KEGG ORTHOLOGY: K10766

ORTHOLOGY: K10766

Entry

K10766                      KO

Symbol

ALKBH4

Name

DNA N6-methyl adenine demethylase [EC:1.14.11.51]

Brite

KEGG Orthology (KO) [BR:ko00001]
09190 Not Included in Pathway or Brite
  09191 Unclassified: metabolism
   99980 Enzymes with EC numbers
    K10766  ALKBH4; DNA N6-methyl adenine demethylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.51  DNA N6-methyladenine demethylase
     K10766  ALKBH4; DNA N6-methyl adenine demethylase

Genes

HSA:	54784(ALKBH4)

PTR:	742069(ALKBH4)

PPS:	100988369(ALKBH4)

GGO:	101126541(ALKBH4)

PON:	100445194(ALKBH4)

PPYG:

129041180(ALKBH4)

NLE:	100584213(ALKBH4)

HMH:	116810990(ALKBH4)

SSYN:

129489710(ALKBH4)

MCC:	715078(ALKBH4)

MCF:	102124694(ALKBH4)

MTHB:

126950388

MNI:	105492754(ALKBH4)

CSAB:

103246675(ALKBH4)

CATY:

105593389(ALKBH4)

PANU:

100997527(ALKBH4)

TGE:	112620429(ALKBH4)

MLEU:

105532900(ALKBH4)

RRO:	104681200(ALKBH4)

RBB:	108518908(ALKBH4)

TFN:	117072446(ALKBH4)

PTEH:

111547075(ALKBH4)

CANG:

105503207(ALKBH4)

CJC:	100387910(ALKBH4)

SBQ:	101032010(ALKBH4)

CIMI:

108307939(ALKBH4)

ANAN:

105714880(ALKBH4)

CSYR:

103259067(ALKBH4)

MMUR:

105868347(ALKBH4)

LCAT:

123632580(ALKBH4)

PCOQ:

105807048(ALKBH4)

OGA:	100959138(ALKBH4)

MMU:	72041(Alkbh4)

MCAL:

110294656(Alkbh4)

MPAH:

110313069(Alkbh4)

RNO:	288587(Alkbh4)

MCOC:

116068559(Alkbh4)

ANU:	117698406(Alkbh4)

ASYL:

127672417(Alkbh4)

MUN:	110557244(Alkbh4)

CGE:	100766685(Alkbh4)

MAUA:

101825428(Alkbh4)

PROB:

127236961(Alkbh4)

PLEU:

114710300(Alkbh4)

MORG:

121446236(Alkbh4)

MFOT:

126491906

AAMP:

119825057(Alkbh4)

NGI:	103733481(Alkbh4)

HGL:	101718060(Alkbh4)

CPOC:

100730732(Alkbh4)

CCAN:

109681586(Alkbh4)

DORD:

105997337(Alkbh4)

DSP:	122113524(Alkbh4)

PLOP:

125368013(Alkbh4)

NCAR:

124969893

MMMA:

107147061(Alkbh4)

ITI:	101962767(Alkbh4)

OCU:

103346669

OPI:	101530034(ALKBH4)

TUP:	102470038(ALKBH4)

GVR:	103610473(ALKBH4)

CFA:	608093(ALKBH4)

CLUD:

112646184(ALKBH4)

VVP:	112935795(ALKBH4)

VLG:	121487505(ALKBH4)

NPO:	129519346(ALKBH4)

AML:	100481448(ALKBH4)

UMR:	103670205(ALKBH4)

UAR:	123777249(ALKBH4)

ELK:

111145577

LLV:

125090923

MPUF:

101693868(ALKBH4)

MNP:	132026593(ALKBH4)

MLK:	131819176(ALKBH4)

NVS:	122895823(ALKBH4)

ORO:	101386281(ALKBH4)

EJU:	114214262(ALKBH4)

ZCA:	113931852(ALKBH4)

MLX:	117999458(ALKBH4)

NSU:	110589869(ALKBH4)

LWW:	102727096(ALKBH4)

FCA:	101090916(ALKBH4)

PYU:	121017689(ALKBH4)

PCOO:

112860002(ALKBH4)

PBG:	122471336(ALKBH4)

PVIV:

125154433(ALKBH4)

LRUF:

124519283

LGF:	123589612(ALKBH4)

AJU:

106980696

PTG:	102949152(ALKBH4)

PPAD:

109250558(ALKBH4)

PUC:

125928516

PLEZ:

122209392(ALKBH4)

HHV:	120239284(ALKBH4)

BTA:	512094(ALKBH4)

BOM:	102279064(ALKBH4)

BIU:	109578590(ALKBH4)

BBUB:

102412920(ALKBH4)

BBIS:

104998966(ALKBH4)

CHX:	102184869(ALKBH4)

OAS:	101117557(ALKBH4)

BTAX:

128065800(ALKBH4)

CSUM:

138076927(ALKBH4)

ODA:	120878718(ALKBH4)

CCAD:

122433595(ALKBH4) 122453675

MREE:

136148672 136160785(ALKBH4)

OVR:	110132168(ALKBH4)

MBEZ:

129545649(ALKBH4)

SSC:	100520070(ALKBH4)

CFR:	102507524(ALKBH4)

CBAI:

105067255(ALKBH4)

CDK:	105092378(ALKBH4)

VPC:	102525754(ALKBH4)

BACU:

103014681(ALKBH4)

BMUS:

118880652(ALKBH4)

LVE:	103087978(ALKBH4)

OOR:	101270029(ALKBH4)

LALB:

132506376(ALKBH4)

DLE:	115803749(ALKBH4)

PCAD:

102981632(ALKBH4)

PSIU:

116739735(ALKBH4)

NASI:

112399859(ALKBH4)

ECB:	100059659(ALKBH4)

EPZ:	103551715(ALKBH4)

EAI:	106839283(ALKBH4)

MYB:	102251655(ALKBH4)

MYD:	102768387(ALKBH4)

MMYO:

118657001(ALKBH4)

MLF:	102440795(ALKBH4)

MDT:	132233226(ALKBH4)

MYUM:

139008935(ALKBH4)

PKL:	118702714(ALKBH4)

EFUS:

103286014(ALKBH4)

MNA:	107526519(ALKBH4)

DRO:	112314883(ALKBH4)

SHON:

118992831(ALKBH4)

AJM:	119044705(ALKBH4)

PDIC:

114497569(ALKBH4)

PHAS:

123806345(ALKBH4)

MMF:	118641418(ALKBH4)

PPAM:

129083438(ALKBH4)

HAI:	109385054(ALKBH4)

RFQ:	117024726(ALKBH4)

PALE:

102897783(ALKBH4)

PGIG:

120591627(ALKBH4)

PVP:	105299708(ALKBH4)

RAY:	107511788(ALKBH4)

MJV:	108383778(ALKBH4)

TOD:	119241545(ALKBH4)

SARA:

101546421(ALKBH4)

SFUM:

130017528(ALKBH4)

SETR:

126029581(ALKBH4)

LAV:	100671203(ALKBH4)

TMU:

101348203

ETF:	101654816(ALKBH4)

DNM:	101428941(ALKBH4)

MDO:	100028803(ALKBH4)

GAS:	123247533(ALKBH4)

SHR:	100930364(ALKBH4)

AFZ:

127558641

PCW:	110221198(ALKBH4)

TVP:	118857042(ALKBH4)

PBRV:

138162351(ALKBH4)

OAA:	100076593(ALKBH4)

TACU:

119939094(ALKBH4)

GGA:	417510(ALKBH4)

PCOC:

116228158(ALKBH4)

MGP:	100543581(ALKBH4)

CJO:	107322459(ALKBH4)

TPAI:

128083519(ALKBH4)

LMUT:

125702927(ALKBH4)

NMEL:

110407627(ALKBH4)

APLA:

101795046(ALKBH4)

ACYG:

106041407(ALKBH4)

CATA:

118254194(ALKBH4)

AFUL:

116497403(ALKBH4)

TGU:	100229056(ALKBH4)

LSR:	110482076(ALKBH4)

SCAN:

103820254(ALKBH4)

PMOA:

120507691(ALKBH4)

OTC:	121345746(ALKBH4)

PRUF:

121361599(ALKBH4)

ATRC:

139600042(ALKBH4)

GFR:	102044814(ALKBH4)

FAB:	101819390(ALKBH4)

OMA:	130261040(ALKBH4)

PHI:	102101282(ALKBH4)

PMAJ:

107212847(ALKBH4)

