KEGG   ORTHOLOGY: K12318
Entry
K12318                      KO                                     

Symbol
GUCY1A
Name
guanylate cyclase soluble subunit alpha [EC:4.6.1.2]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map04022  cGMP-PKG signaling pathway
map04270  Vascular smooth muscle contraction
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04730  Long-term depression
map04921  Oxytocin signaling pathway
map04924  Renin secretion
map04970  Salivary secretion
Disease
H01396  Moyamoya disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
   04924 Renin secretion
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09154 Digestive system
   04970 Salivary secretion
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09156 Nervous system
   04730 Long-term depression
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K12318  GUCY1A; guanylate cyclase soluble subunit alpha
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12318  GUCY1A; guanylate cyclase soluble subunit alpha
Other DBs
RN: R00434
GO: 0004383
Genes
HSA: 2977(GUCY1A2) 2982(GUCY1A1)
PTR: 100608597(GUCY1A1) 466769(GUCY1A2)
PPS: 100985928(GUCY1A3) 100987635(GUCY1A2)
GGO: 101139175(GUCY1A1) 101146114(GUCY1A2)
PON: 100172608(GUCY1A1) 100445361(GUCY1A2)
NLE: 100581660(GUCY1A1) 100592351(GUCY1A2)
MCC: 699365(GUCY1A1) 706615(GUCY1A2)
MCF: 101866366(GUCY1A3) 102127299(GUCY1A2)
CSAB: 103236428(GUCY1A3) 103248387(GUCY1A2)
CATY: 105588741(GUCY1A2) 105597896(GUCY1A3)
PANU: 101014715(GUCY1A2) 103884727(GUCY1A1)
RRO: 104655958(GUCY1A2) 104658100(GUCY1A1)
RBB: 108513181(GUCY1A2) 108527520 108529026(GUCY1A3)
TFN: 117080309(GUCY1A2) 117086065(GUCY1A1)
PTEH: 111539983(GUCY1A2) 111553321(GUCY1A1)
CJC: 100387768(GUCY1A2) 100396127(GUCY1A3)
SBQ: 101040779(GUCY1A3) 101040955(GUCY1A2)
MMUR: 105866563(GUCY1A2) 105881771(GUCY1A3)
MMU: 234889(Gucy1a2) 60596(Gucy1a1)
MCAL: 110291186(Gucy1a3) 110301665(Gucy1a2)
MPAH: 110320296(Gucy1a3) 110327749(Gucy1a2)
RNO: 497757(Gucy1a1) 66012(Gucy1a2)
MCOC: 116074200(Gucy1a2) 116093029(Gucy1a1)
MUN: 110566017(Gucy1a3)
CGE: 100768699(Gucy1a1) 100769238(Gucy1a2)
PLEU: 114700497(Gucy1a1) 114709264(Gucy1a2)
NGI: 103731324(Gucy1a2) 103751001(Gucy1a3)
HGL: 101702803(Gucy1a2) 101712487(Gucy1a3)
CCAN: 109676102(Gucy1a3) 109684240(Gucy1a2)
OCU: 100350099(GUCY1A3) 100357621(GUCY1A2)
OPI: 101528575(GUCY1A1) 101531177(GUCY1A2)
TUP: 102469297(GUCY1A2) 102483882(GUCY1A3)
CFA: 479455(GUCY1A2) 482663(GUCY1A1)
VVP: 112925911(GUCY1A2) 112933458(GUCY1A1)
VLG: 121481102(GUCY1A1) 121499617(GUCY1A2)
AML: 100483617(GUCY1A1)
UMR: 103658044(GUCY1A3) 103662433(GUCY1A2)
UAH: 113255781(GUCY1A1) 113260215(GUCY1A2)
ORO: 101369879(GUCY1A2) 101381618(GUCY1A3)
MPUF: 101670675(GUCY1A2) 101690428(GUCY1A3)
EJU: 114210207(GUCY1A1) 114211229(GUCY1A2)
MLX: 118013176(GUCY1A2) 118022214(GUCY1A1)
FCA: 101098377(GUCY1A1) 101099494(GUCY1A2)
