KEGG ORTHOLOGY: K12459

ORTHOLOGY: K12459

Entry

K12459                      KO

Symbol

SH2B1_3

Name

SH2B adaptor protein 1/3

Pathway

map04722

Neurotrophin signaling pathway

Disease

H00236

Congenital polycythemia

H00408

Type 1 diabetes mellitus

H01605

Myelofibrosis

H01612

Essential thrombocythemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K12459  SH2B1_3; SH2B adaptor protein 1/3

Other DBs

GO:	0005070 0005068

Genes

HSA:	10019(SH2B3) 25970(SH2B1)

PTR:	452245(SH2B3) 738177(SH2B1)

PPS:	100972257(SH2B3) 100993034(SH2B1)

GGO:	101141260(SH2B1) 101148021(SH2B3)

PON:	100433195(SH2B3) 100456313(SH2B1)

PPYG:

129009351(SH2B3) 129015821(SH2B1)

NLE:	100587926(SH2B1) 100592749(SH2B3)

HMH:	116470193(SH2B1) 116477920(SH2B3)

SSYN:

129460611(SH2B3) 129492879(SH2B1)

MCC:	708160(SH2B1) 710839(SH2B3)

MCF:	102118836(SH2B3) 102147269(SH2B1)

MTHB:

126931449 126944436

MNI:	105482865(SH2B1) 105493404(SH2B3)

CSAB:

103230298(SH2B1) 103239128(SH2B3)

CATY:

105573184(SH2B3) 105598581(SH2B1)

PANU:

100998084(SH2B3) 101000723(SH2B1)

TGE:	112614754(SH2B1) 112634119(SH2B3)

MLEU:

105541488(SH2B1) 105552265(SH2B3)

RRO:	104674613(SH2B3) 104682145(SH2B1)

RBB:	108512212(SH2B3) 108523691(SH2B1)

TFN:	117087576(SH2B1) 117089396(SH2B3)

PTEH:

111526915(SH2B1) 111536991(SH2B3)

CANG:

105505619(SH2B1) 105508269(SH2B3)

CJC:	100385268(SH2B1) 100410237(SH2B3)

SBQ:	101033604(SH2B3) 101049482(SH2B1)

CIMI:

108302207(SH2B1) 108313873(SH2B3)

ANAN:

105725521(SH2B1) 105728611(SH2B3)

CSYR:

103252091(SH2B1) 103264686(SH2B3)

MMUR:

105868282(SH2B1) 105878693(SH2B3)

LCAT:

123626051(SH2B3) 123632525(SH2B1)

PCOQ:

105806070(SH2B1) 105825673(SH2B3)

OGA:	100952321(SH2B1) 100953481(SH2B3)

MMU:	16923(Sh2b3) 20399(Sh2b1)

MCAL:

110294037(Sh2b3) 110297584(Sh2b1)

MPAH:

110312744(Sh2b1) 110312914(Sh2b3)

RNO:	58838(Sh2b3) 89817(Sh2b1)

MCOC:

116068349(Sh2b3) 116078780 116102955(Sh2b1)

ANU:	117698211(Sh2b3) 117707693(Sh2b1)

MUN:	110545310(Sh2b3) 110547976(Sh2b1)

CGE:	100763243(Sh2b1) 100773100(Sh2b3)

MAUA:

101822796(Sh2b1) 101831341(Sh2b3)

PROB:

127216052(Sh2b3) 127228319(Sh2b1)

PLEU:

114681895(Sh2b3) 114686668(Sh2b1) 114700308

MORG:

121446318(Sh2b3) 121457739(Sh2b1)

MFOT:

126488237 126511722

AAMP:

119825069(Sh2b1) 119825577(Sh2b3)

NGI:	103726405(Sh2b1) 103745577(Sh2b3)

HGL:	101709458(Sh2b3) 101715023(Sh2b1)

CPOC:

100726510(Sh2b1) 100729040(Sh2b3)

CCAN:

109683485(Sh2b1) 109695406(Sh2b3)

DORD:

105982159(Sh2b1) 105990647(Sh2b3)

DSP:	122096244(Sh2b1) 122098480(Sh2b3)

