KEGG   ORTHOLOGY: K12361
Entry
K12361                      KO                                     
Symbol
RASGRP2
Name
RAS guanyl-releasing protein 2
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04062  Chemokine signaling pathway
map04611  Platelet activation
map05200  Pathways in cancer
Disease
H01235  Bleeding disorder platelet-type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K12361  RASGRP2; RAS guanyl-releasing protein 2
   04014 Ras signaling pathway
    K12361  RASGRP2; RAS guanyl-releasing protein 2
   04015 Rap1 signaling pathway
    K12361  RASGRP2; RAS guanyl-releasing protein 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K12361  RASGRP2; RAS guanyl-releasing protein 2
   04062 Chemokine signaling pathway
    K12361  RASGRP2; RAS guanyl-releasing protein 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K12361  RASGRP2; RAS guanyl-releasing protein 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K12361  RASGRP2; RAS guanyl-releasing protein 2
Domain-containing proteins not elsewhere classified [BR:ko04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   K12361  RASGRP2; RAS guanyl-releasing protein 2
Other DBs
GO: 0005088
Genes
HSA: 10235(RASGRP2)
PTR: 451298(RASGRP2)
PPS: 100993077(RASGRP2)
GGO: 101125864(RASGRP2)
PON: 100447844(RASGRP2)
PPYG: 129008790(RASGRP2)
NLE: 100603817(RASGRP2)
HMH: 116468962(RASGRP2)
SSYN: 129463992(RASGRP2)
MCC: 722044(RASGRP2)
MCF: 102139509(RASGRP2)
MTHB: 126935564
MNI: 105469529(RASGRP2)
CSAB: 103233086(RASGRP2)
CATY: 105577479(RASGRP2)
PANU: 100137599(RASGRP2)
TGE: 112606964(RASGRP2)
MLEU: 105549110(RASGRP2)
RRO: 104673274(RASGRP2)
RBB: 108542853(RASGRP2)
TFN: 117081424(RASGRP2)
PTEH: 111522280(RASGRP2)
CANG: 105512200(RASGRP2)
CJC: 100896269(RASGRP2)
SBQ: 101053574(RASGRP2)
CIMI: 108310283(RASGRP2)
ANAN: 105724462(RASGRP2)
CSYR: 103256290(RASGRP2)
MMUR: 105878487(RASGRP2)
LCAT: 123641412(RASGRP2)
PCOQ: 105827379(RASGRP2)
OGA: 100942339(RASGRP2)
MMU: 19395(Rasgrp2)
MCAL: 110285321(Rasgrp2)
MPAH: 110318723(Rasgrp2)
RNO: 361714(Rasgrp2)
MCOC: 116103453(Rasgrp2)
ANU: 117709994(Rasgrp2)
MUN: 110549343(Rasgrp2)
CGE: 100757059(Rasgrp2)
MAUA: 101840143(Rasgrp2)
PROB: 127228740(Rasgrp2)
PLEU: 114680696(Rasgrp2)
MORG: 121454202(Rasgrp2)
MFOT: 126498235
AAMP: 119802087(Rasgrp2)
NGI: 103738782(Rasgrp2)
HGL: 101714183(Rasgrp2)
CPOC: 100722152(Rasgrp2)
CCAN: 109687177(Rasgrp2)
DORD: 105989216(Rasgrp2)
DSP: 122104915(Rasgrp2)
PLOP: 125362619(Rasgrp2)
NCAR: 124958788
MMMA: 107135982(Rasgrp2)
OPI: 101517768(RASGRP2)
TUP: 102468592(RASGRP2)
GVR: 103590620(RASGRP2)
CFA: 612101(RASGRP2)
CLUD: 112659488(RASGRP2)
VVP: 112924301(RASGRP2)
VLG: 121501819(RASGRP2)
NPO: 129503115(RASGRP2)
AML: 105236463(RASGRP2)
