KEGG ORTHOLOGY: K09635

ORTHOLOGY: K09635

Entry

K09635                      KO

Symbol

TMPRSS4

Name

transmembrane protease serine 4 [EC:3.4.21.-]

Pathway

map05164

Influenza A

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    K09635  TMPRSS4; transmembrane protease serine 4
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K09635  TMPRSS4; transmembrane protease serine 4
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K09635  TMPRSS4; transmembrane protease serine 4

Genes

HSA:	56649(TMPRSS4)

PTR:	451581(TMPRSS4)

PPS:	100982108(TMPRSS4)

GGO:	101147411(TMPRSS4)

PON:	100436934(TMPRSS4)

PPYG:

129008436(TMPRSS4)

NLE:	100607841(TMPRSS4)

HMH:	116476998(TMPRSS4)

SSYN:

129479725(TMPRSS4)

MCC:	704604(TMPRSS4)

MCF:	102128205(TMPRSS4)

MTHB:

126936077

MNI:	105476425(TMPRSS4)

CSAB:

103248572(TMPRSS4)

CATY:

105582463(TMPRSS4)

PANU:

101014717(TMPRSS4)

TGE:	112606917(TMPRSS4)

MLEU:

105528210(TMPRSS4)

RRO:	104665565(TMPRSS4)

RBB:	108536389(TMPRSS4)

TFN:	117080547(TMPRSS4)

PTEH:

111540196(TMPRSS4)

CANG:

105501208(TMPRSS4)

CJC:	100390415(TMPRSS4)

SBQ:	101032470(TMPRSS4)

CIMI:

108300585(TMPRSS4)

ANAN:

105729687(TMPRSS4)

CSYR:

103252349(TMPRSS4)

MMUR:

105876061(TMPRSS4)

LCAT:

123641527(TMPRSS4)

ERUF:

138383797(TMPRSS4)

PCOQ:

105819203(TMPRSS4)

OGA:	100961457(TMPRSS4)

MMU:	214523(Tmprss4)

MCAL:

110302133(Tmprss4)

MPAH:

110328277(Tmprss4)

RNO:	367074(Tmprss4)

MCOC:

116073500(Tmprss4)

ANU:	143439116(Tmprss4)

ASYL:

127689738(Tmprss4)

MMIU:

308431225(TMPRSS4)

MUN:	110549092(Tmprss4)

CGE:	100770511(Tmprss4)

MAUA:

101829963(Tmprss4)

PROB:

127231631(Tmprss4)

PLEU:

114691234(Tmprss4)

PMAV:

102926753(Tmprss4)

MORG:

121438292(Tmprss4)

MFOT:

126510080

AAMP:

119810724(Tmprss4)

CNL:	130873182(Tmprss4)

NGI:	103748333(Tmprss4)

HGL:	101707398(Tmprss4)

CPOC:

100728893(Tmprss4)

CCAN:

109676718(Tmprss4)

DORD:

105980614(Tmprss4)

DSP:	122110222(Tmprss4)

DMER:

138838976(Tmprss4)

PLOP:

125347802(Tmprss4)

NCAR:

124958046

SVUL:

306640299(TMPRSS4)

MMMA:

107145672(Tmprss4)

ITI:	101957051(Tmprss4)

SCIL:

308641663(TMPRSS4)

MAVE:

308278072(TMPRSS4)

OCU:

100355162

OPI:	101520338(TMPRSS4)

OCZ:	121153991(TMPRSS4)

TUP:	102502363(TMPRSS4)

GVR:	103599529(TMPRSS4)

CFA:	489387(TMPRSS4)

CLUD:

112671255(TMPRSS4)

VVP:	112920356(TMPRSS4)

VLG:	121499287(TMPRSS4)

NPO:	129497262(TMPRSS4)

AML:	100463771(TMPRSS4)

UMR:	103662343(TMPRSS4)

UAR:	123792471(TMPRSS4)

ELK:

111154010

LLV:

125078384

MPUF:

101672789(TMPRSS4)

MNP:	132012819(TMPRSS4)

MLK:	131820354(TMPRSS4)

NVS:	122912324(TMPRSS4)

MMAQ:

308351003(TMPRSS4)

ORO:	101363097(TMPRSS4)

EJU:	114211252(TMPRSS4)

ZCA:	113914743(TMPRSS4)

MLX:	118013484(TMPRSS4)

MANO:

123856583(TMPRSS4)

NSU:	110586130(TMPRSS4)

LWW:	102739626(TMPRSS4)

FCA:	101082848(TMPRSS4)

