KEGG ORTHOLOGY: K10721

ORTHOLOGY: K10721

Entry

K10721                      KO

Symbol

DIB, CYP302A1

Name

3-dehydro-2,22-dideoxyecdysone 22-hydroxylase [EC:1.14.15.44]

Pathway

map00981

Insect hormone biosynthesis

Reaction

R08134

2,22-dideoxyecdysone,reduced adrenodoxin:oxygen oxidoreductase (22-hydroxylating)

R08138

3-dehydro-2,22-dideoxyecdysone,reduced adrenodoxin:oxygen oxidoreductase (22-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00981 Insect hormone biosynthesis
    K10721  DIB, CYP302A1; 3-dehydro-2,22-dideoxyecdysone 22-hydroxylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K10721  DIB, CYP302A1; 3-dehydro-2,22-dideoxyecdysone 22-hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.44  3-dehydro-2,22-dideoxyecdysone 22-hydroxylase
     K10721  DIB, CYP302A1; 3-dehydro-2,22-dideoxyecdysone 22-hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP302 family
   K10721  DIB, CYP302A1; 3-dehydro-2,22-dideoxyecdysone 22-hydroxylase

Other DBs

GO:

0042767

Genes

DME:	Dmel_CG12028(dib)

DER:

6543569

DSE:

6610708

DSI:	Dsimw501_GD13808(Dsim_GD13808)

DYA:	Dyak_GE21407

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13888

DAZ:

108613398

DNV:

108651399

DHE:

111597565

DVI:	6623367(dib)

CCAT:

101460308

BOD:

106616584

BDR:

105224875

RZE:	108371648 108373914

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ010826

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139106541(Dib)

TLN:	139816605(Dib)

HST:

DQU:

CFO:

FEX:

PMEC:

138942594(Dib)

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124215983(dib)

NFB:

NLO:

NVG:

AROA:

TCA:	663098(CYP302A1)

TMOL:

138130080

DPA:

109546687

ESIM:

136410240(dib)

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:	111505902 111516498 111516700

DVV:

NVL:

DCOR:

APLN:

PPYR:

OTU:

BMOR:

692499(Cyp302a1)

BMAN:

114244688

MSEX:

115442491

DPL:	KGM_215569

BANY:

MJU:

NIQ:

VCD:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141433315(dib)

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128985621 128986476

PHU:	Phum_PHUM246210

FOC:	113205818 113209887

TPAL:

117640519 117647070

ZNE:

110836735

CSEC:

111865689

PAME:

138694546(dib)

SGRE:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_204789

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123754302(dib)

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

LSM:

TCF:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107360358 112538660

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

129965503 129981265 129984310 129988671

UDV:	129222269 129224134

SDM:	118189374 118203426 118203441

LPOL:

106466752

CJF:

131872744

» show all

Reference

PMID:10976044

Authors

Chavez VM, Marques G, Delbecque JP, Kobayashi K, Hollingsworth M, Burr J, Natzle JE, O'Connor MB

Title

The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels.

Journal

Development 127:4115-26 (2000)
DOI:10.1242/dev.127.19.4115

Sequence

[dme:Dmel_CG12028]

Reference

PMID:16164612

Authors

Niwa R, Sakudoh T, Namiki T, Saida K, Fujimoto Y, Kataoka H

Title

The ecdysteroidogenic P450 Cyp302a1/disembodied from the silkworm, Bombyx mori, is transcriptionally regulated by prothoracicotropic hormone.

Journal

Insect Mol Biol 14:563-71 (2005)
DOI:10.1111/j.1365-2583.2005.00587.x

Sequence

[bmor:692499]

Reference

PMID:16503480

Authors

Rewitz KF, Rybczynski R, Warren JT, Gilbert LI.

Title

Identification, characterization and developmental expression of Halloween genes encoding P450 enzymes mediating ecdysone biosynthesis in the tobacco hornworm, Manduca sexta.

Journal

Insect Biochem Mol Biol 36:188-99 (2006)
DOI:10.1016/j.ibmb.2005.12.002

Sequence

[msex:115442491]

LinkDB

DBGET integrated database retrieval system