KEGG ORTHOLOGY: K09634

ORTHOLOGY: K09634

Entry

K09634                      KO

Symbol

TMPRSS3

Name

transmembrane protease serine 3 [EC:3.4.21.-]

Disease

H00605

Deafness, autosomal recessive

H01705

Bilateral sudden sensorineural hearing loss

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K09634  TMPRSS3; transmembrane protease serine 3
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K09634  TMPRSS3; transmembrane protease serine 3

Genes

HSA:	64699(TMPRSS3)

PTR:	474016(TMPRSS3)

PPS:	100981240(TMPRSS3)

GGO:	101142771(TMPRSS3)

PON:	100171839(TMPRSS3)

PPYG:

129022657(TMPRSS3)

NLE:	100595379(TMPRSS3)

HMH:	116482058(TMPRSS3)

SSYN:

129483031(TMPRSS3)

MCC:	714500(TMPRSS3)

MCF:	102126486(TMPRSS3)

MTHB:

126951515

MNI:	105472586(TMPRSS3)

CSAB:

103219358(TMPRSS3)

CATY:

105575485(TMPRSS3)

PANU:

101014122(TMPRSS3)

TGE:	112621126(TMPRSS3)

MLEU:

105555563(TMPRSS3)

RRO:	104678008(TMPRSS3)

RBB:	108517347(TMPRSS3)

TFN:	117095827(TMPRSS3)

PTEH:

111526380(TMPRSS3)

CANG:

105520383(TMPRSS3)

CJC:	100410672(TMPRSS3)

SBQ:	101037251(TMPRSS3)

CIMI:

108311226(TMPRSS3)

ANAN:

105712044(TMPRSS3)

CSYR:

103272698(TMPRSS3)

MMUR:

105879090(TMPRSS3)

LCAT:

123630769(TMPRSS3)

PCOQ:

105822910(TMPRSS3)

OGA:	100947500(TMPRSS3)

MMU:	140765(Tmprss3)

MCAL:

110284066(Tmprss3)

MPAH:

110338328(Tmprss3)

RNO:	309665(Tmprss3)

MCOC:

116074786(Tmprss3)

ANU:	117724790(Tmprss3)

ASYL:

127669992(Tmprss3)

MUN:	110553320(Tmprss3)

CGE:	100760202(Tmprss3)

MAUA:

101825568(Tmprss3)

PROB:

127223867(Tmprss3)

PLEU:

114704005(Tmprss3)

MORG:

121435474(Tmprss3)

MFOT:

126501610

AAMP:

119823507(Tmprss3)

NGI:	103729329(Tmprss3)

HGL:	101709805(Tmprss3)

CPOC:

100722410(Tmprss3)

CCAN:

109700592(Tmprss3)

DORD:

105993980(Tmprss3)

DSP:	122114210(Tmprss3)

DMER:

138832562(Tmprss3)

PLOP:

125351168(Tmprss3)

NCAR:

124993197

MMMA:

107136505(Tmprss3)

ITI:	101969461(Tmprss3)

OCU:

103347075

OPI:	101522418(TMPRSS3)

TUP:	102484217(TMPRSS3)

GVR:	103593835(TMPRSS3)

CFA:	610987(TMPRSS3)

CLUD:

112669169(TMPRSS3)

VVP:	112908027(TMPRSS3)

VLG:	121479523(TMPRSS3)

NPO:	129502184(TMPRSS3)

AML:	100469939(TMPRSS3)

UMR:	103680714(TMPRSS3)

UAH:	113255681(TMPRSS3)

UAR:	123777488(TMPRSS3)

ELK:

111155742

LLV:

125093825

MPUF:

101675442(TMPRSS3)

MNP:	132010357(TMPRSS3)

MLK:	131826012(TMPRSS3)

NVS:	122910285(TMPRSS3)

ORO:	101386302(TMPRSS3)

EJU:	114226447(TMPRSS3)

ZCA:	113917809(TMPRSS3)

MLX:	118026922(TMPRSS3)

NSU:	110571053(TMPRSS3)

LWW:	102730140(TMPRSS3)

FCA:	101094284(TMPRSS3)

PYU:	121036452(TMPRSS3)

PCOO:

112849452(TMPRSS3)

PBG:	122492247(TMPRSS3)

PVIV:

125159146(TMPRSS3)

LRUF:

124526943

LGF:	123610527(TMPRSS3)