PYU:	121035454(TMPRSS4)

PCOO:

112865852(TMPRSS4)

PBG:	122483017(TMPRSS4)

PVIV:

125176951(TMPRSS4)

LRUF:

124505868

LGF:	123600729(TMPRSS4)

AJU:

106966480

PTG:	102957483(TMPRSS4)

PPAD:

109278572(TMPRSS4)

PUC:

125929660

PLEZ:

122200694(TMPRSS4)

HHV:	120229948(TMPRSS4)

CCRU:

144242844(TMPRSS4)

BTA:	513343(TMPRSS4)

BOM:	102280307(TMPRSS4)

BIU:	109570040(TMPRSS4)

BJV:	133261798(TMPRSS4)

BBUB:

102393211(TMPRSS4)

BKE:	129628758(TMPRSS4)

BBIS:

104981497(TMPRSS4)

CHX:	102189225(TMPRSS4)

OAS:	101121197(TMPRSS4)

OCAN:

138421275(TMPRSS4)

BTAX:

128060662(TMPRSS4)

CSUM:

138092094(TMPRSS4)

ODA:	120876310(TMPRSS4)

CCAD:

122450369(TMPRSS4)

MREE:

136175951(TMPRSS4)

OVR:	110133018(TMPRSS4)

MBEZ:

129554376(TMPRSS4)

SSC:	100514419(TMPRSS4)

CFR:	102506184(TMPRSS4)

CBAI:

105067826(TMPRSS4)

CDK:	105090179(TMPRSS4)

VPC:	102534016(TMPRSS4)

BACU:

103001284(TMPRSS4)

BMUS:

118899377(TMPRSS4)

LVE:	103072300(TMPRSS4)

OOR:	101284924(TMPRSS4)

LALB:

132526343(TMPRSS4)

GMF:	115842747(TMPRSS4)

DDP:	132429497(TMPRSS4)

SCOO:

307190446(TMPRSS4)

PCRS:

137230915(TMPRSS4)

DLE:	111166903(TMPRSS4)

PCAD:

102975998(TMPRSS4)

PSIU:

116757978(TMPRSS4)

PPHC:

136126489(TMPRSS4)

NASI:

112403984(TMPRSS4)

HAMP:

307055663(TMPRSS4)

ECB:	100071190(TMPRSS4)

EPZ:	103546682(TMPRSS4)

EAI:	106840269(TMPRSS4)

MYB:	102242385(TMPRSS4)

MYD:	102765495(TMPRSS4)

MMYO:

118664248(TMPRSS4)

MDT:	132241987(TMPRSS4)

MYUM:

139017554(TMPRSS4)

PKL:	118713382(TMPRSS4)

EFUS:

103293821(TMPRSS4)

POTS:

308233552(TMPRSS4)

MNA:	107530807(TMPRSS4)

DRO:	112314231(TMPRSS4)

SHON:

118994771(TMPRSS4)

AJM:	119050770(TMPRSS4)

PDIC:

114498769(TMPRSS4)

PHAS:

123818730(TMPRSS4)

MMF:	118628081(TMPRSS4)

PPAM:

129086154(TMPRSS4)

HAI:	109385279(TMPRSS4)

RFQ:	117029838(TMPRSS4)

RHII:

308503473(TMPRSS4)

PALE:

102890324(TMPRSS4)

PGIG:

120622042(TMPRSS4)

PVP:	105309266(TMPRSS4)

RAY:	107516174(TMPRSS4)

MJV:	108384976(TMPRSS4)

TOD:	119239883(TMPRSS4)

SARA:

101544593(TMPRSS4)

SFUM:

130016830(TMPRSS4)

SETR:

126015817(TMPRSS4)

LAV:	100653682(TMPRSS4)

TMU:

101360701

ETF:	101657760(TMPRSS4)

MDO:

100031528

GAS:	123241374(TMPRSS4) 123241375

SHR:	105749872(TMPRSS4)

TVP:	118837003(TMPRSS4)

PBRV:

138145068(TMPRSS4)

MLAO:

141507475(TMPRSS4)

OAA:	100084731(TMPRSS4)

TACU:

119934750(TMPRSS4)

GGA:	770454(TMPRSS4)

PCOC:

116233009(TMPRSS4)

MGP:	100545295(TMPRSS4)

CJO:	107324261(TMPRSS4)

TPAI:

128087492(TMPRSS4)

LMUT:

125703538(TMPRSS4)

NMEL:

110387598(TMPRSS4)

APLA:

101795433(TMPRSS4)

AACU:

137843701(TMPRSS4)

