KEGG ORTHOLOGY: K08893

ORTHOLOGY: K08893

Entry

K08893                      KO

Symbol

HCK

Name

hemopoietic cell kinase [EC:2.7.10.2]

Pathway

map04062

Chemokine signaling pathway

map04666

Fc gamma R-mediated phagosome formation

map05167

Kaposi sarcoma-associated herpesvirus infection

Disease

H02660

Autoinflammation with pulmonary and cutaneous vasculitis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagosome formation
    K08893  HCK; hemopoietic cell kinase
   04062 Chemokine signaling pathway
    K08893  HCK; hemopoietic cell kinase
09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K08893  HCK; hemopoietic cell kinase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08893  HCK; hemopoietic cell kinase
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08893  HCK; hemopoietic cell kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08893  HCK; hemopoietic cell kinase
Protein kinases [BR:ko01001]
Non-receptor tyrosine kinases
  SRC family
   K08893  HCK; hemopoietic cell kinase
Membrane trafficking [BR:ko04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K08893  HCK; hemopoietic cell kinase

Other DBs

GO:

0004715

Genes

HSA:

3055(HCK)

PTR:	458163(HCK)

PPS:	100975763(HCK)

GGO:	101149280(HCK)

PON:	100455620(HCK)

PPYG:

129021481(HCK)

NLE:	100587780(HCK)

HMH:	116461143(HCK)

SSYN:

129474502(HCK)

MCC:	715723(HCK)

MCF:	102115729(HCK)

MTHB:

126964221

MNI:	105496179(HCK)

CSAB:

103248155(HCK)

CATY:

105582249(HCK)

PANU:

101016095(HCK)

TGE:	112632946(HCK)

MLEU:

105539484(HCK)

RRO:	104653712(HCK)

RBB:	108524139(HCK)

TFN:	117068628(HCK)

PTEH:

111548133(HCK)

CANG:

105524623(HCK)

CJC:	100389637(HCK)

SBQ:	101032860(HCK)

CIMI:

108291185(HCK)

ANAN:

105719252(HCK)

CSYR:

103255160(HCK)

MMUR:

105865943(HCK)

LCAT:

123622835(HCK)

ERUF:

138400511(HCK)

PCOQ:

105804972(HCK)

OGA:	100954296(HCK)

MMU:	15162(Hck)

MCAL:

110309091(Hck)

MPAH:

110317518(Hck)

RNO:	25734(Hck)

MCOC:

116091190(Hck)

ANU:	117704369(Hck)

ASYL:

127686085(Hck)

MUN:	110550096(Hck)

CGE:	100773315(Hck)

MAUA:

101836672(Hck)

PROB:

127228521(Hck)

PLEU:

114705554(Hck)

PMAV:

102917664(Hck)

MORG:

121460158(Hck)

MFOT:

126507069

AAMP:

119814087(Hck)

CNL:	130881205(Hck)

NGI:	103731073(Hck)

HGL:	101709222(Hck)

CPOC:

100714976(Hck)

CCAN:

109691761(Hck)

DORD:

105981479(Hck)

DSP:	122120233(Hck)

DMER:

138816865(Hck)

PLOP:

125353363(Hck)

NCAR:

124977986

MMMA:

107138980(Hck)

ITI:	101958549(Hck)

OCU:

100343961

OPI:	101519769(HCK)

OCZ:	121157419(HCK)

TUP:	102491330(HCK)

GVR:	103594006(HCK)

CFA:	485828(HCK)

CLUD:

112673783(HCK)

VVP:	112909929(HCK)

VLG:	121477700(HCK)

NPO:	129495206(HCK)

AML:	100468494(HCK)

UMR:	103674340(HCK)

UAH:	113258471(HCK)

UAR:	123798585(HCK)

ELK:

111141509

LLV:

125109120

MPUF:

101670407(HCK)

MNP:	132021825(HCK)

MLK:	131807874(HCK)

NVS:	122916170(HCK)

ORO:	101383723(HCK)

EJU:	114220725(HCK)

ZCA:	113938080(HCK)

MLX:	118011341(HCK)

MANO:

123851646(HCK)

NSU:	110579337(HCK)

LWW:	102739741(HCK)

FCA:	101101207(HCK)

PYU:	121012328(HCK)

PCOO:

112869543(HCK)

PBG:	122496394(HCK)

PVIV:

125161726(HCK)

LRUF:

124503311

LGF:	123580323(HCK)

AJU:

106974647

PTG:	102953452(HCK)

PPAD:

109272582(HCK)

PUC:

125936126

PLEZ:

122215678(HCK)