PLOP:

125341129(Sh2b1) 125349122(Sh2b3)

NCAR:

124970574 124990905

MMMA:

107146892(Sh2b1) 107156356(Sh2b3)

OCU:	100338013 103348605

OPI:	101528640(SH2B1) 101532320(SH2B3)

TUP:	102472949(SH2B3) 102498876(SH2B1)

GVR:	103595594(SH2B1) 103610397(SH2B3)

CFA:	100683018(SH2B3) 612792(SH2B1)

CLUD:

112640027(SH2B1) 112676554(SH2B3)

VVP:	112929190(SH2B1) 112935174(SH2B3)

VLG:	121475526(SH2B3) 121486621(SH2B1)

NPO:	129508178(SH2B3) 129520195(SH2B1)

AML:	100470297(SH2B1) 100475295(SH2B3)

UMR:	103657816(SH2B1) 103661281(SH2B3)

UAH:	113266969(SH2B3) 113267628(SH2B1)

UAR:	123779090(SH2B3) 123784587(SH2B1)

ELK:	111156348 111162207

LLV:	125082114 125090154

MPUF:

101689020(SH2B1) 101691314(SH2B3)

MNP:	132023161(SH2B3) 132026780(SH2B1)

MLK:	131811064(SH2B3) 131819242(SH2B1)

NVS:	122895967(SH2B1) 122903428(SH2B3)

ORO:	101376411(SH2B1) 101384961(SH2B3)

EJU:	114203433 114203443 114219095(SH2B3)

ZCA:	113912474(SH2B3) 113933139(SH2B1)

MLX:	117999659(SH2B1) 118018474(SH2B3)

NSU:	110588309(SH2B3) 110589971(SH2B1)

LWW:	102738987(SH2B1) 102748854(SH2B3)

FCA:	101081760(SH2B3) 101090917(SH2B1)

PYU:	121010335(SH2B3) 121022471(SH2B1)

PCOO:

112856458(SH2B1)

PBG:	122470224(SH2B3) 122471511(SH2B1)

PVIV:

125149217(SH2B3) 125154062(SH2B1)

LRUF:

124517691 124518232

PTG:	102955506(SH2B3) 102971307(SH2B1)

PPAD:

109256499(SH2B1) 109277648(SH2B3)

PUC:	125914559 125928007

AJU:	106966170 106967525

HHV:	120231283(SH2B3) 120242256(SH2B1)

BTA:	506066(SH2B1) 614726(SH2B3)

BOM:	102277767(SH2B1) 102279278(SH2B3)

BIU:	109571091(SH2B3) 109578267(SH2B1)

BBUB:

102395653(SH2B3) 102411995(SH2B1)

BBIS:

104986610(SH2B1) 104989682(SH2B3)

CHX:	102181888(SH2B3) 102188012(SH2B1)

OAS:	101105283(SH2B3) 101112187(SH2B1)

BTAX:

128043942(SH2B1) 128062184(SH2B3)

ODA:	120871041(SH2B3) 120876691(SH2B1)

CCAD:

122423509(SH2B3) 122433617(SH2B1)

MBEZ:

129542564(SH2B3) 129545484(SH2B1)

SSC:	100154922(SH2B3) 100516788(SH2B1)

CFR:	102507870(SH2B1) 102523127(SH2B3)

CBAI:

105080700(SH2B3) 105082883(SH2B1)

CDK:	105102481(SH2B3) 105102782(SH2B1)

VPC:	102531377(SH2B3) 102533238(SH2B1)

BACU:

102998550(SH2B1) 103009464(SH2B3)

BMUS:

118879983(SH2B3) 118881498(SH2B1)

LVE:	103080846(SH2B1) 103085832(SH2B3)

OOR:	101284654(SH2B1) 101287918(SH2B3)

DLE:	111182196(SH2B1) 111186873(SH2B3)

PCAD:

102978790(SH2B3) 102981011(SH2B1)

PSIU:

116738962(SH2B3) 116740095(SH2B1)

NASI:

112399349(SH2B1) 112408798(SH2B3)

ECB:	100057885(SH2B3) 100064371(SH2B1)

