KEGG   ORTHOLOGY: K11121
Entry
K11121                      KO                                     
Symbol
SIR2
Name
NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
Pathway
map00760  Nicotinate and nicotinamide metabolism
map01100  Metabolic pathways
map04213  Longevity regulating pathway - multiple species
Reaction
R10633  
R10634  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K11121  SIR2; NAD-dependent protein deacetylase SIR2
 09150 Organismal Systems
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    K11121  SIR2; NAD-dependent protein deacetylase SIR2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K11121  SIR2; NAD-dependent protein deacetylase SIR2
   03036 Chromosome and associated proteins
    K11121  SIR2; NAD-dependent protein deacetylase SIR2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     K11121  SIR2; NAD-dependent protein deacetylase SIR2
DNA replication proteins [BR:ko03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Telomere proteins
    SIR proteins
     K11121  SIR2; NAD-dependent protein deacetylase SIR2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   Sir proteins
    K11121  SIR2; NAD-dependent protein deacetylase SIR2
Other DBs
COG: COG0846
GO: 0034979
Genes
SCE: YDL042C(SIR2) YDR191W(HST4) YOL068C(HST1) YOR025W(HST3) YPL015C(HST2)
SEUB: DI49_0381 DI49_1021 DI49_2336 DI49_4871 DI49_5441
SPAO: SPAR_D01910 SPAR_D03970 SPAR_O00840 SPAR_O01700 SPAR_P02480
AGO: AGOS_AEL013C AGOS_AEL229W AGOS_AGL018C AGOS_AGL118W
ERC: Ecym_4171 Ecym_5284 Ecym_5587 Ecym_7309
KLA: KLLA0_A07172g KLLA0_D18535g KLLA0_F11033g KLLA0_F14663g
LTH: KLTH0A02596g KLTH0C08690g KLTH0F08514g KLTH0G05720g
VPO: Kpol_1011p1 Kpol_1030p1 Kpol_1032p18 Kpol_479p29 Kpol_495p15
ZRO: ZYRO0A05566g ZYRO0B05148g ZYRO0C04246g ZYRO0F03960g
CGR: 2886842(HST1) 2887775(GVI51_F05247) 2888908(GVI51_H08129) 2890058(SIR2) 2890629(HST2)
NCS: NCAS_0B03050(NCAS0B03050) NCAS_0C03490(NCAS0C03490) NCAS_0G00840(NCAS0G00840) NCAS_0I02150(NCAS0I02150) NCAS_0J00610(NCAS0J00610)
NDI: NDAI_0A06750(NDAI0A06750) NDAI_0B05490(NDAI0B05490) NDAI_0C06280(NDAI0C06280) NDAI_0F00930(NDAI0F00930) NDAI_0G02830(NDAI0G02830)
TPF: TPHA_0A00880(TPHA0A00880) TPHA_0C00480(TPHA0C00480) TPHA_0L00930(TPHA0L00930) TPHA_0M00390(TPHA0M00390) TPHA_0P00380(TPHA0P00380)
TBL: TBLA_0D02680(TBLA0D02680) TBLA_0E03350(TBLA0E03350) TBLA_0F00920(TBLA0F00920) TBLA_0G03160(TBLA0G03160) TBLA_0H03210(TBLA0H03210) TBLA_0J00780(TBLA0J00780)
TGB: HG536_0A06350 HG536_0B06250 HG536_0C00590 HG536_0G02540
TDL: TDEL_0A04790(TDEL0A04790) TDEL_0C01020(TDEL0C01020) TDEL_0D04710(TDEL0D04710) TDEL_0F05200(TDEL0F05200)
KAF: KAFR_0B01640(KAFR0B01640) KAFR_0B06160(KAFR0B06160) KAFR_0C01100(KAFR0C01100) KAFR_0C05870(KAFR0C05870) KAFR_0F02130(KAFR0F02130)
KNG: KNAG_0A04690(KNAG0A04690) KNAG_0B03220(KNAG0B03220) KNAG_0D02670(KNAG0D02670) KNAG_0K01070(KNAG0K01070) KNAG_0K01800(KNAG0K01800)
ZMK: HG535_0C02860 HG535_0F04420 HG535_0H02010 HG535_0H02360
