KEGG ORTHOLOGY: K10859

ORTHOLOGY: K10859

Entry

K10859                      KO

Symbol

ALKBH2

Name

DNA oxidative demethylase [EC:1.14.11.33]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K10859  ALKBH2; DNA oxidative demethylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.33  DNA oxidative demethylase
     K10859  ALKBH2; DNA oxidative demethylase
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
  SSBR (single strand breaks repair)
   Direct repair
    K10859  ALKBH2; DNA oxidative demethylase

Other DBs

GO:	0043734 0051747 0103053

Genes

HSA:	121642(ALKBH2)

PTR:	107967636(ALKBH2)

PPS:	100986873(ALKBH2)

GGO:	101129748(ALKBH2)

PON:	100445747(ALKBH2)

PPYG:

129010253(ALKBH2)

NLE:	100597736(ALKBH2)

HMH:	116477972(ALKBH2)

SSYN:

129460355(ALKBH2)

MCC:	706708(ALKBH2)

MCF:	102116761(ALKBH2)

MTHB:

126931507

MNI:	105498148(ALKBH2)

CSAB:

103239079(ALKBH2)

CATY:

105573226(ALKBH2)

PANU:

101011226(ALKBH2)

TGE:	112634509(ALKBH2)

MLEU:

105536256(ALKBH2)

RRO:	104660194(ALKBH2)

RBB:	108534388(ALKBH2)

TFN:	117089446(ALKBH2)

PTEH:

111532165(ALKBH2)

CANG:

105507467(ALKBH2)

CJC:	100392822(ALKBH2)

SBQ:	101032758(ALKBH2)

CIMI:

108313141(ALKBH2)

ANAN:

105728645(ALKBH2)

CSYR:

103274930(ALKBH2)

MMUR:

105866925(ALKBH2)

LCAT:

123625899(ALKBH2)

PCOQ:

105815080(ALKBH2)

OGA:	100958810(ALKBH2)

MMU:	231642(Alkbh2)

MCAL:

110295084(Alkbh2)

MPAH:

110313193(Alkbh2)

RNO:	304578(Alkbh2)

MCOC:

116068215(Alkbh2)

ANU:	117698047(Alkbh2)

ASYL:

127673404(Alkbh2)

MUN:	110547287(Alkbh2)

CGE:	100753724(Alkbh2)

MAUA:

101824008(Alkbh2)

PROB:

127215958(Alkbh2)

PLEU:

114686980(Alkbh2)

MORG:

121446280(Alkbh2)

MFOT:

126487975

AAMP:

119825014(Alkbh2)

NGI:	103746693(Alkbh2)

HGL:	101716220(Alkbh2)

CPOC:

100731606(Alkbh2)

CCAN:

109690546(Alkbh2)

DORD:

105984229(Alkbh2)

DSP:	122102675(Alkbh2)

PLOP:

125349021(Alkbh2)

MMMA:

107154625(Alkbh2)

ITI:	101958254(Alkbh2)

OCU:

100338111

OPI:	101529310(ALKBH2)

TUP:	102482246(ALKBH2)

GVR:	103588165(ALKBH2)

CFA:	477524(ALKBH2)

CLUD:

112676721(ALKBH2)

VVP:	112910483(ALKBH2)

VLG:	121475675(ALKBH2) 121476118

NPO:	129507761(ALKBH2)

AML:	100474137(ALKBH2)

UMR:	103678299(ALKBH2)

UAH:	113267081(ALKBH2)

UAR:	123788222(ALKBH2)

ELK:

111156371

LLV:

125082060

MPUF:

101680375(ALKBH2)

MNP:	132023260(ALKBH2)

MLK:	131811789(ALKBH2)

NVS:	122890377 122903329(ALKBH2)

ORO:	101365179(ALKBH2)

EJU:	114219108(ALKBH2)

ZCA:	113912497(ALKBH2)

MLX:	118018586(ALKBH2)

NSU:	110592420(ALKBH2)

LWW:	102732246(ALKBH2)

FCA:	101086929(ALKBH2)

PYU:	121010191(ALKBH2)

PCOO:

112870349(ALKBH2)

PBG:	122470343(ALKBH2)

PVIV:

125148752(ALKBH2)

LRUF:

124518250

LGF:	123588518(ALKBH2)

AJU:

106978245

PTG:	102963984(ALKBH2)

PPAD:

109277483(ALKBH2)

PUC:

125914056

PLEZ:

122203180(ALKBH2)

HHV:	120233701(ALKBH2)

BTA:	511380(ALKBH2)

BOM:	102287592(ALKBH2)

BIU:	109571304(ALKBH2)

BBUB:

102407586(ALKBH2)

BBIS:

104980085(ALKBH2)

CHX:	102178649(ALKBH2)

OAS:	101115575(ALKBH2)

BTAX:

128062212(ALKBH2)

CSUM:

138093513(ALKBH2)

ODA:	120871188(ALKBH2)

CCAD:

122422148(ALKBH2)

MREE:

136145717(ALKBH2)

OVR:	110126400(ALKBH2)

MBEZ:

129542532(ALKBH2)

SSC:	100520333(ALKBH2)

CFR:	102512485(ALKBH2)

CBAI:

105075666(ALKBH2)

CDK:	105105353(ALKBH2)

VPC:	102534169(ALKBH2)

BACU:

103018941(ALKBH2)

BMUS:

118906864(ALKBH2)

LVE:	103090535(ALKBH2)

OOR:	101276374(ALKBH2)

LALB:

132532399(ALKBH2)

DLE:	111162703(ALKBH2)

PCAD:

102991764(ALKBH2)

PSIU:

116738971(ALKBH2)

NASI:

112397333(ALKBH2)

ECB:	100059785(ALKBH2)

EPZ:	103551426(ALKBH2)

EAI:	106848078(ALKBH2)

MYB:	102240138(ALKBH2)

MYD:	102759865(ALKBH2)

MMYO:

118678330(ALKBH2)

MLF:	102431401(ALKBH2)

MDT:	132221948(ALKBH2)

MYUM:

138998176(ALKBH2)

PKL:	118725355(ALKBH2)

EFUS:

103286901(ALKBH2)

MNA:	107533877 107533878(ALKBH2)

DRO:	112310616(ALKBH2)

SHON:

118991213(ALKBH2)

AJM:	119057425(ALKBH2)

PDIC:

114510019(ALKBH2)

PHAS:

123821945(ALKBH2)

MMF:	118640101(ALKBH2)

PPAM:

129087444(ALKBH2)

HAI:	109386165(ALKBH2)

RFQ:	117017595(ALKBH2)

PALE:

102887953(ALKBH2)

PGIG:

120601866(ALKBH2)

PVP:	105303940(ALKBH2)

RAY:	107500143(ALKBH2)

MJV:	108399870(ALKBH2)

TOD:	119244884(ALKBH2)

SARA:

101546312(ALKBH2)

SFUM:

130023918(ALKBH2)

SETR:

126031091(ALKBH2)

LAV:	100658050(ALKBH2)

TMU:

101352121

ETF:	101663843(ALKBH2)

DNM:	101423827(ALKBH2)

MDO:	103106540(ALKBH2)

GAS:	123245235(ALKBH2)

SHR:	100932939(ALKBH2)

AFZ:

127545594

PCW:	110222756(ALKBH2)

TVP:	118851195(ALKBH2)

PBRV:

138156301(ALKBH2)

OAA:	100076849(ALKBH2)

TACU:

119942356(ALKBH2)

GGA:	416897(ALKBH2)

PCOC:

116228550(ALKBH2)

MGP:	100538906(ALKBH2)

CJO:	107321303(ALKBH2)

TPAI:

128084694(ALKBH2)

LMUT:

125701721(ALKBH2)

NMEL:

110406575(ALKBH2)

APLA:

119718593(ALKBH2)

ACYG:

106031396(ALKBH2)

CATA:

118257573(ALKBH2)

AFUL:

116496143(ALKBH2)

TGU:	100228613(ALKBH2)

LSR:	110478190(ALKBH2)

SCAN:

103818298(ALKBH2)

PMOA:

120509669(ALKBH2)

OTC:	121338831(ALKBH2)

PRUF:

121364822(ALKBH2)

ATRC:

139598619(ALKBH2)

GFR:	102044910(ALKBH2)

FAB:	101811160(ALKBH2)

OMA:	130259557(ALKBH2)

PHI:	102104467(ALKBH2)

PMAJ:

107211511(ALKBH2)

CCAE:

111936719(ALKBH2)

CCW:	104688809(ALKBH2)

CBRC:

103616064(ALKBH2)

ACOE:

138119172(ALKBH2)

ETL:	114062653(ALKBH2)

ZAB:	102067499(ALKBH2)