PYU: 121028162(GUCY1A1) 121035306(GUCY1A2)
PBG: 122475128(GUCY1A1) 122482909(GUCY1A2)
PTG: 102956040(GUCY1A2) 102969669(GUCY1A3)
PPAD: 109262490(GUCY1A3) 109278730(GUCY1A2)
AJU: 106982463(GUCY1A1) 106983909
HHV: 120221373(GUCY1A1) 120244223(GUCY1A2)
BTA: 281216(GUCY1A1) 613600(GUCY1A2)
BOM: 102280817(GUCY1A2) 102281834(GUCY1A3)
BIU: 109570022(GUCY1A2) 109571318(GUCY1A3)
BBUB: 102390736(GUCY1A2) 102394541(GUCY1A1)
CHX: 102169692(GUCY1A3) 102184168(GUCY1A2)
OAS: 101104339(GUCY1A2) 101110000(GUCY1A1)
ODA: 120871516(GUCY1A1) 120876201(GUCY1A2)
CCAD: 122449537(GUCY1A2) 122453663(GUCY1A1)
SSC: 100522091(GUCY1A2) 553100(GUCY1A3)
CFR: 102508002(GUCY1A1) 102523651(GUCY1A2)
CBAI: 105067608(GUCY1A2) 105069394(GUCY1A3)
CDK: 105099193(GUCY1A2) 105101181(GUCY1A1)
BACU: 103007177(GUCY1A2) 103020991
LVE: 103069938(GUCY1A2) 103075302
OOR: 101275975(GUCY1A2) 101279277(GUCY1A3)
DLE: 111167557(GUCY1A2) 111179006(GUCY1A1)
PCAD: 102978888(GUCY1A2) 102994352(GUCY1A1)
ECB: 100069474(GUCY1A2) 100069573(GUCY1A1)
EPZ: 103562610(GUCY1A3) 103563826
EAI: 106832984(GUCY1A1) 106837662(GUCY1A2)
MYB: 102250686(GUCY1A3) 102260196(GUCY1A2)
MYD: 102764771(GUCY1A3) 102767033(GUCY1A2)
MMYO: 118658830(GUCY1A1) 118664399(GUCY1A2)
MNA: 107527534(GUCY1A3) 107532921(GUCY1A2)
PKL: 118711195(GUCY1A1) 118712763(GUCY1A2)
HAI: 109371447(GUCY1A2) 109377496(GUCY1A3)
DRO: 112312473(GUCY1A1) 112314356(GUCY1A2)
SHON: 118988251(GUCY1A2) 118995343(GUCY1A1)
AJM: 119034624(GUCY1A1) 119055449(GUCY1A2)
MMF: 118615917(GUCY1A1) 118628194(GUCY1A2)
PALE: 102889502(GUCY1A1) 102896673(GUCY1A2)
PGIG: 120599652(GUCY1A2) 120613432(GUCY1A1)
RAY: 107507549(GUCY1A3) 107518221(GUCY1A2)
MJV: 108408486(GUCY1A3)
TOD: 119234846(GUCY1A1) 119240897(GUCY1A2)
LAV: 100662779(GUCY1A2) 100663946(GUCY1A1)
MDO: 100017038(GUCY1A3) 100027037(GUCY1A2)
SHR: 100928661(GUCY1A1) 100929308(GUCY1A2)
PCW: 110213640(GUCY1A3) 110214955(GUCY1A2)
OAA: 100075186(GUCY1A1) 100077965(GUCY1A2)
GGA: 422407(GUCY1A3) 771678(GUCY1A2)
PCOC: 116237203(GUCY1A2) 116243161(GUCY1A1)
MGP: 100542159(GUCY1A2) 100547213(GUCY1A1)
CJO: 107308362(GUCY1A2) 107313055(GUCY1A1)
NMEL: 110398017(GUCY1A3) 110403886(GUCY1A2)
APLA: 101790692(GUCY1A2) 101799600(GUCY1A1)
ACYG: 106032273(GUCY1A3) 106047549(GUCY1A2)
TGU: 100217644(GUCY1A2) 100223563(GUCY1A1)
LSR: 110470028(GUCY1A2) 110478231(GUCY1A1)
SCAN: 103812526(GUCY1A2) 103825957(GUCY1A1)
PMOA: 120497954(GUCY1A1) 120506622(GUCY1A2)
OTC: 121341157(GUCY1A2) 121348436(GUCY1A1)
PRUF: 121360240(GUCY1A1) 121364166(GUCY1A2)
GFR: 102043874(GUCY1A3) 102044723(GUCY1A2)
FAB: 101812872(GUCY1A2) 101814320(GUCY1A3)
PHI: 102106220(GUCY1A3) 102113474(GUCY1A2)
PMAJ: 107203218(GUCY1A3) 107210410(GUCY1A2)
CCAE: 111924184(GUCY1A2) 111927848(GUCY1A1)
CCW: 104690109(GUCY1A2) 104697178(GUCY1A1)
ETL: 114065469(GUCY1A1) 114066011(GUCY1A2)
FPG: 101914436(GUCY1A2) 101922339(GUCY1A3)
