KEGG ORTHOLOGY: K11413

ORTHOLOGY: K11413

Entry

K11413                      KO

Symbol

SIRT3, SIR2L3

Name

NAD-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]

Pathway

map00760

Nicotinate and nicotinamide metabolism

map01100

Metabolic pathways

map05230

Central carbon metabolism in cancer

Reaction

R10633

R10634

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3
09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     K11413  SIRT3, SIR2L3; NAD-dependent protein deacetylase sirtuin 3

Other DBs

GO:

0034979

Genes

HSA:	23410(SIRT3)

PTR:	450911(SIRT3)

PPS:	100973326(SIRT3)

GGO:	101126809(SIRT3)

PON:	100453970(SIRT3)

PPYG:

129007159(SIRT3)

NLE:	100604320(SIRT3)

HMH:	116466558(SIRT3)

SSYN:

129471045(SIRT3)

MCC:	720737(SIRT3)

MCF:	102142238(SIRT3)

MTHB:

126936316

MNI:	105494169(SIRT3)

CSAB:

103234991(SIRT3)

CATY:

105577180(SIRT3)

PANU:

100997286(SIRT3)

TGE:	112606036(SIRT3)

MLEU:

105530799(SIRT3)

RRO:	104672643(SIRT3)

RBB:	108538000(SIRT3)

TFN:	117081578(SIRT3)

PTEH:

111520566(SIRT3)

CANG:

105503183(SIRT3)

CJC:	100386098(SIRT3)

SBQ:	101050089(SIRT3)

CIMI:

108298293(SIRT3)

ANAN:

105719837(SIRT3)

CSYR:

103254939

MMUR:

105874078(SIRT3)

LCAT:

123642989(SIRT3)

PCOQ:

105816543(SIRT3)

OGA:	100962343(SIRT3)

MMU:	64384(Sirt3)

MCAL:

110297529(Sirt3)

MPAH:

110334277(Sirt3)

RNO:	293615(Sirt3)

MCOC:

116103195(Sirt3)

ANU:	117709494(Sirt3)

MUN:	110553899(Sirt3)

CGE:	100762304(Sirt3)

MAUA:

101841665(Sirt3)

PROB:

127228513(Sirt3)

PLEU:

114693438(Sirt3)

MORG:

121458149(Sirt3)

MFOT:

126498264

AAMP:

119808247(Sirt3)

NGI:	103751056(Sirt3)

HGL:	101697494(Sirt3)

CPOC:

100714713(Sirt3)

CCAN:

109691498(Sirt3)

DORD:

105998614(Sirt3)

DSP:	122095019(Sirt3)

PLOP:

125362242(Sirt3)

NCAR:

124958475

MMMA:

107156918(Sirt3)

OPI:	101536062(SIRT3)

TUP:	102502361(SIRT3)

GVR:	103602147(SIRT3)

CFA:	475933(SIRT3)

CLUD:

112663554(SIRT3)

VVP:	112914416(SIRT3)

VLG:	121501456(SIRT3)

NPO:	129494303(SIRT3)

AML:	100468963(SIRT3)

UMR:	103671025(SIRT3)

UAH:	113248769(SIRT3)

UAR:	123775543(SIRT3)

ELK:

111149798

LLV:

125079297

MPUF:

101672731(SIRT3)

MNP:	132016241(SIRT3)

MLK:	131818537(SIRT3)

NVS:	122913205(SIRT3)

ORO:	101370518(SIRT3)

EJU:	114201523(SIRT3)

ZCA:	113914000(SIRT3)

MLX:	118016233(SIRT3)

NSU:	110582210(SIRT3)

LWW:	102739910(SIRT3)

FCA:	101087609(SIRT3)

PYU:	121022774(SIRT3)

PCOO:

112852121(SIRT3)

PBG:	122484196(SIRT3)

PVIV:

125176267(SIRT3)

LRUF:

124527515

PTG:	102948876(SIRT3)

PPAD:

109259795(SIRT3)

PUC:

125937742

AJU:

106987944

HHV:	120223429(SIRT3)

