KEGG ORTHOLOGY: K08879

ORTHOLOGY: K08879

Entry

K08879                      KO

Symbol

HSPB8

Name

heat shock protein beta-8

Disease

H00264

Charcot-Marie-Tooth disease

H00595

Myofibrillar myopathies

H00856

Distal hereditary motor neuropathies

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08879  HSPB8; heat shock protein beta-8
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K08879  HSPB8; heat shock protein beta-8
   04131 Membrane trafficking
    K08879  HSPB8; heat shock protein beta-8
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  H11 family
   K08879  HSPB8; heat shock protein beta-8
Chaperones and folding catalysts [BR:ko03110]
Heat shock proteins
  HSP20
   K08879  HSPB8; heat shock protein beta-8
Membrane trafficking [BR:ko04131]
Autophagy
  Aggrephagy
   Other aggrephagy associated proteins
    K08879  HSPB8; heat shock protein beta-8

Genes

HSA:	26353(HSPB8)

PTR:	452295(HSPB8)

PPS:	100976237(HSPB8)

GGO:	101124797(HSPB8)

PON:	100174469(HSPB8)

PPYG:

129010026(HSPB8)

NLE:	100603286(HSPB8)

HMH:	116477845(HSPB8)

SSYN:

129460423(HSPB8)

MCC:	574341(HSPB8)

MCF:	102131106(HSPB8)

MTHB:

126930698

MNI:	105494974(HSPB8)

CSAB:

103239232(HSPB8)

CATY:

105592754(HSPB8)

PANU:

101000423(HSPB8)

TGE:	112634623(HSPB8)

MLEU:

105527915(HSPB8)

RRO:	104666237(HSPB8)

RBB:	108534011(HSPB8)

TFN:	117089320(HSPB8)

PTEH:

111537584(HSPB8)

CANG:

105502307(HSPB8)

CJC:	100409042(HSPB8)

SBQ:	101030641(HSPB8)

CIMI:

108305054(HSPB8)

ANAN:

105728557(HSPB8)

CSYR:

103255667(HSPB8)

MMUR:

105866876(HSPB8)

LCAT:

123625950(HSPB8)

ERUF:

138401479(HSPB8)

PCOQ:

105815090(HSPB8)

OGA:	100944297(HSPB8)

MMU:	80888(Hspb8)

MCAL:

110294346(Hspb8)

MPAH:

110312966(Hspb8)

RNO:	113906(Hspb8)

MCOC:

116068272(Hspb8)

ANU:	117697939(Hspb8)

ASYL:

127672993(Hspb8)

MUN:	110545602(Hspb8)

CGE:	100754642(Hspb8)

MAUA:

101835699(Hspb8)

PROB:

127216003(Hspb8)

PLEU:

114682607(Hspb8)

PMAV:

102911747(Hspb8)

MORG:

121444081(Hspb8)

MFOT:

126511681

AAMP:

119825064(Hspb8)

CNL:	130871511(Hspb8)

NGI:	103726791(Hspb8)

HGL:	101707078(Hspb8)

CPOC:

100734199(Hspb8)

CCAN:

109686348

DORD:

105984231(Hspb8)

DSP:	122099027(Hspb8)

DMER:

138808477 138829865

PLOP:

125349067(Hspb8)

NCAR:

124990792

MMMA:

107158687(Hspb8)

ITI:	101965479(Hspb8)

OCU:

100349029

OPI:	101523972(HSPB8)

OCZ:	121160803(HSPB8)

TUP:	102473690(HSPB8)

GVR:	103608315(HSPB8) 103610898

CFA:	403553(HSPB8)

CLUD:

112676645(HSPB8)

VVP:	112932889(HSPB8)

VLG:	121475677(HSPB8)

NPO:	129508074(HSPB8)

AML:	100463910(HSPB8)

UMR:	103678334(HSPB8)

UAH:	113267026(HSPB8)

UAR:	123788296(HSPB8)

ELK:

111156505

LLV:

125082022

MPUF:

101671632(HSPB8)

MNP:	132023218(HSPB8)

