin oxidoreductase [EC:1.3.7.4]
Other DBs
RHEA: 16380
LinkDB

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