OJA:	118178004(TMPRSS4)

BCLA:

308452136(TMPRSS4)

ACYG:

106039728(TMPRSS4)

ABRC:

308182677(TMPRSS4)

CATA:

118252460(TMPRSS4)

AFUL:

116497810(TMPRSS4)

TGU:	100227344(TMPRSS4)

LSR:	110470451(TMPRSS4)

VMC:	128818083(TMPRSS4)

VCHA:

128799172(TMPRSS4)

AIB:	137462137(TMPRSS4)

SCAN:

103823017(TMPRSS4)

PMOA:

120508481(TMPRSS4)

OTC:	121340863(TMPRSS4)

PRUF:

121348523(TMPRSS4)

ATRC:

139600896(TMPRSS4)

GFR:	102033736(TMPRSS4)

FAB:	101817564(TMPRSS4)

OMA:	130262458(TMPRSS4) 130262461

PHI:	102101120(TMPRSS4)

PMAJ:

107214476(TMPRSS4)

CCAE:

111942605(TMPRSS4)

CCW:	104692176(TMPRSS4)

CBRC:

103618608(TMPRSS4)

ACOE:

138098326(TMPRSS4)

ETL:	114056268(TMPRSS4)

ZLE:	135457354(TMPRSS4)

ACHL:

103804481(TMPRSS4)

SVG:	106858155(TMPRSS4)

MMEA:

130583265(TMPRSS4)

LCAI:

146427580(TMPRSS4)

HRT:	120762596(TMPRSS4)

SATI:

136371118(TMPRSS4)

CFAI:

136300863(TMPRSS4)

CCIC:

134053533

NNT:	104401842(TMPRSS4)

SHAB:

115616375(TMPRSS4)

POCC:

134158564(TMPRSS4)

PECH:

308228340(TMPRSS4)

FPG:	101915864(TMPRSS4)

FCH:	102052767(TMPRSS4)

FRS:	119158316(TMPRSS4)

CCRI:

104160581(TMPRSS4)

ACUN:

113488459(TMPRSS4)

ANOC:

141970718(TMPRSS4)

SURA:

141935055(TMPRSS4)

TALA:

116964929(TMPRSS4)

ACHC:

115344459(TMPRSS4)

HLE:	104836485(TMPRSS4)

AGEN:

126038410

HHAR:

128141201

BBUT:

142034919(TMPRSS4)

LDI:	104349226(TMPRSS4)

MNB:

103774916

DPUB:

104301569(TMPRSS4)

PPUS:

135191142(TMPRSS4)

IIN:	128977864(TMPRSS4)

BRHI:

104496370

EGZ:

104124574

NNI:	104019055(TMPRSS4)

PLEC:

309599266(TMPRSS4)

PARX:

142067538(TMPRSS4)

PADL:

103921562

AFOR:

103894954(TMPRSS4)

CBOR:

142092551(TMPRSS4)

CBOY:

140661859(TMPRSS4)

CLV:	102087741(TMPRSS4)

CNIC:

135998844(TMPRSS4)

NMAY:

308048722(TMPRSS4)

MUI:	104548469(TMPRSS4)

EHS:	104506258(TMPRSS4)

CUCA:

104054270(TMPRSS4)

PCUR:

138730822(TMPRSS4)

TEO:	104373512(TMPRSS4)

BREG:

104635325(TMPRSS4)

GAME:

129196157(TMPRSS4)

OHA:	104332038(TMPRSS4)

ACAR:

104525092(TMPRSS4)

CEUR:

306728738(TMPRSS4)

CPEA:

104398750(TMPRSS4)

CVF:	104295035(TMPRSS4)

RTD:	128918717(TMPRSS4)

CRID:

134524903(TMPRSS4)

LMIC:

141732253(TMPRSS4)

NARQ:

141474495(TMPRSS4)

AROW:

112962047(TMPRSS4)

NPD:	112948084(TMPRSS4)

TGT:	104569308(TMPRSS4)

DNE:	112991729(TMPRSS4)

ASN:	102386477(TMPRSS4)

AMJ:	102573179(TMPRSS4)

CPOO:

109315430(TMPRSS4)

GGN:	109294015(TMPRSS4)

CIZ:	142001640(TMPRSS4)

CMY:	102939948(TMPRSS4)

CCAY:

125625428(TMPRSS4)

LKP:	140901545(TMPRSS4)

NDS:	141975873(TMPRSS4)

DCC:	119846591(TMPRSS4)

CPIC:

101932353(TMPRSS4)

TST:	117868596(TMPRSS4)