HHV:	120235421(HCK)

CCRU:

144235746(HCK)

BTA:	280814(HCK)

BOM:	102274987(HCK)

BIU:	109567352(HCK)

BJV:	133259574(HCK)

BBUB:

102410643(HCK)

BKE:	129625833(HCK)

BBIS:

104989906(HCK)

CHX:	102183977(HCK)

OAS:	101113167(HCK)

OCAN:

138417640(HCK)

BTAX:

128058279(HCK)

CSUM:

138091761(HCK)

ODA:	120868750(HCK)

CCAD:

122448276(HCK)

MREE:

136157959(HCK)

OVR:	110152405(HCK)

MBEZ:

129562253(HCK)

SSC:	100526085(HCK)

CFR:	102507677(HCK)

CBAI:

105073576(HCK)

CDK:	105100829(HCK)

VPC:	102528858(HCK)

BACU:

103015546(HCK)

BMUS:

118882005(HCK)

LVE:	103078130(HCK)

OOR:	101288667(HCK)

LALB:

132504828(HCK)

GMF:	115839352(HCK)

DDP:	132438557(HCK)

DLE:	111184309(HCK) 111184310

PCAD:

102977689(HCK)

PSIU:

116740009(HCK)

PPHC:

136134968(HCK)

NASI:

112398513(HCK)

ECB:	100068557(HCK)

EPZ:	103554273(HCK)

EAI:	106833726(HCK)

MYB:	102256952(HCK)

MYD:	102756136(HCK)

MMYO:

118663803(HCK)

MLF:	102418447(HCK)

MDT:	132239509(HCK)

MYUM:

139013803(HCK)

PKL:	118708178(HCK)

EFUS:

103285800(HCK)

MNA:	107527783(HCK)

DRO:	112303915(HCK)

SHON:

118985350(HCK)

AJM:	119047732(HCK)

PDIC:

114506945(HCK)

PHAS:

123814888(HCK)

MMF:	118618187(HCK)

PPAM:

129070785(HCK)

HAI:	109384426(HCK)

RFQ:	117015950(HCK)

PALE:

102890019(HCK)

PGIG:

120603531(HCK)

PVP:	105305509(HCK)

RAY:	107512878(HCK)

MJV:	108397287(HCK)

TOD:	119234305(HCK)

SARA:

101556901(HCK)

SFUM:

130017145 130030411(HCK)

SETR:

126017360(HCK)

LAV:	100660288(HCK)

TMU:

101344005

ETF:	101646312(HCK)

DNM:	101436877(HCK)

MDO:	100010539(HCK)

GAS:	123235427(HCK)

SHR:	100913992(HCK)

AFZ:

127550442

PCW:	110211423(HCK)

TVP:	118843648(HCK)

PBRV:

138150458(HCK)

MLAO:

141505744(HCK)

OAA:	100085668(HCK)

TACU:

119931519(HCK)

GGA:	419280(HCK)

PCOC:

116225952(HCK)

MGP:	100543739(HCK)

CJO:	107323072(HCK)

TPAI:

128080951(HCK)

LMUT:

125701152(HCK)

NMEL:

110408000(HCK)

APLA:

101792612(HCK)

AACU:

137865701(HCK)

OJA:	118176652(HCK)

ACYG:

106047123(HCK)

CATA:

118258329(HCK)

AFUL:

116495852(HCK)

TGU:	100220059(HCK)

LSR:	110469018(HCK)

VMC:	128815936(HCK)

VCHA:

128796660(HCK)

AIB:	137484127(HCK)

SCAN:

103818665(HCK)

PMOA:

120507022(HCK)

OTC:	121331606(HCK)

PRUF:

121348635(HCK)

ATRC:

139599582(HCK)

MATE:

118694485(HCK)

MAEN:

136563744(HCK)

GFR:	102036877(HCK)

FAB:	101812195(HCK)

OMA:	130261414(HCK)

PHI:	102101716(HCK)

PMAJ:

107213469(HCK)

CCAE:

111943147(HCK)

CCW:	104687710(HCK)

CBRC:

103616038(HCK)

ACOE:

138121013(HCK)

ETL:	114063045(HCK)

ZAB:	102067552(HCK)

ZLE:	135456067(HCK)

ACHL:

103802604(HCK)

SVG:	106861614(HCK)

MMEA:

130573537(HCK)

HRT:	120760001(HCK)

SATI:

136368491(HCK)

CFAI:

136298295(HCK)

CCIC:

134051380(HCK)

FPG:	101910593(HCK)

FCH:	102055899(HCK)

FRS:	119154975(HCK)

NNT:

104402536

SHAB:

115615189(HCK)

POCC:

134166298(HCK)

ACUN:

113487683(HCK)

ANOC:

141966786(HCK)

SURA:

141951914(HCK)

TALA:

116964001(HCK)

ACHC:

115339158(HCK)

HLE:	104832964(HCK)

AGEN:

126045472

HHAR:

128140085(HCK)

BBUT:

142027961(HCK)

GCL:

127023131

CSTI:

104558234

MNB:

103772812

DPUB:

104301445(HCK)

PPUS:

135188328(HCK)

IIN:	128975100(HCK)

EGZ:	104127632(HCK)

NNI:	104018316(HCK)

PCAO:

104047975

PARX:

142064230(HCK)

PADL:

103912489(HCK)

AFOR:

103899157(HCK)

CBOR:

142089854(HCK)

CBOY:

140659449(HCK)

MAME:

142416955(HCK)

CLV:	102096776(HCK)

CNIC:

135995038(HCK)

MUI:

104540920

CUCA:

104060798(HCK)

PCUR:

138728297(HCK)

BREG:

104635059

GAME:

129214293(HCK)

OHA:	104326489(LCK)

CPEA:

104385534(HCK)

CVF:	104293860(HCK)

RTD:	128916756(HCK)

CRID:

134522496(HCK)

LMIC:

141750348(HCK)

NARQ:

141471020(HCK)

AAM:	106497371(HCK)

AROW:

112961963(HCK)

NPD:	112949614(HCK)

DNE:	112987294(HCK)

ASN:	102368801(HCK)

AMJ:	106737579(HCK)

CPOO:

109313085(HCK)

GGN:	109292514(HCK)

PSS:	106732490(HCK)

CIZ:	142022074(HCK)

CMY:	102941333(HCK)

CCAY:

125621983(HCK)

LKP:	140896848(HCK)

NDS:	141997273(HCK)

DCC:	119841906(HCK)

CPIC:

101948814(HCK)

TST:	117885820(HCK)

EOB:	135887233(HCK)

CABI:

116816783(HCK)

MRV:	120380306(HCK)

EMQ:	137156951(HCK)

ACS:	100557519(hck)

ASAO:

132772977(HCK)

PVT:	110086725(HCK)

SUND:

121928438(HCK)

PBI:	103054220(HCK)

PMUR:

107299503(HCK)

CTIG:

120296871(HCK)

PCAE:

139315494(HCK)

APRI:

131194111(HCK)

PTEX:

113451379(HCK)

NSS:

113428839

VKO:	123036314(HCK)

PMUA:

114599837(HCK)

PRAF:

128416665(HCK)

ZVI:	118089194(HCK)

HCG:	128324743(HCK)

GJA:	107123021(HCK)

STOW:

125433774(HCK)

EMC:	129331352(HCK)

XLA:	373700(hck.L)

XTR:	548439(hck)

NPR:	108786954(HCK)

RTEM:

120919363(HCK)

ACAT:

141113936(HCK)

PADS:

140332956(HCK)

BBUF:

121003346(HCK)

BGAR:

122940304(HCK)

DTC:	141094778(HCK)

PWL:	138303876(HCK)

DRE:	101885596(hck)

DAES:

130217071(hck)

SRX:	107707747 107747493

SANH:

107681869 107690859

SGH:	107558239(hck) 107559464

CCAR:

109048064(hck) 109066820

CAUA:

113041145 113078068

CGIB:

127944748 128011780

LROH:

127154760(hck)

GRF:	141291646(hck)

OMC:	131532434(hck)

PPRM:

120463238(hck)

RKG:	130077499(hck)

MAMB:

125259890(hck)

CIDE:

127504938

CERY:

137009820(hck)

MASI:

127419047 127420385

TROS:

130545341(hck)

TDW:	130409248(hck)

MANU:

129431031(hck)

PDAB:

135775724(hck)

IPU:

108275896

IFU:	128619664(hck)

PHYP:

113530620(hck)

SMEO:

124398777(hck)

TFD:	113641889(hck)

TVC:	132861872(hck)

CGAR:

128510232(hck)

NGRA:

132896888(hck)

TRN:	134333811(hck)

AMEX:

103036768(hck)

CMAO:

118822535(hck)

EEE:	113575473(hck)

CHAR:

105898956(hck)

SPIL:

134087125(hck)

ASAD:

121713636(hck)

TRU:	101067815(hck)

TFS:	130519911(hck)

TNG:	GSTEN00003489G001

LCO:	104933734(hck)

TBEN:

117492629(hck)

CGOB:

115010682(hck)

