KEGG ORTHOLOGY: K12420

ORTHOLOGY: K12420

Entry

K12420                      KO

Symbol

actIII, oxyJ, snoaD, aknA

Name

ketoreductase [EC:1.1.1.-]

Pathway

map00253

Tetracycline biosynthesis

map01056

Biosynthesis of type II polyketide backbone

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00778

Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide

Reaction

R06642

R09262

R09263

R09264

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01056 Biosynthesis of type II polyketide backbone
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
   00253 Tetracycline biosynthesis
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
   01008 Polyketide biosynthesis proteins
    K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
Lipid biosynthesis proteins [BR:ko01004]
Polyketide synthase
  Component type
   K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide synthase (PKS)
  Type II PKS
   C7-C14 cyclized polyketide type
    Octaketide PKS
     K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
    Nonaketide PKS
     K12420  actIII, oxyJ, snoaD, aknA; ketoreductase
    Decaketide PKS
     K12420  actIII, oxyJ, snoaD, aknA; ketoreductase

Genes

PLU:

plu4194

PLUM:

A4R40_20800

PTT:	VY86_11235

PAKH:

B0X70_21805

PLUI:

CE143_21850

DLA:	I6G47_07195

HOE:	IMCC20628_03245

ABF:	AMK58_25505

RAZ:	U9J35_22015

MANA:

MAMMFC1_01617(actIII)

MSAO:

MYCSP_12660

MSAL:

DSM43276_02535(actIII)

NBR:	O3I_007460

NNO:	NONO_c10780

NTP:	CRH09_08635

NTC:	KHQ06_29985

NYA:	LTV02_09660

NGP:	LTT66_26620

NSPU:

IFM12276_10990(actIII)

SCO:	SCO5086(actIII)

SFI:

SFUL_4005

SANL:

KZO11_29495(fabG)

SGRF:

SGFS_016140

SCYE:

R2B67_24760(fabG)

SSX:	SACTE_6349

SFA:

Sfla_5324

SBH:

SBI_06852

SVE:

SVEN_5983

SDV:	BN159_2469 BN159_2517

SALS:

SLNWT_5124

STRP:

F750_1299

SCI:	B446_13340

SLV:	SLIV_12955(actIII)

SVT:	SVTN_18785 SVTN_28610

STRE:

GZL_p00217

SCW:	TU94_31820

SLD:

T261_6833

SXI:	SXIM_35690

STRC:

AA958_30270

SAMB:

SAM23877_0193(alpD) SAM23877_7480(alpD)

SPRI:

SPRI_0200 SPRI_0260 SPRI_7093 SPRI_7153

SCZ:	ABE83_16230

SCX:	AS200_01420

SRW:	TUE45_01316(actIII_1) TUE45_01559(actIII_2)

STRF:

ASR50_01285 ASR50_34160

SPAV:

Spa2297_32765

SGS:	AVL59_46175

SPHW:

NFX46_12155(fabG)

SLS:	SLINC_6892

SALU:

SALL:

STRD:

SPUN:

SLAU:

SALJ:

SMD11_0674(actIII) SMD11_1159(actIII) SMD11_6047(actIII)

SLX:	SLAV_40230(actIII2) SLAV_40505(actIII3)

SNZ:	DC008_13165

SGE:	DWG14_07357(actIII_2)

SLK:	SLUN_38485

SDX:	C4B68_09610

SGD:	ELQ87_00830 ELQ87_08020

SCYA:

EJ357_29960 EJ357_34765

SNQ:	CP978_29735

STIR:

DDW44_27855

SKA:	CP970_39750

SGZ:	C0216_31880

SNK:	CP967_10395

SHAW:

CEB94_23585

SRK:	FGW37_04270 FGW37_16250

SFIC:

EIZ62_04115

SGAL:

CP966_29060

SVR:	CP971_23995

SFY:	GFH48_20440

SAQU:

EJC51_31370

SGF:	HEP81_07937

SCAV:

SRIM:

SSUB:

SCIN:

SPAC:

B1H29_00825 B1H29_36235

STSU:

B7R87_22045

SCHA:

CP983_03575 CP983_03670 CP983_27905

SGX:	H4W23_11735(fabG)

SCOE:

CP976_32925

SSPB:

CP982_18990

SNF:	JYK04_04015(actIII_3)

SPLA:

CP981_11570 CP981_34485

SCHF:

IPT68_15415(fabG)

SHUN:

DWB77_05169(actIII_2)

SHAR:

HUT13_24905(fabG)

SCYG:

S1361_29870(actIII3)

SFEU:

IM697_37750

SLIA:

HA039_01270(fabG) HA039_05700

SDW:	K7C20_32490

SMOB:

J7W19_30850(fabG)

SPEU:

CGZ69_24325

SROI:

IAG44_38010(fabG) IAG44_41445(fabG)

SXN:	IAG42_35975 IAG42_36835(fabG)

SANU:

K7396_04595

SDD:	D9753_08675

SACT:

DMT42_11830

SMAO:

CAG99_12140

SGOB:

test1122_15645

SLF:	JEQ17_32825

SDEC:

L3078_20590(fabG)

SYAN:

NRK68_34845(fabG)

STAA:

LDH80_09595

SNIG:

HEK616_47200(actIII)

SSPN:

LXH13_13960(fabG)

SCIR:

STRCI_006076

SLON:

LGI35_31625

SDRZ:

NEH16_30120(fabG) NEH16_32460

STUD:

STRTU_005097(fabG)

SARG:

HKX69_34120(fabG)

SJN:	RI060_18350

SCYN:

N8I84_12700

SOV:	QZH56_16730(fabG) QZH56_23730

SHAU:

K9S39_40685

SKG:	KJK29_16150

SLAI:

P8A22_09030(fabG)

STTN:

BSL84_24920

SINN:

ABB07_18360

KBU:	Q4V64_27190(fabG)

STPB:

QR97_20455 QR97_38690

SRPA:

HEP86_12780

SMIB:

SMIR_18345(fabG)

SCAJ:

O1G22_43270(fabG)

KAB:	B7C62_31020

KAU:	B6264_18570

KIS:	HUT16_23705

KCH:	O1G21_22150(fabG)

YIA:	LO772_34345

ABRY:

NYE86_15455(fabG) NYE86_15950(fabG)

LMOI:

TFU:

TALX:

TCU:

ACIR:

FRA:	Francci3_4103 Francci3_4144 Francci3_4146

FRI:	FraEuI1c_1326

AORI:

APRT:

PSEQ:

PECQ:

PHH:	AFB00_31110

PSDS:

K1T35_37400

SESP:

BN6_54890(fabG7)

SSYI:

EKG83_16370 EKG83_32190

SACX:

IOD16_13140(fabG)

KAL:

KALB_7825

KUT:	JJ691_15710

LED:	BBK82_02525

PMAD:

BAY61_07695

STP:	Strop_2194

MAU:	Micau_4010

MIL:

ML5_4411

VER:	HUT12_05275

MENO:

Jiend_53220(actIII)

MFEU:

H1D33_25710

MCAY:

PVK37_24395(fabG)

AMS:	AMIS_50680

ACTL:

L3i22_085340(actIII)

DROS:

Drose_14685 Drose_24350

DAUR:

Daura_28620(fabG)

NHY:	JQS43_06220(fabG)

CAI:	Caci_3549 Caci_6493

CEP:	Cri9333_4738

CSG:	Cylst_0020

APIB:

G8C43_05870

AG:	AAA65204(dpsE) AAF70104(aknA) AAZ78333(oxyJ) CAA12013(snoaD)

» show all

Reference

PMID:2469622

Authors

Hallam SE, Malpartida F, Hopwood DA

Title

Nucleotide sequence, transcription and deduced function of a gene involved in polyketide antibiotic synthesis in Streptomyces coelicolor.

Journal

Gene 74:305-20 (1988)
DOI:10.1016/0378-1119(88)90165-5

Sequence

[sco:SCO5086]

Reference

PMID:15544323

Authors

Korman TP, Hill JA, Vu TN, Tsai SC

Title

Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.

Journal

Biochemistry 43:14529-38 (2004)
DOI:10.1021/bi048133a

Reference

PMID:16597959

Authors

Zhang W, Ames BD, Tsai SC, Tang Y

Title

Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.

Journal

Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006

Sequence

[ag:AAZ78333]

Reference

PMID:20522541

Authors

Pickens LB, Tang Y

Title

Oxytetracycline biosynthesis.

Journal

J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419

Reference

PMID:8668120

Authors

Ylihonko K, Tuikkanen J, Jussila S, Cong L, Mantsala P

Title

A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway.

Journal

Mol Gen Genet 251:113-20 (1996)
DOI:10.1007/BF02172908

Sequence

[ag:CAA12013]

Reference

PMID:12137949

Authors

Raty K, Kantola J, Hautala A, Hakala J, Ylihonko K, Mantsala P

Title

Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.

Journal

Gene 293:115-22 (2002)
DOI:10.1016/S0378-1119(02)00699-6

Sequence

[ag:AAF70104]

LinkDB

REACTION: R06642

Entry

R06642                      Reaction

Definition

18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + NADPH + H+ <=> C-9 Reduced nonaketamide + NADP+

Equation

C12441 + C00005 + C00080 <=> C12442 + C00006

Comment

ketoreductase, OxyJ (otcY2-1)

Reaction class

RC00001

C00005_C00006

RC00029

C12441_C12442

Enzyme

1.1.1.-

Pathway

rn00253

Tetracycline biosynthesis

rn01056

Biosynthesis of type II polyketide backbone

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00778

Type II polyketide backbone biosynthesis, acyl-CoA + malonyl-CoA => polyketide

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R06642  18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + NADPH + H+ <=> C-9 Reduced nonaketamide + NADP+

Orthology

K12420

ketoreductase [EC:1.1.1.-]

LinkDB

DBGET integrated database retrieval system