CABI:

116822957(TMPRSS4)

MRV:	120375418(TMPRSS4)

EMQ:	137163007(TMPRSS4)

ASAO:

132782787

PVT:	110079465(TMPRSS4)

PMUA:

114585957(TMPRSS4)

PRAF:

128402745(TMPRSS4)

ZVI:	118097298(TMPRSS4)

EMC:	129342264(TMPRSS4)

XLA:	108696461(tmprss4.L) 108697596(tmprss4.S)

XTR:	733869(tmprss4)

NPR:

108792157

RTEM:

120915174(TMPRSS4)

ACAT:

PADS:

BBUF:

BGAR:

DTC:	141097803(TMPRSS4)

PWL:	138285143(TMPRSS4)

MUO:	115481806 115482154 115482282

GSH:

117347761

DRE:	327651(tmprss4b) 777630(tmprss4a)

DAES:

130229506(tmprss4b) 130242243

SRX:	107728158 107734130 107746388 107752293

SANH:

107661196 107663417 107699181 107699212

SGH:	107561486 107564058 107596117 107599211

CCAR:

109080222 109090157(tmprss4b) 109101293(tmprss4a) 109113086

CAUA:

113049066 113058731 113077054 113081958 113115255

CGIB:

127958897 127972620 128004024 128028796

PTET:

122345478(tmprss4b) 122358550(tmprss4a)

LROH:

127165719(tmprss4b) 127177677(tmprss4a)

GRF:	141284839(tmprss4a) 141334810(tmprss4b)

OMC:	131520406(tmprss4a) 131541630(tmprss4b)

PPRM:

120469606(tmprss4b) 120478903(tmprss4a)

RKG:	130068919(tmprss4b) 130095715(tmprss4a)

SCEP:

307158609(tmprss4b)

PPHX:

306995214(tmprss4b)

MAMB:

125249149(tmprss4a) 125266345(tmprss4b)

CIDE:

127496157 127513443

CERY:

137004580(tmprss4a) 137034991(tmprss4b)

MASI:

127420604 127422513 127429565

TROS:

130545680(tmprss4b) 130564621(tmprss4a)

TDW:	130418753(tmprss4b) 130428551(tmprss4a)

MANU:

129437730 129437731 129440424(tmprss4b)

PDAB:

135748686(tmprss4b) 135771353(tmprss4a) 135771355

IPU:	108259861(tmprss4b) 108277792(tmprss4a)

IFU:	128620988(tmprss4a)

PHYP:

113531195 113544578

SMEO:

124379245(tmprss4b) 124394380(tmprss4a)

TFD:	113638801(tmprss4a) 113662862(tmprss4b)

TVC:	132840969(tmprss4b) 132857736(tmprss4a)

CGAR:

128512061(tmprss4b) 128532764(tmprss4a)

NGRA:

132876152 132900886 132901103

TRN:	134334377(tmprss4a)

AMEX:

103023567(tmprss4b) 103047440(tmprss4a)

CMAO:

118798198(tmprss4a) 118815016(tmprss4b)

EEE:	113579443 113579461 113589129

CHAR:

105901060(tmprss4b) 105902156(tmprss4a)

SPIL:

134079875(tmprss4b) 134099076(tmprss4a)

ASAD:

121684078(tmprss4a) 121708786

TRU:	101074126(tmprss4a)

TFS:	130534987(tmprss4a)

NCC:

104966014

TBEN:

117470312(tmprss4a)

CGOB:

115018173

PGEO:

117457089(tmprss4a)

GACU:

117552117(tmprss4a)

EMAC:

134880396(tmprss4a)

ELY:	117259684(tmprss4a)

EFO:	125888410(tmprss4a)

PLEP:

121943229(tmprss4a)

SLUC:

116047756(tmprss4a)

SVIT:

144515392(tmprss4a)

ECRA:

117942538(tmprss4a)

ESP:

116682715

PFLV:

114552049

PFLT:

120548219(tmprss4a)

GAT:	120832243(tmprss4a)

PPUG:

119213702(tmprss4a)

AFB:	129092560(tmprss4a)

CLUM:

117741985(tmprss4a)

PSWI:

130211205(tmprss4a)

CANA:

137790803(tmprss4a)

TBU:	306742193(tmprss4a)

CVE:	137872698(tmprss4a)

MSAM:

119882606(tmprss4a)

SCHU:

122879693(tmprss4a)

EARM:

139285310(tmprss4a)

CUD:	121518106(tmprss4a)

SPUL:

138597282(tmprss4a)