MLK:	131811301(HSPB8)

NVS:	122903372(HSPB8)

ORO:	101372753(HSPB8)

EJU:	114219153(HSPB8)

ZCA:	113912752(HSPB8)

MLX:	118018529(HSPB8)

NSU:	110592412(HSPB8)

LWW:	102741701(HSPB8)

FCA:	101093804(HSPB8)

PYU:	121010252(HSPB8)

PCOO:

112870331(HSPB8)

PBG:	122470288(HSPB8)

PVIV:

125149553(HSPB8)

LRUF:

124518539

LGF:	123588289(HSPB8)

AJU:

106971703

PTG:	102964997(HSPB8)

PPAD:

109277555(HSPB8)

PUC:

125914119

PLEZ:

122203442(HSPB8)

HHV:	120220252(HSPB8)

BTA:	539524(HSPB8)

BOM:	102278718(HSPB8)

BIU:	109571185(HSPB8)

BBUB:

102389122(HSPB8)

BKE:	129630078(HSPB8)

BBIS:

104989656(HSPB8)

CHX:	102182717(HSPB8)

OAS:	101108164(HSPB8)

BTAX:

128062437(HSPB8)

CSUM:

138093901(HSPB8)

ODA:	120871114(HSPB8)

CCAD:

122423338(HSPB8)

MREE:

136145736(HSPB8)

OVR:	139037788(HSPB8)

MBEZ:

129542409(HSPB8)

SSC:	100155338(HSPB8)

CFR:	102510583(HSPB8)

CBAI:

105080551(HSPB8)

CDK:	105104902(HSPB8)

VPC:	102544407(HSPB8)

BACU:

103012557(HSPB8)

BMUS:

118880024(HSPB8)

LVE:	103085010(HSPB8)

OOR:	101289827(HSPB8)

LALB:

132532346(HSPB8)

GMF:	115855293(HSPB8)

DDP:	132436471(HSPB8)

DLE:	111186865(HSPB8)

PCAD:

102995663(HSPB8)

PSIU:

116764901(HSPB8)

PPHC:

136132966(HSPB8)

NASI:

112408792(HSPB8)

ECB:	100050779(HSPB8)

EPZ:	103540761(HSPB8)

EAI:	106839673(HSPB8)

MYB:	102257286(HSPB8)

MYD:	102769449(HSPB8)

MMYO:

118678392(HSPB8)

MLF:	102430968(HSPB8)

MDT:	132221989(HSPB8)

MYUM:

138997604(HSPB8)

PKL:	118725443(HSPB8)

EFUS:

103287094(HSPB8)

MNA:	107528481(HSPB8)

DRO:	112310852(HSPB8)

SHON:

118991161(HSPB8)

AJM:	119057454(HSPB8)

PDIC:

114509549(HSPB8)

PHAS:

123821761(HSPB8)

MMF:	118639988(HSPB8)

PPAM:

129087317(HSPB8)

HAI:	109386135(HSPB8)

RFQ:	117017199(HSPB8)

PALE:

102886478(HSPB8)

PGIG:

120606773(HSPB8)

PVP:	105289263 105289264(HSPB8)

RAY:	107513172(HSPB8)

MJV:	108401051(HSPB8)

TOD:	119244927(HSPB8)

SARA:

101541710(HSPB8)

SFUM:

130039153(HSPB8)

SETR:

126030648(HSPB8)

LAV:	100676830(HSPB8)

TMU:

101361613

ETF:	101657021(HSPB8)

MDO:	100014083(HSPB8)

GAS:	123245072(HSPB8)

SHR:	100918702(HSPB8)

AFZ:

127545535

PCW:	110222797(HSPB8)

TVP:	118834536(HSPB8)

PBRV:

138156447(HSPB8)

MLAO:

141501712(HSPB8)

OAA:	114806307(HSPB8)

TACU:

119942418(HSPB8)

GGA:	416988(HSPB8)

PCOC:

116228404(HSPB8)

CJO:	107321451(HSPB8)

TPAI:

128083827(HSPB8)

LMUT:

125701863(HSPB8)

NMEL:

110406201(HSPB8)

APLA:

110353991(HSPB8)

AACU:

137841181(HSPB8)

ACYG:

106031451(HSPB8)

CATA:

118252940(HSPB8)

AFUL:

116496340(HSPB8)

TGU:	100223755(HSPB8)

LSR:	110481283(HSPB8)

SCAN:

103818048(HSPB8)

PMOA:

120510296(HSPB8)

OTC:	121344468(HSPB8)

PRUF:

121364962(HSPB8)

ATRC:

139598743(HSPB8)

GFR:	102044125(HSPB8)

FAB:	101807709(HSPB8)

OMA:	130259646(HSPB8)

PHI:	102107840(HSPB8)

PMAJ:

107211439(HSPB8)

CCAE:

111936580(HSPB8)

CCW:	104695013(HSPB8)

CBRC:

103623752(HSPB8)

ACOE:

138119308(HSPB8)

ETL:

114056603

ZAB:	102074733(HSPB8)

ZLE:	135454555(HSPB8)

SVG:	106864888(HSPB8)

MMEA:

130578264(HSPB8)

HRT:	120760730(HSPB8)

SATI:

136368889(HSPB8)

CFAI:

136298753(HSPB8)

CCIC:

134051043(HSPB8)

FPG:	101918612(HSPB8)

FCH:	102057936(HSPB8)

SHAB:

115614405(HSPB8)

ACUN:

113486287(HSPB8)

SURA:

141951155(HSPB8)

TALA:

116963765(HSPB8)

ACHC:

115345920(HSPB8)

HLE:	104836075(HSPB8)

AGEN:

126040723

HHAR:

128146451(HSPB8)

BBUT:

142037407(HSPB8)

GCL:

127022821

LDI:	104343180(HSPB8)

DPUB:

104308538(HSPB8)

PPUS:

135188907(HSPB8)

EGZ:	104129863(HSPB8)

NNI:	104011466(HSPB8)

PCRI:

104033975(HSPB8)

PARX:

142064817(HSPB8)

PADL:

103922699(HSPB8)

AFOR:

103905788(HSPB8)

CBOR:

142090046(HSPB8)

CBOY:

140659781(HSPB8)

MAME:

142416745(HSPB8)

CLV:	102084571(HSPB8)

CNIC:

135995284(HSPB8)

MUI:	104541545(HSPB8)

EHS:	104513021(HSPB8)

CUCA:

104064272(HSPB8)

TEO:	104370600(HSPB8)

GAME:

129213935(HSPB8)

CPEA:

104395192(HSPB8)

CVF:	104289655(HSPB8)

RTD:	128917298(HSPB8)

CRID:

134523017(HSPB8)

LMIC:

141750761(HSPB8)

NARQ:

141472680(HSPB8)

AROW:

112970628(HSPB8)

NPD:	112945950(HSPB8)

TGT:	104577457(HSPB8)

DNE:	112994598(HSPB8)

ASN:	102381904(HSPB8)

AMJ:	102569686(HSPB8)

CPOO:

109312895(HSPB8)

GGN:	109290324(HSPB8)

PSS:	102450119(HSPB8)

CIZ:	142022482(HSPB8)

CMY:	102942714(HSPB8)

CCAY:

125623042(HSPB8)

LKP:	140898511(HSPB8)

NDS:	141999285(HSPB8)

DCC:	119843724(HSPB8)

CPIC:

101941505(HSPB8)

TST:	117888089(HSPB8)

CABI:

116825804(HSPB8)

MRV:	120386225(HSPB8)

ACS:	100559087(hspb8)

ASAO:

132781288(HSPB8)

PVT:	110086268(HSPB8)

SUND:

121916460(HSPB8)

PBI:	103066714(HSPB8)

PMUR:

107288825(HSPB8)

CTIG:

120303278(HSPB8)

TSR:	106544112(HSPB8)

PGUT:

117659639(HSPB8)

PCAE:

139321728(HSPB8)

APRI:

131185764(HSPB8)

PTEX:

113448069(HSPB8)