UMR: 103679557(RASGRP2)
UAH: 113244161(RASGRP2)
UAR: 123778290(RASGRP2)
ELK: 111149468
LLV: 125078503
MPUF: 101678429(RASGRP2)
MNP: 132019319(RASGRP2)
MLK: 131814933(RASGRP2)
NVS: 122913071(RASGRP2)
ORO: 101369676(RASGRP2)
EJU: 114220482(RASGRP2)
ZCA: 113914097(RASGRP2)
MLX: 118016009(RASGRP2)
NSU: 110575955(RASGRP2)
LWW: 102750966(RASGRP2)
FCA: 101094450(RASGRP2)
PYU: 121023900(RASGRP2)
PBG: 122483972(RASGRP2)
PVIV: 125147101(RASGRP2)
LRUF: 124504875
PTG: 102958860(RASGRP2)
PPAD: 109246682(RASGRP2)
PUC: 125931466
AJU: 106981708
HHV: 120240123(RASGRP2)
BTA: 512056(RASGRP2)
BOM: 102264750(RASGRP2)
BBUB: 102391415(RASGRP2)
BBIS: 104987195(RASGRP2)
CHX: 102168515(RASGRP2)
OAS: 101104023(RASGRP2)
BTAX: 128068739(RASGRP2)
ODA: 120874643(RASGRP2)
CCAD: 122430799(RASGRP2)
MBEZ: 129548806(RASGRP2)
SSC: 100626093(RASGRP2)
CFR: 102515600(RASGRP2)
CBAI: 105070645(RASGRP2)
CDK: 105101557(RASGRP2)
VPC: 102542043(RASGRP2)
BACU: 103000066(RASGRP2)
BMUS: 118899994(RASGRP2)
LVE: 103078201(RASGRP2)
OOR: 101278371(RASGRP2)
DLE: 111183796(RASGRP2)
PCAD: 102990537
PSIU: 116757885(RASGRP2)
NASI: 112402393(RASGRP2)
ECB: 102150244(RASGRP2)
EPZ: 103565063(RASGRP2)
EAI: 106833617(RASGRP2)
MYB: 102242639(RASGRP2)
MYD: 102766192(RASGRP2)
MMYO: 118665351(RASGRP2)
MLF: 102427498(RASGRP2)
PKL: 118714968(RASGRP2)
EFUS: 103302054(RASGRP2)
MNA: 107542784(RASGRP2)
DRO: 112317389(RASGRP2)
SHON: 118991686(RASGRP2)
AJM: 119050243(RASGRP2)
PDIC: 114500603(RASGRP2)
PHAS: 123829277(RASGRP2)
MMF: 118628048(RASGRP2)
PPAM: 129068603(RASGRP2)
HAI: 109384326(RASGRP2)
RFQ: 117029919(RASGRP2)
PALE: 102896690(RASGRP2)
PGIG: 120600706(RASGRP2)
PVP: 105297993(RASGRP2)
RAY: 107517268(RASGRP2)
MJV: 108396371(RASGRP2)
TOD: 119250013(RASGRP2)
SARA: 101552845(RASGRP2)
SETR: 126019028(RASGRP2)
LAV: 100661291(RASGRP2)
TMU: 101347941
ETF: 101660297(RASGRP2)
DNM: 101431978(RASGRP2)
GAS: 123253095(RASGRP2)
SHR: 100916150(RASGRP2)
AFZ: 127540089
PCW: 110195541(RASGRP2)
TVP: 118853027(RASGRP2)
OAA: 100090421(RASGRP2)
PHI: 106628736(RASGRP2)
ZLE: 135460224
SHAB: 115602966
AROW: 112967180
ASN: 102372838(RASGRP2)
AMJ: 102566493(RASGRP2)
PSS: 102445100(RASGRP2)
CMY: 102937915(RASGRP2)
CCAY: 125640235(RASGRP2)
DCC: 119858970(RASGRP2)
CPIC: 101946976(RASGRP2)
TST: 117880418(RASGRP2)
CABI: 116835374(RASGRP2)
MRV: 120368749(RASGRP2)
ACS: 103282338
ASAO: 132764363(RASGRP2)
PVT: 110083762(RASGRP2)
SUND: 121916085(RASGRP2)
PBI: 103054829
PMUR: 107289925(RASGRP2)
CTIG: 120318482(RASGRP2)
PGUT: 117669710(RASGRP2)
APRI: 131186521(RASGRP2)
PTEX: 113447484(RASGRP2)
NSS: 113424368(RASGRP2)
VKO: 123032547(RASGRP2)
PMUA: 114586605(RASGRP2)
PRAF: 128403787(RASGRP2)
ZVI: 118076297(RASGRP2)
HCG: 128337328(RASGRP2)
GJA: 107121068(RASGRP2)
STOW: 125442732(RASGRP2)