PGEO:

117442834(hck)

GACU:

117539034(hck)

EMAC:

134872372(hck)

ELY:	117257637(hck)

EFO:	125891249(hck)

PLEP:

121947517(hck)

SLUC:

116040767(hck)

SVIT:

144520510(hck)

ECRA:

117948366(hck)

ESP:	116693216(hck)

PFLV:

114558466(hck)

PFLT:

120559136(hck)

GAT:	120828828(hck)

PPUG:

119200291(hck)

AFB:	129100415(hck)

CLUM:

117733005(hck)

PSWI:

130199315(hck)

CANA:

137800279(hck)

CVE:	137889130(hck)

AMIR:

142954412(hck)

MSAM:

119905779(hck)

SCHU:

122882906(hck)

EARM:

139289020(hck)

CUD:	121517388(hck)

SPUL:

138590423(hck)

LMIX:

132990291(hck)

HTC:	141799487(hck)

ALAT:

119022948(hck)

ASTR:

137603058(hck)

PKLU:

139209534(hck)

MZE:	101483358(hck)

ONL:	100699435(hck)

OAU:	116315560(hck)

OLA:	101163900(hck)

OML:	112159674(hck)

CSAI:

133457530(hck)

XMA:	102216930(hck)

XCO:	114145598(hck)

XHE:	116724078(hck)

PRET:

103466927(hck)

PFOR:

103150214(hck)

PLAI:

106939342

PMEI:

106908045

GAF:	122830438(hck)

PPRL:

129371700(hck)

CVG:

107098932

CTUL:

119787601(hck)

GMU:	124875239(hck)

NFU:

107386929

KMR:	108246117(hck)

ALIM:

106523041(hck)

NWH:	119417202(hck)

LTU:	140271340(hck)

AOCE:

111570488(hck)

EJA:	138210166(hck)

BFRE:

138626624(hck)

MCEP:

125006698(hck)

CSEM:

103384757(hck)

POV:	109630933(hck)

SSEN:

122777515(hck)

SSOE:

131468865(hck)

HHIP:

117764119(hck)

HSP:	118111169(hck)

PPLT:

128441787(hck)

SMAU:

118316439(hck)

LCF:

108885037

SDU:	111237026(hck)

SLAL:

111651844

XGL:	120803647(hck)

HCQ:	109511820(hck)

SSCV:

125989058(hck)

SBIA:

133490674(hck)

PEE:	133400095(hck)

PTAO:

133475285(hck)

BPEC:

110169150(hck)

ENY:	140365141 140372404

MALB:

109969986(hck)

BSPL:

114858678(hck)

SJO:	128357771(hck)

SSCO:

133987265(hck)

TTY:	137184040(hck)

GMH:	115548397(hck)

SASA:

100136375(hck) 106572127

STRU:

115166008 115168643

OTW:	112215985(hck) 112221354

OMY:	110492657 110532244

OGO:	124031908 124045508

ONE:	115122634 115132122

OKI:	109880577 109907963

OKE:	118361063 118376471

OMM:	135504441 135527762

OCLA:

139368965 139416463

SALP:

111976955(hck) 112068453

SNH:	120058931 120061488(hck)

SFON:

129830043 129861281

CCLU:

121538305 121546120

ELS:

105013770

OEP:	134019467 134019473

SFM:	108925655(hck) 108926451

PKI:	111839877 111858947

AANG:

118207244(hck) 118211520

AROT:

135234016(hck) 135237312

CCOG:

133109668 133138263(hck)

LOC:	102689082(hck)

PSPA:

121297688 121319271

ARUT:

117421328 117430462 117963906

PSEX:

120514189(hck)

LCM:

102352014

CMK:

103172176

RTP:	109911600(hck) 125485490

CPLA:

122559930 122560162

CPUN:

140463080(hck) 140463207

HOC:	132822857 132822957

SCAU:

119969589(hck) 119969757

LERI:

129707536(hck)

HAKA:

140736101

PMRN:

116942512 116946671 116955526

LRJ:	133347747 133349194 133352966

PFLL:

PVUL:

RPHI:

LLON:

Reference

PMID:9407116

Authors

Warmuth M, Bergmann M, Priess A, Hauslmann K, Emmerich B, Hallek M

Title

The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.

Journal

J Biol Chem 272:33260-70 (1997)
DOI:10.1074/jbc.272.52.33260

Reference

PMID:3496523

Authors

Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD

Title

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

Journal

Mol Cell Biol 7:2267-75 (1987)
DOI:10.1128/MCB.7.6.2267

Sequence

[hsa:3055]

LinkDB

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