KEGG   ORTHOLOGY: K11030
Entry
K11030                      KO                                     
Symbol
pagA
Name
protective antigen
Pathway
map04621  NOD-like receptor signaling pathway
Module
M00859  Bacillus anthracis pathogenicity signature, anthrax toxin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K11030  pagA; protective antigen
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02042 Bacterial toxins
    K11030  pagA; protective antigen
Bacterial toxins [BR:ko02042]
 Type III toxins: Intracellular toxins
  Metalloprotease
   Anthrax lethal toxin
    K11030  pagA; protective antigen
  Adenylate cyclase
   Anthrax edema toxin
    K11030  pagA; protective antigen
Genes
BAR: GBAA_pXO1_0164(pagA)
BAH: BAMEG_A0160(pagA)
BAI: BAA_A0168(pagA)
BAX: H9401_5636
BANT: A16_60350
BANR: A16R_61370
BANS: BAPAT_pXO10161
BANH: HYU01_28775
BANV: DJ46_5665(pagA)
BAL: BACI_pCIXO101530(pagA)
BCX: BCA_A0144(pagA_1) BCA_A0148(pagA_2)
BTRO: FJR70_30660
BLR: BRLA_c029530(pagA_1) BRLA_c029820(pagA_2)
BRW: GOP56_07275 GOP56_07415
SMEI: SRED_002788
FRN: F1C15_14655
 » show all
Reference
PMID:18490752
  Authors
Warfel JM, D'Agnillo F
  Title
Anthrax lethal toxin enhances TNF-induced endothelial VCAM-1 expression via an IFN regulatory factor-1-dependent mechanism.
  Journal
J Immunol 180:7516-24 (2008)
DOI:10.4049/jimmunol.180.11.7516
Reference
PMID:3148491
  Authors
Welkos SL, Lowe JR, Eden-McCutchan F, Vodkin M, Leppla SH, Schmidt JJ
  Title
Sequence and analysis of the DNA encoding protective antigen of Bacillus anthracis.
  Journal
Gene 69:287-300 (1988)
DOI:10.1016/0378-1119(88)90439-8
  Sequence
[bar:GBAA_pXO1_0164]
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