CCAE:

111937929(ALKBH4)

CCW:	104691111(ALKBH4)

CBRC:

103621611(ALKBH4)

ACOE:

138120466(ALKBH4)

ETL:	114056703(ALKBH4)

ZAB:	102073254(ALKBH4)

ZLE:	135455690(ALKBH4)

ACHL:

103807129(ALKBH4)

SVG:	106853246(ALKBH4)

MMEA:

130577780(ALKBH4)

HRT:	120761492(ALKBH4)

SATI:

136370021(ALKBH4)

CCIC:

134052404(ALKBH4)

FPG:	101924573(ALKBH4)

FCH:	102052603(ALKBH4)

CCRI:

104155503(ALKBH4)

NNT:	104399379(ALKBH4)

SHAB:

115601830(ALKBH4)

ACUN:

113487054(ALKBH4)

TALA:

104366469 122153332(ALKBH4)

ACHC:

115347532(ALKBH4)

HALD:

104322302(ALKBH4)

HLE:	104835733(ALKBH4)

AGEN:

126039215

HHAR:

128149381(ALKBH4)

GCL:

127024250

CSTI:

104563327(ALKBH4)

LDI:	104354961(ALKBH4)

DPUB:

104298374(ALKBH4)

PPUS:

135187247(ALKBH4)

AVIT:

104267580(ALKBH4)

BRHI:

104500125(ALKBH4)

EGZ:	104131791(ALKBH4)

NNI:	104016143(ALKBH4)

PCRI:

104028769(ALKBH4)

PCAO:

104039923(ALKBH4)

PADL:

103912920(ALKBH4)

AFOR:

103895793(ALKBH4)

FGA:	104084215(ALKBH4)

GSTE:

104251325(ALKBH4)

CLV:	102087748(ALKBH4)

MUI:	104547589(ALKBH4)

PGUU:

104471244(ALKBH4)

PLET:

104616849(ALKBH4)

EHS:	104506637(ALKBH4)

CMAC:

104473994(ALKBH4)

CUCA:

104058680(ALKBH4)

TEO:	104372636(ALKBH4)

BREG:

104631094(ALKBH4)

OHA:	104328733(ALKBH4)

ACAR:

104518612(ALKBH4)

CPEA:

104396230(ALKBH4)

CVF:	104286585(ALKBH4)

RTD:	128912280(ALKBH4)

CRID:

134518477(ALKBH4)

AAM:	106497319(ALKBH4)

NPD:	112956652(ALKBH4)

TGT:	104579644(ALKBH4)

DNE:	112987412(ALKBH4)

SCAM:

104146242(ALKBH4)

ASN:	102381671(ALKBH4)

AMJ:	102573667(ALKBH4)

CPOO:

109316920(ALKBH4)

GGN:	109293423(ALKBH4)

PSS:	112544818(ALKBH4)

CMY:	102947777(ALKBH4)

CCAY:

125624110(ALKBH4)

DCC:	119844725(ALKBH4)

CPIC:

101953961(ALKBH4)

TST:	117867304(ALKBH4)

CABI:

116823454(ALKBH4)

MRV:	120387152(ALKBH4)

ASAO:

132763830 132763911(ALKBH4)

PVT:	110085148(ALKBH4)

SUND:

121916870(ALKBH4)

PBI:	103067747(ALKBH4)

PMUR:

107297547(ALKBH4)

CTIG:

120303967(ALKBH4)

TSR:	106555926(ALKBH4)

PGUT:

117667480(ALKBH4)

APRI:

131188799

PTEX:

113441615(ALKBH4)

NSS:	113415135(ALKBH4)

VKO:	123023605(ALKBH4)

PMUA:

114585800(ALKBH4)

PRAF:

128403235(ALKBH4)

ZVI:	118096845(ALKBH4)

HCG:	128336216(ALKBH4)

GJA:	107107732(ALKBH4)

STOW:

125445492(ALKBH4)

EMC:	129344611(ALKBH4)

XLA:	431831(alkbh4.L)

XTR:	100488023(alkbh4)

NPR:	108801831(ALKBH4)

RTEM:

120927616(ALKBH4)

BBUF:

120994744(ALKBH4)

BGAR:

122922785(ALKBH4)

PWL:	138286439(ALKBH4)

MUO:	115482612(ALKBH4)

