Entry
Name
cyclic dehypoxanthinyl futalosine synthase;
MqnC;
dehypoxanthinyl futalosine cyclase
Class
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
dehypoxanthine futalosine:S-adenosyl-L-methionine oxidoreductase (cyclizing)
Reaction(IUBMB)
dehypoxanthine futalosine + S-adenosyl-L-methionine = cyclic dehypoxanthinyl futalosine + 5'-deoxyadenosine + L-methionine [RN:
R08588 ]
Reaction(KEGG)
Substrate
dehypoxanthine futalosine [CPD:
C17010 ];
S-adenosyl-L-methionine [CPD:
C00019 ]
Product
cyclic dehypoxanthinyl futalosine;
5'-deoxyadenosine [CPD:
C05198 ];
L-methionine [CPD:
C00073 ]
Comment
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
History
EC 1.21.98.1 created 2014 as EC 1.21.99.2, transferred 2014 to EC 1.21.98.1
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K11784 cyclic dehypoxanthinyl futalosine synthase
Genes
CJV : MTVDSCj20_0435(mqnC)
CFV : CFVI03293_0948(mqnC)
CAMP : CFT03427_0795(mqnC)
CCOC : CCON33237_0611(mqnC)
CLR : UPTC16701_0697(mqnC)
CLM : UPTC16712_0699(mqnC)
CCOO : ATE51_03290(mqnE_2)
CAMR : CAQ16704_1170(mqnC)
CHV : CHELV3228_0571(mqnC)
CPIN : CPIN18020_0716(mqnC)
CAMZ : CVIC12175_0647(mqnC)
GEC : GEO60473_33140(mqnC)
GBN : GEOBRER4_02300(mqnC-1)
DVE : DESUT3_01700(mqnC-1)
PPOR : JCM14722_28650(mqnC)
BKW : BkAM31D_18575(mqnE_1)
BCOP : JD108_15885(mqnC) JD108_16415(mqnC)
BAYD : BSPP4475_14860(mqnC)
BRUM : NDK47_14155(mqnC) NDK47_19440(mqnC)
PPQ : PPSQR21_015390(thiH)
PCHI : PC41400_07165(mqnC)
PNK : AASFL403_12520(mqnC)
PKP : SK3146_05305(mqnE_1)
COHN : KCTCHS21_16170(mqnC)
MANA : MAMMFC1_02997(mqnE_2)
SALS : SLNWT_0693 SLNWT_2685
SAMB : SAM23877_4373(mqnC)
SLE : sle_30800(sle_30800)
SGM : GCM10017557_48280(mqnC)
SBRO : GQF42_25490(mqnC) GQF42_32260(mqnC)
STUI : GCM10017668_41300(mqnC)
SAUH : SU9_015200(mqnC) SU9_033105(mqnC)
SANU : K7396_19825(mqnC) K7396_33660(mqnC)
SGOB : test1122_15430(mqnC)
SXT : KPP03845_104391(mqnC_1) KPP03845_105702(mqnC_2)
SOV : QZH56_15330(mqnC) QZH56_19700(mqnC)
STRI : C7M71_017895(mqnC) C7M71_025775(mqnC)
MSAG : GCM10017556_29550(mqnC)
ACTR : Asp14428_43670 Asp14428_43680
DVC : Dvina_00870(mqnC) Dvina_31250(mqnC)
DFU : Dfulv_00985(mqnC) Dfulv_29050(mqnC)
DAUR : Daura_00940(mqnC) Daura_29865(mqnC)
DMAT : Dmats_00915(mqnC) Dmats_26285(mqnC)
DEIN : DAAJ005_10050(mqnC)
CSUI : Chls_169(Cyclic_dehypoxanthine_futalosine_synthase)
RML : FF011L_03920(mqnE_1)
MFF : MFFC18_36010(mqnE_2)
RCF : Poly24_43290(mqnE_2)
LCRE : Pla8534_56090(mqnE_2)
AAGG : ETAA8_60550(mqnE_2)
SMAM : Mal15_11980(mqnE_1)
SNEP : Enr13x_60230(mqnE_2)
AMUC : Pan181_26780(mqnE_2)
PND : Pla175_20840(mqnE_2)
AMOB : HG15A2_28400(mqnE_1)
BMEI : Spa11_27990(mqnE_1)
GPN : Pan110_05300(mqnE_1)
GFM : Enr17x_06410(mqnE_1)
GAZ : Pan241w_05330(mqnE_1)
GAX : Pan161_30040(mqnE_1)
SDYN : Mal52_11520(mqnE_1)
PLON : Pla110_04270(mqnE_1)
SVP : Pan189_39620(mqnE_1)
TPOL : Mal48_38790(mqnE_2)
CCOS : Pan44_36580(mqnE_1)
CCOP : Mal65_39680(mqnE_1)
MCAD : Pan265_21350(mqnE_2)
PBAP : Pla133_33900(mqnE_1)
ACM : AciX9_0902 AciX9_1851
GRW : FTO74_03185 FTO74_05260
TGI : RBB81_19540 RBB81_22420
TEMP : RBB75_01125 RBB75_12825
TPSC : RBB77_07760 RBB77_10250
PSPC : Strain318_001478(mqnC)
ACOU : A5CBH24_05510(mqnC-1)
MGOT : MgSA37_02114(mqnE_1)
TVO : TVG1452246(TVG1452246)
» show all
Taxonomy
Reference
Authors
Hiratsuka T, Furihata K, Ishikawa J, Yamashita H, Itoh N, Seto H, Dairi T
Title
An alternative menaquinone biosynthetic pathway operating in microorganisms.
Journal
Sequence
Reference
Authors
Cooper LE, Fedoseyenko D, Abdelwahed SH, Kim SH, Dairi T, Begley TP
Title
In vitro reconstitution of the radical S-adenosylmethionine enzyme MqnC involved in the biosynthesis of futalosine-derived menaquinone.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.21.98.1
LinkDB
All DBs