KEGG ORTHOLOGY: K12321

ORTHOLOGY: K12321

Entry

K12321                      KO

Symbol

GUCY2D_E

Name

guanylate cyclase 2D/E [EC:4.6.1.2]

Pathway

map00230

Purine metabolism

map01100

Metabolic pathways

map04740

Olfactory transduction

map04744

Phototransduction

Reaction

R00434

GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)

Disease

H00481

Cone-rod dystrophy and cone dystrophy

H00787

Congenital stationary night blindness

H00837

Leber congenital amaurosis

H01768

Central areolar choroidal dystrophy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K12321  GUCY2D_E; guanylate cyclase 2D/E
09150 Organismal Systems
  09157 Sensory system
   04744 Phototransduction
    K12321  GUCY2D_E; guanylate cyclase 2D/E
   04740 Olfactory transduction
    K12321  GUCY2D_E; guanylate cyclase 2D/E
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K12321  GUCY2D_E; guanylate cyclase 2D/E
Enzymes [BR:ko01000]
4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.2  guanylate cyclase
     K12321  GUCY2D_E; guanylate cyclase 2D/E
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  RGC family [OT]
   K12321  GUCY2D_E; guanylate cyclase 2D/E

Other DBs

GO:

0004383

Genes

HSA:	3000(GUCY2D)

PTR:	750641(GUCY2D)

PPS:	100976525(GUCY2D)

GGO:	101140749(GUCY2D)

PON:	100443214(GUCY2D)

PPYG:

129016924(GUCY2D)

NLE:	100585866(GUCY2D) 100587777

HMH:	116458763(GUCY2D) 116476162

SSYN:

129469757(GUCY2D) 129485293

MCC:	100430188 716734(GUCY2D)

MCF:	102146353(GUCY2D)

MTHB:

126939663

MNI:	105473858(GUCY2D)

CSAB:

103242335(GUCY2D)

CATY:

105582008(GUCY2D)

PANU:

101013904(GUCY2D)

TGE:	112609922(GUCY2D)

MLEU:

105549856(GUCY2D)

RRO:	104661674(GUCY2D)

RBB:	108514277(GUCY2D)

TFN:	117067741(GUCY2D)

PTEH:

111527098(GUCY2D) 111540965

CANG:

105509646 105523692(GUCY2D)

CJC:	100412242(GUCY2D)

SBQ:	101031889(GUCY2D)

CIMI:

108306546(GUCY2D)

ANAN:

105720821(GUCY2D)

CSYR:

103264653(GUCY2D) 103266817

MMUR:

105860273 105877334(GUCY2D)

LCAT:

123642009 123650915(GUCY2D)

ERUF:

138384821 138392515(GUCY2D)

PCOQ:

105811399 105819418(GUCY2D)

OGA:	100945296 100959975(GUCY2D)

MMU:	14918(Gucy2d) 14919(Gucy2e)

MCAL:

110298578 110305918(Gucy2d)

MPAH:

110330114 110332384(Gucy2d)

RNO:	113911(Gucy2e) 79222(Gucy2d)

MCOC:

116077646(Gucy2d) 116101297

ANU:	117710716(Gucy2d) 117722973

ASYL:

127684938 127693969(Gucy2d)

MUN:	110551701(Gucy2d) 110560570

CGE:	100750501 100754759(Gucy2d)

MAUA:

101837853(Gucy2d) 101843871

PROB:

127219079(Gucy2d) 127228932

PLEU:

114693159(Gucy2d) 114698642

PMAV:

102926775(Gucy2d)

MORG:

121452679 121456935(Gucy2d) 121458641

MFOT:

126508948 126514114

AAMP:

119802524 119813098(Gucy2d)

CNL:	130877638(Gucy2d)

NGI:	103743062 103752104(Gucy2d)

HGL:	101697777(Gucy2d) 101717731

CPOC:

100732548(Gucy2d) 100735737

CCAN:

109688562 109693913(Gucy2d)

DORD:

105983282(Gucy2d) 105983940

DSP:	122100432(Gucy2d) 122113673

DMER:

138813133(Gucy2d) 138836566

PLOP:

125361910 125365805(Gucy2d)

NCAR:

124959602 124980577

MMMA:

107156799 107158019(Gucy2d)

ITI:	101961646(Gucy2d) 101969867

OCU:

100344095

OPI:	101525702(GUCY2D) 101527485

OCZ:	121145311 121170149(GUCY2D)

