KEGG   ORTHOLOGY: K10216
Entry
K10216                      KO                                     
Symbol
dmpD, xylF
Name
2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9]
Pathway
map00362  Benzoate degradation
map00622  Xylene degradation
map00643  Styrene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase
   00622 Xylene degradation
    K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase
   00643 Styrene degradation
    K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.9  2-hydroxymuconate-6-semialdehyde hydrolase
     K10216  dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K10216
Other DBs
RN: R02604 R05362 R05865
COG: COG0596
GO: 0018775
Genes
RTG: NCTC13098_00853(xylF_2)
PSD: DSC_09175
RTH: LRK53_10270
RBD: ALSL_0879
PPSE: BN5_3615(nahN)
PFUW: KF707C_15550(bzaE) KF707C_16080(salE)
PPI: ND087(nahN)
PPJ: RK21_04238
PSC: A458_06525
PSTU: UIB01_22735
MAD: HP15_1112(dmpD) HP15_4033(xylF)
PAT: Patl_0074
PPHE: PP2015_462
PAGA: PAGA_a1999
AEH: Mlg_2456
HCH: HCH_03715
APAC: S7S_13285
TBN: TBH_C0921
RPI: Rpic_4621
RME: Rmet_1306
BCEN: DM39_4829(xylF)
BCT: GEM_5398
BCED: DM42_4988(xylF)
BCON: NL30_24575
BTEI: WS51_00585
BPSL: WS57_12140
BPAR: BN117_2519
BPA: BPP3695
BBR: BB4129
AJS: Ajs_0221
VEI: Veis_2786
HPSE: HPF_01875(xylF1)
MPT: Mpe_A2274
LCH: Lcho_3344
ABRE: pbN1_20610
AZO: azo1968(xylF)
AOA: dqs_2123
ACIB: ACBT_0256(bphD)
AFC: AFAEC_1841(bphD)
AAQI: AAQM_0986(bphD)
ACLO: ACLO_a0135(bphD)
ADZ: ADFLV_2548(bphD)
ALK: ALEK_0387(bphD)
AANA: AANAER_1263(bphD)
ARC: ABLL_2439
MTUN: MTUNDRAET4_3903(dmpD)
SMAZ: LH19_27440
SGI: SGRAN_2799(thnD)
HTL: HPTL_0051
PCAL: BV455_00230(xylF)
SAY: TPY_0645(mhpC)
MIA: OCU_07410
MID: MIP_01280
MYO: OEM_07480
MIR: OCQ_07550
MMM: W7S_03620
MCOO: MCOO_07730
MHAS: MHAS_04027(xylF)
MANY: MANY_01950
CAMG: CAMM_02590
COK: COCCU_04420(xylF)
RRT: 4535765_04589(xylF_2)
RCR: NCTC10994_02703(bphD1)
SMAL: SMALA_1217
SRO: Sros_4719
NML: Namu_4111
AMQ: AMETH_2411(mhpC)
PDX: Psed_6034
PSEE: FRP1_12950
PAUT: Pdca_36310
CAU: Caur_1353
TRO: trd_1390
TTJ: TTHB237(TTHB237)
AG: CAA36993(dmpD)
 » show all
Reference
PMID:2194577
  Authors
Nordlund I, Shingler V
  Title
Nucleotide sequences of the meta-cleavage pathway enzymes 2-hydroxymuconic semialdehyde dehydrogenase and 2-hydroxymuconic semialdehyde hydrolase from Pseudomonas CF600.
  Journal
Biochim Biophys Acta 1049:227-30 (1990)
DOI:10.1016/0167-4781(90)90046-5
  Sequence
LinkDB

KEGG   ENZYME: 3.7.1.9
Entry
EC 3.7.1.9                  Enzyme                                 
Name
2-hydroxymuconate-6-semialdehyde hydrolase;
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
2-hydroxymuconic semialdehyde hydrolase;
HMSH;
HOD hydrolase;
xylF (gene name);
2-hydroxymuconate-semialdehyde formylhydrolase;
2-hydroxymuconate-semialdehyde hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
Sysname
2-hydroxymuconate-6-semialdehyde formylhydrolase
Reaction(IUBMB)
2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate [RN:R02604]
Reaction(KEGG)
R02604;
(other) R05296 R05362 R05865
Substrate
2-hydroxymuconate-6-semialdehyde [CPD:C00682];
H2O [CPD:C00001]
Product
formate [CPD:C00058];
2-oxopent-4-enoate [CPD:C00596]
Comment
The enzyme is involved in the degradation of catechols.