LMIX:

132980426(tmprss4a)

HTC:	141797416(tmprss4a)

ALAT:

119004296(tmprss4a)

ASTR:

137596895(tmprss4a)

PKLU:

139200533(tmprss4a)

LCO:

104918009

MZE:	101477707(tmprss4a)

ONL:

100694080

OAU:	116314741(tmprss4a)

OLA:

101166070

OML:	112149086(tmprss4a)

CSAI:

133441752(tmprss4a)

XMA:

102227268

XCO:

114161902

XHE:

116707732

PRET:

103474603(tmprss4a)

PFOR:

103136220

PLAI:

106935808

PMEI:

106928674

GAF:	122833223(tmprss4a)

PPRL:

129358999(tmprss4a)

CVG:

107086381

CTUL:

119792129(tmprss4a)

GMU:	124884300(tmprss4a)

NFU:

107380318

KMR:	108243495(tmprss4a)

ALIM:

106515429

NWH:	119411236(tmprss4a)

LTU:	140314300(tmprss4a)

MCEP:

125013938(tmprss4a)

AOCE:

111587763(tmprss4a)

EJA:	138197340(tmprss4a)

BFRE:

138625482(tmprss4a)

LCF:

108895265

CSEM:

103378440

POV:

109630323

SSEN:

122773217(tmprss4a)

SSOE:

131462508(tmprss4a)

HHIP:

117772793(tmprss4a)

HSP:	118106169(tmprss4a)

PPLT:

128440880(tmprss4a)

SMAU:

118299394(tmprss4a)

SDU:

111228073

SLAL:

111656001

XGL:	120791728(tmprss4a)

HCQ:

109526363

SSCV:

125972803(tmprss4a)

SBIA:

133505298(tmprss4a)

PEE:	133404753(tmprss4a)

PTAO:

133482694(tmprss4a)

BPEC:

110154114

ENY:	140377761(tmprss4a)

MALB:

109960250

BSPL:

114868524(tmprss4a)

SJO:	128360391(tmprss4a)

SSCO:

133980775(tmprss4a)

TTY:	137186094(tmprss4a)

GMH:

115528954

SASA:

106603365 106612727

STRU:

115154477(tmprss4b) 115163012(tmprss4a) 115205971

OTW:	112236567 112266060(tmprss4a) 112266752

OMY:	110503305(tmprss4a) 110507446 110533778(tmprss4b)

OGO:	123993044 124005005(tmprss4a) 124009265

ONE:	115118295 115137062 115141527

OKI:	109872542 109905442 109908893

OKE:	118385768(tmprss4a) 118390142 118397155

OMM:	135546117(tmprss4a) 135552597

OCLA:

139382446 139385459 139419220

SALP:

111949715 111951007 111960551

SNH:	120018392(tmprss4a) 120028861 120042534(tmprss4b)

SFON:

129821899(tmprss4a) 129832344 129868540

CCLU:

121567084 121567396 121580362

ELS:

105012341

OEP:	134013715(tmprss4b) 134029166(tmprss4a)

SFM:

108932092

PKI:

111854951

AANG:

118208849(tmprss4a)

AROT:

135237039(tmprss4a)

CCOG:

133108449(tmprss4a)

LOC:

102696352

PSPA:

121304044(tmprss4a)

ARUT:

117397309 117968705

LCM:

102360524

CMK:

103180325

RTP:	109938770(tmprss4a)

CPLA:

122540598

CPUN:

140494214

HOC:	132829527(tmprss4a)

SCAU:

119953975

LERI:

129712244

HAKA:

140716907(tmprss4b)

AARA:

CFEL:

MSEX:

PRAP:

LSIN:

DVV:

APLN:

ALAB:

NVI:

TPRE:

AGIF:

HAZT:

CRG:

CANU:

NGR:	NAEGRDRAFT_75580

» show all

Reference

PMID:10825129

Authors

Wallrapp C, Hahnel S, Muller-Pillasch F, Burghardt B, Iwamura T, Ruthenburger M, Lerch MM, Adler G, Gress TM

Title

A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer.

Journal

Cancer Res 60:2602-6 (2000)

Sequence

[hsa:56649]

Reference

PMID:21993886

Authors

Passero CJ, Mueller GM, Myerburg MM, Carattino MD, Hughey RP, Kleyman TR

Title

TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the gamma-subunit distal to the furin cleavage site.

Journal

Am J Physiol Renal Physiol 302:F1-8 (2012)
DOI:10.1152/ajprenal.00330.2011

Sequence

[mmu:214523]

LinkDB

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