TUP:	102494681 102496410(GUCY2D)

GVR:	103593653(GUCY2D)

CFA:	403863(GUCY2D) 485179

CLUD:

112641940 112647414(GUCY2D)

VVP:	112924739(GUCY2D) 112928727

VLG:	121476182 121499354(GUCY2D)

NPO:	129497953(GUCY2D) 129506588

AML:	100476540 100480095(GUCY2D)

UMR:	103660485(GUCY2D) 103678130

UAH:	113269343 113271141(GUCY2D)

UAR:	123792118(GUCY2D) 123804220

ELK:	111159348 111161167

LLV:	125079706 125086718

MPUF:

101673015(GUCY2D) 101683029

MNP:	132003268(GUCY2D) 132017563

MLK:	131815657(GUCY2D) 131832805

NVS:	122907776(GUCY2D) 122913491

ORO:	101377149 101383563(GUCY2D)

EJU:	114218609 114225449(GUCY2D)

ZCA:	113913683 113939024(GUCY2D)

MLX:	118000184(GUCY2D) 118004023

MANO:

123853596(GUCY2D) 123856508

NSU:	110584667(GUCY2D) 110593412

LWW:	102740295(GUCY2D) 102740621

FCA:	101099582 101101009(GUCY2D)

PYU:	121015964(GUCY2D) 121039318

PCOO:

112865759

PBG:	122484234 122484918(GUCY2D)

PVIV:

125146801 125152205(GUCY2D)

LRUF:

124505923 124519647

LGF:	123600401 123602991(GUCY2D)

AJU:	106972445 106976443

PTG:	102960287(GUCY2D) 102971963

PPAD:

109245911 109267234

PUC:	125927016 125929388

PLEZ:

122201192 122207118(GUCY2D)

HHV:	120229599 120231361(GUCY2D)

CCRU:

144217198(GUCY2D) 144242690

BTA:	282245(GUCY2D)

BOM:	102281141(GUCY2D)

BIU:	109574462(GUCY2D)

BBUB:

102406724(GUCY2D) 112579622

BKE:	129649314(GUCY2D)

BBIS:

104990890(GUCY2D)

CHX:	102169418(GUCY2D)

OAS:	101109482 101120932(GUCY2D)

BTAX:

128059923 128065392(GUCY2D)

CSUM:

138084149(GUCY2D) 138092217

ODA:	120866023(GUCY2D) 120875958

CCAD:

122445557(GUCY2D) 122449330

MREE:

136149311(GUCY2D) 136175740

OVR:	110121785(GUCY2D)

MBEZ:

129543346(GUCY2D) 129553663

SSC:	100523457 100625536(GUCY2D)

CFR:	102503713(GUCY2D) 102509037

CBAI:

105077586(GUCY2D) 105083617

CDK:	105098241 105102998(GUCY2D)

VPC:	102532665(GUCY2D) 107033440

BACU:

103002685 103016360(GUCY2D)

BMUS:

118887321(GUCY2D) 118899508

LVE:	103070106(GUCY2D)

OOR:	101274865 101282297(GUCY2D)

LALB:

132511217(GUCY2D) 132526512

GMF:	115841840 115855856(GUCY2D)

DDP:	132415225(GUCY2D) 132430244

DLE:	111185889(GUCY2D)

PCAD:

102991189(GUCY2D)

PSIU:

116746475(GUCY2D)

PPHC:

136126929 136138435(GUCY2D)

NASI:

112401912(GUCY2D) 112408003

ECB:	100073037(GUCY2D) 100630860

EPZ:	103548241 103566602(GUCY2D)

EAI:	106840416 106844230(GUCY2D)

MYB:	102242149 102243506(GUCY2D)

MYD:	102751706(GUCY2D) 102760543

MMYO:

118664217 118672108(GUCY2D)

MLF:	102430842 102435067(GUCY2D)

MDT:	132218043(GUCY2D) 132241662

MYUM:

138994319(GUCY2D) 139018443

PKL:	118713730 118727033(GUCY2D)

EFUS:

103293685 103296883(GUCY2D)

MNA:	107524472 107544495(GUCY2D)

DRO:	112308750(GUCY2D)

SHON:

118974632(GUCY2D) 118981631

AJM:	119049023(GUCY2D)

PDIC:

114515200(GUCY2D)

PHAS:

123805339 123809404(GUCY2D)