History
EC 3.7.1.9 created 1990, modified 2013
Pathway
ec00362  Benzoate degradation
ec00622  Xylene degradation
ec00643  Styrene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10216  2-hydroxymuconate-semialdehyde hydrolase
Genes
RTGNCTC13098_00853(xylF_2)
PSDDSC_09175
RTHLRK53_10270
RBDALSL_0879
PPSEBN5_3615(nahN)
PFUWKF707C_15550(bzaE) KF707C_16080(salE)
PPIND087(nahN)
PPJRK21_04238
PSCA458_06525
PSTUUIB01_22735
PBMCL52_14705
PFKPFAS1_28780
PALLUYA_06715 UYA_06985 UYA_20160
PPHABVH74_06150
HPEGEAO82_00560 EAO82_09420
HAESLO767_17665
MADHP15_1112(dmpD) HP15_4033(xylF)
MSRAU15_09325 AU15_21085
MLQASQ50_09220
MSQBKP64_13855
PRWPsycPRwf_0068
PSYYDLE54_00385
ALCOTEC02_08830
AEIAOY20_01960
AJORZ95_18625
ASJAsACE_CH00356
ADVDJ533_01800 DJ533_16950
ARJDOM24_01590
AWUBEN71_02710
ACUMC9E88_006025
ALWFOB21_11730
ATNFM020_13970
ACHICDG60_02975
ALJG8D99_13390
AWGGFH30_01725
ASHAG8E00_02265
ATGJ4G44_04400
AVBRYU24_27110
ABOUACBO_15400 ACBO_27720
PATPatl_0074
PPHEPP2015_462
PLZS4054249_08565
PAGAPAGA_a1999
PCARPC2016_1616
GAGGlaag_0079
PMESFX988_02538
SPOIIMCC21906_00397 IMCC21906_02716
ZALAZF00_03860 AZF00_17825
AFUSEYZ66_02710
CYQQ91_0515 Q91_1790(bphD1) Q91_2195
CZACYCME_0226 CYCME_0664 CYCME_2092
CYYCPC19_01825 CPC19_03865 CPC19_10485
THISHZT40_13305
AEHMlg_2456
HCHHCH_03715
HAHEENC22_13740
APACS7S_13285
MGEOCFI10_04955
NIKF5I99_10110
SINIGT972_13725
GBIPG2T_02985 PG2T_07330 PG2T_09695
TBNTBH_C0921
VFFVITFI_CDS1372
AQLBXU06_16870
RPIRpic_4621
RPFRpic12D_3545
REUReut_B5690
RMERmet_1306
CUPBKK80_32180
BVIBcep1808_7611
BURBcep18194_B1183 Bcep18194_B2956
BCENDM39_4829(xylF)
BCTGEM_5398
BCEDDM42_4988(xylF)
BCONNL30_24575
BDFWI26_16010
BTEIWS51_00585
BPSLWS57_12140
BSTLBBJ41_10595
BANNJFN94_18695 JFN94_19150
BUQAC233_11165
BGEBC1002_4118
BUZAYM40_21205
PARBCJU94_37815 CJU94_38205
PPKU875_01820
PRBX636_07650
LIMNHKT17_03815
BPARBN117_2519
BPABPP3695
BBHBN112_0534 BN112_4274
BBRBB4129
BBMBN115_2405
BBXBBS798_2549 BBS798_3919
BOJCBF45_04515
PIGEGT29_06680
KGYEHF36_04900
AJSAjs_0221
ACIDCBP33_01100 CBP33_05470
ACIPCBP36_01195 CBP36_05920
ACINCBP34_01105 CBP34_05305
ACISCBP35_13025 CBP35_17755
AMONH9L24_14210
VEIVeis_2786
VBOCKY39_28510
CTTCtCNB1_3150
CSERCCO03_05855
COFFOZ74_08300
ADNAlide_0336
ADKAlide2_0281
HYLLPB072_18175
HPSEHPF_01875(xylF1)
HYNF9K07_02740 F9K07_09975 F9K07_30355
HTNKI616_01970
DIHG7047_01675
DRGH9K76_11640
SIMPC6571_19105
MJELVC68_01000
STHMIS481_10525
MPTMpe_A2274
METPC1M51_15405
MASWAM586_18645
LCHLcho_3344
IDCLRM40_19565
RBUPG1C_08185 PG1C_11270
ABREpbN1_20610
DARDaro_1331 Daro_3786
DEYHYN24_14220
FLEKI610_15470
AZOazo1968(xylF)
AOAdqs_2123
AZIAzCIB_4406
ACOMCEW83_03630
AZDCDA09_10320 CDA09_21415
AZRCJ010_12815
TMZTmz1t_3110
THKCCZ27_04595 CCZ27_20840
AZQG3580_08265
ACIBACBT_0256(bphD)
AFCAFAEC_1841(bphD)
AAQIAAQM_0986(bphD)
ACLOACLO_a0135(bphD)
ADZADFLV_2548(bphD)
ALKALEK_0387(bphD)
AANAAANAER_1263(bphD)
ARCABLL_2439
MESOBSQ44_10055
SAMESAMCFNEI73_pB0463
ABAWD5400_20365
MTUNMTUNDRAET4_3903(dmpD)
OCTFTO60_10545
CEHCEW89_11485
MONG8E03_15160
NARSaro_3858 Saro_3884
NPPPP1Y_AT15435 PP1Y_AT15665 PP1Y_AT31623 PP1Y_AT31854
NPNJI59_24610
NREBES08_18550 BES08_20400
NOGGKE62_05115
SMAZLH19_27440
SGISGRAN_2799(thnD)
SBARH5V43_22190 H5V43_22310
SPHYCHN51_06800 CHN51_06945 CHN51_18340