AJU:

106985641

PTG:	102964160(TMPRSS3)

PPAD:

109256960(TMPRSS3)

PUC:	125918135 125918392

PLEZ:

122230092(TMPRSS3)

HHV:	120240677(TMPRSS3)

BTA:	537914(TMPRSS3)

BOM:	102283159(TMPRSS3)

BIU:	109564693(TMPRSS3)

BBUB:

102414745(TMPRSS3)

BBIS:

104984954(TMPRSS3)

CHX:	102182449(TMPRSS3)

OAS:	101121487(TMPRSS3)

BTAX:

128053253(TMPRSS3)

CSUM:

138083073(TMPRSS3)

ODA:	120872775(TMPRSS3)

CCAD:

122445167(TMPRSS3)

MREE:

136173457(TMPRSS3)

OVR:	110125798(TMPRSS3)

MBEZ:

129552341(TMPRSS3)

SSC:	100627826(TMPRSS3)

CFR:	102510974(TMPRSS3)

CBAI:

105078040(TMPRSS3)

CDK:	105101653(TMPRSS3)

VPC:	102533662(TMPRSS3)

BACU:

102998489(TMPRSS3)

BMUS:

118894670(TMPRSS3)

LVE:	103081936(TMPRSS3)

OOR:	101278861(TMPRSS3)

LALB:

132520739(TMPRSS3)

GMF:	115841466(TMPRSS3)

DLE:	111163807(TMPRSS3)

PCAD:

102974325(TMPRSS3)

PSIU:

116753264(TMPRSS3)

PPHC:

136122327(TMPRSS3)

NASI:

112408607(TMPRSS3)

ECB:	100057972(TMPRSS3)

EPZ:	103560947(TMPRSS3)

EAI:	106829955(TMPRSS3)

MYB:	102248036(TMPRSS3)

MYD:	102762490(TMPRSS3)

MMYO:

118676867(TMPRSS3)

MLF:	102427087 102432282

MDT:	132229909(TMPRSS3)

MYUM:

139002332(TMPRSS3)

PKL:	118724450(TMPRSS3)

EFUS:

103289798(TMPRSS3)

MNA:	107543737(TMPRSS3)

DRO:	112304206(TMPRSS3)

SHON:

118984854(TMPRSS3)

AJM:	119048846(TMPRSS3)

PDIC:

114490808(TMPRSS3)

PHAS:

123828090(TMPRSS3)

MMF:	118617342(TMPRSS3)

PPAM:

129072717(TMPRSS3)

HAI:	109395185(TMPRSS3)

RFQ:	117014340(TMPRSS3)

PALE:

102893915(TMPRSS3)

PGIG:

120598597(TMPRSS3)

PVP:	105300569(TMPRSS3)

MJV:	108397496(TMPRSS3)

TOD:	119257073(TMPRSS3)

SARA:

101544759(TMPRSS3)

SFUM:

130028752(TMPRSS3)

SETR:

126025644(TMPRSS3)

LAV:	100670277(TMPRSS3)

TMU:

101353512

ETF:	101650068(TMPRSS3)

DNM:	101427227(TMPRSS3)

MDO:	100023782(TMPRSS3)

GAS:	123241645(TMPRSS3)

SHR:	100918620(TMPRSS3)

AFZ:

127557138

PCW:	110199149(TMPRSS3)

TVP:	118837211(TMPRSS3)

PBRV:

138142413(TMPRSS3)

OAA:	100080632(TMPRSS3)

TACU:

119940317(TMPRSS3)

GGA:	427988(TMPRSS3)

PCOC:

116229828(TMPRSS3)

MGP:	100549195(TMPRSS3)

CJO:	107323145(TMPRSS3)

TPAI:

128076407(TMPRSS3)

LMUT:

125687808(TMPRSS3)

NMEL:

110403356(TMPRSS3)

APLA:

101798478(TMPRSS3)

ACYG:

106036038(TMPRSS3)

CATA:

118247692(TMPRSS3)

AFUL:

116494756(TMPRSS3)

TGU:	100220345(TMPRSS3)

LSR:	110475865(TMPRSS3)

SCAN:

103815747(TMPRSS3)

PMOA:

120511864(TMPRSS3)

OTC:	121333489(TMPRSS3)

PRUF:

121364479(TMPRSS3)

ATRC:

139591904(TMPRSS3)

