KEGG ORTHOLOGY: K11994

ORTHOLOGY: K11994

Entry

K11994                      KO

Symbol

DNASE1

Name

deoxyribonuclease-1 [EC:3.1.21.1]

Disease

H00080

Systemic lupus erythematosus

Brite

KEGG Orthology (KO) [BR:ko00001]
09190 Not Included in Pathway or Brite
  09191 Unclassified: metabolism
   99980 Enzymes with EC numbers
    K11994  DNASE1; deoxyribonuclease-1
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.21  Endodeoxyribonucleases producing 5'-phosphomonoesters
    3.1.21.1  deoxyribonuclease I
     K11994  DNASE1; deoxyribonuclease-1

Other DBs

GO:

0004530

Genes

HSA:	1773(DNASE1)

PTR:	453867(DNASE1)

PPS:	100973052(DNASE1)

GGO:	101143572(DNASE1)

PON:	100447376(DNASE1)

PPYG:

129016352(DNASE1)

NLE:	100596660(DNASE1)

HMH:	116462755(DNASE1)

SSYN:

129462452(DNASE1)

MCC:	704119(DNASE1)

MCF:	102133646(DNASE1)

MTHB:

126944709

MNI:	105467855(DNASE1)

CSAB:

103227555(DNASE1)

CATY:

105572091(DNASE1)

PANU:

101001882(DNASE1)

TGE:	112613768(DNASE1)

MLEU:

105541510(DNASE1)

RRO:	104672290(DNASE1)

RBB:	108538303(DNASE1)

TFN:	117097728(DNASE1)

PTEH:

111551661(DNASE1)

CANG:

105517601(DNASE1)

CJC:	100390788(DNASE1)

SBQ:	101050756(DNASE1)

CIMI:

108286566(DNASE1)

ANAN:

105709763(DNASE1)

CSYR:

103273677(DNASE1)

MMUR:

105859714(DNASE1)

LCAT:

123632316(DNASE1)

PCOQ:

105813108(DNASE1)

OGA:	100942827(DNASE1)

MMU:	13419(Dnase1)

MCAL:

110311419(Dnase1)

MPAH:

110329523(Dnase1)

RNO:	25633(Dnase1)

MCOC:

116084164(Dnase1)

ANU:	117710696(Dnase1)

MUN:	110545965(Dnase1)

CGE:	100764185(Dnase1)

MAUA:

101841834(Dnase1)

PROB:

127219615(Dnase1)

PLEU:

114710611(Dnase1)

MORG:

121464019(Dnase1)

MFOT:

126493660

AAMP:

119812628(Dnase1)

NGI:	103744421(Dnase1)

HGL:	101713435(Dnase1)

CPOC:

100718441(Dnase1)

CCAN:

109681685(Dnase1)

DORD:

105982114(Dnase1)

DSP:	122123756(Dnase1)

PLOP:

125341199(Dnase1)

NCAR:

124970289

MMMA:

107146667(Dnase1)

ITI:	101974802(Dnase1)

OCU:	100009513(DNASE1)

OPI:	101516837(DNASE1)

TUP:	102478050(DNASE1)

GVR:	103595034(DNASE1)

CFA:	403413(DNASE1)

CLUD:

112640449(DNASE1)

VVP:	112923263(DNASE1)

VLG:	121486667(DNASE1)

NPO:	129519298(DNASE1)

AML:	100476244(DNASE1)

UMR:	103668546(DNASE1)

UAH:	113270861(DNASE1)

UAR:	123783345(DNASE1)

ELK:

111156151

LLV:

125091010

MPUF:

101681897(DNASE1)

MNP:	132026958(DNASE1)

MLK:	131819746(DNASE1)

NVS:	122895906(DNASE1)

ORO:	101363331(DNASE1)

EJU:	114219918(DNASE1)

ZCA:	113933714(DNASE1)

MLX:	118021767(DNASE1)

NSU:	110587818(DNASE1)

LWW:	102747714(DNASE1)

FCA:	101096195(DNASE1)

PYU:	121019605(DNASE1)

PCOO:

112853278(DNASE1)

