KEGG ORTHOLOGY: K11412

ORTHOLOGY: K11412

Entry

K11412                      KO

Symbol

SIRT2, SIR2L2

Name

NAD-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]

Pathway

map00760

Nicotinate and nicotinamide metabolism

map01100

Metabolic pathways

Reaction

R10633

R10634

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K11412  SIRT2, SIR2L2; NAD-dependent protein deacetylase sirtuin 2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11412  SIRT2, SIR2L2; NAD-dependent protein deacetylase sirtuin 2
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     K11412  SIRT2, SIR2L2; NAD-dependent protein deacetylase sirtuin 2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     K11412  SIRT2, SIR2L2; NAD-dependent protein deacetylase sirtuin 2

Other DBs

GO:

0034979

Genes

HSA:	22933(SIRT2)

PTR:	456013(SIRT2)

PPS:	100979564(SIRT2)

GGO:	101148685(SIRT2)

PON:	100172430(SIRT2)

NLE:	100599033(SIRT2)

HMH:	116480729(SIRT2)

MCC:	100425019(SIRT2)

MCF:	101865690(SIRT2)

MTHB:

126942052

MNI:	105495391(SIRT2)

CSAB:

103234644(SIRT2)

CATY:

105594379(SIRT2)

PANU:

100997912(SIRT2)

TGE:	112612948(SIRT2)

MLEU:

105534590(SIRT2)

RRO:	104676170(SIRT2)

RBB:	108539022(SIRT2)

TFN:	117092493(SIRT2)

PTEH:

111554047(SIRT2)

CANG:

105519140(SIRT2)

CJC:	100393634(SIRT2)

SBQ:	101028915(SIRT2)

CIMI:

108287872(SIRT2)

CSYR:

103276939(SIRT2)

MMUR:

105876806(SIRT2)

LCAT:

123624356(SIRT2)

PCOQ:

105820493(SIRT2)

OGA:	100942889(SIRT2)

MMU:	64383(Sirt2)

MCAL:

110297295(Sirt2)

MPAH:

110319971(Sirt2)

RNO:	361532(Sirt2)

MCOC:

116101927(Sirt2)

ANU:	117694305(Sirt2)

MUN:	110552523(Sirt2)

CGE:	100768923(Sirt2)

MAUA:

101842575(Sirt2)

PROB:

127238825(Sirt2)

PLEU:

114684686(Sirt2)

MORG:

121449425(Sirt2)

MFOT:

126486713

AAMP:

119820509(Sirt2)

NGI:	103750724(Sirt2)

HGL:	101715152(Sirt2)

CPOC:

100734519(Sirt2)

CCAN:

109695820(Sirt2)

DORD:

105993163(Sirt2)

DSP:	122097405(Sirt2) 122125256

PLOP:

125338827(Sirt2)

NCAR:

124966782

MMMA:

107151484(Sirt2)

OCU:

100337887

OPI:	101521100(SIRT2)

TUP:	102497077(SIRT2)

GVR:	103591465(SIRT2)

CFA:	612558(SIRT2)

CLUD:

112645502(SIRT2)

VVP:	112928407(SIRT2)

VLG:	121479917(SIRT2)

NPO:	129500322(SIRT2)

AML:	100467019(SIRT2)

UMR:

103661014

UAH:	113243599(SIRT2)

UAR:	123784455(SIRT2)

ELK:

111161432

LLV:

125088498

MPUF:

101682580(SIRT2)

MNP:	132004750(SIRT2)

MLK:	131817749(SIRT2)

NVS:	122911648(SIRT2)

ORO:	101386846(SIRT2)

EJU:	114198944(SIRT2)

ZCA:	113936109(SIRT2)

MLX:	118022689(SIRT2)

NSU:	110590085(SIRT2)

LWW:	102731992(SIRT2)

FCA:	101099513(SIRT2)

PYU:	121011488(SIRT2)

PCOO:

112851296(SIRT2)

PBG:	122494082(SIRT2)

PVIV:

125152514(SIRT2)

LRUF:

124511149

PTG:	102948519(SIRT2)

PPAD:

109256621(SIRT2)

PUC:

125915461

AJU:

106988309

HHV:	120244602(SIRT2)

BTA:	504463(SIRT2)

BOM:	102284477(SIRT2)

BIU:	109572599(SIRT2)

BBUB:

102408248(SIRT2)

BBIS:

104995323(SIRT2)

CHX:	102181151(SIRT2)

OAS:	101113169(SIRT2)

BTAX:

128063116(SIRT2)