SLUD: SCDLUD_000703 SCDLUD_005062
DHA: DEHA2E13596g DEHA2E15202g DEHA2F07656g
PIC: PICST_2658(SIR2) PICST_32025(HST2) PICST_40594(SIR3) PICST_49645(HST3)
PGU: PGUG_00838 PGUG_01441 PGUG_03325 PGUG_04958
SPAA: SPAPADRAFT_149340 SPAPADRAFT_50403 SPAPADRAFT_61129 SPAPADRAFT_61518
LEL: PVL30_000121(HST2) PVL30_000453(SIR2) PVL30_004610(HST3)
LBG: 92205823(LODBEIA_P06270) 92206159(LODBEIA_P09630) 92209668(LODBEIA_P44720) 92210874(LODBEIA_P56780)
CAL: CAALFM_C109050WA(HST1) CAALFM_C201330CA(SIR2) CAALFM_C501340WA(HST3) CAALFM_CR01800CA(HST2)
CTP: CTRG_00859 CTRG_01223 CTRG_03242 CTRG_05386
COT: CORT_0A00850 CORT_0A03930 CORT_0E05440
CDU: CD36_08540 CD36_16190(SIR2) CD36_26820 CD36_51000
CTEN: 18247463(HST3) 18247807(SIR2)
CLU: CLUG_01277 CLUG_04582 CLUG_04799
CLUS: A9F13_06g00781 A9F13_11g02090 A9F13_27g00209
CAUR: CJI96_0000754 CJI96_0002733 CJI96_0003019
ASAU: 88172185(PUMCH_001118) 88175074(PUMCH_004011) 88175963(PUMCH_004903)
PPA: PAS_chr1-1_0374 PAS_chr1-4_0315 PAS_chr2-1_0513 PAS_chr4_0474
BNN: FOA43_001692 FOA43_001720 FOA43_002495
BBRX: BRETT_000046 BRETT_004580 BRETT_004786 BRETT_004816
OPA: HPODL_00091 HPODL_00539 HPODL_04088 HPODL_04178
YLI: 2909643(YALI2_B00366g) 2910515(YALI2_D00044g)
NCR: NCU00523(nst-2) NCU03059(nst-3) NCU04737(nst-1)
NTE: NEUTE1DRAFT72738(NEUTE1DRAFT_72738) NEUTE1DRAFT88650(NEUTE1DRAFT_88650) NEUTE1DRAFT92837(NEUTE1DRAFT_92837)
SMP: 10805751(SMAC4_02788) 10810721(SMAC4_03384)
PAN: PODANSg2997 PODANSg4030 PODANSg5918
PBEL: QC761_112140 QC761_115580 QC761_408570(SIR2)
PPSD: QC762_112140 QC762_115580 QC762_408570(SIR2)
PPSP: QC763_112140 QC763_115580 QC763_408570(SIR2)
PPSA: QC764_112140 QC764_115580 QC764_408570(SIR2)
TTT: THITE_35412 THITE_68068 THITE_74295
MTM: MYCTH_106388 MYCTH_10995 MYCTH_99461
CTHR: CTHT_0004190 CTHT_0042890 CTHT_0059870
RTHE: 98123031(VTJ83DRAFT_2149) 98124748(VTJ83DRAFT_3698) 98126693(VTJ83DRAFT_5448)
MGR: MGG_02488 MGG_04588 MGG_17827
PPEI: PpBr36_00291 PpBr36_07079 PpBr36_09601 PpBr36_09971
PGRI: PgNI_04812 PgNI_05640 PgNI_10094 PgNI_10972 PgNI_12399
TMN: UCRPA7_2879 UCRPA7_751 UCRPA7_7604
FPOA: FPOAC1_000480 FPOAC1_012147 FPOAC1_012478
FVN: FVRRES_00629 FVRRES_13222 FVRRES_13566
NHE: NECHADRAFT_103157 NECHADRAFT_104568(SRT2102) NECHADRAFT_33808(SRT2107)
FFC: NCS54_00105000 NCS54_00296200 NCS54_00730600
FKR: NCS57_00103000 NCS57_00291400 NCS57_00770900
FMU: J7337_001077 J7337_003899 J7337_004069
TRE: TRIREDRAFT_120404 TRIREDRAFT_50268 TRIREDRAFT_54330
TRR: M419DRAFT_101213 M419DRAFT_31691 M419DRAFT_96437
TATV: 25776733(TrAtP1_012958) 25777720(TrAtP1_000739) 25785021(TrAtP1_007673)
TASP: 36608900(TrAFT101_007762) 36610812(TrAFT101_009789) 36617933(TrAFT101_001669)
MAW: 19247021(SIR2_1) 19248078(J3458_003025) 19251202(HST2_2)
MAJ: MAA_01056 MAA_02098 MAA_04246
MBRN: 26239666(NPhst1) 26240570(hst4) 26244319(HST21)
PCHM: VFPPC_00359 VFPPC_01595 VFPPC_10002
CMT: CCM_04691 CCM_05249 CCM_05955