PBG:	122471740(DNASE1)

PVIV:

125154016(DNASE1)

LRUF:

124517808

LGF:	123589390(DNASE1)

AJU:

106978802

PTG:	102957825(DNASE1)

PPAD:

109278244(DNASE1)

PUC:

125927246

PLEZ:

122209582(DNASE1)

HHV:	120236466(DNASE1)

BTA:	282217(DNASE1)

BOM:	102285085(DNASE1)

BIU:	109578432(DNASE1)

BBUB:

102403103(DNASE1)

BBIS:

104988908(DNASE1)

CHX:	102183198(DNASE1)

OAS:	101122154(DNASE1)

BTAX:

128070309(DNASE1)

CSUM:

138075318(DNASE1)

ODA:	120874309(DNASE1)

CCAD:

122432741(DNASE1)

MREE:

136160487(DNASE1)

OVR:	110151856(DNASE1)

MBEZ:

129545324(DNASE1)

SSC:	397051(DNASE1)

CFR:	102505777(DNASE1)

CBAI:

105064901(DNASE1)

CDK:	105099830(DNASE1)

VPC:	102534897(DNASE1)

BACU:

103017369(DNASE1)

BMUS:

118881885(DNASE1)

LVE:	103071650(DNASE1)

OOR:	101282720(DNASE1)

LALB:

132506152(DNASE1)

DLE:	111185247(DNASE1)

PCAD:

102990919(DNASE1)

PSIU:

116739988(DNASE1)

NASI:

112409339(DNASE1)

ECB:	100034219(DNASE1)

EPZ:	103553016(DNASE1)

EAI:	106826048(DNASE1)

MYB:	102258251(DNASE1)

MYD:	102759269(DNASE1)

MMYO:

118656437(DNASE1)

MLF:	102422781(DNASE1)

MDT:	132233021(DNASE1)

MYUM:

139009111(DNASE1)

PKL:	118703172(DNASE1)

EFUS:

103286159(DNASE1)

MNA:	107535785(DNASE1)

DRO:	112298355(DNASE1)

SHON:

118975820(DNASE1)

AJM:	119056237(DNASE1)

PDIC:

114495525(DNASE1)

PHAS:

123807142(DNASE1)

MMF:	118642561(DNASE1)

PPAM:

129083383(DNASE1)

HAI:	109392139(DNASE1)

RFQ:	117019540(DNASE1)

PALE:

102886418(DNASE1)

PGIG:

120620327(DNASE1)

PVP:	105303099(DNASE1)

RAY:	107521669(DNASE1)

MJV:	108406385(DNASE1)

TOD:	119241986(DNASE1)

SARA:

101558487(DNASE1)

SFUM:

130042808(DNASE1)

SETR:

126001279(DNASE1)

LAV:	100664011(DNASE1)

TMU:

101343582

ETF:	101661410(DNASE1)

DNM:	101444854(DNASE1)

MDO:	100013962(DNASE1)

GAS:	123231704(DNASE1)

SHR:	100926547(DNASE1)

AFZ:

127542202

PCW:	110214547(DNASE1)

TVP:	118831689(DNASE1)

PBRV:

138175979(DNASE1)

OAA:	114809016(DNASE1)

TACU:

119942387(DNASE1)

GGA:	395725(DNASE1)

CJO:

TPAI:

LMUT:

NMEL:

APLA:

CATA:

AFUL:

TGU:

LSR:

PMOA:

PRUF:

ATRC:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

ETL:

ZAB:

ZLE:

ACHL:

103807409(DNASE1L2)

SVG:

MMEA:

HRT:

SATI:

CCIC:

FPG:

FCH:

CCRI:

104154626(DNASE1)

NNT:

SHAB:

TALA:

HALD:

HHAR:

GCL:

LDI:

MNB:	103777371(DNASE1)

DPUB:

104300277(DNASE1)

PPUS:

135180725

BRHI:

104495639

PCRI:

104023951(DNASE1L2)

PCAO:

104047721

PADL:

103917536(DNASE1)

AFOR:

103898386

FGA:	104074575(DNASE1)