ODA:	120872410(SIRT2)

CCAD:

122420575(SIRT2)

MBEZ:

129546848(SIRT2)

SSC:	100125964(SIRT2)

CFR:	102522802(SIRT2)

CBAI:

105062824(SIRT2)

CDK:	105093303(SIRT2)

VPC:	102531981(SIRT2)

BACU:

103016517(SIRT2)

BMUS:

118885507(SIRT2)

LVE:	103075387(SIRT2)

OOR:	101280224(SIRT2)

DLE:	111180885(SIRT2)

PCAD:

102995091(SIRT2)

PSIU:

116744134(SIRT2)

NASI:

112415415(SIRT2)

ECB:	100146611(SIRT2)

EPZ:	103564559(SIRT2)

EAI:	106836076(SIRT2)

MYB:	102261472(SIRT2)

MYD:	102769161(SIRT2)

MMYO:

118674329(SIRT2)

MLF:	102417115(SIRT2)

PKL:	118702446(SIRT2)

EFUS:

103284341(SIRT2)

MNA:	107532201(SIRT2)

DRO:	112320128(SIRT2)

SHON:

118976300(SIRT2)

AJM:	119040097(SIRT2)

PDIC:

114511420(SIRT2)

PHAS:

123823838(SIRT2)

MMF:	118639034(SIRT2)

PPAM:

129076654(SIRT2)

HAI:	109395378(SIRT2)

RFQ:	117034493(SIRT2)

PALE:

102882055(SIRT2)

PGIG:

120596235(SIRT2)

PVP:	105300229(SIRT2)

RAY:	107520972(SIRT2)

MJV:	108395443(SIRT2)

TOD:	119249285(SIRT2)

SARA:

101550101(SIRT2)

SETR:

126027630(SIRT2)

LAV:	100660519(SIRT2)

TMU:

101357511

ETF:	101648221(SIRT2)

DNM:	101434208(SIRT2)

MDO:	100013652(SIRT2)

GAS:	123240045(SIRT2)

AFZ:

127556145

PCW:	110202303(SIRT2)

OAA:	103166548(SIRT2)

GGA:	548628(SIRT2)

PCOC:

116237790(SIRT2)

MGP:

100543343

TPAI:

128073343(SIRT2)

LMUT:

125686383(SIRT2)

NMEL:

110389127(SIRT2)

APLA:

119714255(SIRT2)

CATA:

118261466(SIRT2)

AFUL:

116501513(SIRT2)

LSR:	110478778(SIRT2)

PMOA:

120505724(SIRT2)

OTC:	121339782(SIRT2)

PRUF:

121360729(SIRT2)

GFR:

102031922

OMA:	130262769(SIRT2)

PHI:	102100758(SIRT2)

PMAJ:

107199375(SIRT2)

ETL:	114071415(SIRT2)

ZAB:

102074630

SVG:	106864054(SIRT2)

MMEA:

130586518(SIRT2)

ACHC:

115338166(SIRT2)

GCL:

127028225

SHAB:

115603345(SIRT2)

CUCA:

104068697(SIRT2)

AAM:

106491452

ASN:	102385173(SIRT2)

AMJ:	102560050(SIRT2)

PSS:	102444070(SIRT2)

CMY:	102933136(SIRT2)

CCAY:

125628238(SIRT2)

DCC:	119847295(SIRT2)

CPIC:

101948487(SIRT2)

TST:	117888696(SIRT2)

CABI:

116822396(SIRT2)

MRV:	120388878(SIRT2)

ACS:	100559366(sirt2)

ASAO:

132782148(SIRT2)

PVT:	110075685(SIRT2)

SUND:

121915158(SIRT2)

PBI:	103058243(SIRT2)

PMUR:

107297307(SIRT2)

CTIG:

120299851 120299852 120317253

PGUT:

117677731(SIRT2)

APRI:

131204166(SIRT2)

PTEX:

113445924(SIRT2)

NSS:	113425832(SIRT2)

VKO:	123025839(SIRT2)

PMUA:

114603233(SIRT2)

PRAF:

128420266(SIRT2)

ZVI:	118087394(SIRT2)

HCG:	128332639(SIRT2)

GJA:	107121997(SIRT2)

STOW:

125435094(SIRT2)

EMC:	129343526(SIRT2)

XLA:	108708898 495688(sirt2.S)

XTR:	100489469(sirt2)

NPR:	108787683(SIRT2)

RTEM:

120926995(SIRT2)

BBUF:

120994943(SIRT2)

BGAR:

122930296(SIRT2)

