KEGG ORTHOLOGY: K08370

ORTHOLOGY: K08370

Entry

K08370                      KO

Symbol

CYBRD1, Dcytb

Name

plasma membrane ascorbate-dependent reductase [EC:7.2.1.3]

Pathway

map04978

Mineral absorption

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09154 Digestive system
   04978 Mineral absorption
    K08370  CYBRD1, Dcytb; plasma membrane ascorbate-dependent reductase
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K08370  CYBRD1, Dcytb; plasma membrane ascorbate-dependent reductase
Enzymes [BR:ko01000]
7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.1  Linked to oxidoreductase reactions
    7.2.1.3  ascorbate ferrireductase (transmembrane)
     K08370  CYBRD1, Dcytb; plasma membrane ascorbate-dependent reductase
Transporters [BR:ko02000]
Other transporters
  Transmembrane electron carriers
   K08370  CYBRD1, Dcytb; plasma membrane ascorbate-dependent reductase

Other DBs

TC:

5.B.2.1

Genes

HSA:	79901(CYBRD1)

PTR:	737081(CYBRD1)

PPS:

100972759

GGO:

101141704

PON:	100172640(CYBRD1)

PPYG:

NLE:

HMH:

SSYN:

MCC:	694818(CYBRD1)

MCF:	102120369(CYBRD1)

MTHB:

126932498

MNI:

105483245

CSAB:

103217305(CYBRD1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100408533(CYBRD1)

SBQ:

CIMI:

ANAN:

CSYR:

MMUR:

LCAT:

ERUF:

138385237(CYBRD1)

PCOQ:

105815585

OGA:

100959080

MMU:	73649(Cybrd1)

MCAL:

110290000

MPAH:

110319194

RNO:	295669(Cybrd1)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

PMAV:

102928772(Cybrd1)

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138826068(Cybrd1)

PLOP:

NCAR:

ITI:

OCU:

OPI:

OCZ:

TUP:

GVR:

CFA:	478796(CYBRD1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101089456(CYBRD1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:	125917098 125917922

PLEZ:

122226238

HHV:

120236394

BTA:	534257(CYBRD1)

BOM:	102268926(CYBRD1)

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

138075700(CYBRD1)

ODA:

120854918

CCAD:

122453721

MREE:

136165379(CYBRD1)

OVR:	110138902(CYBRD1)

MBEZ:

129537693

SSC:	100144591(CYBRD1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:	115850310(CYBRD1)

DDP:	132428563(CYBRD1)

DLE:

111172859

PCAD:

102991492

PSIU:

116756648

PPHC:

136125715(CYBRD1)

NASI:

112413674

ECB:

100063657

EPZ:	103555659(CYBRD1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139015238(CYBRD1)

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138154904(CYBRD1)

OAA:

100083870

TACU:

119932123

GGA:	424152(CYBRD1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

AACU:

137858241(CYBRD1)

ACYG:

106029992(CYBRD1)

CATA:

118257643

AFUL:

116490844

TGU:

100230314

LSR:	110482848(CYBRD1)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139593691(CYBRD1)

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138112980(CYBRD1)

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136363510(CYBRD1)

CCIC:

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

SURA:

141945286(CYBRD1)

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

BBUT:

142031275(CYBRD1)

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

CBOR:

142083587(CYBRD1)

GSTE:

104256621

CBOY:

140657738(CYBRD1)

MAME:

142414229(CYBRD1)

CLV:

CNIC:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

GAME:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

LMIC:

141746601(CYBRD1)

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102575142(CYBRD1)

CPOO:

109322876

GGN:

109301555

PSS:

102449908

CIZ:	142016772(CYBRD1)

CMY:

102931375

CCAY:

125644526

LKP:	140895638(CYBRD1)

NDS:	141995969(CYBRD1)

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139311971(CYBRD1)

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108702990(cybrd1.S) 445864(cybrd1.L)

XTR:	548408(cybrd1)

NPR:

108797881

RTEM:

120944020

ACAT:

141147001(CYBRD1)

PADS:

140335590(CYBRD1)

BBUF:

121008157

BGAR:

122944720

DTC:	141049413(CYBRD1)

PWL:	138285423(CYBRD1)

MUO:

115474753

DRE:	552960(cybrd1)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137035792(cybrd1)

MASI:

127446855

TROS:

130555843

TDW:

130427329

MANU:

129452237(cybrd1)

PDAB:

135782751(cybrd1)

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:

TFS:

TNG:	GSTEN00031422G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

117466502(cybrd1)

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:	120833663 120833664

PPUG:

AFB:

CLUM:

PSWI:

CVE:	137890851(cybrd1)

MSAM:

119904099

SCHU:

122885527

CUD:	121520658 121522318

SPUL:

138592782(cybrd1)

LMIX:

132979473 132987403

HTC:	141804724 141808524(cybrd1)

ALAT:

119026229

ASTR:

137605181(cybrd1)

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

EJA:	138200689(cybrd1)

BFRE:

138623114(cybrd1)

MCEP:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125973414(cybrd1)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140359160(cybrd1)

MALB:

BSPL:

SJO:

SSCO:

TTY:	137192678(cybrd1)

GMH:

115532825

SASA:

106581770(CYBR1) 106586222(CYBR1)

STRU:

115156023 115160755

OTW:	112225232 112236571

OMY:	110501459 110520104

OGO:	124043100 124043858

ONE:	115102115 115109066

OKI:	109866637 109871331

OKE:	118367078 118386038

OMM:	135519545 135547218

OCLA:

139380439 139398112

SALP:

111959972 111975083

SNH:	120058248 120063828

SFON:

CCLU:

OEP:

SFM:

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

CPUN:

140482226(cybrd1)

HOC:

132817461

SCAU:

119961932

LERI:

129698781

HAKA:

140728497(cybrd1)

PMRN:

116937885

LRJ:

133346181

DMO:	Dmoj_GI19919

DAZ:

DNV:

DHE:

NVL:

Reference

PMID:11230685

Authors

McKie AT, Barrow D, Latunde-Dada GO, Rolfs A, Sager G, Mudaly E, Mudaly M, Richardson C, Barlow D, Bomford A, Peters TJ, Raja KB, Shirali S, Hediger MA, Farzaneh F, Simpson RJ

Title

An iron-regulated ferric reductase associated with the absorption of dietary iron.

Journal

Science 291:1755-9 (2001)
DOI:10.1126/science.1057206

Sequence

[mmu:73649]

Reference

PMID:12547225

Authors

Latunde-Dada GO, Van der Westhuizen J, Vulpe CD, Anderson GJ, Simpson RJ, McKie AT

Title

Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism.

Journal

Blood Cells Mol Dis 29:356-60 (2002)
DOI:10.1006/bcmd.2002.0574

Reference

PMID:16286504

Authors

Mackenzie B, Garrick MD

Title

Iron Imports. II. Iron uptake at the apical membrane in the intestine.

Journal

Am J Physiol Gastrointest Liver Physiol 289:G981-6 (2005)
DOI:10.1152/ajpgi.00363.2005

LinkDB

DBGET integrated database retrieval system