Entry
Name
dermatan 4-sulfotransferase;
dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase;
dermatan-4-sulfotransferase-1;
dermatan-4-sulfotransferase 1;
D4ST-1;
dermatan N-acetylgalactosamine 4-O-sulfotransferase;
CHST14 protein;
CHST14;
3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfonotransferase
Reaction(IUBMB)
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine [RN:
R10873 ]
Reaction(KEGG)
Substrate
3'-phospho-5'-adenylyl sulfate [CPD:
C00053 ];
[dermatan]-N-acetyl-D-galactosamine
Product
adenosine 3',5'-bisphosphate [CPD:
C00054 ];
[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine
Comment
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4) [1].
History
EC 2.8.2.35 created 2010
Pathway
ec00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Orthology
K08105 dermatan 4-sulfotransferase 1
Genes
AGEN : 126047428 126047565
ASAO : 132765087 132778515
HCG : 128335804(CHST14) 128343038
SANH : 107665414 107683987
CCAR : 109051416(chst14) 109051417
CAUA : 113062921 113063186 113120968
CGIB : 127938293 127984551
MASI : 127415901 127456720
SPIL : 134102745 134102796
HCQ : 109509816(chst14) 109531938
OTW : 112249207(chst14) 112251823
CCLU : 121533959 121540147
PSPA : 121298231(chst14) 121321872
ARUT : 117408979 117962415 117964072
BFO : 118418852 118418914 118419511
BBEL : 109470576 109477578 109487724
LPIC : 129260684 129272558 129280509 129280687 129281244
AJJ : 139967438 139968557 139968727 139969233 139973311 139980335 139980919 139980921 139981296
APLC : 110982416 110984100
ARUN : 117288145 117288886 117293785 117300288 117304967
AAMU : 139935452 139936327 139937560 139949146 139952109 139952847 139952848 139952872 139953762
AFIL : 140136979 140142088 140142630 140146403 140146476 140150416 140150417 140158834 140160546 140160558 140161682 140161711 140164047 140165834
PFLL : 139121190 139123969 139124072 139124120 139124173 139124363 139128975 139128978 139131052 139142761
PCHN : 125029590 125044089
GAE : 121375076 121375996 121387646
HRJ : 124270120 124284355 124286545
HASI : 137296061 137297197
PMAX : 117330379 117331116 117331261 117331861
MMER : 123525561 123530092 123543360 123545014 123548793 123548795 123549850 123550094 123550468 123551983 123551993 123554238 123559763 123559814
NVE : 116607440 116609250 5507697 5510750 5521879
AMIL : 114955404 114955419
MFOO : 137990823 138000205
PDAM : 113664665 113665176
DGT : 114523817 114524044 114524489 114524510
XEN : 124434836 124445724 124446126
SYNR : KR49_06610 KR49_06620
» show all
Taxonomy
Reference
Authors
Evers MR, Xia G, Kang HG, Schachner M, Baenziger JU
Title
Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.
Journal
Sequence
Reference
Authors
Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K
Title
Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.
Journal
Sequence
Reference
Authors
Pacheco B, Maccarana M, Malmstrom A
Title
Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate.
Journal
Sequence
Reference
Authors
Mitsunaga C, Mikami T, Mizumoto S, Fukuda J, Sugahara K
Title
Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.35
ExPASy - ENZYME nomenclature database: 2.8.2.35
LinkDB
All DBs