GFR:	102035193(TMPRSS3)

FAB:	101816413(TMPRSS3)

OMA:	130260310(TMPRSS3)

PHI:	102109363(TMPRSS3)

PMAJ:

107212521(TMPRSS3)

CCAE:

111927620(TMPRSS3)

CCW:	104686267(TMPRSS3)

CBRC:

103612868(TMPRSS3)

ACOE:

138117697(TMPRSS3)

ETL:	114066746(TMPRSS3)

ZAB:	102067024(TMPRSS3)

ZLE:	135442673(TMPRSS3)

ACHL:

103799114(TMPRSS3)

SVG:	106855731(TMPRSS3)

MMEA:

130583385(TMPRSS3)

HRT:	120749070(TMPRSS3)

SATI:

136374736(TMPRSS3)

CCIC:

134058117(TMPRSS3)

FPG:	101912598(TMPRSS3)

FCH:	102053868(TMPRSS3)

CCRI:

104163802(TMPRSS3)

NNT:	104413774(TMPRSS3)

SHAB:

115604021(TMPRSS3)

ACUN:

113485316(TMPRSS3)

TALA:

104361853(TMPRSS3)

ACHC:

115344143(TMPRSS3)

HALD:

104318687(TMPRSS3)

HLE:	104839787(TMPRSS3)

AGEN:

126053259

HHAR:

128144954(TMPRSS3)

GCL:

127026320

CSTI:

104552324

LDI:	104352497(TMPRSS3)

MNB:	103779336(TMPRSS3)

DPUB:

104305014(TMPRSS3)

PPUS:

135179998(TMPRSS3)

AVIT:

104270233(TMPRSS3)

BRHI:

104492445(TMPRSS3)

EGZ:	104128261(TMPRSS3)

NNI:	104020842(TMPRSS3)

PCRI:

104035553(TMPRSS3)

PCAO:

104048670(TMPRSS3)

PADL:

103920294(TMPRSS3)

AFOR:

103902011(TMPRSS3)

FGA:	104074895(TMPRSS3)

GSTE:

104264574(TMPRSS3)

CBOY:

140647516(TMPRSS3)

CLV:	102094155(TMPRSS3)

CNIC:

135991663(TMPRSS3)

MUI:	104545937(TMPRSS3)

PGUU:

104471777(TMPRSS3)

PLET:

104625899(TMPRSS3)

EHS:	104517019(TMPRSS3)

CMAC:

104485075(TMPRSS3)

CUCA:

104059236(TMPRSS3)

TEO:	104372998(TMPRSS3)

BREG:

104641519(TMPRSS3)

OHA:	104327701(TMPRSS3)

ACAR:

104520713

CPEA:

104389055(TMPRSS3)

CVF:	104292026(TMPRSS3)

RTD:	128914738(TMPRSS3)

CRID:

134524642(TMPRSS3)

AAM:	106483663(TMPRSS3)

AROW:

112968443(TMPRSS3)

NPD:	112944696(TMPRSS3)

TGT:	104573910(TMPRSS3)

DNE:	112981990(TMPRSS3)

SCAM:

104147107(TMPRSS3)

ASN:	102385067(TMPRSS3)

AMJ:	102569379(TMPRSS3)

CPOO:

109324976(TMPRSS3)

GGN:	109302317(TMPRSS3)

PSS:	102460517(TMPRSS3)

CMY:	102943134(TMPRSS3)

CCAY:

125630032(TMPRSS3)

DCC:	119844485(TMPRSS3)

CPIC:

101943789(TMPRSS3)

TST:	117877673(TMPRSS3)

CABI:

116815389(TMPRSS3)

MRV:	120406725(TMPRSS3)

ACS:	100567712(tmprss3)

ASAO:

132770241(TMPRSS3)

PVT:	110074043(TMPRSS3)

SUND:

121925812(TMPRSS3)

PBI:	103063743(TMPRSS3)

PMUR:

107292796(TMPRSS3)

CTIG:

120319776(TMPRSS3)

TSR:

106554175

PGUT:

117669463(TMPRSS3)

PCAE:

139317249(TMPRSS3)

APRI:

131199933(TMPRSS3)

PTEX:

113444758(TMPRSS3)

NSS:	113416216(TMPRSS3)

VKO:	123029120(TMPRSS3)

PMUA:

114596478(TMPRSS3)

PRAF:

128412336(TMPRSS3)