ZLE:	135454476(ALKBH2)

ACHL:

103805224(ALKBH2)

SVG:	106852323(ALKBH2)

MMEA:

130580530(ALKBH2)

HRT:	120760546(ALKBH2)

SATI:

136368999(ALKBH2)

CCIC:

134051065(ALKBH2)

FCH:	102059728(ALKBH2)

CCRI:

104164366(ALKBH2)

NNT:	104400811(ALKBH2)

SHAB:

115614418(ALKBH2)

ACUN:

113486086(ALKBH2)

TALA:

104366706(ALKBH2)

HALD:

104310536(ALKBH2)

HLE:	104840839(ALKBH2)

AGEN:

126041173

HHAR:

128145846(ALKBH2)

GCL:

127022939

CSTI:

104549937(ALKBH2)

LDI:	104348943(ALKBH2)

MNB:	103771519(ALKBH2)

DPUB:

104308502(ALKBH2)

PPUS:

135188786(ALKBH2)

AVIT:

104279928(ALKBH2)

BRHI:

104487891(ALKBH2)

EGZ:	104123694(ALKBH2)

NNI:	104020524(ALKBH2)

PCRI:

104036954(ALKBH2)

PCAO:

104039425(ALKBH2)

PADL:

103925693(ALKBH2)

AFOR:

103902757(ALKBH2)

FGA:	104071490(ALKBH2)

GSTE:

104258624(ALKBH2)

CBOY:

140659737(ALKBH2)

CLV:	102094885(ALKBH2)

MUI:	104533616(ALKBH2)

PGUU:

104465913(ALKBH2)

PLET:

104615554(ALKBH2)

EHS:	104502911(ALKBH2)

CMAC:

104474710(ALKBH2)

CUCA:

104058906(ALKBH2)

TEO:	104377173(ALKBH2)

BREG:

104643564(ALKBH2)

OHA:	104331921(ALKBH2)

ACAR:

104522124(ALKBH2)

CPEA:

104388035(ALKBH2)

CVF:	104282235(ALKBH2)

RTD:	128917081(ALKBH2)

CRID:

134522783(ALKBH2)

AAM:	106487416(ALKBH2)

AROW:

112963341(ALKBH2)

NPD:	112945172(ALKBH2)

TGT:	104573466(ALKBH2)

DNE:	112991782(ALKBH2)

SCAM:

104149387(ALKBH2)

ASN:	102367908(ALKBH2)

AMJ:	102565511(ALKBH2)

CPOO:

109312687(ALKBH2)

GGN:	109290539(ALKBH2)

PSS:	102461954(ALKBH2)

CMY:	102942598(ALKBH2)

CCAY:

125622934(ALKBH2)

DCC:	119843721(ALKBH2)

CPIC:

101942935(ALKBH2)

TST:	117888037(ALKBH2)

CABI:

116839479(ALKBH2)

MRV:	120386392(ALKBH2)

ASAO:

132781714(ALKBH2)

PVT:	110083417(ALKBH2)

SUND:

121918205

PBI:	103067031(ALKBH2)

PMUR:

107287267(ALKBH2)

CTIG:

120316757(ALKBH2)

TSR:	106551113(ALKBH2)

PGUT:

117672277

APRI:

131185907(ALKBH2)

PTEX:

113448675(ALKBH2)

NSS:	113423922(ALKBH2)

VKO:	123028656(ALKBH2)

PMUA:

114582667(ALKBH2)

PRAF:

128400217(ALKBH2)

ZVI:	118094946(ALKBH2)

HCG:	128338114(ALKBH2)

GJA:	107112166(ALKBH2)

STOW:

125442719(ALKBH2)

EMC:	129341460(ALKBH2)

XLA:	108716036(alkbh2.L)

XTR:	100492480(alkbh2)

NPR:	108790221(ALKBH2)

RTEM:

120938209(ALKBH2)

BBUF:

120988863(ALKBH2)

BGAR:

122924352(ALKBH2)

PWL:	138266229(ALKBH2)

MUO:	115480515(ALKBH2)

GSH:	117365897(ALKBH2)

DRE:	569291(alkbh2)

SRX:

107746816

SANH:

107676640

SGH:

107552593

CCAR:

122137466(alkbh2)

CAUA:

113049159

CGIB:

127958435

PTET:

122345629(alkbh2)

LROH:

127166051(alkbh2)

OMC:	131540229(alkbh2)

