KEGG   ORTHOLOGY: K11038
Entry
K11038                      KO                                     
Symbol
hlg, luk
Name
leukocidin/hemolysin toxin family protein
Pathway
map05150  Staphylococcus aureus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K11038  hlg, luk; leukocidin/hemolysin toxin family protein
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K11038  hlg, luk; leukocidin/hemolysin toxin family protein
   02042 Bacterial toxins
    K11038  hlg, luk; leukocidin/hemolysin toxin family protein
Transporters [BR:ko02000]
 Other transporters
  Pores ion channels
   K11038  hlg, luk; leukocidin/hemolysin toxin family protein
Bacterial toxins [BR:ko02042]
 Type II toxins: Membrane damaging toxins
  Pore-forming toxins, Beta-pore-forming/Cholesterol-dependent
   K11038  hlg, luk; leukocidin/hemolysin toxin family protein
Other DBs
TC: 1.C.3.3 1.C.3.4
Genes
HCH: HCH_05158
HAHE: ENC22_07235
ARAC: E0W69_013915
BASD: LCG60_29010
SAU: SA1637(lukD) SA1638(lukE) SA1812 SA1813 SA2207(hlgA) SA2208(hlgC) SA2209(hlgB)
SAV: SAV1819(lukD) SAV1820(lukE) SAV2004 SAV2005 SAV2419(hlgA) SAV2420(hlgC) SAV2421(hlgB)
SAW: SAHV_1804(lukD) SAHV_1805(lukE) SAHV_1990 SAHV_1991 SAHV_2403(hlgA) SAHV_2404(hlgC) SAHV_2405(hlgB)
SAH: SaurJH1_1904 SaurJH1_1905 SaurJH1_2099 SaurJH1_2100 SaurJH1_2493 SaurJH1_2494 SaurJH1_2495
SAJ: SaurJH9_1870 SaurJH9_1871 SaurJH9_2062 SaurJH9_2063 SaurJH9_2445 SaurJH9_2446 SaurJH9_2447
SAM: MW1378(lukF) MW1379(lukS) MW1767(lukD) MW1768(lukE) MW1941 MW1942 MW2342(hlgA) MW2343(hlgC) MW2344(hlgB)
SAS: SAS1748(hlgB) SAS1749(hlgA) SAS1924 SAS1925 SAS2310 SAS2311 SAS2312
SAR: SAR2107 SAR2108 SAR2509(hlgA) SAR2510(hlgC) SAR2511(hlgB)
SAC: SACOL1880(lukD) SACOL1881(lukE) SACOL2004 SACOL2006 SACOL2419(hlgA) SACOL2421(hlgC) SACOL2422(hlgB)
SAX: USA300HOU_1430(lukF-PV) USA300HOU_1431(lukS-PV) USA300HOU_1817(lukD) USA300HOU_1818(lukE) USA300HOU_2011 USA300HOU_2013 USA300HOU_2402(hlgA) USA300HOU_2404(hlgC) USA300HOU_2405(hlgB)
SAA: SAUSA300_1381(lukF-PV) SAUSA300_1382(lukS-PV) SAUSA300_1768(lukD) SAUSA300_1769(lukE) SAUSA300_1974 SAUSA300_1975 SAUSA300_2365(hlgA) SAUSA300_2366(hlgC) SAUSA300_2367(hlgB)
SAO: SAOUHSC_01954 SAOUHSC_01955 SAOUHSC_02241 SAOUHSC_02243 SAOUHSC_02708 SAOUHSC_02709 SAOUHSC_02710
SAE: NWMN_1718(lukD) NWMN_1719(lukE) NWMN_1927(lukF) NWMN_1928(lukS) NWMN_2318(hlgA) NWMN_2319(hlgC) NWMN_2320(hlgB)
SAD: SAAV_1828(lukD) SAAV_1829(lukE) SAAV_2072 SAAV_2073 SAAV_2485(hlgA) SAAV_2486(hlgC) SAAV_2487(hlgB)
SUU: M013TW_1436(lukF-PV) M013TW_1437(lukS-PV) M013TW_1976(lukG) M013TW_1977(lukH) M013TW_2380(hlgA) M013TW_2382(hlgC) M013TW_2383(hlgB)
SUV: SAVC_08360 SAVC_08365 SAVC_08965 SAVC_08970 SAVC_10970 SAVC_10975 SAVC_10980
SUE: SAOV_1812(lukD) SAOV_1908 SAOV_1909 SAOV_2041 SAOV_2042 SAOV_2467 SAOV_2469 SAOV_2470
SUJ: SAA6159_01353(lukF-PV) SAA6159_01354(lukS-PV) SAA6159_01750 SAA6159_01751(lukE) SAA6159_01939(lukG) SAA6159_01940(lukH) SAA6159_02320(hlgA) SAA6159_02321(hlgC) SAA6159_02322(hlgB)