NSS:	113423282(HSPB8)

VKO:	123032810(HSPB8)

PMUA:

114586665(HSPB8)

PRAF:

128404330(HSPB8)

ZVI:	118075823(HSPB8)

HCG:	128337808(HSPB8)

GJA:	107122280(HSPB8)

STOW:

125442838(HSPB8)

EMC:	129341157(HSPB8)

XLA:	108707182(hspb8.S) 379472(hspb8.L)

XTR:	448147(hspb8)

NPR:	108798748(HSPB8)

RTEM:

120932820(HSPB8)

ACAT:

141139423(HSPB8)

PADS:

140333938(HSPB8)

BBUF:

120988514(HSPB8)

BGAR:

122935103(HSPB8)

DTC:	141069648(HSPB8)

HSQ:	130285773(HSPB8)

PWL:	138266094(HSPB8)

MUO:	115480726(HSPB8)

GSH:	117364414(HSPB8)

DRE:	791580(hspb8)

SRX:	107720866 107755871(hspb8)

SANH:

107656808(hspb8)

SGH:	107561261 107577774(hspb8)

CCAR:

109057949(hspb8) 109090760

CAUA:

113048954 113071496(hspb8)

CGIB:

127956991 128013582

PTET:

122345410 122345444(hspb8)

LROH:

127165574(hspb8)

OMC:	131541524(hspb8)

PPRM:

120470071(hspb8)

RKG:	130099269(hspb8)

MAMB:

125267374(hspb8)

CIDE:

127512844

CERY:

137034349(hspb8)

MASI:

127425467 127440111

TROS:

130551422(hspb8)

TDW:	130419992(hspb8)

MANU:

129439765(hspb8)

PDAB:

135732625(hspb8)

IPU:

108255940

IFU:	128625420(hspb8)

PHYP:

113537148(hspb8)

SMEO:

124380929(hspb8)

TFD:	113653417(hspb8)

TVC:	132855092(hspb8)

CGAR:

128508965(hspb8)

NGRA:

132872166(hspb8)

TRN:	134335359(hspb8)

AMEX:

103021595(hspb8)

CMAO:

118827498(hspb8)

EEE:	113589479(hspb8)

CHAR:

105893882(hspb8)

SPIL:

134088508(hspb8)

ASAD:

121715767(hspb8)

TRU:	101066003(hspb8)

TFS:	130525795(hspb8)

TNG:	GSTEN00029063G001

LCO:	104920645(hspb8)

NCC:	104947579(hspb8)

TBEN:

117473202(hspb8)

CGOB:

115013420(hspb8)

PGEO:

117452328(hspb8)

GACU:

117552100(hspb8)

EMAC:

134873240(hspb8)

ELY:	117252725(hspb8)

EFO:	125890149(hspb8)

PLEP:

121943887(hspb8)

SLUC:

116053965(hspb8)

ECRA:

117945323(hspb8)

ESP:	116690297(hspb8)

PFLV:

114555797(hspb8)

GAT:	120830693(hspb8)

PPUG:

119225454(hspb8)

AFB:	129101341(hspb8)

CLUM:

117736419(hspb8)

PSWI:

130197196(hspb8)

CANA:

137805118(hspb8)

CVE:	137880041(hspb8)

MSAM:

119891789(hspb8)

SCHU:

122876515(hspb8)

EARM:

139284698(hspb8)

CUD:	121509658(hspb8)

SPUL:

138610475(hspb8)

LMIX:

132974362(hspb8)

HTC:	141790007(hspb8)

ALAT:

119020151(hspb8)

ASTR:

137593112(hspb8)

PKLU:

139204512(hspb8)

MZE:	101481210(hspb8)

ONL:	100698886(hspb8)

OAU:	116325842(hspb8)

OLA:	101166228(hspb8)

OML:	112147971(hspb8)

CSAI:

133451485(hspb8)

XMA:	102218542(hspb8)

XCO:	114154496(hspb8)

XHE:	116729687(hspb8)

PRET:

103469859(hspb8)

PFOR:

103134939(hspb8)