PPRM:

120489880(alkbh2)

RKG:	130103754(alkbh2)

MAMB:

125267034(alkbh2)

CIDE:

127513058

CERY:

137034325(alkbh2)

MASI:

127427572

TROS:

130550053(alkbh2)

TDW:	130419374(alkbh2)

MANU:

129440577(alkbh2)

PDAB:

135748580(alkbh2)

IPU:

108255908

IFU:	128598962(alkbh2)

PHYP:

113542623(alkbh2)

SMEO:

124380761(alkbh2)

TFD:	113642317(alkbh2)

TVC:	132855206(alkbh2)

CGAR:

128509604(alkbh2)

NGRA:

132872342(alkbh2)

TRN:	134335058(alkbh2)

AMEX:

103024811(alkbh2)

CMAO:

118826905(alkbh2)

EEE:	113576930(alkbh2)

CHAR:

105894490(alkbh2)

SPIL:

134089249(alkbh2)

TRU:	101075045(alkbh2)

TFS:	130525635(alkbh2)

TNG:	GSTEN00029512G001

LCO:	104937265(alkbh2)

NCC:	104962058(alkbh2)

TBEN:

117496802(alkbh2)

CGOB:

115013221(alkbh2)

PGEO:

117452212(alkbh2)

GACU:

117561061(alkbh2)

EMAC:

134873330(alkbh2)

ELY:	117253131(alkbh2)

EFO:	125890462(alkbh2)

PLEP:

121944398(alkbh2)

SLUC:

116056586(alkbh2)

ECRA:

117945181(alkbh2)

ESP:	116689037(alkbh2)

PFLV:

114555107(alkbh2)

GAT:	120831318(alkbh2)

PPUG:

119224726(alkbh2)

AFB:	129101318(alkbh2)

CLUM:

117736458(alkbh2)

PSWI:

130197421(alkbh2)

CANA:

137778935(alkbh2)

CVE:	137867230(alkbh2)

MSAM:

119891169(alkbh2)

SCHU:

122876129(alkbh2)

CUD:	121509837(alkbh2)

SPUL:

138609823(alkbh2)

LMIX:

132974869(alkbh2)

ALAT:

119020146(alkbh2)

ASTR:

137593062(alkbh2)

MZE:	101485138(alkbh2)

ONL:	100706764(alkbh2)

OAU:	116332507(alkbh2)

OLA:	110015618(alkbh2)

OML:	112148040(alkbh2)

CSAI:

133451068(alkbh2)

XMA:	102225587(alkbh2)

XCO:	114154995(alkbh2)

XHE:	116730027(alkbh2)

PRET:

103470322(alkbh2)

PFOR:

103142871(alkbh2)

PLAI:

106937330(alkbh2)

PMEI:

106918217(alkbh2)

GAF:	122828882(alkbh2)

PPRL:

129372004(alkbh2)

CVG:	107097248(alkbh2)

CTUL:

119786607(alkbh2)

GMU:	124877627(alkbh2)

NFU:	107393978(alkbh2)

KMR:	108234636(alkbh2)

ALIM:

106521692(alkbh2)

NWH:	119413080(alkbh2)

AOCE:

111588555(alkbh2)

EJA:	138191918(alkbh2)

BFRE:

138627275(alkbh2)

MCEP:

125012184(alkbh2)

CSEM:

103397328(alkbh2)

POV:	109638133(alkbh2)

SSEN:

122769611(alkbh2)

SSOE:

131463749(alkbh2)

HHIP:

117767691(alkbh2)

HSP:	118114951(alkbh2)

PPLT:

128438578(alkbh2)

SMAU:

118313550(alkbh2)

LCF:

108878200

SDU:	111228283(alkbh2)

SLAL:

111660391(alkbh2)

XGL:	120804685(alkbh2)

HCQ:	109511488(alkbh2)

SSCV:

125994679(alkbh2)

SBIA:

133499921(alkbh2)

PEE:	133399782(alkbh2)

PTAO:

133475471

BPEC:

110169775(alkbh2)

ENY:	140346562(alkbh2)

MALB:

109956899(alkbh2)

BSPL:

114862224(alkbh2)

SJO:	128365064(alkbh2)

SSCO:

133979006(alkbh2)

SASA:

106580307(alkbh2)

STRU:

115200220(alkbh2)

OTW:	112262829(alkbh2)

OMY:	110536121(alkbh2)

