KEGG ORTHOLOGY: K09637

ORTHOLOGY: K09637

Entry

K09637                      KO

Symbol

TMPRSS6

Name

transmembrane protease serine 6 [EC:3.4.21.-]

Disease

H01278

Iron-refractory iron deficiency anemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K09637  TMPRSS6; transmembrane protease serine 6
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K09637  TMPRSS6; transmembrane protease serine 6

Genes

HSA:	164656(TMPRSS6)

PTR:	458805(TMPRSS6)

PPS:	100991084(TMPRSS6)

GGO:	101138107(TMPRSS6)

PON:	100460608(TMPRSS6)

PPYG:

129023026(TMPRSS6)

NLE:	100581044(TMPRSS6)

HMH:	116458673(TMPRSS6)

SSYN:

129467856(TMPRSS6)

MCC:	696094(TMPRSS6)

MCF:	102139590(TMPRSS6)

MTHB:

126963705

MNI:	105464499(TMPRSS6)

CSAB:

103223267(TMPRSS6)

CATY:

105575814(TMPRSS6)

PANU:

101013972(TMPRSS6)

TGE:	112633274(TMPRSS6)

MLEU:

105538907(TMPRSS6)

RRO:	104682497(TMPRSS6)

RBB:	108512724(TMPRSS6)

TFN:	117069998 117096515(TMPRSS6)

PTEH:

111549079(TMPRSS6)

CANG:

105527811(TMPRSS6)

CJC:	100394553(TMPRSS6)

SBQ:	101031384(TMPRSS6)

CIMI:

108289464(TMPRSS6)

ANAN:

105733747(TMPRSS6)

CSYR:

103258831(TMPRSS6)

MMUR:

105883736(TMPRSS6)

LCAT:

123639297(TMPRSS6)

PCOQ:

105805208(TMPRSS6)

OGA:	100958128(TMPRSS6)

MMU:	71753(Tmprss6)

MCAL:

110310168(Tmprss6)

MPAH:

110334977(Tmprss6)

RNO:	315388(Tmprss6)

MCOC:

116075420(Tmprss6)

ANU:	117718737(Tmprss6)

ASYL:

127667688(Tmprss6)

MUN:	110548467(Tmprss6)

CGE:	100762768(Tmprss6)

MAUA:

101831200(Tmprss6)

PROB:

127225751(Tmprss6)

PLEU:

114694228(Tmprss6)

MORG:

121461160(Tmprss6)

MFOT:

126515705

AAMP:

119824004(Tmprss6)

NGI:	103748620(Tmprss6)

HGL:	101726737(Tmprss6)

CPOC:

100730361(Tmprss6)

CCAN:

109698252(Tmprss6)

DORD:

105992036(Tmprss6)

DSP:	122119236(Tmprss6)

DMER:

138811703(Tmprss6) 138823824

PLOP:

125353764(Tmprss6)

NCAR:

124982498

MMMA:

107139663(Tmprss6)

ITI:	101969180(Tmprss6)

OCU:

127490197

OPI:	101532873(TMPRSS6)

OCZ:	121163513(TMPRSS6)

TUP:	102503001(TMPRSS6)

GVR:	103602073(TMPRSS6)

CFA:	608593(TMPRSS6)

CLUD:

112668472(TMPRSS6)

VVP:	112929100(TMPRSS6)

VLG:	121490388(TMPRSS6)

NPO:	129511825(TMPRSS6)

AML:	100468980(TMPRSS6)

UMR:	103676412(TMPRSS6)

UAH:	113255955(TMPRSS6)

UAR:	123780841(TMPRSS6)

ELK:

111157540

LLV:

125106147

MPUF:

101677828(TMPRSS6)

MNP:	132019256(TMPRSS6)

MLK:	131839434(TMPRSS6)

NVS:	122891616(TMPRSS6)

ORO:	101387010(TMPRSS6)

EJU:	114218338(TMPRSS6)

ZCA:	113922591(TMPRSS6)

MLX:	117998720(TMPRSS6)

NSU:	110578108(TMPRSS6)

LWW:	102733101(TMPRSS6)

FCA:	101092375(TMPRSS6)

PYU:	121026677 121026679

PCOO:

112863354(TMPRSS6)

PBG:	122472703(TMPRSS6)

PVIV:

125170778(TMPRSS6)

LRUF:

124501004

LGF:	123589900(TMPRSS6)

AJU:

106981028

PTG:	102962212(TMPRSS6)

PPAD:

109265526(TMPRSS6)

PUC:

125919565

PLEZ:

122225090(TMPRSS6)