GSH:	117349415(ALKBH4)

DRE:	553475(alkbh4)

SRX:	107710716 107712145

SANH:

107681883 107685860(alkbh4)

SGH:	107587687(alkbh4)

CAUA:

113049750(alkbh4)

CGIB:

127957274

PTET:

122345969(alkbh4)

LROH:

127165102(alkbh4)

OMC:	131541016(alkbh4)

PPRM:

120472365(alkbh4)

RKG:	130082438(alkbh4)

MAMB:

125267710(alkbh4)

CIDE:

127513387

CERY:

137034470(alkbh4)

MASI:

127421478 127440080

TROS:

130569610(alkbh4)

TDW:	130419413(alkbh4)

MANU:

129440911(alkbh4)

PDAB:

135774248(alkbh4)

IPU:

108259719

IFU:	128603500(alkbh4)

PHYP:

113531536(alkbh4)

SMEO:

124379157(alkbh4)

TFD:	113663427(alkbh4)

TVC:	132840846(alkbh4)

CGAR:

128512486(alkbh4)

NGRA:

132876044(alkbh4)

TRN:	134303445(alkbh4)

AMEX:

103026086(alkbh4)

CMAO:

118814331(alkbh4)

EEE:	113573767(alkbh4)

CHAR:

105895373(alkbh4)

SPIL:

134079471(alkbh4)

TRU:	101070603(alkbh4)

TFS:	130538066(alkbh4)

LCO:	104921116(alkbh4)

NCC:	104951123(alkbh4)

TBEN:

117482490 117490438(alkbh4)

CGOB:

115018641(alkbh4)

PGEO:

117458362(alkbh4)

GACU:

117547107(alkbh4)

EMAC:

134871727(alkbh4)

ELY:	117263869(alkbh4)

EFO:	125898980(alkbh4)

PLEP:

121952170(alkbh4)

SLUC:

116056044(alkbh4)

ECRA:

117954976(alkbh4)

ESP:	116700206(alkbh4)

PFLV:

114567137(alkbh4)

GAT:	120822933(alkbh4)

PPUG:

119215491(alkbh4)

AFB:	129113105(alkbh4)

CLUM:

117743083(alkbh4)

PSWI:

130188241(alkbh4)

CANA:

137802909(alkbh4)

CVE:	137876665(alkbh4)

MSAM:

119895867(alkbh4)

SCHU:

122887981(alkbh4)

CUD:	121518337(alkbh4)

SPUL:

138603567(alkbh4)

LMIX:

132988823(alkbh4)

ALAT:

119030884(alkbh4)

ASTR:

137606015(alkbh4)

MZE:	105940443(alkbh4)

ONL:	100692915(alkbh4)

OAU:

116326359

OLA:	101172431(alkbh4)

OML:	112142876(alkbh4)

CSAI:

133459948(alkbh4)

XMA:	102232650(alkbh4)

XCO:	114153040(alkbh4)

XHE:	116728236(alkbh4)

PRET:

103476313(alkbh4)

PFOR:

103145534(alkbh4)

PLAI:

106946272(alkbh4)

PMEI:

106915551(alkbh4)

GAF:	122844652(alkbh4)

PPRL:

129370631(alkbh4)

CVG:	107098206(alkbh4)

CTUL:

119786824(alkbh4)

GMU:	124876944(alkbh4)

NFU:	107387217(alkbh4)

KMR:	108238050(alkbh4)

ALIM:

106525418(alkbh4)

NWH:	119420422(alkbh4)

AOCE:

111586757(alkbh4)

EJA:	138196095(alkbh4)

BFRE:

138627421(alkbh4)

MCEP:

125020745(alkbh4)

POV:	109635795(alkbh4)

SSEN:

122779230(alkbh4)

SSOE:

131458493(alkbh4)

HHIP:

117773985(alkbh4)

HSP:	118122635(alkbh4)

PPLT:

128456682(alkbh4)

SMAU:

118301537(alkbh4)

LCF:

108893639

SDU:	111217088(alkbh4)

SLAL:

111651632(alkbh4)

XGL:	120802142(alkbh4)

HCQ:	109517959(alkbh4)

SSCV:

125982531(alkbh4)

SBIA:

133491832(alkbh4)

PEE:	133416009(alkbh4)

PTAO:

133467756(alkbh4)