MMF:	118627780 118634460(GUCY2D)

PPAM:

129072172(GUCY2D) 129072688

HAI:	109395113(GUCY2D)

RFQ:	117013594(GUCY2D)

PALE:

102884807 102892708(GUCY2D)

PGIG:

120589911(GUCY2D) 120590531

PVP:	105291238(GUCY2D) 105297649

RAY:	107515672(GUCY2D) 107519122

MJV:	108383381(GUCY2D) 108398545

TOD:	119231504(GUCY2D) 119255046

SARA:

101538539 101539935(GUCY2D)

SFUM:

130024162(GUCY2D) 130025501

SETR:

125997936(GUCY2D) 126018417

LAV:	100656347 100670740(GUCY2D)

TMU:	101355351 101355713

ETF:	101637887(GUCY2D) 101651594

DNM:	101430783(GUCY2D) 101442492

MDO:	100014788(GUCY2D) 100028110

GAS:	123241224(GUCY2F) 123245158(GUCY2D)

SHR:	100921433(GUCY2D) 100932093

AFZ:	127557364 127559059

PCW:	110194405(GUCY2D) 110210716

TVP:	118836725(GUCY2F) 118858228(GUCY2D)

PBRV:

138148218 138174024(GUCY2D)

MLAO:

141488649(GUCY2F) 141512145(GUCY2D)

OAA:

100074490

TACU:

119941311 119947342(GUCY2D)

NMEL:

110391669

AACU:

137848915

ACYG:

106029423(GUCY2D)

CATA:

118261678

TGU:

115492653

LSR:	110482103 110482480

OTC:

121340599

PRUF:

121362549

ATRC:

139586521(GUCY2D)

OMA:	130263334(GUCY2D)

PHI:

102114027

ACOE:

138101400 138101474

ZLE:	135460875(GUCY2D)

CCIC:

134055727(GUCY2D)

FPG:

FCH:

SHAB:

HLE:

AGEN:

BBUT:

142037682(GUCY2D)

DPUB:

104299628

NNI:

104015339

CBOR:

142077517

CBOY:

140645282(GUCY2D)

MAME:

CLV:

OHA:

CPEA:

CVF:

RTD:

CRID:

LMIC:

AAM:

AROW:

DNE:

ASN:	102375187(GUCY2D)

AMJ:	102564997(GUCY2D)

PSS:	102451086(GUCY2D)

CIZ:	142006097(GUCY2D)

CMY:	102946484(GUCY2D)

CCAY:

125628597(GUCY2D)

LKP:	140904282(GUCY2D)

NDS:	141978819(GUCY2D)

DCC:	119849360(GUCY2D)

CPIC:

101953314

TST:	117869962(GUCY2D)

CABI:

116839656(GUCY2D)

MRV:	120381502(GUCY2D)

ACS:	100558820(gucy2d)

ASAO:

132777568(GUCY2D)

PVT:	110087765(GUCY2D)

SUND:

121934439(GUCY2D)

PBI:	103064925(GUCY2D)

PMUR:

107297126

CTIG:

120305731(GUCY2D)

TSR:

106557179

PGUT:

117671248(GUCY2D)

PCAE:

139324595(GUCY2D)

APRI:

131196699(GUCY2D)

PTEX:

113451307(GUCY2D)

VKO:	123016599(GUCY2D)

PRAF:

128400131(GUCY2D)

ZVI:	118095007(GUCY2D)

HCG:	128329660(GUCY2D)

EMC:	129339998(GUCY2D)

XLA:	108703527(gucy2d.S) 108711755(gucy2d.L)

XTR:	100496590(gucy2d)

NPR:	108793773(GUCY2D)

RTEM:

120933532(GUCY2D)

ACAT:

141133509(GUCY2D)

PADS:

140322770(GUCY2D)

BBUF:

120987271(GUCY2D)

DTC:	141049977(GUCY2D)

PWL:

138268707

MUO:	115457009(GUCY2D)

GSH:	117350674(GUCY2D)

DRE:	140426(gucy2d)

SRX:

107734113

SANH:

107661246

SGH:	107579190 107599205

CCAR:

109105317 109107681(gucy2d)

CAUA:

113049096 113077325

CGIB:

127957078 127986910 128003861

PTET:

122345192(gucy2d)

LROH:

127166183(gucy2d)

GRF:	141334993(gucy2d)

OMC:	131540256(gucy2d)

PPRM:

120470177(gucy2d)

MAMB:

125266951(gucy2d)

CIDE:

127512352

CERY:

137034109(gucy2d)

MASI:

127429412 127439204

TROS:

130551413(gucy2d)

TDW:	130419367(gucy2d)

MANU:

129440437(gucy2d)

PDAB:

135748746(gucy2d)

IPU:	108259769(gucy2d)

IFU:	128603425(gucy2d)

PHYP:

113531167

SMEO:

124379516(gucy2d)

TFD:	113641486(gucy2d)

TVC:	132841156(gucy2d)

CGAR:

128512542(gucy2d)

NGRA:

132875916(gucy2d)

TRN:	134303400(gucy2d)

AMEX:

103038304(gucy2d)

CMAO:

118803838(gucy2d)

EEE:

113586825

CHAR:

105891408 105906578(gucy2d)

SPIL:

134060451 134079771(gucy2d)

ASAD:

121689549 121709689(gucy2d)

TRU:	101072371 101072570

TFS:

130522461

TNG:	GSTEN00004053G001 GSTEN00022134G001

LCO:	104921674 104937329

TBEN:

CGOB:

GACU:

EMAC:

ELY:

EFO:

SLUC:

ECRA:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

CANA:

CVE:

MSAM:

119894851(gucy2d) 119913480

SCHU:

EARM:

CUD:

SPUL:

LMIX:

HTC:

ALAT:

ASTR:

PKLU:

MZE:	101464262 101473519 112431903

ONL:

100708131

OAU:

116334465

OLA:	100192404(olgc3)

OML:	112138944 118600246

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

EJA:

BFRE:

MCEP:

CSEM:

103390041(gucy2d) 103395410

POV:	109628395 109642927

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:	108882212 108892323 108893131(gucy2d)

SDU:	111234372 111236830

SLAL:

111654011 111673609

XGL:	120797535 120802631(gucy2d)

HCQ:	109512405 109516536

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

ENY:

MALB:

BSPL:

SJO:

SSCO:

TTY:

GMH:	115529988 115547870

SASA:

106567882 106603596

STRU:

115148960 115154416

OTW:	112228627 112257778

OMY:	110534896(gucy2d) 110537393

OGO:	123998652 124009850

ONE:	115105619 115135839

OKI:	109875631 109891792

OKE:	118390746 118391689

OMM:	135548517 135549188(gucy2d)

OCLA:

139423043

SALP:

111950226 111980318

SNH:	120043799 120056536

SFON:

129867792 129868769

CCLU:

121573628 121579826

ELS:	105023924 105030948

OEP:	134015598 134039787(gucy2d)

SFM:	108918669 108923000

PKI:	111835016 111860850

AANG:

118223909 118236272(gucy2d)

AROT:

135251468 135263352(gucy2d)

CCOG:

133123425(gucy2d) 133133276

PSPA:

121305656

ARUT:

117404493 117969961

PSEX:

120526471

LCM:	102362141(GUCY2D)

CPUN:

CLEP:

AGA:

AMAP:

AMRS:

ADAR:

ACOS:

AAG:	110680669 5565611

ASUA:

134202262 134225844

CQU:	CpipJ_CPIJ005363

LDA:

142333959

GAE:	121376777 121389236

CRG:

105318117

MMER:

123554762

» show all

Reference

PMID:1356371

Authors

Shyjan AW, de Sauvage FJ, Gillett NA, Goeddel DV, Lowe DG

Title

Molecular cloning of a retina-specific membrane guanylyl cyclase.

Journal

Neuron 9:727-37 (1992)
DOI:10.1016/0896-6273(92)90035-C

Sequence

[hsa:3000]

Reference

PMID:18500817

Authors

Venkataraman V, Duda T, Ravichandran S, Sharma RK

Title

Neurocalcin delta modulation of ROS-GC1, a new model of Ca(2+) signaling.

Journal

Biochemistry 47:6590-601 (2008)
DOI:10.1021/bi800394s

Sequence

[hsa:3000]

Reference

PMID:15623748

Authors

Coleman JE, Semple-Rowland SL

Title

GC1 deletion prevents light-dependent arrestin translocation in mouse cone photoreceptor cells.

Journal

Invest Ophthalmol Vis Sci 46:12-6 (2005)
DOI:10.1167/iovs.04-0691

Sequence

[mmu:14919]

LinkDB

DBGET integrated database retrieval system