SUK: SAA6008_02058 SAA6008_02059 SAA6008_02460(hlgA) SAA6008_02461(hlgC) SAA6008_02462(hlgB)
SUC: ECTR2_1652 ECTR2_1653 ECTR2_1876 ECTR2_1877 ECTR2_2278 ECTR2_2279 ECTR2_2280
SUT: SAT0131_01946 SAT0131_01947 SAT0131_02140 SAT0131_02142 SAT0131_02612 SAT0131_02615 SAT0131_02616
SUQ: HMPREF0772_10766(hlgB) HMPREF0772_10767(lukS) HMPREF0772_10768(hlgA) HMPREF0772_11177 HMPREF0772_11178 HMPREF0772_11713 HMPREF0772_11714
SUZ: MS7_1444 MS7_1445(lukS-PV) MS7_1824 MS7_1825(lukE) MS7_2036 MS7_2037 MS7_2434(hlgA) MS7_2435(hlgC) MS7_2436
SUD: ST398NM01_2060 ST398NM01_2061 ST398NM01_2471 ST398NM01_2473 ST398NM01_2474
SUX: SAEMRSA15_19270 SAEMRSA15_19280 SAEMRSA15_23180(hlgA) SAEMRSA15_23190(hlgC) SAEMRSA15_23200(hlgB)
SUW: SATW20_18210(hlgB) SATW20_18220(hlgA) SATW20_20010 SATW20_20020 SATW20_25490(hlgA) SATW20_25500(hlgC) SATW20_25510(hlgB)
SUG: SAPIG2060 SAPIG2061 SAPIG2471 SAPIG2473 SAPIG2474
SUF: SARLGA251_17080(hlgB) SARLGA251_17090(hlgA) SARLGA251_18230 SARLGA251_22010(hlgA) SARLGA251_22020(hlgC) SARLGA251_22030(hlgB)
SAUA: SAAG_00246 SAAG_00247 SAAG_00248 SAAG_02096 SAAG_02097 SAAG_02521 SAAG_02522
SAUE: RSAU_001674(lukD) RSAU_001675(lukE) RSAU_001837(lukG) RSAU_001838(lukH) RSAU_002258(hlgA) RSAU_002259(hlgC) RSAU_002260(hlgB)
SAUN: SAKOR_01767 SAKOR_01768 SAKOR_01986 SAKOR_01987 SAKOR_02399 SAKOR_02401 SAKOR_02402
SAUS: SA40_1780 SA40_1781 SA40_2168(hlgA) SA40_2170(hlgC) SA40_2171(hlgB)
SAUU: SA957_1377(lukF-PV) SA957_1378(lukS-PV) SA957_1864 SA957_1865 SA957_2252(hlgA) SA957_2254(hlgC) SA957_2255(hlgB)
SAUG: SA268_1381(lukF-PV) SA268_1382(lukS-PV) SA268_1936 SA268_1937 SA268_2325(hlgA) SA268_2327(hlgC) SA268_2328(hlgB)
SAUZ: SAZ172_1838(lukD) SAZ172_1839(lukE) SAZ172_2019 SAZ172_2020 SAZ172_2523(hlgA) SAZ172_2525(hlgC) SAZ172_2526(hlgB)
SAUT: SAI1T1_2013340(lukD) SAI1T1_2013350(lukE) SAI1T1_2017940(hlgA) SAI1T1_2017950(hlgC) SAI1T1_2017960(hlgB)
SAUJ: SAI2T2_1013350(lukD) SAI2T2_1013360(lukE) SAI2T2_1017950(hlgA) SAI2T2_1017960(hlgC) SAI2T2_1017970(hlgB)
SAUK: SAI3T3_1013340(lukD) SAI3T3_1013350(lukE) SAI3T3_1017940(hlgA) SAI3T3_1017950(hlgC) SAI3T3_1017960(hlgB)
SAUQ: SAI4T8_1013350(lukD) SAI4T8_1013360(lukE) SAI4T8_1017950(hlgA) SAI4T8_1017960(hlgC) SAI4T8_1017970(hlgB)
SAUV: SAI7S6_1013360(lukD) SAI7S6_1013370(lukE) SAI7S6_1017940(hlgA) SAI7S6_1017950(hlgC) SAI7S6_1017960(hlgB)
SAUW: SAI5S5_1013300(lukD) SAI5S5_1013310(lukE) SAI5S5_1017880(hlgA) SAI5S5_1017890(hlgC) SAI5S5_1017900(hlgB)
SAUX: SAI6T6_1013320(lukD) SAI6T6_1013330(lukE) SAI6T6_1017880(hlgA) SAI6T6_1017890(hlgC) SAI6T6_1017900(hlgB)
SAUY: SAI8T7_1013340(lukD) SAI8T7_1013350(lukE) SAI8T7_1017920(hlgA) SAI8T7_1017930(hlgC) SAI8T7_1017940(hlgB)
SAUF: X998_1843(lukD) X998_1844 X998_1995(lukG) X998_1996(lukH) X998_2404(hlgA) X998_2406(hlgC) X998_2407(hlgB)
SAB: SAB0782 SAB0783 SAB1686c(lukD) SAB1687c(lukE) SAB1875c SAB1876c SAB2300(hlgA) SAB2301(hlgC) SAB2302(hlgB)
SUY: SA2981_1774(lukD) SA2981_1775(lukE) SA2981_1966 SA2981_1967 SA2981_2356(hlgA) SA2981_2357(hlgC) SA2981_2358(hlgB)