ZVI:	118085729(TMPRSS3)

HCG:	128349490(TMPRSS3)

GJA:	107117588(TMPRSS3)

STOW:

125431758(TMPRSS3)

EMC:	129326239(TMPRSS3)

XLA:	108707842(tmprss3.L)

XTR:	100490444(tmprss3)

NPR:	108796172(TMPRSS3)

RTEM:

120927997(TMPRSS3)

ACAT:

141130111(TMPRSS3)

BBUF:

120993600(TMPRSS3)

BGAR:

122931819(TMPRSS3)

DTC:	141091556(TMPRSS3)

PWL:	138249610(TMPRSS3)

MUO:	115470550(TMPRSS3)

GSH:	117359713(TMPRSS3)

DRE:	100000148(tmprss3a) 101885235(tmprss3b)

SRX:	107713697 107718848 107746297 107748899

SANH:

107661315(tmprss3) 107676845 107692180

SGH:	107551969(tmprss3) 107560973 107603005

CCAR:

109075666 109091223 109094176(tmprss3a)

CAUA:

113067577 113074033 113098230 113108976(tmprss3)

CGIB:

127948587 127965025

PTET:

122332314(tmprss3a) 122348949

LROH:

127169382 127171235(tmprss3a)

GRF:	141336841(tmprss3b) 141340595(tmprss3a)

OMC:	131543228(tmprss3b) 131547071(tmprss3a)

PPRM:

120487200(tmprss3a) 120490662

RKG:	130075987(tmprss3a) 130085508

MAMB:

125269940(tmprss3a) 125271978

CIDE:

127518699 127521514

CERY:

137032364(tmprss3b) 137035799(tmprss3a)

MASI:

127444785 127447826

TROS:

130549504(tmprss3a) 130552599

TDW:	130427894(tmprss3a) 130435017

MANU:

129444181(tmprss3b) 129451644(tmprss3a)

PDAB:

135760577 135782613(tmprss3a) 135786269(tmprss3b)

IPU:	108258610 108266193(tmprss3a)

IFU:	128602407 128609100(tmprss3a)

PHYP:

113526096(tmprss3) 113537761

SMEO:

124378615 124382724(tmprss3a)

TFD:	113648861 113660864(tmprss3a)

TVC:	132839073(tmprss3b) 132850562(tmprss3a)

CGAR:

128506337 128524407(tmprss3a)

NGRA:

132865773(tmprss3b) 132892202(tmprss3a)

TRN:	134303089(tmprss4b) 134324068(tmprss3a) 134329212(tmprss3b)

AMEX:

103026237(tmprss3a) 103032463

CMAO:

118802948 118810405(tmprss3a)

EEE:	113577508 113590622(tmprss3)

CHAR:

105913325 116223329(tmprss3a)

SPIL:

134071757 134079098(tmprss3a)

TRU:	105419604(tmprss3)

TFS:	130537439(tmprss3a)

TBEN:

117485840(tmprss3a)

CGOB:

115026466(tmprss3)

PGEO:

117466852(tmprss3a)

EMAC:

134866943(tmprss3a)

ELY:	117251484(tmprss3a)

EFO:	125900257(tmprss3a)

PLEP:

121949060(tmprss3a)

SLUC:

116043155(tmprss3a)

ECRA:

117952402(tmprss3a)

ESP:	116698447(tmprss3)

PFLV:

114563696(tmprss3)

GAT:	120834204(tmprss3a)

PPUG:

119229057(tmprss3a)

AFB:	129104888(tmprss3a)

CLUM:

117750030(tmprss3a)

PSWI:

130201534(tmprss3a)

CANA:

137783225(tmprss3a)

CVE:	137883616(tmprss3a)

MSAM:

119903572(tmprss3a)

SCHU:

122885072(tmprss3a)

CUD:	121506587(tmprss3a)

SPUL:

138592045(tmprss3a)

LMIX:

132987153(tmprss3a)

ALAT:

119025945(tmprss3a)

ASTR:

137605513(tmprss3a)

ONL:	100700773(tmprss3)

OAU:	116312846(tmprss3a)

OLA:	101164532(tmprss3)

OML:	112155450(tmprss3a)

CSAI:

133446273(tmprss3a)

XMA:	106700226(tmprss3)

XCO:	114148802(tmprss3)

XHE:	116722789(tmprss3)

PRET:

103482404(tmprss3)