AMUS: LMH87_005588 LMH87_009194 LMH87_011200
PLJ: 28886131(PLICBS_007626) 28887240(PLICBS_002502) 28888246(PLICBS_003449)
PTKZ: JDV02_000394(HST2) JDV02_001359 JDV02_004528(SIR2)
VAL: VDBG_08142
CLUP: CLUP02_12416
CHIG: CH63R_07333 CH63R_11748 CH63R_14085
CDET: 87944512(CDEST_08009) 87946497(CDEST_09995) 87947655(CDEST_11155)
ELA: UCREL1_1878 UCREL1_9444
SSL: SS1G_02855 SS1G_06621 SS1G_06667
BFU: BCIN_06g03080(Bchst2) BCIN_11g03810(Bchst4) BCIN_11g04080
MBE: MBM_06261 MBM_09679
ANI: ANIA_01226 ANIA_07461 ANIA_10449
AFM: AFUA_1G10540 AFUA_2G05900 AFUA_3G00520 AFUA_4G12120
ACT: ACLA_024990 ACLA_051130 ACLA_063800 ACLA_068430
NFI: NFIA_001090 NFIA_015110 NFIA_082620 NFIA_104130
AOR: AO090001000709 AO090003000996 AO090005000284 AO090038000370
ANG: An01g07390 An02g14390 An08g02500
AFV: AFLA_000671 AFLA_008853 AFLA_012842
ALUC: AKAW2_11209A AKAW2_20814S(SIR2) AKAW2_20956S(HST2) AKAW2_30747A
ACHE: ACHE_10260S(SIR2) ACHE_30817A ACHE_31250S(HST2) ACHE_80280A
APUU: APUU_50509S APUU_60226A(SIR2) APUU_80586S
PCS: N7525_000026 N7525_005392 N7525_005695 N7525_011039
PDP: PDIP_31420 PDIP_86010 PDIP_87290
POU: POX_a01435 POX_d05605 POX_f07728
TMF: EYB26_001346 EYB26_003111 EYB26_005429
TRG: TRUGW13939_02900 TRUGW13939_03117 TRUGW13939_05546 TRUGW13939_06045
CIM: CIMG_00999 CIMG_01641 CIMG_08957
CPW: 9691080(SIR2) 9691600(HST2) 9692434(D8B26_007374)
URE: UREG_00949 UREG_03407 UREG_05367
ABE: ARB_00428 ARB_03174 ARB_05066
TVE: TRV_01432 TRV_02692 TRV_02961
PBL: PAAG_01016 PAAG_02777 PAAG_02891
PBN: PADG_01806 PADG_01916 PADG_03812
AJE: HCAG_01483 HCAG_03417 HCAG_03662
BGH: BDBG_05426 BDBG_05884 BDBG_06011
PNO: SNOG_06735 SNOG_06917 SNOG_14933
PTE: PTT_15970 PTT_16825 PTT_18697
PTRR: 6338336(PtrM4_026970) 6340265(PtrM4_008610) 6340375(PtrM4_010570)
BZE: COCCADRAFT_100720 COCCADRAFT_22769 COCCADRAFT_40630
BSC: COCSADRAFT_39257 COCSADRAFT_96538 COCSADRAFT_98584
BOR: COCMIDRAFT_109961 COCMIDRAFT_34173 COCMIDRAFT_4479
AALT: CC77DRAFT_1019217 CC77DRAFT_794575 CC77DRAFT_944193
ADAC: 96088009(ACET3X_007687) 96090204(ACET3X_009882) 96090225(ACET3X_009903)
ARAB: EKO05_0001022 EKO05_0001307 EKO05_0001632
ZTR: MYCGRDRAFT_100618 MYCGRDRAFT_54552 MYCGRDRAFT_98741
PFJ: MYCFIDRAFT_155490 MYCFIDRAFT_2219 MYCFIDRAFT_28021
FFU: CLAFUR5_00458 CLAFUR5_01203 CLAFUR5_08807
CBET: CB0940_00430 CB0940_00591 CB0940_10724
BCOM: BAUCODRAFT_54779
NPA: UCRNP2_1183 UCRNP2_1267 UCRNP2_2286
SPO: 2538868(hst2) 2542366(hst4) 3361342(sir2)
SOM: SOMG_00663(sir2) SOMG_00732(hst2) SOMG_02733(hst4)
CNE: CNA03250 CNG04320 CNJ02940
CNB: CNBA3140 CNBG0370 CNBJ0580
CNG: CNAG_00343 CNAG_04866 CNAG_07712
CGI: CGB_B3740C CGB_G0410C CGB_J0520C
CDEU: CNBG_0231 CNBG_2451 CNBG_5794
CDEC: 89989785(IAS62_003012) 89990157(IAS62_003385) 89993387(IAS62_006619)
CTEG: 91989489(I308_102633) 91990902(I308_104046) 91993494(I308_106639)
CBAS: 91982776(I312_102729) 91985186(I312_105141) 91986731(I312_106688)
CDEP: 91087802(L203_103591) 91088718(L203_104508)