SAUB: C248_2027 C248_2028 C248_2466(hlgA) C248_2468(hlgC) C248_2469(hlgB)
SAUM: BN843_18300 BN843_18310 BN843_20530 BN843_20540 BN843_24600 BN843_24620 BN843_24630
SAUC: CA347_2097(lukF) CA347_2098 CA347_2499(hlgA) CA347_2500(hlgC) CA347_2501(lukF)
SAUR: SABB_01254(hlgB) SABB_01255(hlgC) SABB_01946 SABB_01947(hlgA) SABB_05239 SABB_05442 SABB_06296
SAUI: AZ30_07280 AZ30_07285 AZ30_09245 AZ30_09250 AZ30_10660 AZ30_10665 AZ30_12720 AZ30_12725 AZ30_12730
SAUD: CH52_06875 CH52_06880 CH52_06885 CH52_08870 CH52_08875 CH52_10030 CH52_10035
SAMS: NI36_07380 NI36_07385 NI36_07715 NI36_07720 NI36_12000 NI36_12005 NI36_12010
SUH: SAMSHR1132_16620(hlgB) SAMSHR1132_18470 SAMSHR1132_18480 SAMSHR1132_22480 SAMSHR1132_22490 SAMSHR1132_22500
SSD: SPSINT_1566 SPSINT_1567
SDT: SPSE_0990(lukF-I) SPSE_0991(lukS-I)
SDP: NCTC12225_01194(lukF-I) NCTC12225_01195(lukS-I)
SSCH: LH95_04815 LH95_04820 LH95_04825 LH95_04830
SSCZ: RN70_05015 RN70_05020 RN70_05025 RN70_05030
SCV: A4G25_07450 A4G25_07455
SSH: NCTC13712_01959 NCTC13712_01960 NCTC13712_02370(hlgA) NCTC13712_02371(hlgC) NCTC13712_02372(hlgB)
SROT: ML435_11640(hlgB)
SFF: FOB90_02930 FOB90_02935 FOB90_02940 FOB90_02945
MCAK: MCCS_01180(hlgB) MCCS_01190(hlgC)
VG: 1262726(PVL_26) 1262730(PVL_27) 1262954(phiPV83p62) 1262967(phiPV83p61) 14296837(LukS-PV) 14296842(LukF-PV) 14515443(lukS-PV) 14515446(lukF-PV) 22112714(lukS-PV) 22112715(lukF-PV) 4594537(LukF-PV) 4594538(LukS-PV) 5525303(lukF-PV) 5525304(lukS-PV) 55599747(HWA91_gp27) 55605704(lukF-PV) 55605749(lukS-PV) 55632401(LukS-PV) 55632406(LukF-PV) 65072322(KMD29_gp66) 65072323(KMD29_gp67) 65072334(lukS-PV) 65072335(lukF-PV) 65072410(KMD31_gp28) 65072411(KMD31_gp29) 65072513(KMD32_gp63) 65072514(KMD32_gp64) 65072595(lukF-PV) 65072644(lukS-PV) 65072661(lukF-PV) 65072722(lukS-PV) 65072740(lukF-PV) 65072788(lukS-PV) 65072806(lukF-PV) 65072856(lukS-PV) 65072874(lukF-PV) 65072922(lukS-PV) 6965668(LukS-PV) 6965674(LukF-PV) 7967046(lukS-PV) 7967047(lukF-PV) 920148(lukF-PV) 920172(lukS-PV)
 » show all
Reference
PMID:16782383
  Authors
Barrio MB, Rainard P, Prevost G
  Title
LukM/LukF'-PV is the most active Staphylococcus aureus leukotoxin on bovine neutrophils.
  Journal
Microbes Infect 8:2068-74 (2006)
DOI:10.1016/j.micinf.2006.03.004
Reference
PMID:9781679
  Authors
Gravet A, Colin DA, Keller D, Girardot R, Monteil H, Prevost G
  Title
Characterization of a novel structural member, LukE-LukD, of the bi-component staphylococcal leucotoxins family.
  Journal
FEBS Lett 436:202-8 (1998)
DOI:10.1016/S0014-5793(98)01130-2
  Sequence
[sau:SA1637 SA1638]
Reference
PMID:10368297
  Authors
Pedelacq JD, Maveyraud L, Prevost G, Baba-Moussa L, Gonzalez A, Courcelle E, Shepard W, Monteil H, Samama JP, Mourey L
  Title
The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins.
  Journal
Structure 7:277-87 (1999)
DOI:10.1016/S0969-2126(99)80038-0
  Sequence
[sax:USA300HOU_1430 USA300HOU_1431]
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