OGO:	124036384(alkbh2)

ONE:	115140126(alkbh2)

OKI:	109895973(alkbh2)

OKE:	118358416(alkbh2)

OMM:	135514016(alkbh2)

OCLA:

139389826 139389829 139400332

SALP:

111958162(alkbh2)

SNH:	120063290(alkbh2)

CCLU:

121573936(alkbh2)

ELS:	105025591(alkbh2)

OEP:	134012184(alkbh2)

SFM:	108932555(alkbh2)

PKI:	111854895(alkbh2)

AANG:

118206529(alkbh2)

AROT:

135264742(alkbh2)

CCOG:

133140610(alkbh2)

LOC:	102694971(alkbh2)

PSPA:

121299989(alkbh2)

ARUT:

117426315 117427819

PSEX:

120540769(alkbh2)

LCM:	102351876(ALKBH2)

CMK:	103184019(alkbh2)

RTP:	109916259(alkbh2)

CPLA:

122562561(alkbh2)

HOC:	132827053(alkbh2)

LERI:

129709194(alkbh2)

PMRN:

116945288(ALKBH2)

LRJ:	133353318(ALKBH2)

BFO:

118410285

BBEL:

109474732 109474733 109481451 109485891

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

BCOO:

TCA:

TMOL:

ESIM:

EFOR:

SOY:

ATD:

CSET:

HAXR:

AGB:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

MJU:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HZE:

TNL:

OFU:

ONU:

ATRA:

PXY:

PGW:

CSTB:

CFEL:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

MQU:	128983522 129005373

FOC:

ZNE:

CSEC:

PAME:

SGRE:

BROR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:	126992476 126995498

MNZ:

MRJ:

PORN:

HAZT:

LSM:

TCF:

DSV:

RSAN:

RMP:

CSCU:

CVS:

PTEP:

ABRU:

129959448 129961136 129968355 129972045

UDV:	129218749 129220588 129221248 129230186

SDM:	118184484 118185316 118188581 118200752 118201220 118201427 118203052 118203235

LPOL:

106470253

TSP:

Tsp_00487

LGI:	LOTGIDRAFT_103779

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:

ATH:	AT2G22260(ALKBH2)

ALY:

CRB:

CSAT:

BRP:

BNA:	106365187 106412235

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10016440mg

PVY:

MINC:

TCC:

GRA:

GHI:	107924937 107930358

GAB:

108458208

HSYR:

120169350 120174262 120174885 120215819

DZI:

111278327

EGR:	104445577 104445579

RARG:

115726926 115742972

GMX:	100785387 100817233

GSJ:	114366957 114388162

PVU:	137832126 137832132

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

127076097 127076346 127101210 127106829 127107409 127114583 127126874 127136114

VVO:

LJA:

ADU:

AIP:

AHF:	112741364 112796077

LANG:

109333743

PCIN:

129287225

QSA:	O6P43_012052

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

PCOX:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

PNZ:

JRE:

CILL:

CAVE:

AGLU:

QSU:	111986514 111986527

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107766002 107797606

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

DLT:

BVG:

SOE:

CQI:	110687503 110731099

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119334678 119338757

TAES:

123150215 123157784 123164576

TUA:

LPER:

LRD:

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PAUA:

PDA:	103720690 103720695 120107605

EGU:

105060733

MUS:

135609779

ZOF:	121967419 122052640

DCT:

PEQ:

AOF:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

KMG:	30160533(I203_104333)

KNE:	92178745(IAR55_001486)

KDJ:	28968458(I303_104264)

KBI:	30209238(I302_105719)

SGRA:

EX895_000181

MBR:	MONBRDRAFT_16363

SRE:	PTSG_06623

NGR:	NAEGRDRAFT_63689

» show all

Reference

PMID:18519673

Authors

Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A, Dedon PC, Bjelland S, Samson LD, Falnes PO, Klungland A

Title

AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA.

Journal

Cancer Res 68:4142-9 (2008)
DOI:10.1158/0008-5472.CAN-08-0796

Sequence

[hsa:121642] [mmu:231642]

Reference

PMID:22532610

Authors

Meza TJ, Moen MN, Vagbo CB, Krokan HE, Klungland A, Grini PE, Falnes PO

Title

The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.

Journal

Nucleic Acids Res 40:6620-31 (2012)
DOI:10.1093/nar/gks327

Sequence

[ath:AT2G22260]

LinkDB

DBGET integrated database retrieval system