FCH: 102046999(GUCY1A1) 102059430(GUCY1A2)
CLV: 102090855(GUCY1A3) 102097143(GUCY1A2)
EGZ: 104124168(GUCY1A3) 104130062(GUCY1A2)
NNI: 104021238(GUCY1A3) 104023120(GUCY1A2)
ACUN: 113479562(GUCY1A1) 113484388(GUCY1A2)
PADL: 103915456(GUCY1A2) 103921780(GUCY1A3)
AAM: 106492053(GUCY1A3)
AROW: 112973467(GUCY1A2) 112976711(GUCY1A1)
NPD: 112949263(GUCY1A1) 112952705(GUCY1A2)
DNE: 112983213(GUCY1A2) 112995311(GUCY1A1)
ASN: 102383277(GUCY1A2) 102383335(GUCY1A1)
AMJ: 102569074(GUCY1A3) 106737232(GUCY1A2)
CPOO: 109305539(GUCY1A2) 109309696(GUCY1A3)
GGN: 109300842(GUCY1A3) 109302218(GUCY1A2)
PSS: 102444454(GUCY1A2) 102446826(GUCY1A1)
CMY: 102934622(GUCY1A2) 102938442(GUCY1A1)
CPIC: 101945080(GUCY1A2) 101948053(GUCY1A1)
TST: 117871159(GUCY1A2) 117878580(GUCY1A1)
CABI: 116824085(GUCY1A1) 116830980(GUCY1A2)
ACS: 100554615(gucy1a2) 100563220(gucy1a3)
PVT: 110072775(GUCY1A3) 110084083(GUCY1A2)
PBI: 103052921(GUCY1A2) 103063344(GUCY1A1)
PMUR: 107287977(GUCY1A1) 107294718 107294950
TSR: 106553741(GUCY1A3) 106555835(GUCY1A2)
PGUT: 117660990(GUCY1A2) 117674723(GUCY1A1)
PMUA: 114595672(GUCY1A2) 114603793(GUCY1A1)
ZVI: 118083656(GUCY1A1) 118084668(GUCY1A2)
GJA: 107109446(GUCY1A3) 107123339(GUCY1A2)
XLA: 108704686 108706648(gucy1a1.S) 108709988
XTR: 100145454(gucy1a2) 100496677(gucy1a1)
NPR: 108789645(GUCY1A3) 108798037
DRE: 100330875(gucy1a2) 550420(gucy1a1)
IPU: 108260481(gucy1a3) 108278235(gucy1a2)
PHYP: 113524511(gucy1a1) 113544642(gucy1a2)
AMEX: 103040541(gucy1a2) 103041681(gucy1a3)
EEE: 113578734(gucy1a2) 113583870(gucy1a1)
TRU: 101068334(gucy1a2) 446059(gucy1a1)
LCO: 104928518(gucy1a2) 104930192(gucy1a1)
NCC: 104945126(gucy1a2) 104949644(gucy1a3)
CGOB: 115009130(gucy1a1) 115017286(gucy1a2)
ELY: 117255283(gucy1a1) 117259948(gucy1a2)
PLEP: 121942367(gucy1a1) 121943236(gucy1a2)
SLUC: 116034290(gucy1a1) 116048256(gucy1a2)
ECRA: 117941946(gucy1a2) 117955346(gucy1a1)
PFLV: 114552700(gucy1a2) 114569342(gucy1a1)
GAT: 120822380(gucy1a2) 120825405(gucy1a1)
PPUG: 119213088(gucy1a2) 119218514(gucy1a1)
MSAM: 119882990(gucy1a2) 119898971(gucy1a1)
CUD: 121508114(gucy1a1) 121526518(gucy1a2)
MZE: 101471149(gucy1a2) 101483862(gucy1a1)
ONL: 100705742(gucy1a2) 100710791(gucy1a1)
OAU: 116323052(gucy1a2) 116329994(gucy1a1)
OLA: 100049248(gucy1a2)
OML: 112149224(gucy1a2) 112157142(gucy1a1)
XMA: 102218476(gucy1a2) 102228906(gucy1a1)
XCO: 114133238(gucy1a2) 114145011(gucy1a1)
XHE: 116720174(gucy1a1) 116737505(gucy1a2)
PRET: 103466154(gucy1a3) 103474497(gucy1a2)
CVG: 107093944(gucy1a2) 107097704(gucy1a3)
CTUL: 119796271(gucy1a1) 119798310(gucy1a2)
NFU: 107375309(gucy1a3) 107380439(gucy1a2)
KMR: 108244641(gucy1a2) 108250689(gucy1a1)
ALIM: 106517183 106521477(gucy1a2)
AOCE: 111575320(gucy1a1) 111580973(gucy1a2)
CSEM: 103378532(gucy1a2) 103383661(gucy1a3)
POV: 109630163(gucy1a2) 109637781(gucy1a3)
LCF: 108890865(gucy1a2) 108896510(gucy1a3)