EMC: 129337135(RASGRP2)
XLA: 379250(rasgrp2.S) 447008(rasgrp2.L)
XTR: 101733706(rasgrp2)
NPR: 108800280(RASGRP2)
RTEM: 120916813(RASGRP2)
BBUF: 120980454(RASGRP2)
BGAR: 122920212(RASGRP2)
MUO: 115479883(RASGRP2)
GSH: 117365668(RASGRP2)
DRE: 557063(rasgrp2) 797658
PTET: 122326088(rasgrp2) 122348779
LROH: 127152742(rasgrp2) 127168114
OMC: 131529312(rasgrp2) 131544217
PPRM: 120477835 120494593(rasgrp2)
RKG: 130072824 130095300(rasgrp2)
MAMB: 125252910(rasgrp2) 125263983
TROS: 130570195(rasgrp2)
TDW: 130407549(rasgrp2)
MANU: 129423661(rasgrp2)
IPU: 108261011 108279010(rasgrp2)
IFU: 128604189 128622217(rasgrp2)
SMEO: 124381478 124398230(rasgrp2)
TFD: 113635487 113648807(rasgrp2)
TVC: 132841760 132859715(rasgrp2)
TRN: 134326609 134330932(rasgrp2)
AMEX: 103025965(rasgrp2) 103046990
CMAO: 118816665 118820318(rasgrp2)
EEE: 113585260(rasgrp2)
CHAR: 105895053(rasgrp2) 105895414
TRU: 101074408(rasgrp2)
TFS: 130522868
LCO: 104924060(rasgrp2)
NCC: 104942268
TBEN: 117487710
CGOB: 115023498(rasgrp2)
PGEO: 117463895
GACU: 117542718
EMAC: 134875712
ELY: 117272648
EFO: 125883513
PLEP: 121962248
SLUC: 116042255
ECRA: 117935227
PFLV: 114545322(rasgrp2)
GAT: 120822490
PPUG: 119221651
AFB: 129093774
CLUM: 117747422
PSWI: 130212035
MSAM: 119912454
SCHU: 122869789
CUD: 121504388
ALAT: 119027385
MZE: 101465816(rasgrp2)
ONL: 100692458(rasgrp2)
OAU: 116315508
OLA: 101160849(rasgrp2)
OML: 112141550
CSAI: 133419935
XMA: 102220152(rasgrp2)
XCO: 114157439(rasgrp2)
XHE: 116732898(rasgrp2)
PRET: 103480179(rasgrp2)
PFOR: 103140618(rasgrp2)
PLAI: 106947368(rasgrp2)
PMEI: 106933619(rasgrp2)
GAF: 122820515
PPRL: 129378255
CVG: 107100159(rasgrp2)
CTUL: 119772167
GMU: 124880556
NFU: 107384786(rasgrp2)
KMR: 108239371
ALIM: 106528460(rasgrp2)
NWH: 119414713
AOCE: 111562544(rasgrp2)
MCEP: 125017774
CSEM: 103391165(rasgrp2)
POV: 109637668(rasgrp2)
SSEN: 122766352
HHIP: 117779283
HSP: 118102494
PPLT: 128430449
SMAU: 118300111
LCF: 108882034
SDU: 111226917(rasgrp2)
SLAL: 111654226(rasgrp2)
XGL: 120797441
HCQ: 109511891(rasgrp2)
SSCV: 125985500
SBIA: 133494862
PEE: 133397865
PTAO: 133472924
BPEC: 110168337(rasgrp2)
MALB: 109969412(rasgrp2)
BSPL: 114846438
SJO: 128383738
SASA: 100194852(grp2) 106577535(rasgrp2) 106608563
CCLU: 121542092(rasgrp2) 121554592 121571119
ELS: 105010908 105020724(rasgrp2)
SFM: 108934392(rasgrp2)
PSPA: 121310087
PSEX: 120539268
LCM: 102348970(RASGRP2)
HOC: 132836141
 » show all
Reference
  Authors
Clyde-Smith J, Silins G, Gartside M, Grimmond S, Etheridge M, Apolloni A, Hayward N, Hancock JF
  Title
Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.
  Journal
J Biol Chem 275:32260-7 (2000)
DOI:10.1074/jbc.M006087200
  Sequence
[hsa:10235]
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