PFOR:

103154135(tmprss3)

PLAI:

106934874(tmprss3)

PMEI:

106904185(tmprss3)

GAF:	122839906(tmprss3a)

PPRL:

129353160(tmprss3a) 129356601

CVG:	107100084(tmprss3)

CTUL:

119789314(tmprss3a)

GMU:	124870961(tmprss3a)

NFU:

107389419

KMR:	108238874(tmprss3a)

ALIM:

106536295

AOCE:

111564917(tmprss3a)

EJA:	138201694(tmprss3a)

BFRE:

138636488(tmprss3a)

MCEP:

125017295(tmprss3a)

CSEM:

103391529(tmprss3)

POV:	109637386(tmprss3)

SSEN:

122760227 122765623(tmprss3a)

SSOE:

131448677(tmprss3a)

HHIP:

117754499(tmprss3a)

HSP:	118119695(tmprss3a)

PPLT:

128456179(tmprss3a)

SMAU:

118282602(tmprss3a)

LCF:	108897153(tmprss3a)

SDU:	111228104(tmprss3)

SLAL:

111663434(tmprss3)

XGL:	120801587(tmprss3a)

HCQ:	109519236(tmprss3)

PEE:	133410666(tmprss3a)

PTAO:

133487289(tmprss3a)

BPEC:

110159949(tmprss3)

ENY:	140359968(tmprss3a)

MALB:

109963762(tmprss3)

BSPL:

114847063(tmprss3a)

SJO:	128368294(tmprss3a)

SSCO:

133992662(tmprss3a)

GMH:	115533559(tmprss3)

SASA:

106574361 106575139 106586097

STRU:

115161487 115179367

OTW:	112224186(tmprss3a) 112255193

OMY:

110504232

OGO:	124008023 124042905

ONE:	115115527 115134258

OKI:	109890446 109904289

OKE:	118366488 118369974

OMM:	135519585(tmprss3a) 135541669

OCLA:

139385736 139412565

SALP:

111971105 111972815

SNH:	120033179 120057793

CCLU:

121536111(tmprss3a) 121554187

ELS:	105019684 105024768

OEP:	134007478(tmprss3b) 134017606

SFM:	108926894(tmprss3)

PKI:	111834045(tmprss3)

AANG:

118223199(tmprss3a)

AROT:

135251939(tmprss3a)

CCOG:

133123455(tmprss3a)

LOC:	102692160(tmprss3)

PSPA:

121304158 121321048(tmprss3a)

ARUT:

117406230(tmprss3a)

LCM:

102358926

CMK:	103185192(tmprss3a)

CPLA:

122554849(tmprss3a)

HOC:	132820627(tmprss3a)

LERI:

129703052

HAKA:

140727435(tmprss3a)

PMRN:

116955349 116955946

LRJ:	133347757 133358502

BFO:

CIN:

LPIC:

ARUN:

AAMU:

AGA:

AARA:

ASTE:

AMAP:

ACOS:

AAG:	5570687 5579962

AALB:

109430122

ASUA:

134219969

CQU:	CpipJ_CPIJ002753

CPII:

BCOO:

PPAP:

DQU:

LHU:

AGIF:

CCIN:

HAME:

MNZ:

DSV:

GOE:

CSCU:

PTEP:

UDV:

PMEO:

HRO:	HELRODRAFT_110109 HELRODRAFT_193530

PVUL:

126810563 126816516

LSAX:

138950375 138950644 138951303

BGT:	106059022 106071027

HRJ:	124257951 124265101 124280187 124289368

HASI:

HCRA:

CANU:

PMAX:

AIRR:

MMER:

MAEA:

OBI:

LJP:

ADF:

AMIL:

PDAM:

DGT:

MSD:	MYSTI_02806

CCX:	COCOR_03349(tlp1)

» show all

Reference

PMID:12393794

Authors

Guipponi M, Vuagniaux G, Wattenhofer M, Shibuya K, Vazquez M, Dougherty L, Scamuffa N, Guida E, Okui M, Rossier C, Hancock M, Buchet K, Reymond A, Hummler E, Marzella PL, Kudoh J, Shimizu N, Scott HS, Antonarakis SE, Rossier BC

Title

The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro.

Journal

Hum Mol Genet 11:2829-36 (2002)
DOI:10.1093/hmg/11.23.2829

Sequence

[mmu:140765]

LinkDB

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