PLAI:

106964089(hspb8)

PMEI:

106925365(hspb8)

GAF:	122828365(hspb8)

PPRL:

129366144(hspb8)

CVG:	107103839(hspb8)

CTUL:

119788791(hspb8)

GMU:	124877769(hspb8)

NFU:	107386236(hspb8)

KMR:	108242735(hspb8)

ALIM:

106519460(hspb8)

NWH:	119413176(hspb8)

AOCE:

111573245(hspb8)

EJA:	138192047(hspb8)

BFRE:

138631419(hspb8)

MCEP:

125011870(hspb8)

CSEM:

103396884 103397860(hspb8)

POV:	109637141(hspb8)

SSEN:

122770041(hspb8)

SSOE:

131464520(hspb8)

HHIP:

117767597(hspb8)

HSP:	118114861(hspb8)

PPLT:

128438340(hspb8)

SMAU:

118314247(hspb8)

LCF:

108901796

SDU:	111227363(hspb8)

SLAL:

111663065(hspb8)

XGL:	120805503(hspb8)

HCQ:	109525143(hspb8)

SSCV:

125993836(hspb8)

SBIA:

133499413(hspb8)

PEE:	133399649(hspb8)

PTAO:

133475685(hspb8)

BPEC:

110155033(hspb8)

ENY:	140346456(hspb8) 140346934

MALB:

109973993(hspb8)

BSPL:

114861940(hspb8)

SJO:	128364134(hspb8)

SSCO:

133979517(hspb8)

TTY:	137168105(hspb8)

GMH:	115548984(hspb8)

SASA:

106579825 106584909(hspb8)

STRU:

115164122 115200514

OTW:	112248870(hspb8) 112251465

OMY:	110526027 110536389

OGO:	124034037 124036597

ONE:	115111923(hspb8) 115126719

OKI:	109883705 109896192

OKE:	118375390 118393542

OMM:	135513786 135545454

OCLA:

139389342 139411200

SALP:

111974018 112074276

SNH:	120055342 120063424

SFON:

129826623 129853897(hspb8)

CCLU:

121530789 121584628(hspb8)

ELS:	105014053(hspb8)

OEP:	134011906(hspb8)

SFM:	108925667(hspb8) 108933157

PKI:	111844159(hspb8) 111849900

AANG:

118206427(hspb8)

AROT:

135264809(hspb8)

CCOG:

133141351(hspb8)

LOC:	102688935(hspb8)

PSPA:

121297206 121300125

ARUT:

117426971 117428084

PSEX:

120540569(hspb8)

LCM:	102347524(HSPB8)

CMK:	103182172(hspb8)

RTP:	109925192(hspb8)

CPLA:

122562752(hspb8)

CPUN:

140487893(hspb8)

HOC:	132827374(hspb8)

SCAU:

119962967(hspb8)

LERI:

129709298(hspb8)

HAKA:

140738280(hspb8)

PPOI:

119104665

RMP:

119160733

» show all

Reference

PMID:21731611

Authors

Ke L, Meijering RA, Hoogstra-Berends F, Mackovicova K, Vos MJ, Van Gelder IC, Henning RH, Kampinga HH, Brundel BJ

Title

HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.

Journal

PLoS One 6:e20395 (2011)
DOI:10.1371/journal.pone.0020395

Sequence

[hsa:26353]

Reference

PMID:21526341

Authors

Shemetov AA, Seit-Nebi AS, Gusev NB

Title

Phosphorylation of human small heat shock protein HspB8 (Hsp22) by ERK1 protein kinase.

Journal

Mol Cell Biochem 355:47-55 (2011)
DOI:10.1007/s11010-011-0837-y

Sequence

[hsa:26353]

Reference

PMID:15030316

Authors

Chowdary TK, Raman B, Ramakrishna T, Rao CM

Title

Mammalian Hsp22 is a heat-inducible small heat-shock protein with chaperone-like activity.

Journal

Biochem J 381:379-87 (2004)
DOI:10.1042/BJ20031958

Sequence

[rno:113906]

LinkDB

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