BTA:	614027(SIRT3)

BOM:	102274743(SIRT3)

BBUB:

102403716(SIRT3)

BBIS:

104983503(SIRT3)

CHX:	102181661(SIRT3)

OAS:	101105454(SIRT3)

BTAX:

128068683(SIRT3)

ODA:	120874226(SIRT3)

CCAD:

122430539(SIRT3)

MBEZ:

129548581(SIRT3)

SSC:	100125971(SIRT3)

CFR:	102512075(SIRT3)

CBAI:

105064452(SIRT3)

CDK:	105105732(SIRT3)

VPC:	102539977(SIRT3)

BACU:

103011694(SIRT3)

BMUS:

118900219(SIRT3)

LVE:	103073899(SIRT3)

OOR:	101288599(SIRT3)

DLE:	111170308(SIRT3)

PCAD:

102992890

PSIU:

116757516(SIRT3)

NASI:

112392078

ECB:	100054908(SIRT3)

EPZ:	103539966(SIRT3)

EAI:	106843865(SIRT3)

MYB:	102252773(SIRT3)

MMYO:

118648968(SIRT3)

MDT:	132241594(SIRT3)

PKL:	118713658(SIRT3)

EFUS:

114229034(SIRT3)

MNA:	107544448(SIRT3)

DRO:	112317110(SIRT3)

SHON:

118974905(SIRT3)

AJM:	119060969(SIRT3)

PDIC:

114500668(SIRT3)

PHAS:

123807298(SIRT3)

MMF:	118643122(SIRT3)

PPAM:

129073147(SIRT3)

HAI:	109378085(SIRT3)

RFQ:	117030090(SIRT3)

PALE:

102887102(SIRT3)

PGIG:

120614163(SIRT3)

PVP:	105309811(SIRT3)

RAY:	107506500(SIRT3)

MJV:	108384848(SIRT3)

SARA:

101551453(SIRT3)

SETR:

126019039(SIRT3)

LAV:	100654664(SIRT3)

TMU:

101348992

ETF:	101642648(SIRT3)

DNM:	101418583(SIRT3)

MDO:	100030763(SIRT3)

GAS:	123251135(SIRT3)

SHR:	100924073(SIRT3)

AFZ:

127541155

PCW:	110203709(SIRT3)

TVP:	118855396(SIRT3)

OAA:	100089118(SIRT3)

GGA:	422988(SIRT3)

PCOC:

116237927(SIRT3)

MGP:	100538676(SIRT3)

CJO:	107314282(SIRT3)

TPAI:

128085622(SIRT3)

LMUT:

125694907(SIRT3)

NMEL:

110401506(SIRT3)

APLA:

101794570(SIRT3)

ACYG:

106047042(SIRT3)

CATA:

118244236(SIRT3)

AFUL:

116489366(SIRT3)

TGU:	100225810(SIRT3)

LSR:	110467555(SIRT3)

SCAN:

103826814(SIRT3)

PMOA:

120500988(SIRT3)

OTC:	121334796(SIRT3)

PRUF:

121352278(SIRT3)

GFR:	102035189(SIRT3)

FAB:	101821658(SIRT3)

OMA:	130253958(SIRT3)

PHI:	102106576(SIRT3)

PMAJ:

107205276(SIRT3)

CCAE:

111930585(SIRT3)

CCW:	104684530(SIRT3)

CBRC:

103614562(SIRT3)

ETL:	114063308(SIRT3)

ZAB:	102067392(SIRT3)

ZLE:	135449065(SIRT3)

ACHL:

103799582(SIRT3)

SVG:	106854803(SIRT3)

MMEA:

130581626(SIRT3)

HRT:	120753941(SIRT3)

SATI:

136362244(SIRT3)

FPG:	101914765(SIRT3)

FCH:	102049786(SIRT3)

CCRI:

104156542(SIRT3)

NNT:	104406670(SIRT3)

SHAB:

115607579(SIRT3)

ACUN:

113481210(SIRT3)

TALA:

104365567(SIRT3)

ACHC:

115351893(SIRT3)

HALD:

104313998(SIRT3)

HLE:	104832070(SIRT3)

AGEN:

126047546

GCL:

127016599

LDI:	104345363(SIRT3)

MNB:	103780638(SIRT3)

DPUB:

104297529(SIRT3)

AVIT:

104281120(SIRT3)

BRHI:

104499785(SIRT3)

EGZ:	104127879(SIRT3)

NNI:	104011402(SIRT3)

PCRI:

104035100(SIRT3)

PCAO:

104047924(SIRT3)

PADL:

103925062(SIRT3)

AFOR:

103906283(SIRT3)

FGA:	104071129(SIRT3)

GSTE:

104252105(SIRT3)

CLV:	102089394(SIRT3)

MUI:

104534860

PGUU:

104459668(SIRT3)

PLET:

104617382(SIRT3)

CMAC:

104478032(SIRT3)

CUCA:

104057244(SIRT3)

TEO:	104377873(SIRT3)

BREG:

104632830(SIRT3)

OHA:	104333129(SIRT3)

ACAR:

104524771(SIRT3)

CPEA:

104392097(SIRT3)

CVF:	104282470(SIRT3)

RTD:	128908406(SIRT3)

AAM:	106489140(SIRT3)

AROW:

112973758(SIRT3)

NPD:	112948055(SIRT3)

TGT:	104574670(SIRT3)

DNE:	112993819(SIRT3)

SCAM:

104149781(SIRT3)

ASN:	102384882(SIRT3)

AMJ:	102562277(SIRT3)

CPOO:

109318161(SIRT3)

GGN:	109299263(SIRT3)

PSS:	102457485(SIRT3)

CMY:	102935907(SIRT3)

CCAY:

125638240(SIRT3)

DCC:	119858071(SIRT3)

CPIC:

101933048(SIRT3)

TST:	117877399(SIRT3)

CABI:

116836380(SIRT3)

MRV:	120404419(SIRT3)

ACS:	100555836(sirt3)

ASAO:

132771851(SIRT3)

PVT:	110086196(SIRT3)

SUND:

121935192(SIRT3)

PBI:	103067152(SIRT3)

PMUR:

107294462(SIRT3) 107300980

CTIG:

120312461(SIRT3)

TSR:	106547596(SIRT3)

PGUT:

117667005(SIRT3)

APRI:

131184523(SIRT3)

PTEX:

113440348(SIRT3)

VKO:	123021329(SIRT3)

PMUA:

114600420(SIRT3)

PRAF:

128417515(SIRT3)

ZVI:	118088914(SIRT3)

HCG:	128337799(SIRT3)

GJA:	107112732(SIRT3)

STOW:

125427235(SIRT3)

EMC:	129325109(SIRT3)

XLA:	108715195(sirt3.1.S) 734623(sirt3.2.L)

XTR:	100145681(sirt3.2) 100487410(sirt3.1)

NPR:	108787963 108795891

RTEM:

120917267(SIRT3) 120932667

BBUF:

120980349(SIRT3) 121007545

BGAR:

122920369(SIRT3) 122926538

MUO:	115468983(SIRT3)

DRE:	557125(si:dkey-103i16.6) 558775(sirt3)

SRX:	107712611 107730173 107749280

SANH:

107663051 107664689 107672161

SGH:	107553976 107561440 107600351

CCAR:

109082995

CAUA:

113106362(sirt3) 113118268

CGIB:

127961116 127977187(si:dkey-103i16.6)

PTET:

122348020(sirt3) 122362709(si:dkey-103i16.6)

LROH:

127168943(sirt3) 127181158(si:dkey-103i16.6)

OMC:	131524054(si:dkey-103i16.6) 131544508(sirt3)

PPRM:

120462016(si:dkey-103i16.6) 120492756(sirt3)

RKG:	130094786(si:dkey-103i16.6) 130100339(sirt3)

MAMB:

125253836(si:dkey-103i16.6) 125265819(sirt3)

CIDE:

127499947(si:dkey-103i16.6) 127516672

CERY:

137023300(si:dkey-103i16.6) 137030103(sirt3)

MASI:

127411845 127417378

TROS:

130555068(sirt3) 130563226(si:dkey-103i16.6)

TDW:	130428573(sirt3) 130435502(si:dkey-103i16.6)

MANU:

129418874(si:dkey-103i16.6) 129451653(sirt3)

IPU:	108264662(si:dkey-103i16.6) 108270931

IFU:	128606613(si:dkey-103i16.6) 128613761(sirt3)

PHYP:

113534831 113536463(sirt3)

SMEO:

124391500(sirt3) 124395567(si:dkey-103i16.6)

TFD:	113646657(sirt3) 113652438(si:dkey-103i16.6)

TVC:	132842631(sirt3) 132851358(si:dkey-103i16.6)

TRN:	134323287(si:dkey-103i16.6) 134331242(sirt3)

AMEX:

103043515(si:dkey-103i16.6) 103044645(sirt3)

CMAO:

118817950(si:dkey-103i16.6) 118819368(sirt3)

EEE:	113578364(sirt3) 113589963

CHAR:

105892937(sirt3) 105911299(si:dkey-103i16.6)

TRU:	101066119 101067563(sirt3)

TFS:	130518814(sirt3) 130536027(si:dkey-103i16.6)

TNG:	GSTEN00022785G001

LCO:	104936507 104937696

NCC:	104948251 104965729(sirt3)

TBEN:

117471565(sirt3) 117491502(si:dkey-103i16.6)

CGOB:

115009559 115027046(sirt3)

PGEO:

117447905(si:dkey-103i16.6) 117463578(sirt3)

GACU:

117533645(sirt3) 117545689(si:dkey-103i16.6)

EMAC:

134860268(si:dkey-103i16.6) 134863312(sirt3)

ELY:	117259276(sirt3) 117261914(si:dkey-103i16.6)

EFO:	125881086(sirt3) 125887348(si:dkey-103i16.6)

PLEP:

121937964 121950324(si:dkey-103i16.6)

SLUC:

116062566(si:dkey-103i16.6) 116067290(sirt3)

ECRA:

117941237(sirt3) 117949565(si:dkey-103i16.6)

ESP:	116687214(sirt3) 116693552

PFLV:

114557257(sirt3) 114560259

GAT:	120809870 120812723 120814993(sirt3)

PPUG:

119195804(si:dkey-103i16.6) 119224969(sirt3)

AFB:	129106454(sirt3) 129108022(si:dkey-103i16.6)

CLUM:

117728693(sirt3) 117732709(si:dkey-103i16.6)

PSWI:

130193032(sirt3) 130195004(si:dkey-103i16.6)

MSAM:

119890223(sirt3) 119894261(si:dkey-103i16.6)

SCHU:

122875128(si:dkey-103i16.6) 122877377(sirt3)

CUD:	121510582(sirt3) 121514920(si:dkey-103i16.6)

ALAT:

119017919(sirt3) 119024364(si:dkey-103i16.6)

ASTR:

137593689(sirt3) 137593927(si:dkey-103i16.6)

MZE:	101471570 101474545(sirt3)

ONL:	100692411 100693812(sirt3)

OAU:	116318280(si:dkey-103i16.6) 116334284(sirt3)

OLA:	101161471(sirt3) 101165477

OML:	112141986(sirt3) 112152513(si:dkey-103i16.6)

CSAI:

133419708(sirt3) 133444776(si:dkey-103i16.6)

XMA:	102221405(sirt3) 102237357

XCO:	114143546(sirt3) 114156786

XHE:	116719278(sirt3)

PRET:

103463032(sirt3) 103466083

PFOR:

103133698 103155218(sirt3)

PLAI:

106949361(sirt3) 106950932

PMEI:

106909191(sirt3) 106916066

GAF:	122824620(sirt3) 122835474(si:dkey-103i16.6)

PPRL:

129356384 129356655 129363849(si:dkey-103i16.6)

CVG:	107082761(sirt3) 107104162

CTUL:

119780599(sirt3) 119793041(si:dkey-103i16.6)

GMU:	124866511(sirt3) 124882421(si:dkey-103i16.6)

NFU:	107382055(sirt3) 107388944

KMR:	108239958(si:dkey-103i16.6) 108249846(sirt3)

ALIM:

106513124(sirt3) 106515597

NWH:	119415654(si:dkey-103i16.6)

AOCE:

111582551(sirt3) 111586640

MCEP:

125005433(sirt3) 125014902

CSEM:

103378865(sirt3) 103380163

POV:	109624168 109646116(sirt3)

SSEN:

122772393(sirt3) 122775915(si:dkey-103i16.6)

HHIP:

117759158(sirt3) 117762865(si:dkey-103i16.6)

HSP:	118108308(sirt3) 118109674(si:dkey-103i16.6)

PPLT:

128437907(sirt3) 128444225(si:dkey-103i16.6)

SMAU:

118315567(si:dkey-103i16.6)

LCF:	108875294(si:dkey-103i16.6) 108894168

SDU:	111223343(sirt3) 111228405

SLAL:

111656651(sirt3) 111661779

XGL:	120790500(sirt3) 120793035(si:dkey-103i16.6)

HCQ:	109514431(sirt3) 109531260

SSCV:

125967092 125970395(si:dkey-103i16.6)

SBIA:

133498653(sirt3) 133501788(si:dkey-103i16.6)

PEE:	133395600(sirt3) 133403318(si:dkey-103i16.6)

PTAO:

133473350(sirt3) 133478337(si:dkey-103i16.6)

BPEC:

110163823 110164021(sirt3)

MALB:

109966902 109971564(sirt3)

BSPL:

114851854(sirt3) 114857005(si:dkey-103i16.6)

SJO:	128354968(sirt3) 128358697(si:dkey-103i16.6)

SASA:

106561415 106587827 106592787(SIRT3)

STRU:

115166719 115197379 115203601

OTW:	112218731(si:dkey-103i16.6) 112240896(sirt3)

OMY:	110497810(si:dkey-103i16.6) 110526845 110526847

OGO:	124019858 124019886 124023653 124035008(si:dkey-103i16.6)

ONE:	115116328 115134104

OKI:	109867695 109877165 116371138

OKE:	118380616(sirt3) 118395807(si:dkey-103i16.6)

SALP:

111962500(sirt3)

SNH:	120037906 120037907 120066412(si:dkey-103i16.6)

CCLU:

121532261(si:dkey-103i16.6) 121583051(sirt3)

ELS:	105007371(sirt3) 105022153

SFM:	108935931 108942368(sirt3)

PKI:	111838705 111859490(sirt3)

AANG:

118215292(sirt3) 118219001(si:dkey-103i16.6)

LOC:	102692048(sirt3) 102694551

PSPA:

121319693(si:dkey-103i16.6) 121329928

ARUT:

117415213 117432270 117434777

PSEX:

120516448 120534221(si:dkey-103i16.6)

LCM:	102363985(SIRT3) 102364335

CMK:	103179899(si:dkey-103i16.6)

RTP:	109928812(sirt3)

CPLA:

122557755

HOC:	132824455(sirt3)

LERI:

129705537

PMRN:

116940004(SIRT3)

LRJ:

133350224

BFO:

118413992

BBEL:

109465588

CIN:	494364(sir2-a)

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

HVI:

MQU:

ZNE:

CSEC:

SGRE:

IEL:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

HAZT:

EAF:

TCF:

LPOL:

TSP:

OBI:

OSN:

LJP:

LAK:

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

RES:

TAD:	TRIADDRAFT_19190 TRIADDRAFT_52084

AQU:

100638465

EHX:	EMIHUDRAFT_65804 EMIHUDRAFT_77385

» show all

Reference

PMID:18794531

Authors

Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T

Title

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.

Journal

Proc Natl Acad Sci U S A 105:14447-52 (2008)
DOI:10.1073/pnas.0803790105

Sequence

[hsa:23410] [mmu:64384]

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