EPZ:	103554573(SH2B3) 103562736(SH2B1)

EAI:	106829101(SH2B1) 106842213(SH2B3)

MYB:	102240140(SH2B1) 102257437(SH2B3)

MYD:	102755008(SH2B3) 102759434(SH2B1)

MMYO:

118652867(SH2B1) 118657025 118678323(SH2B3)

MLF:	102432499(SH2B1) 102438656(SH2B3)

MDT:	132221846(SH2B3) 132232807(SH2B1)

PKL:	118704866(SH2B1) 118725461(SH2B3)

EFUS:

103287055(SH2B3) 103300798(SH2B1)

MNA:	107529568(SH2B3) 107541017(SH2B1)

DRO:	112304807(SH2B1) 112310463(SH2B3)

SHON:

118991099(SH2B3)

AJM:	119040444(SH2B3) 119045361(SH2B1)

PDIC:

114509693(SH2B3) 114511080(SH2B1)

PHAS:

123822979(SH2B3) 123825464(SH2B1)

MMF:	118640237(SH2B3) 118642287(SH2B1)

PPAM:

129078082(SH2B1) 129087399(SH2B3)

HAI:	109382249(SH2B3) 109385860(SH2B1)

RFQ:	117017461(SH2B3) 117019582(SH2B1)

PALE:

102880921(SH2B3) 102885677(SH2B1)

PGIG:

120616103(SH2B3) 120620140(SH2B1)

PVP:	105289385(SH2B3) 105304580(SH2B1)

RAY:	107513254(SH2B3) 107515802(SH2B1)

MJV:	108385495(SH2B1) 108400539(SH2B3)

TOD:	119241791(SH2B1) 119244985(SH2B3)

SARA:

101549386(SH2B3) 101556732(SH2B1)

SETR:

126029518(SH2B1) 126031065(SH2B3)

LAV:	100656348(SH2B3) 100676735(SH2B1)

TMU:	101351245 101358435

ETF:	101651060(SH2B1) 101657430(SH2B3)

DNM:	101411127 101413556 101422135(SH2B1) 101423273 101424410 101425166 101434686 101440979 101441286 101442671(SH2B3) 101447433 105746051

MDO:	100014902(SH2B1) 100017994(SH2B3)

GAS:	123230686(SH2B1) 123255565

SHR:	100913226(SH2B1) 100919741(SH2B3)

AFZ:	127545475 127555874

PCW:	110196799(SH2B3) 110222058(SH2B1)

TVP:	118829998(SH2B3) 118831664(SH2B1)

OAA:	100074705(SH2B3) 103166520(SH2B1)

GGA:	416876(SH2B3)

PCOC:

116228582(SH2B3)

MGP:	100547898(SH2B3)

CJO:	107321152(SH2B3)

TPAI:

128072972 128084721(SH2B3)

LMUT:

125701949(SH2B3)

NMEL:

110406647(SH2B3)

APLA:

119718606(SH2B3)

CATA:

118257525(SH2B3)

AFUL:

116496152(SH2B3)

TGU:	100223819(SH2B3)

LSR:	110478167(SH2B3) 110483487

SCAN:

103818144(SH2B3)

PMOA:

120509715(SH2B3)

OTC:	121339025(SH2B3)

PRUF:

121365113(SH2B3)

GFR:	102042571(SH2B3)

FAB:	101807789(SH2B3)

OMA:	130259932(SH2B3)

PHI:	102102318(SH2B3)

PMAJ:

107211632(SH2B3)

CCAE:

111936715(SH2B3)

CCW:	120410849(SH2B3)

CBRC:

103615934(SH2B3)

ETL:	114062689(SH2B3)

ZLE:	135454551(SH2B3)

SVG:	106852357(SH2B3)

MMEA:

130580361(SH2B3)

HRT:	120760701(SH2B3)

SATI:

136369029(SH2B3)

FPG:	101924617(SH2B3)

FCH:	102046699(SH2B3)

SHAB:

115614451(SH2B3)

TALA:

116965358(SH2B3)

ACHC:

115346373(SH2B3)

HLE:	104840865(SH2B3)