GSTE:

CBOY:

CLV:

PLET:

EHS:

CMAC:

BREG:

104634990(DNASE1)

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

AROW:

NPD:

TGT:

DNE:

ASN:	102381685(DNASE1)

AMJ:	102567153(DNASE1)

PSS:

102449226

CMY:

102946716

CCAY:

125644177

DCC:	119862615(DNASE1)

CPIC:

TST:

CABI:

MRV:

ACS:	100560207(dnase1) 100562917

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

PMUA:

114584918(DNASE1)

PRAF:

128402057(DNASE1)

ZVI:	118093246(DNASE1)

HCG:

128336640

GJA:

107109287

STOW:

125430625

EMC:	129338591(DNASE1)

DRE:	436947(dnase1)

SRX:	107733840 107738635

SANH:

107676287 107685934 107690335

SGH:

107568632

CCAR:

109058271(dnase1)

CAUA:

113041462 113046984

CGIB:

127948762 127952055

PTET:

122333880(dnase1)

LROH:

127160032(dnase1)

OMC:	131537661(dnase1)

PPRM:

120490133(dnase1)

RKG:	130090688(dnase1)

MAMB:

125250199(dnase1)

CIDE:

127508550

CERY:

137017529(dnase1)

MASI:

127450110

TROS:

130561368(dnase1)

TDW:	130426718(dnase1)

MANU:

129436186(dnase1)

PDAB:

135759054(dnase1)

AMEX:

103021506(dnase1)

CMAO:

118821422(dnase1)

EEE:	113572846(dnase1)

CHAR:

105899892 105899997

SPIL:

134077194(dnase1)

TRU:

101064907

TFS:	130515050(dnase1)

TBEN:

117479089(dnase1) 117479098 117479099 117479101 117479102

CGOB:

115012624

PGEO:

117441045 117442354 117442356 117442360 139432829

GACU:

117554384 117554386 117554388 117554389

EMAC:

134877452 134877453 134878079(dnase1)

ELY:	117268880(dnase1)

EFO:	125879135 125879161

PLEP:

121956796(dnase1)

SLUC:

116063821(dnase1)

ECRA:

117957709(dnase1)

ESP:	116702599(dnase1)

PFLV:

114569486

GAT:

120827432

PPUG:

119220213

AFB:	129098718 129098775

CLUM:

117735266(dnase1)

PSWI:

130189377 130189378

CANA:

137787043(dnase1)

CVE:	137892098 137892101 137892102 137892103 137892112 137892119 137892120 137892138 137892140

MSAM:

119882710(dnase1)

SCHU:

122869165(dnase1)

CUD:	121503626(dnase1)

SPUL:

138603076(dnase1)

LMIX:

132995704(dnase1)

ALAT:

119014409(dnase1)

ASTR:

137610298(dnase1)

MZE:	101472954 101477007 101485654 112429679 112431505 112431506 112431507 112431513

ONL:	100700560 100700928 102076094 109202009

OAU:	120440001 120440002

OLA:

101169858

OML:	112138565(dnase1)

CSAI:

133422199(dnase1)

XMA:

102226062

XCO:	114148703(dnase1l2)

XHE:

116736067

PRET:

103468312(dnase1l2)

PFOR:

103152599

PLAI:

106952982

PMEI:

106933030

GAF:	122821385(dnase1)

PPRL:

129363632(dnase1)

CVG:	107099649(dnase1l2) 107103768(dnase1)

CTUL:

119772698 119772714(dnase1)

GMU:	124863076 124864667(dnase1)

NFU:	107376192(dnase1l2)

KMR:	108249601(dnase1)

ALIM:

106526804(dnase1l2)

NWH:	119422065(dnase1)

AOCE:

111566383(dnase1)

EJA:	138197695(dnase1)

BFRE:

138627663(dnase1)

MCEP:

124997997(dnase1)

CSEM:

103393635(dnase1l2)

POV:	109642737(dnase1)

SSEN:

122785775(dnase1)

SSOE:

131476145(dnase1)

HHIP:

117766366(dnase1)

HSP:	118123817(dnase1)

