KEGG ORTHOLOGY: K08778

ORTHOLOGY: K08778

Entry

K08778                      KO

Symbol

ASTL

Name

astacin-like metalloendopeptidase [EC:3.4.-.-]

Disease

H01897

Oocyte/zygote/embryo maturation arrest

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08778  ASTL; astacin-like metalloendopeptidase
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M12: astacin/adamalysin family
   K08778  ASTL; astacin-like metalloendopeptidase

Genes

HSA:	431705(ASTL)

PTR:	741606(ASTL)

PPS:	100974579(ASTL)

GGO:	101150399(ASTL)

PON:	100441506(ASTL)

NLE:	100599801(ASTL)

HMH:	116483757(ASTL)

MCC:	100430790(ASTL)

MCF:	102116648(ASTL)

MTHB:

126934352

MNI:	105490026(ASTL)

CSAB:

103241061(ASTL) 103247128

CATY:

105583721(ASTL)

PANU:

101026033(ASTL)

TGE:	112604466(ASTL)

MLEU:

105531676(ASTL)

RRO:	104661451(ASTL)

RBB:	108520911(ASTL)

TFN:	117099581(ASTL)

PTEH:

111542235(ASTL)

CANG:

105522204(ASTL)

CJC:	100412413(ASTL)

SBQ:	101054354(ASTL)

CIMI:

108301067(ASTL)

CSYR:

103261412(ASTL)

MMUR:

105883610(ASTL)

LCAT:

123637462(ASTL)

PCOQ:

105808282(ASTL)

OGA:	100940342(ASTL)

MMU:	215095(Astl)

MCAL:

110289797(Astl)

MPAH:

110318899(Astl)

RNO:	296129(Astl)

MCOC:

116092344(Astl)

ANU:	117703757(Astl)

CGE:	100750643(Astl)

MAUA:

101823004(Astl)

PROB:

127221274(Astl)

PLEU:

114709092(Astl)

MORG:

121460559 121465887

MFOT:

126496719

AAMP:

119815803(Astl)

NGI:	103738284(Astl)

HGL:	101717278(Astl)

CPOC:

100716830(Astl)

CCAN:

109695219(Astl)

DORD:

105988179(Astl)

DSP:	122121217(Astl)

NCAR:

124963627

MMMA:

107154024(Astl)

TUP:	102497678(ASTL)

GVR:	103605027(ASTL)

CFA:	100856523(ASTL)

CLUD:

112664440(ASTL)

VVP:	112916848(ASTL)

VLG:	121491862(ASTL)

NPO:	129510864(ASTL)

AML:	100480520(ASTL)

UMR:	103671880(ASTL)

UAH:	113268695(ASTL)

UAR:	123799691(ASTL)

ELK:

111158388

LLV:

125109793

MPUF:

101694285(ASTL)

MNP:	132022321(ASTL)

MLK:	131808427(ASTL)

NVS:	122915469(ASTL)

ORO:	101385596(ASTL)

EJU:	114219689(ASTL)

ZCA:	113937847(ASTL)

MLX:	118007523(ASTL)

NSU:	110587491(ASTL)

LWW:	102725675(ASTL)

FCA:	101092598(ASTL)

PYU:	121044408(ASTL)

PCOO:

112864141(ASTL)

PBG:	122497212(ASTL)

PVIV:

125162448(ASTL)

LRUF:

124502956

PTG:	102969664(ASTL)

PPAD:

109265116(ASTL)

PUC:

125937481

AJU:

106976046

HHV:	120231540(ASTL)

BTA:	511079(ASTL)

BOM:	102264739(ASTL)

BIU:	109565741(ASTL)

BBUB:

102416548(ASTL)

BBIS:

104980965(ASTL)

CHX:	102173096(ASTL)

OAS:	101115954(ASTL)

BTAX:

128055649(ASTL)

ODA:	120883538(ASTL)

CCAD:

122441357(ASTL)

MBEZ:

129539534(ASTL)

SSC:	100739686(ASTL)

CFR:	102511683(ASTL)

CBAI:

105072276(ASTL)

CDK:	105093715(ASTL)

VPC:	102532839(ASTL)

BACU:

103016594(ASTL)

BMUS:

118906302(ASTL)

LVE:	103075979(ASTL)

OOR:	101280160(ASTL)

DLE:	111187424(ASTL)

PCAD:

102986676(ASTL)

PSIU:

116764063(ASTL)

NASI:

112399011(ASTL)

ECB:	100062491(ASTL)

EPZ:	103564063(ASTL)

EAI:	106845792(ASTL)

MYB:	102256047(ASTL)

MYD:	102765386(ASTL)

MMYO:

118655226(ASTL)

MLF:	102440692(ASTL)

PKL:	118717693(ASTL)

EFUS:

103303587(ASTL)

MNA:	107534511(ASTL)

DRO:	112319411(ASTL)

SHON:

118994175(ASTL)

AJM:	119050001(ASTL)

PHAS:

123811272(ASTL)

MMF:	118630589(ASTL)

PPAM:

129072110(ASTL)

HAI:	109392023(ASTL)

RFQ:	117019281(ASTL)

PALE:

102898489(ASTL)

PGIG:

120610317(ASTL)

PVP:	105306818(ASTL)

RAY:	107509949(ASTL)

MJV:	108396789(ASTL)

TOD:	119258622(ASTL)

SARA:

101544788(ASTL)

SETR:

126024110(ASTL)

LAV:	100662705(ASTL)

TMU:

101350167

ETF:	101645730(ASTL)

MDO:	100033191(ASTL)

SHR:	100929627(ASTL)

AFZ:

127552407

PCW:	110209751 110210502(ASTL)

AFUL:

116499306(ASTL)

AAM:	106491485(ASTL)

AROW:

112975342(ASTL)

CMY:	102933691(ASTL)

CCAY:

125626282(ASTL)

TST:	117871765(ASTL)

CABI:

116815249(ASTL)

CTIG:

120299442

PGUT:

117673321(ASTL)

PRAF:

128420364(ASTL)

ZVI:	118086865(ASTL)

GJA:	107106746(ASTL)

XTR:	101730245(astl)

PSPA:

ARUT:

LERI:

BBEL:

MYI:

Reference

PMID:22472438

Authors

Burkart AD, Xiong B, Baibakov B, Jimenez-Movilla M, Dean J

Title

Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy.

Journal

J Cell Biol 197:37-44 (2012)
DOI:10.1083/jcb.201112094

Sequence

[hsa:431705]

LinkDB

DBGET integrated database retrieval system