BPEC:

110166972(alkbh4)

ENY:	140360386(alkbh4)

MALB:

109959269(alkbh4)

BSPL:

114869990(alkbh4)

SJO:	128371025(alkbh4)

SSCO:

133994169(alkbh4)

GMH:	115546791(alkbh4)

SASA:

100195578(alkbh4)

STRU:

115154246(alkbh4)

OTW:	112228108(alkbh4)

OMY:	110533572(alkbh4)

OGO:	123994635(alkbh4)

ONE:	115136488(alkbh4)

OKI:	109873401(alkbh4)

OKE:	118390704(alkbh4)

OMM:	135549210(alkbh4)

OCLA:

139419487

SALP:

111951006(alkbh4)

SNH:	120056505(alkbh4)

CCLU:

121579373(alkbh4)

ELS:	105011090(alkbh4)

OEP:	134039476(alkbh4)

SFM:	108928133(alkbh4)

PKI:	111847879(alkbh4)

AANG:

118236010(alkbh4)

AROT:

135263873(alkbh4)

CCOG:

133132845(alkbh4)

LOC:	102699176(alkbh4)

PSPA:

121308467(alkbh4)

ARUT:

117430181(alkbh4)

PSEX:

120531322(alkbh4)

LCM:	102354460(ALKBH4)

CMK:	103180531(alkbh4)

RTP:	109915599(alkbh4)

CPLA:

122564135(alkbh4)

HOC:	132830448(alkbh4)

LERI:

129710725(alkbh4)

PMRN:

116956070(ALKBH4)

LRJ:	133357925(ALKBH4)

BFO:

BBEL:

CIN:

SCLV:

SPU:	105446801 105447299

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AJC:

SKO:

PFLL:

DME:	Dmel_CG4036(CG4036)

DER:

6541613

DSE:

6611858

DSI:	Dsimw501_GD26983(Dsim_GD26983)

DYA:	Dyak_GE18871

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI20151

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ012007

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OLG:

MGEN:

NMEA:

CGIG:

SOC:	105203109 120356879

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

TLN:

HST:

DQU:

CFO:

FEX:

PMEC:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

DPA:

ESIM:

EFOR:

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_200141

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM437930

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_48015

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F09F7.7(nmad-1)

CBR:

CBG_24043

CRQ:	GCK72_010564

NAI:	NECAME_02458

BMY:	BM_BM3238(Bma-nmad-1)

LOA:	LOAG_18028

TSP:

Tsp_01540

LGI:	LOTGIDRAFT_142409

PVUL:

126823806

PCAN:

112561797

LSAX:

138976666

BGT:	106067165 106074243

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:	135683689 135683690

AQU:

100633647

MBR:	MONBRDRAFT_26078

SRE:	PTSG_09879

TBR:	Tb10.70.0360

TBG:	TbgDal_X7900

TCR:	510187.490

LMA:	LMJF_36_1970

LIF:	LINJ_36_2080

LDO:	LDBPK_362080

LMI:	LMXM_36_1970

LMAT:

92510368(LSCM1_00203)

LBZ:	LBRM_35_2190

LPAN:

LPMP_352050

LOI:	92356226(LSCM4_00203)

LEIS:

94175859(GH5_00208)

LENR:

94167503(CUR178_00202)

LEIN:

94183981(JIQ42_00206)

PHET:

94286320(JKF63_00191)

» show all

Reference

PMID:23145062

Authors

Bjornstad LG, Meza TJ, Otterlei M, Olafsrud SM, Meza-Zepeda LA, Falnes PO

Title

Human ALKBH4 interacts with proteins associated with transcription.

Journal

PLoS One 7:e49045 (2012)
DOI:10.1371/journal.pone.0049045

Sequence

[hsa:54784]

Reference

PMID:23673617

Authors

Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG

Title

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.

Journal

Nat Commun 4:1832 (2013)
DOI:10.1038/ncomms2863

Sequence

[hsa:54784]

Reference

PMID:30982744

Authors

Kweon SM, Chen Y, Moon E, Kvederaviciute K, Klimasauskas S, Feldman DE

Title

An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing.

Journal

Mol Cell 74:1138-1147.e6 (2019)
DOI:10.1016/j.molcel.2019.03.018

Sequence

[mmu:72041]

LinkDB

DBGET integrated database retrieval system