MUO:	115480417(SIRT2)

GSH:	117365308(SIRT2)

DRE:	322309(sirt2)

SRX:	107726128 107741523

SANH:

107655297 107677097

SGH:	107567264(sirt2) 107598806

CCAR:

109065797 109075032

CAUA:

113115348(sirt2)

CGIB:

127972550

PTET:

122358881(sirt2)

LROH:

127177163(sirt2)

OMC:	131520553(sirt2)

PPRM:

120464760(sirt2)

RKG:	130076521(sirt2)

MAMB:

125248472(sirt2)

CIDE:

127496270

MASI:

127421796 127429502

TROS:

130564674(sirt2)

TDW:	130428569(sirt2)

MANU:

129437464(sirt2)

IPU:

128628623

IFU:	128623940(sirt2)

PHYP:

113543155(sirt2)

SMEO:

124402970(sirt2)

TFD:	113652853(sirt2)

TVC:	132849783(sirt2)

TRN:	134302343(sirt2)

AMEX:

103038996(sirt2)

CMAO:

118797071(sirt2)

EEE:	113584652(sirt2)

CHAR:

122129064(sirt2) 122130545

TRU:	101073832(sirt2)

TFS:	130534798(sirt2)

LCO:	104939914(sirt2)

TBEN:

117470047(sirt2)

CGOB:

115017284(sirt2)

PGEO:

117457456(sirt2)

GACU:

117535116(sirt2)

EMAC:

134879819(sirt2)

ELY:	117259068(sirt2)

EFO:	125888361(sirt2)

PLEP:

121943160

SLUC:

116038962(sirt2)

ECRA:

117941855(sirt2)

ESP:	116681307(sirt2)

PFLV:

114552360(sirt2)

GAT:	120822485(sirt2)

PPUG:

119218573(sirt2)

AFB:	129090181(sirt2)

CLUM:

117741871(sirt2)

PSWI:

130210546(sirt2)

MSAM:

119883108(sirt2)

SCHU:

122878488(sirt2)

CUD:	121527322(sirt2)

ALAT:

119031806(sirt2)

MZE:	101487109(sirt2)

ONL:	100690476(sirt2)

OAU:	116321646(sirt2)

OLA:	101155450(sirt2)

OML:	112149952(sirt2)

CSAI:

133441573(sirt2)

XMA:	102238400(sirt2)

XCO:	114161611(sirt2)

XHE:	116737346(sirt2)

PRET:

103474864(sirt2)

PFOR:

103155951(sirt2)

PLAI:

106935462(sirt2)

PMEI:

106914198(sirt2)

GAF:	122832242(sirt2)

PPRL:

129359019(sirt2)

CVG:	107100054(sirt2)

CTUL:

119775270(sirt2)

GMU:	124883559(sirt2)

NFU:	107373563(sirt2)

KMR:	108250375(sirt2)

ALIM:

106522134(sirt2)

NWH:	119411135(sirt2)

AOCE:

111566026(sirt2)

MCEP:

125013632(sirt2)

CSEM:

103378255(sirt2)

POV:	109634618(sirt2)

SSEN:

122773885(sirt2)

HHIP:

117772917(sirt2)

HSP:	118106332(sirt2)

PPLT:

128439871(sirt2)

SMAU:

118299053(sirt2)

LCF:

108883126

SDU:	111232857(sirt2)

SLAL:

111654251(sirt2)

XGL:	120792547(sirt2)

HCQ:	109510864(sirt2)

SSCV:

125972001

PEE:	133404875(sirt2)

BPEC:

110153590(sirt2)

MALB:

109952557(sirt2)

BSPL:

114868153(sirt2)

SJO:	128360236(sirt2)

SASA:

100380582(sirt2)

STRU:

115163165(sirt2)

OTW:	112265282(sirt2)

OMY:	110507579(sirt2)

OGO:	123992934(sirt2)

ONE:	115136946(sirt2)

OKI:

109905546

OKE:	118397287(sirt2)

SALP:

111949522(sirt2)

SNH:	120018319(sirt2)

CCLU:

121567114 121567515

ELS:	105026873(sirt2)

SFM:	108928676(sirt2)

PKI:	111844087(sirt2)

AANG:

118210426(sirt2)

LOC:	102686459(sirt2)

PSPA:

121303702(sirt2)

ARUT:

117415113(sirt2)

PSEX:

120533691(sirt2)

LCM:	102353165(SIRT2)

CMK:	103171827(sirt2)

CPLA:

122542769(sirt2)

HOC:	132836609(sirt2)

LERI:

129714123(sirt2)

PMRN:

116947788(SIRT2)

LRJ:	133341367(SIRT2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

110980912 110985960 110988414

AJC:

117105735

SKO:	100377002 102809250

DME:	Dmel_CG5085(Sirt2)

DER:

6553774

DSE:	116802593 6619279

DSI:	Dsimw501_GD19348(Dsim_GD19348)

DYA:	Dyak_GE25662

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10678 Dmoj_GI22229

DAZ:	108609186 108615331

DNV:	108649011 115562442

DHE:	111595979 111598482

DVI:

CCAT:

BOD:

BDR:

RZE:	108366404 108378303

AOQ:

129235917

TDA:	119676357 119681661

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ016710

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

692483(Sirt2)

BMAN:

114246434

MSEX:

115454639

DPL:	KGM_204184

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105390844 105392938 105397146

PGW:

CFEL:

CCRN:

BTAB:

DCI:

CLEC:

HHAL:

106679204 106685690 106690585

NLU:

111044349

HVI:	124353124 124374903

MQU:

128987334

PHU:	Phum_PHUM420680

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_307576

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

119568950 119568951 119589943

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111695049 111710553

LSM:	121119199 121124497

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

LPOL:

NAI:	NECAME_12546

BMY:	BM_BM10453(Bm10453)

LOA:	LOAG_05338

HRO:	HELRODRAFT_114428

LGI:	LOTGIDRAFT_206064

PVUL:

PCAN:

GAE:

HRF:

HRJ:

CRG:	105326889 105342789

CVN:	111111252 111111633

CANU:

128176100 128176374

OED:	125651989 125652644

MYI:	110466350 110466366

PMAX:

117324062 117324064

MCAF:

127699133

RPHI:

132730384 132730394 132730407 132732417 132736648

DPOL:

127874966 127874969

OBI:

106876924

OSN:

115222604

LAK:	106172500 106173633

SMM:	Smp_084140.1

SHX:	MS3_00010467(SIRT2)

OVI:	T265_10265 T265_14142

EGL:

EGR_05039

NVE:	5518876 5520709

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

TAD:	TRIADDRAFT_26227 TRIADDRAFT_26603

AQU:	100641113 100641763 109589498

MNG:	MNEG_2330 MNEG_2628

CVR:	CHLNCDRAFT_31016

OLU:	OSTLU_16771(SRT3501)

OTA:	OT_ostta09g02160

BPG:	Bathy10g02400

MIS:	MICPUN_86067

MPP:	MICPUCDRAFT_15302(JGI:MicpuC2_15302)

CME:	CYME_CML119C

TMS:	TREMEDRAFT_22252

WSE:	WALSEDRAFT_31899

SGRA:

MGL:

MRT:

PTRC:

PSTR:

MLR:	MELLADRAFT_27327

MBR:	MONBRDRAFT_28881

SRE:	PTSG_08102

DDI:	DDB_G0283917(sir2A)

DPP:	DICPUDRAFT_28319

DFA:	DFA_07194(sir2C)

EHI:	EHI_151300(2.t00031)

EDI:	EDI_112570

EIV:	EIN_097040

ACAN:

ACA1_064910 ACA1_329490

SMIN:

v1.2.013706.t1(symbB.v1.2.013706.t1) v1.2.035092.t1(symbB.v1.2.035092.t1)

PTI:	PHATRDRAFT_12305 PHATRDRAFT_16859

FCY:	FRACYDRAFT_140979

TPS:	THAPSDRAFT_264809 THAPS_16405

AAF:	AURANDRAFT_27485

EHX:	EMIHUDRAFT_110864 EMIHUDRAFT_122167 EMIHUDRAFT_450371 EMIHUDRAFT_76502

NGR:	NAEGRDRAFT_60863 NAEGRDRAFT_65800 NAEGRDRAFT_76504 NAEGRDRAFT_81281

TVA:	TVAG_2v0456500 TVAG_2v0773290 TVAG_2v1043820

» show all

Reference

PMID:21949390

Authors

Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michan S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J

Title

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.

Journal

Proc Natl Acad Sci U S A 108:E952-61 (2011)
DOI:10.1073/pnas.1104969108

Sequence

[hsa:22933] [mmu:64383] [rno:361532]

Reference

PMID:12620231

Authors

North BJ, Marshall BL, Borra MT, Denu JM, Verdin E

Title

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

Journal

Mol Cell 11:437-44 (2003)
DOI:10.1016/S1097-2765(03)00038-8

Sequence

[hsa:22933]

LinkDB

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