PPLT:

128458627(dnase1)

SMAU:

118289210(dnase1)

LCF:	108889278 108889279 108898604

SDU:

111223716

SLAL:

111662443

XGL:	120788212(dnase1)

HCQ:

109530001

SSCV:

125983070(dnase1)

SBIA:

133514596(dnase1)

PEE:	133415202(dnase1)

PTAO:

133465999(dnase1)

BPEC:

110171440(dnase1l2)

ENY:	140358618(dnase1)

MALB:

109967577(dnase1l2)

BSPL:

114860691(dnase1)

SJO:	128378721(dnase1)

SSCO:

133999901(dnase1)

GMH:

115538407

SASA:

106591197

STRU:

115171982 115208375

OTW:	112246364(dnase1)

OMY:	110487138(dnase1) 110515889

OGO:	124020921 124022736 124022827 124029970

OKI:	109887017 109887399

OKE:	127919743(dnase1)

OMM:

135532811

OCLA:

139421742 139422507

SALP:

112079016

SNH:	120041645 120041658

CCLU:

121556135(dnase1)

ELS:	105013474(dnase1)

OEP:	134008779(dnase1)

SFM:	108937315 108937317

PKI:	111849332(dnase1)

AANG:

118217399(dnase1)

AROT:

135243395(dnase1)

CCOG:

133114557(dnase1)

LOC:

102696530

PSPA:

121294185(dnase1) 121301220

ARUT:

117417984(dnase1)

PSEX:

120542436(dnase1)

LCM:	102363946(DNASE1L2)

CMK:	103178822(dnase1)

RTP:	109927092(dnase1)

CPLA:

122560676(dnase1)

HOC:	132825195(dnase1)

PMRN:

116949680(DNASE1)

LRJ:	133345717(DNASE1)

BFO:	118408747 118411538 118411692 118412585 118421836 118427705

BBEL:

109463851 109465490 109478323

CIN:

104265585

SPU:	100889861 100891312

LPIC:

129255357 129256304

AJJ:	139966705 139966708

ARUN:

117288528

AAMU:

139937592

AFIL:

140141770 140142677 140142745

AJC:	117105309 117108016 117118217

SKO:	100368587 100368897

PFLL:

139117763 139117983 139117984

PVM:	113811515 113816693 138865901

PJA:	122253984 122268081

PCHN:

PMOO:

HAME:

MNZ:

MRJ:

PORN:

HAZT:

PPOI:

CSCU:

UDV:

LGI:	LOTGIDRAFT_105537 LOTGIDRAFT_121655 LOTGIDRAFT_168246

PVUL:

PCAN:

LSAX:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111109917 111109972 111125844 111125855 111125865 111125873

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

132721199 132748733 132752110

DPOL:

127855864 127866072 127873105

MAEA:

128218149 128235312 128236002

OBI:

106867620

OSN:

115220565

LAK:	106168371 106172672 106179924

LLON:

135498003

EPA:

110234993

ADF:	107327287 107351594

AMIL:

114966736 114972136

PDAM:

113664567

SPIS:

111332263 111334753

HSY:	130639588 130642558 130655400 130655433

TAD:	TRIADDRAFT_25440 TRIADDRAFT_37773

MBR:	MONBRDRAFT_37144

LMB:	C9I47_0973

CCX:	COCOR_07416

ARG:	QT11_C0001G0218

VG:	25479096(AMQ81_gp047)

» show all

Reference

PMID:2251263

Authors

Shak S, Capon DJ, Hellmiss R, Marsters SA, Baker CL

Title

Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.

Journal

Proc Natl Acad Sci U S A 87:9188-92 (1990)
DOI:10.1073/pnas.87.23.9188

Sequence

[hsa:1773]

Reference

PMID:22701800

Authors

Morgan AR, Lam WJ, Han DY, Fraser AG, Ferguson LR

Title

DNase1: No Association with Crohn's Disease in a New Zealand Population.

Journal

ISRN Gastroenterol 2012:826323 (2012)
DOI:10.5402/2012/826323

LinkDB

DBGET integrated database retrieval system