SDU: 111224115(gucy1a2) 111231447(gucy1a3)
SLAL: 111651815(gucy1a2) 111654817 111664043(gucy1a1)
XGL: 120792408(gucy1a2) 120800087(gucy1a1)
HCQ: 109511512(gucy1a3) 109525417(gucy1a2)
BPEC: 110165413(gucy1a3) 110174338(gucy1a2)
MALB: 109961420(gucy1a3) 109971610(gucy1a2)
OMY: 110497490 110503398 110507972(gucy1a2) 110534295(gucy1a1)
SALP: 111959269(gucy1a2) 111971540(gucy1a1) 112068693 112080371
ELS: 105024076(gucy1a2) 105028905(gucy1a1)
SFM: 108924492(gucy1a1) 108924639(gucy1a2)
PKI: 111833824(gucy1a2) 111837347(gucy1a1)
AANG: 118209281(gucy1a2) 118227037(gucy1a1) 118231281
LOC: 102693998(gucy1a2) 102698134(gucy1a3)
PSPA: 121320459(gucy1a2) 121322959 121326435
LCM: 102362175(GUCY1A3)
CMK: 103185780(gucy1a2) 103187183(gucy1a1)
BFO: 118419466
CIN: 100178591
SCLV: 120334993
SPU: 100889569
APLC: 110983731
DME: Dmel_CG1912(Gycalpha99B)
DER: 6554597
DSE: 6612719
DSI: Dsimw501_GD21450(Dsim_GD21450)
DAN: 6506001
DSR: 110186477
DPE: 6595164
DMN: 108157189
DWI: 6647577
DGR: 6564101
DAZ: 108610366
DNV: 108656204
DHE: 111599443
DVI: 6632721
CCAT: 101461137
BOD: 106617815
SCAC: 106080643
LCQ: 111690487
ACOZ: 120959411
AARA: 120906490
AAG: 5570698
CPII: 120419623
AME: 408879(sGC-alpha1)
ACER: 107993816
BIM: 100749092
BBIF: 117213625
BVK: 117243170
BVAN: 117163177
BTER: 100647693
CCAL: 108624087
MGEN: 117219015
NMEA: 116429633
CGIG: 122399378
SOC: 105196464
MPHA: 105831031
AEC: 105146046
ACEP: 105617197
PBAR: 105432005
VEM: 105564904
HST: 105180850
DQU: 106751694
CFO: 105254454
FEX: 115239283
LHU: 105668450
PGC: 109854999
OBO: 105279309
PCF: 106785349
PFUC: 122520842
NVI: 100118554
CSOL: 105363410
TPRE: 106650857
MDL: 103570076
FAS: 105264506
DAM: 107048381
CCIN: 107272195
TCA: 659086
ATD: 109609386
AGB: 108912801
LDC: 111506705
NVL: 108562076
APLN: 108740637
PPYR: 116167723
OTU: 111413112
BMOR: 100642185(GC-a1)
BMAN: 114242746
MSEX: 115441412
BANY: 112049774
PMAC: 106711336
PPOT: 106105603
PXU: 106120864
PRAP: 110997097
ZCE: 119837489
HAW: 110373281
TNL: 113500001
PXY: 105383491
API: 100167238
DNX: 107167885
AGS: 114119225
RMD: 113556210
BTAB: 109029770
DCI: 103506302
CLEC: 106663391
HHAL: 106680637
NLU: 111049624
FOC: 113205903
ZNE: 110840164
CSEC: 111863428
FCD: 110858207
DMK: 116924336
PVM: 113823998
HAME: 121860639
DSV: 119448591
RMP: 119169307
TUT: 107363705
DPTE: 113791936
PTEP: 107436806
SDM: 118188803
PCAN: 112560072
BGT: 106058259
GAE: 121373977
CRG: 105333172
MYI: 110452448
PMAX: 117329070
OBI: 106869877
EPA: 110248038
ATEN: 116291859
DGT: 114523321
HMG: 100197914
 » show all
Reference
PMID:1683630
  Authors
Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G
  Title
Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme.
  Journal
FEBS Lett 292:217-22 (1991)
DOI:10.1016/0014-5793(91)80871-Y
  Sequence
[hsa:2977]
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