KMG: 30161603(I203_107043) 30166156(I203_104039) 30167256(I203_103183)
KNE: 92178972(IAR55_001713) 92181419(IAR55_004161) 92182685(IAR55_005427)
KDJ: 28965341(I303_102218) 28968091(I303_104629) 90830162(I303_107469)
KBI: 30207973(I302_100201) 30209531(I302_106008) 30211544(I302_108479)
KPIN: 30172781(I206_104013) 30173420(I206_106225) 30175224(I206_102052)
KSH: 87953664(IL334_001533) 87955524(IL334_003393) 87959103(IL334_006973)
KER: 91099908(V865_001104) 91100746(V865_001942) 91104365(V865_005564)
TMS: TREMEDRAFT_16281
TASA: A1Q1_00407 A1Q1_06134 A1Q1_06177
CCAC: CcaHIS019_0106130(SIR2) CcaHIS019_0410640(HST2) CcaHIS019_0701020(HST3)
PPL: POSPLDRAFT_23327
DSQ: DICSQDRAFT_164669
PCO: PHACADRAFT_131245 PHACADRAFT_180496
SHS: STEHIDRAFT_104072 STEHIDRAFT_47224
PSQ: PUNSTDRAFT_141389
ADL: AURDEDRAFT_157118 AURDEDRAFT_186606
FME: FOMMEDRAFT_83466 FOMMEDRAFT_97591
GTR: GLOTRDRAFT_67957 GLOTRDRAFT_81523
RSX: RhiXN_08689
LBC: LACBIDRAFT_244575 LACBIDRAFT_245936(SRT16201)
CCI: CC1G_00984 CC1G_08055
ABP: AGABI1DRAFT110720(AGABI1DRAFT_110720) AGABI1DRAFT74670(AGABI1DRAFT_74670)
ABV: AGABI2DRAFT189378(AGABI2DRAFT_189378) AGABI2DRAFT224508(AGABI2DRAFT_224508)
PCUB: JR316_0000601 JR316_0007335
MPR: MPER_12403
MRR: Moror_399 Moror_8451
MORE: E1B28_003996 E1B28_012115
SCM: SCHCO_02528569(SCHCODRAFT_02528569)
CPUT: CONPUDRAFT_96281
SLA: SERLADRAFT_444740
UMA: UMAG_00963 UMAG_05892
SGRA: EX895_006241
PTRC: PtA15_14A261
VNX: VNE69_11068
RIE: OCT59_003147
MBR: MONBRDRAFT_1942
TET: TTHERM_00313730 TTHERM_00526990 TTHERM_01018420 TTHERM_01018450
PTM: GSPATT00035536001
TPS: THAPSDRAFT_35956
TBR: Tb927.7.1690
TBG: TbgDal_VII1700
TCR: 507519.60 508207.150
LMA: LMJF_26_0210(SIR2RP1)
LIF: LINJ_26_0200(SIR2RP1)
LDO: LDBPK_260200
LMI: LMXM_26_0210
LMAT: 92514064(LSCM1_04027)
LBZ: LBRM_26_0210a(SIR2)
LPAN: LPMP_260210(SIR2)
LOI: 92360912(LSCM4_05004)
LEIS: 94180430(GH5_05019)
LENR: 94171006(CUR178_03767)
LEIN: 94188581(JIQ42_04934)
PHET: 94290122(JKF63_04051)
TVA: 4731263(TVAGG3_0970540) 4749079(TVAGG3_0899870) 4772293(TVAGG3_0504690)
GLA: GL50803_0010707 GL50803_0010708
SSAO: 94296993(SS50377_22970)
 » show all
Reference
PMID:12867036
  Authors
Shankaranarayana GD, Motamedi MR, Moazed D, Grewal SI
  Title
Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast.
  Journal
Curr Biol 13:1240-6 (2003)
DOI:10.1016/S0960-9822(03)00489-5
  Sequence
[spo:3361342]
Reference
PMID:16815704
  Authors
Celic I, Masumoto H, Griffith WP, Meluh P, Cotter RJ, Boeke JD, Verreault A
  Title
The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.
  Journal
Curr Biol 16:1280-9 (2006)
DOI:10.1016/j.cub.2006.06.023
  Sequence
[sce:YOR025W YDR191W]
Reference
PMID:15274642
  Authors
Borra MT, Langer MR, Slama JT, Denu JM
  Title
Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.
  Journal
Biochemistry 43:9877-87 (2004)
DOI:10.1021/bi049592e
  Sequence
[sce:YDL042C YPL015C]
LinkDB

DBGET integrated database retrieval system