AGEN:

126041228

GCL:

127022851

DPUB:

104308486(SH2B3)

EGZ:	104122729(SH2B3)

NNI:	104019390(SH2B3)

AFOR:

103902850(SH2B3)

CLV:	102085187(SH2B3)

CUCA:

104058810(SH2B3)

CPEA:

104389457(SH2B3)

CVF:	104282278(SH2B3)

RTD:	128917093(SH2B3)

NPD:	112949396(SH2B3)

ASN:	102374776(SH2B3) 102382286(SH2B1)

AMJ:	102570853(SH2B1) 106739026(SH2B3)

CPOO:

109312658(SH2B3)

GGN:	109290567(SH2B3)

PSS:	102444347 106731741

CMY:	102938314(SH2B3) 102945147(SH2B1)

CCAY:

125622709(SH2B3) 125639026(SH2B1)

DCC:	119843490(SH2B3) 119858051(SH2B1)

CPIC:

101945736(SH2B1) 101954103(SH2B3)

TST:	117870238 117870666 117887946(SH2B3)

CABI:

116822349(SH2B1) 116836706(SH2B3)

MRV:	120386112(SH2B3) 120404388(SH2B1)

ACS:	100564804(sh2b1) 100568136(sh2b3)

ASAO:

132777962(SH2B1) 132781677(SH2B3)

PVT:	110078507(SH2B1) 110083866(SH2B3)

SUND:

121916371(SH2B3) 121934251(SH2B1)

PBI:	103052881(SH2B1) 103054901(SH2B3)

PMUR:

107282509(SH2B1) 107286973(SH2B3) 107297019

CTIG:

120304559(SH2B1) 120316713(SH2B3)

TSR:	106551553 106555990(SH2B3)

PGUT:

117669145(SH2B1) 117672152(SH2B3)

APRI:

131185553(SH2B3) 131197619(SH2B1)

PTEX:

113443543(SH2B1) 113448637(SH2B3)

NSS:	113418567(SH2B1)

VKO:	123028624(SH2B3) 123032215(SH2B1)

PMUA:

114581736(SH2B1) 114602739(SH2B3)

PRAF:

128399561(SH2B1) 128419947(SH2B3)

ZVI:	118087619(SH2B3) 118095134(SH2B1)

HCG:	128330229(SH2B1) 128338181(SH2B3)

GJA:	107112144(SH2B3) 107122684(SH2B1)

STOW:

125442507(SH2B3) 125444493(SH2B1)

EMC:	129340295(SH2B1) 129341400(SH2B3)

XLA:	108704216(sh2b1.S) 108704727(sh2b1.L) 108707168(sh2b3.S) 108716905(sh2b3.L)

XTR:	100101733(sh2b3) 101730577(sh2b1)

NPR:	108788537(SH2B3) 108796530(SH2B1)

RTEM:

120933251(SH2B3) 120943133(SH2B1)

BBUF:

120988572(SH2B3) 121007467(SH2B1)

BGAR:

122934961(SH2B3) 122944804(SH2B1)

MUO:	115473828(SH2B1) 115479438(SH2B3)

GSH:	117360617(SH2B1) 117365408(SH2B3)

DRE:	101884640(sh2b3) 558152(sh2b1)

SRX:	107723297 107725115(sh2b3) 107739405 107754626

SANH:

107660817 107667373(sh2b3) 107689073 107704923

SGH:	107550292 107552475(sh2b1) 107567095 107594562

CCAR:

109048522 109048602 109053002 109053012 109103150

CAUA:

113044010 113046876 113067950 113069464 113072665 113094185

CGIB:

127947319 127952028 127957648 128014274 128021613

PTET:

122341934(sh2b1) 122345445(sh2b3) 122348751

LROH:

127163080(sh2b1) 127165310(sh2b3)

OMC:	131537310(sh2b1) 131540401(sh2b3)

PPRM:

120470149(sh2b3) 120490263(sh2b1)

RKG:	130075242(sh2b1) 130088157(sh2b3)

MAMB:

125267284(sh2b3) 125278918(sh2b1)

CIDE:

127509199 127513197

CERY:

137017445(sh2b1) 137033706(sh2b3)

MASI:

127430205 127437688 127449760 127451688

TROS:

130548144(sh2b3) 130562002(sh2b1)

TDW:	130419646(sh2b3) 130425580(sh2b1)

MANU:

129436310(sh2b1) 129439649(sh2b3)

IPU:	108255638 108280004

IFU:	128601011(sh2b1)

PHYP:

113528148 113528211(sh2b1)

SMEO:

124380452(sh2b3) 124397291(sh2b1)

TFD:	113638095(sh2b1) 113656787(sh2b3)

TVC:	132855216(sh2b3) 132860681(sh2b1)

TRN:	134335468(sh2b3) 134335993(sh2b1)

AMEX:

103044007(sh2b3) 111192071(sh2b1)

CMAO:

118821852(sh2b1) 118827010(sh2b3)

EEE:	113569841(sh2b1) 113586788(sh2b3)

CHAR:

105889916(sh2b3) 105912525(sh2b1)

TRU:	101061983(sh2b1) 101062576(sh2b3)

TFS:	130515038(sh2b1) 130525783(sh2b3)

TNG:	GSTEN00010433G001 GSTEN00012344G001

LCO:	104935891(sh2b1)

NCC:	104950649 104965654

TBEN:

117472355(sh2b3) 117492484(sh2b1)

CGOB:

115013940(sh2b3)

PGEO:

117451188(sh2b1) 117452480(sh2b3)

GACU:

117539807(sh2b1) 117558596(sh2b3)

EMAC:

134873625(sh2b3) 134878306(sh2b1)

ELY:	117252638(sh2b3) 117268419(sh2b1)

EFO:	125879587(sh2b1) 125890210(sh2b3)

PLEP:

121944016(sh2b3) 121956343(sh2b1)

SLUC:

116054047(sh2b3) 116060874(sh2b1)

ECRA:

117945554(sh2b3)

ESP:	116686832(sh2b1) 116690369(sh2b3)

PFLV:

114556241(sh2b3) 114570291

GAT:	120828166(sh2b1) 120830782(sh2b3)

PPUG:

119220937(sh2b1) 119225665(sh2b3)

AFB:	129099046(sh2b1) 129101508(sh2b3)

CLUM:

117735504(sh2b1) 117735982(sh2b3)

PSWI:

130188085(sh2b1) 130196134(sh2b3)

MSAM:

119891310(sh2b3) 119895336(sh2b1)

SCHU:

122869029(sh2b1) 122876924(sh2b3)

CUD:	121509585(sh2b3) 121529472(sh2b1)

ALAT:

119013911(sh2b1) 119019114(sh2b3)

ASTR:

137592611(sh2b3) 137610103(sh2b1)

MZE:	101469716(sh2b3) 101483387

ONL:	100698340(sh2b3) 100699816(sh2b1)

OAU:	116310502(sh2b3) 116318641(sh2b1)

OLA:	101160415(sh2b3) 101168212(sh2b1)

OML:	112139450(sh2b1) 112148726(sh2b3)

CSAI:

133421952(sh2b1) 133450634(sh2b3)

XMA:	102233963(sh2b1) 102234238(sh2b3)

XCO:	114154567(sh2b3) 114159415(sh2b1)

XHE:	116729791(sh2b3) 116734941(sh2b1)

PRET:

103469479(sh2b1) 103470099(sh2b3)

PFOR:

103141763(sh2b3) 103153099

PLAI:

106944941(sh2b3) 106961648

PMEI:

106906754 106923066(sh2b3)

GAF:	122821636(sh2b1) 122827453(sh2b3)

PPRL:

129365737(sh2b3) 129373832(sh2b1)

CVG:	107086307(sh2b3) 107096979(sh2b1)

CTUL:

119789972(sh2b1) 119798553(sh2b3)

GMU:	124862995 124864200 124878596(sh2b3)

NFU:	107372822 107394146(sh2b3)

KMR:	108228486(sh2b1) 108233769(sh2b3)

ALIM:

106533630(sh2b3) 106533907

NWH:	119413273(sh2b3) 119429811

AOCE:

111564708(sh2b3) 111571259

MCEP:

124998016(sh2b1) 125011857(sh2b3)

CSEM:

103393456 103396966 103397715

POV:	109636959(sh2b3) 109646143

SSEN:

122769475(sh2b3) 122784820(sh2b1)

HHIP:

117766008(sh2b1) 117768549(sh2b3)

HSP:	118114792(sh2b3) 118123471(sh2b1)

PPLT:

128437790(sh2b3) 128458222(sh2b1)

SMAU:

118289085(sh2b1) 118313792(sh2b3)

LCF:	108882177 108892191 108892213

SDU:	111230793(sh2b3) 111238916(sh2b1)

SLAL:

111645154(sh2b3) 111652879

XGL:	120788237(sh2b1) 120804868(sh2b3)

HCQ:	109513824 109526724(sh2b3)

SSCV:

125983256 125993726

SBIA:

133498886(sh2b3) 133514125(sh2b1)

PEE:	133399933(sh2b3) 133414610(sh2b1)

PTAO:

133466446(sh2b1) 133475201(sh2b3)

BPEC:

110167044(sh2b3) 110170328(sh2b1)

MALB:

109956564(sh2b3) 109967551(sh2b1)

BSPL:

114860577(sh2b1) 114861824(sh2b3)

SJO:	128365420(sh2b3) 128378575(sh2b1)

SASA:

106580188 106583900 106585852 106600738(sh2b1)

STRU:

115164959 115170810 115192146 115199718

OTW:	112247097(sh2b3) 112251431 112251622(sh2b1) 112263423

OMY:	110525097(sh2b3) 110535686 110537914(sh2b1)

OGO:	123999665 124034630 124035970 124037953

ONE:	115110029(sh2b1) 115111277 115139694 115145257

OKI:	109872018 109893090(sh2b1) 109895595 109897235

OKE:	118357991 118358928 118370860(sh2b3) 118384296

SALP:

111957992 111971451 111974922 111981694(sh2b1)

SNH:	120032892(sh2b1) 120045589 120063028

CCLU:

121550345 121584413(sh2b3) 121587496 123491215

ELS:	105012812(sh2b1) 105014604(sh2b3)

SFM:	108934747(sh2b3) 108941541(sh2b1)

PKI:	111833753(sh2b1) 111850583(sh2b3)

AANG:

118212969 118216537(sh2b1) 118237517(sh2b3)

LOC:	102682340(sh2b3)

PSPA:

121297170 121299787 121305219 121307323

ARUT:

117399073(sh2b1) 117428246 117973373

PSEX:

120536409(sh2b1) 120540971(sh2b3)

LCM:	102361027(SH2B1) 102361425(SH2B3)

CMK:	103184328(sh2b3)

RTP:	109911048 125481653

CPLA:

122547858

HOC:	132827328(sh2b3)

LERI:

129709426(sh2b3)

PMRN:

LRJ:

BFO:

BBEL:

SPU:

APLC:

ARUN:

SKO:

CQU:	CpipJ_CPIJ013686

CPII:

DPA:

DNX:

ACOO:

DVT:

HHAL:

106691473(Lnk)

FCD:

HAZT:

DFR:

PCAN:

CRG:

CANU:

CVN:	111133564 111134824

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OSN:

LAK:

SMM:	Smp_154870

OVI:	T265_00100

EGL:

EPA:

ADF:

AMIL:

PDAM:

DGT:

XEN:

HMG:

AQU:

Reference

PMID:15767667

Authors

Nishi M, Werner ED, Oh BC, Frantz JD, Dhe-Paganon S, Hansen L, Lee J, Shoelson SE

Title

Kinase activation through dimerization by human SH2-B.

Journal

Mol Cell Biol 25:2607-21 (2005)
DOI:10.1128/MCB.25.7.2607-2621.2005

Sequence

[hsa:25970]

Reference

PMID:14565960

Authors

Wang X, Chen L, Maures TJ, Herrington J, Carter-Su C

Title

SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells.

Journal

J Biol Chem 279:133-41 (2004)
DOI:10.1074/jbc.M310040200

LinkDB

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