HHV:	120241148(TMPRSS6)

BTA:	614844(TMPRSS6)

BOM:	102278375(TMPRSS6)

BIU:	109558530 109559532(TMPRSS6)

BBUB:

102391322(TMPRSS6)

BBIS:

105003411(TMPRSS6)

CHX:	102178888(TMPRSS6)

OAS:	101102553(TMPRSS6)

BTAX:

128048497(TMPRSS6)

CSUM:

138077885(TMPRSS6)

ODA:	120858562 120861187

CCAD:

122423964(TMPRSS6)

MREE:

136159376(TMPRSS6)

OVR:	110128768(TMPRSS6)

MBEZ:

129536324(TMPRSS6)

SSC:	100516673(TMPRSS6)

CFR:	102519836(TMPRSS6)

CBAI:

105073157(TMPRSS6)

CDK:	105101577(TMPRSS6)

VPC:	102541222(TMPRSS6)

BACU:

103008188(TMPRSS6)

BMUS:

118902226(TMPRSS6)

LVE:	103077358(TMPRSS6)

OOR:	101290328(TMPRSS6)

LALB:

132528734(TMPRSS6)

GMF:	115852844(TMPRSS6)

DDP:	132434053(TMPRSS6)

DLE:	111186274(TMPRSS6)

PCAD:

102991591 114485200

PSIU:

116760807(TMPRSS6)

PPHC:

136130709(TMPRSS6)

NASI:

112410815(TMPRSS6)

ECB:	100069647(TMPRSS6)

EPZ:	103542657(TMPRSS6)

EAI:	106837579(TMPRSS6)

MYB:	102241421(TMPRSS6)

MYD:	102752236(TMPRSS6)

MMYO:

118651129(TMPRSS6)

MLF:	102417077(TMPRSS6)

MDT:	132227011(TMPRSS6)

MYUM:

139005771(TMPRSS6)

PKL:	118730451(TMPRSS6)

EFUS:

103288896(TMPRSS6)

MNA:	107545302(TMPRSS6)

DRO:	112321714(TMPRSS6)

SHON:

119002322(TMPRSS6)

AJM:	119060315(TMPRSS6)

PDIC:

114513455(TMPRSS6)

PHAS:

123816269(TMPRSS6)

MMF:	118624179(TMPRSS6)

PPAM:

129071323(TMPRSS6)

HAI:	109394513(TMPRSS6)

RFQ:	117029313(TMPRSS6)

PALE:

102884593(TMPRSS6) 102885180

PGIG:

120614852(TMPRSS6)

PVP:	105288309(TMPRSS6)

RAY:	107519304(TMPRSS6)

MJV:	108392660(TMPRSS6)

TOD:	119248241(TMPRSS6)

SARA:

101539864(TMPRSS6)

SFUM:

130044867(TMPRSS6)

SETR:

126006211(TMPRSS6)

LAV:	100669423(TMPRSS6)

TMU:

101344116

ETF:	101664417(TMPRSS6)

DNM:	101421062(TMPRSS6)

MDO:	100025330(TMPRSS6)

SHR:	100935245(TMPRSS6)

AFZ:

127538168

PCW:	110205741(TMPRSS6)

TVP:	118849959(TMPRSS6)

PBRV:

138156744(TMPRSS6)

MLAO:

141515359(TMPRSS6)

OAA:	100092848(TMPRSS6)

TACU:

119936716(TMPRSS6)

GGA:	418046(TMPRSS6)

PCOC:

116233234(TMPRSS6)

MGP:	100538769(TMPRSS6)

CJO:	107313761(TMPRSS6)

TPAI:

128073634(TMPRSS6)

LMUT:

125699585(TMPRSS6)

NMEL:

110393208(TMPRSS6)

APLA:

101792037(TMPRSS6)

ACYG:

106035770(TMPRSS6)

CATA:

118250666(TMPRSS6)

AFUL:

116501560(TMPRSS6)

TGU:	100220511(TMPRSS6)

LSR:	110483868(TMPRSS6)

SCAN:

103813229(TMPRSS6)

PMOA:

120510080(TMPRSS6)

OTC:	121342389(TMPRSS6)

PRUF:

121361169(TMPRSS6)

ATRC:

139588670(TMPRSS6)

GFR:	102031334(TMPRSS6)

FAB:	101809510(TMPRSS6)

OMA:	130248313(TMPRSS6)

PHI:	102106193(TMPRSS6)

PMAJ:

107204848(TMPRSS6)

CCAE:

111935367(TMPRSS6)

CCW:	104696291(TMPRSS6)