SPHJBSL82_11340
TFVIDJ81_04985
CNAAB433_18150
ERYCP97_03160 CP97_14075 CP97_14200
HTQFRZ44_10720
HADHFRZ61_10400
HTLHPTL_0051
BACIB1NLA3E_01490 B1NLA3E_14010
BSMBSM4216_1785
GMCGY4MC1_1593
GJFM493_17935
GTHGeoth_1676
PTLAOT13_14455
PCALBV455_00230(xylF)
LYGC1N55_08045 C1N55_08150
PRDF7984_08670 F7984_12055 F7984_12065
HYIK2M58_09765
PNPIJ22_06980 IJ22_48610
BTSBtus_0963 Btus_2330 Btus_2553 Btus_2900
KYRCVV65_11320
SIVSSIL_0071 SSIL_3698
SSILSOLI23_18480 SOLI23_19565
JPOG7058_08100
SAYTPY_0645(mhpC)
SAPSulac_2994
MIAOCU_07410
MIDMIP_01280
MYOOEM_07480
MCHIAN480_04855
MIROCQ_07550
MMMW7S_03620
MPAGC0J29_30965
MGORH0P51_00410
MCOOMCOO_07730
MNED174_16970
MYNMyAD_16575 MyAD_16635
MHASMHAS_04027(xylF)
MANYMANY_01950
CAMGCAMM_02590
CRFFRC0190_02107
CLIZG7Y31_11625
COKCOCCU_04420(xylF)
NTCKHQ06_23915
NGPLTT66_32650
RHARHA1_ro08081
ROAPd630_LPD12026
RAVAAT18_00600
RRZCS378_10945
RRT4535765_04589(xylF_2)
RCRNCTC10994_02703(bphD1)
RGOKYT97_18210
GOQACH46_18245
SMALSMALA_1217
SGMGCM10017557_80400
SAUOBV401_09860
SNKCP967_06185
SPRACP972_28050
ARZAUT26_01405
ARXARZXY2_3585
ARTPE5206_04555 E5206_14585
NAEBHE16_09080
ICAIntca_1090 Intca_3172
JTEASJ30_00170
JLIEXU32_15285
JMEEEW87_015390
AUSIPK37_03225
GEZFE251_04640
RAINRai3103_08985 Rai3103_16615
SROSros_4719
NOABKM31_20825
NOWGBF35_42640
NGNLCN96_15435
FSYFsymDg_2032
NMLNamu_4111
AMQAMETH_2411(mhpC)
PDXPsed_6034
PSEEFRP1_12950
PSEQAD006_20630
PECQAD017_00210
PAUTPdca_36310
PBROHOP40_26765
MICHFJK98_21300
MCABHXZ27_20900
VMAVAB18032_17465
AFSAFR_13095 AFR_28670
PSUUPsuf_068110 Psuf_083190
RMARGBA65_17525
CAUCaur_1353
CHLChy400_1475
TROtrd_1390
CAPCLDAP_40940
KBSEPA93_11995
TTJTTHB237(TTHB237)
TTLTtJL18_2419
TPITREPR_1321
FLASY85_23985
 » show all
Reference
1  [PMID:4325686]
  Authors
Sala-Trepat JM, Evans WC.
  Title
The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway.
  Journal
Eur J Biochem 20:400-13 (1971)
DOI:10.1111/j.1432-1033.1971.tb01406.x
Reference
2  [PMID:3481421]
  Authors
Harayama S, Rekik M, Wasserfallen A, Bairoch A.
  Title
Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids.
  Journal
Mol Gen Genet 210:241-7 (1987)
DOI:10.1007/bf00325689
Reference
3  [PMID:7890778]
  Authors
Diaz E, Timmis KN
  Title
Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which  cleaves carbon-carbon bonds.
  Journal
J Biol Chem 270:6403-411 (1995)
DOI:10.1074/jbc.270.11.6403
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.9
IUBMB Enzyme Nomenclature: 3.7.1.9
ExPASy - ENZYME nomenclature database: 3.7.1.9
UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.9
BRENDA, the Enzyme Database: 3.7.1.9
CAS: 54004-61-4
LinkDB

KEGG   REACTION: R05865
Entry
R05865                      Reaction                               
Name
2-Hydroxy-5-methyl-cis,cis-muconic-semialdehyde formylhydrolase
Definition
2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde + H2O <=> Formate + 2-Hydroxy-cis-hex-2,4-dienoate
Equation
Comment
Ref.1: J Biol Chem 1995 Mar 17;270(11):6403-411
Reaction class
RC00272  C00058_C06760
RC01485  C06760_C11354
Enzyme
Pathway
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Orthology
K10216  2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9]
LinkDB

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