CBRC:

103618065(TMPRSS6)

ACOE:

138104088(TMPRSS6)

ETL:	114055418(TMPRSS6)

ZAB:	102071477(TMPRSS6)

ZLE:	135457563(TMPRSS6)

ACHL:

103811053(TMPRSS6)

SVG:	106858520(TMPRSS6)

MMEA:

130586753(TMPRSS6)

HRT:	120752059(TMPRSS6)

SATI:

136361922(TMPRSS6)

CCIC:

134043184(TMPRSS6)

FPG:	101915089(TMPRSS6)

FCH:	102058575(TMPRSS6)

CCRI:

104169332(TMPRSS6)

NNT:	104409152(TMPRSS6)

SHAB:

115604927(TMPRSS6)

ACUN:

113491336(TMPRSS6)

TALA:

104362149(TMPRSS6)

ACHC:

115352723(TMPRSS6)

HALD:

104316500(TMPRSS6)

HLE:	104842805(TMPRSS6)

AGEN:

126047794

HHAR:

128143365(TMPRSS6)

GCL:

127016947

CSTI:

104557105(TMPRSS6)

LDI:	104343968(TMPRSS6)

MNB:	103771297(TMPRSS6)

DPUB:

104302046(TMPRSS6)

PPUS:

135181556(TMPRSS6)

AVIT:

104273384(TMPRSS6)

BRHI:

104501042(TMPRSS6)

EGZ:	104134298(TMPRSS6)

NNI:	104021586(TMPRSS6)

PCRI:

104035329(TMPRSS6)

PCAO:

104047661(TMPRSS6)

PADL:

103924178(TMPRSS6)

AFOR:

103907723(TMPRSS6)

FGA:	104074076(TMPRSS6)

CBOR:

142084838(TMPRSS6)

GSTE:

104260061(TMPRSS6)

CBOY:

140644986(TMPRSS6)

MAME:

142404687(TMPRSS6)

CLV:	102091291(TMPRSS6)

CNIC:

135999009(TMPRSS6)

MUI:	104545015(TMPRSS6)

PGUU:

104465981(TMPRSS6)

PLET:

104623812(TMPRSS6)

EHS:	104515453(TMPRSS6)

CMAC:

104487051(TMPRSS6)

CUCA:

104065860(TMPRSS6)

TEO:	104376811(TMPRSS6)

BREG:

104636091(TMPRSS6)

OHA:	104332365(TMPRSS6)

ACAR:

104520855(TMPRSS6)

CPEA:

104395981(TMPRSS6)

CVF:	104283650(TMPRSS6)

RTD:	128904189(TMPRSS6)

CRID:

134509538(TMPRSS6)

LMIC:

141740641(TMPRSS6)

AAM:	106488413(TMPRSS6)

AROW:

112969310(TMPRSS6)

NPD:	112947749(TMPRSS6)

TGT:	104576728(TMPRSS6)

DNE:	112993905(TMPRSS6)

SCAM:

104150236(TMPRSS6)

ASN:	102377108(TMPRSS6)

AMJ:	102571953(TMPRSS6)

CPOO:

109316633(TMPRSS6)

GGN:	109296053(TMPRSS6)

PSS:	102444568(TMPRSS6)

CIZ:	142020567(TMPRSS6)

CMY:	102943942(TMPRSS6)

CCAY:

125628232(TMPRSS6)

DCC:	119857174(TMPRSS6)

CPIC:

101951084(TMPRSS6)

TST:	117880789(TMPRSS6)

CABI:

116824118(TMPRSS6)

MRV:	120393405(TMPRSS6)

ACS:	100560846(tmprss6)

ASAO:

132775910(TMPRSS6)

PVT:	110075956(TMPRSS6)

SUND:

121931316(TMPRSS6)

PBI:	103060257(TMPRSS6)

PMUR:

107302576(TMPRSS6)

CTIG:

120312415(TMPRSS6)

PGUT:

117655804(TMPRSS6)

PCAE:

139319502(TMPRSS6)

APRI:

131201630(TMPRSS6)

PTEX:

113433297(TMPRSS6)

NSS:	113432758(TMPRSS6)

VKO:	123028868(TMPRSS6)

PMUA:

114604982(TMPRSS6)

PRAF:

128422868(TMPRSS6)

ZVI:	118090826(TMPRSS6)

HCG:	128327548(TMPRSS6)

GJA:	107123255(TMPRSS6)

STOW:

125434914(TMPRSS6)

EMC:	129335397(TMPRSS6)

XLA:	108714560(tmprss6.L) 108715798(tmprss6.S)

XTR:	100489045(tmprss6)

NPR:	108783676(TMPRSS6)

RTEM:

120945329(TMPRSS6)

ACAT:

141103168(TMPRSS6)

PADS:

140337345(TMPRSS6)

BBUF:

120978930(TMPRSS6)

BGAR:

122943610(TMPRSS6)

DTC:	141088312(TMPRSS6)

PWL:	138292648(TMPRSS6)

MUO:	115474634(TMPRSS6)

GSH:	117354877(TMPRSS6)

DRE:	100005420(tmprss6)

SRX:	107705912(tmprss6)

SANH:

107676729(tmprss6)

SGH:	107554700(tmprss6)

CCAR:

109075509

CAUA:

113095154(tmprss6)

CGIB:

PTET:

LROH:

GRF:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TROS:

TDW:

MANU:

129450666(tmprss6)

PDAB:

135720785(tmprss6)

IPU:

108272331

IFU:

128616170

PHYP:

113538293(tmprss6)

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:	113580369(tmprss6)

SPIL:

134093867

ASAD:

121718175

TRU:	101063402(tmprss6)

TFS:

130526777

TNG:	GSTEN00034830G001

LCO:	104925441(tmprss6)

NCC:	104943494(tmprss6)

TBEN:

117496537

CGOB:

115005485(tmprss6)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116700872(tmprss6)

PFLV:

114547077(tmprss6)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

CUD:

SPUL:

LMIX:

HTC:	141785818(tmprss6)

ALAT:

119015510

ASTR:

137599889

MZE:	101464220(tmprss6)

ONL:	100708847(tmprss6)

OAU:

116329129

OLA:	101162577(tmprss6)

OML:

112137093

CSAI:

133442526

XMA:	102235853(tmprss6)

XCO:	114143838(tmprss6)

XHE:	116719314(tmprss6)

PRET:

103478195(tmprss6)

PFOR:

103156072(tmprss6)

PLAI:

106936824(tmprss6)

PMEI:

106919789(tmprss6)

GAF:

122830323

PPRL:

129367324

CVG:	107084268(tmprss6)

CTUL:

119798244

GMU:

124868419

NFU:	107375159(tmprss6)

KMR:

108236269

ALIM:

106522492(tmprss6)

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103383424(tmprss6)

POV:	109639254(tmprss6)

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111216629(tmprss6)

SLAL:

111671818(tmprss6)

XGL:

120800341

BPEC:

110157758

MALB:

109975045(tmprss6)

BSPL:

SJO:

SSCO:

TTY:

GMH:	115540331 115540332

SASA:

106592627

STRU:

115177913 115181701(tmprss6)

OTW:

121845347

OMY:	110487257 110494898

OGO:	124002815 124024590

OKI:	109878994 109879002

OKE:	127927222 127931938

OMM:

135534888

OCLA:

139424403

SNH:	120032926 120032927

SFON:

129839949

CCLU:

121555847

ELS:	105009014(tmprss6)

OEP:

134023785

SFM:	108930688(tmprss6)

PKI:	111845213(tmprss6)

AANG:

118217831

AROT:

135248795

CCOG:

133121890

LOC:	102688318(tmprss6)

PSPA:

121309366

PSEX:

120536975

LCM:	102366556(TMPRSS6) 106705517

CMK:

103189770

CPLA:

122542255

CPUN:

140489271(tmprss6)

HOC:

132831221

SCAU:

119956568

LERI:

129713929

HAKA:

140719383(tmprss6)

PMRN:

LRJ:

SCLV:

SOC:

AEC:

ACEP:

VEM:

TSP:

LGI:	LOTGIDRAFT_104147

PCAN:

112574799

MYI:

110465206

OVI:	T265_09328

NVE:

5511325

EPA:	110233036 110239604 110242890 110253551

ATEN:

116290560 116302412

PDAM:

113664816 113665346 113667498

SPIS:

111320578 111335944 111335949

DGT:

114516205

» show all

Reference

PMID:12149247

Authors

Velasco G, Cal S, Quesada V, Sanchez LM, Lopez-Otin C

Title

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins.

Journal

J Biol Chem 277:37637-46 (2002)
DOI:10.1074/jbc.M203007200

Sequence

[hsa:164656]

Reference

PMID:18408718

Authors

Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, Hartman KR, Mayo MM, Samuel SM, Strouse JJ, Markianos K, Andrews NC, Fleming MD

Title

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA).

Journal

Nat Genet 40:569-71 (2008)
DOI:10.1038/ng.130

LinkDB

DBGET integrated database retrieval system