KEGG   ORTHOLOGY: K12459
Entry
K12459                      KO                                     
Symbol
SH2B1_3
Name
SH2B adaptor protein 1/3
Pathway
map04722  Neurotrophin signaling pathway
Disease
H00236  Congenital polycythemia
H00408  Type 1 diabetes mellitus
H01605  Myelofibrosis
H01612  Essential thrombocytosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K12459  SH2B1_3; SH2B adaptor protein 1/3
Other DBs
GO: 0005070 0005068
Genes
HSA: 10019(SH2B3) 25970(SH2B1)
PTR: 452245(SH2B3) 738177(SH2B1)
PPS: 100972257(SH2B3) 100993034(SH2B1)
GGO: 101141260(SH2B1) 101148021(SH2B3)
PON: 100433195(SH2B3) 100456313(SH2B1)
NLE: 100587926(SH2B1) 100592749(SH2B3)
MCC: 708160(SH2B1) 710839(SH2B3)
MCF: 102118836(SH2B3) 102147269(SH2B1)
CSAB: 103230298(SH2B1) 103239128(SH2B3)
CATY: 105573184(SH2B3) 105598581(SH2B1)
PANU: 100998084(SH2B3) 101000723(SH2B1)
TGE: 112614754(SH2B1) 112634119(SH2B3)
RRO: 104674613(SH2B3) 104682145(SH2B1)
RBB: 108512212(SH2B3) 108523691(SH2B1)
TFN: 117087576(SH2B1) 117089396(SH2B3)
PTEH: 111526915(SH2B1) 111536991(SH2B3)
CJC: 100385268(SH2B1) 100410237(SH2B3)
SBQ: 101033604(SH2B3) 101049482(SH2B1)
CSYR: 103252091(SH2B1) 103264686(SH2B3)
MMUR: 105868282(SH2B1) 105878693(SH2B3)
LCAT: 123626051(SH2B3) 123632525(SH2B1)
OGA: 100952321(SH2B1) 100953481(SH2B3)
MMU: 16923(Sh2b3) 20399(Sh2b1)
MCAL: 110294037(Sh2b3) 110297584(Sh2b1)
MPAH: 110312744(Sh2b1) 110312914(Sh2b3)
RNO: 58838(Sh2b3) 89817(Sh2b1)
MCOC: 116068349(Sh2b3) 116078780 116102955(Sh2b1)
MUN: 110545310(Sh2b3) 110547976(Sh2b1)
CGE: 100763243(Sh2b1) 100773100(Sh2b3)
MAUA: 101822796(Sh2b1) 101831341(Sh2b3)
PLEU: 114681895(Sh2b3) 114686668(Sh2b1) 114700308
MORG: 121446318(Sh2b3) 121457739(Sh2b1)
AAMP: 119825069(Sh2b1) 119825577(Sh2b3)
NGI: 103726405(Sh2b1) 103745577(Sh2b3)
HGL: 101709458(Sh2b3) 101715023(Sh2b1)
CPOC: 100726510(Sh2b1) 100729040(Sh2b3)
CCAN: 109683485(Sh2b1) 109695406(Sh2b3)
DORD: 105982159(Sh2b1) 105990647(Sh2b3)
DSP: 122096244(Sh2b1) 122098480(Sh2b3)
OCU: 100338013(SH2B3) 103348605(SH2B1)
OPI: 101528640(SH2B1) 101532320(SH2B3)
TUP: 102472949(SH2B3) 102498876(SH2B1)
CFA: 100683018(SH2B3) 612792(SH2B1)
VVP: 112929190(SH2B1) 112935174(SH2B3)
VLG: 121475526(SH2B3) 121486621(SH2B1)
AML: 100470297(SH2B1) 100475295(SH2B3)
UMR: 103657816(SH2B1) 103661281(SH2B3)
UAH: 113266969(SH2B3) 113267628(SH2B1)
UAR: 123779090(SH2B3) 123784587(SH2B1)
MPUF: 101689020(SH2B1) 101691314(SH2B3)
ORO: 101376411(SH2B1) 101384961(SH2B3)
ZCA: 113912474(SH2B3) 113933139(SH2B1)
MLX: 117999659(SH2B1) 118018474(SH2B3)
FCA: 101081760(SH2B3) 101090917(SH2B1)
PYU: 121010335(SH2B3) 121022471(SH2B1)
PBG: 122470224(SH2B3) 122471511(SH2B1)
PTG: 102955506(SH2B3) 102971307(SH2B1)
PPAD: 109256499(SH2B1) 109277648(SH2B3)
AJU: 106966170(SH2B1) 106967525(SH2B3)
HHV: 120231283(SH2B3) 120242256(SH2B1)
BTA: 506066(SH2B1) 614726(SH2B3)
BOM: 102277767(SH2B1) 102279278(SH2B3)
BIU: 109571091(SH2B3) 109578267(SH2B1)
BBUB: 102395653(SH2B3) 102411995(SH2B1)
CHX: 102181888(SH2B3) 102188012(SH2B1)
OAS: 101105283(SH2B3) 101112187(SH2B1)
ODA: 120871041(SH2B3) 120876691(SH2B1)
CCAD: 122423509(SH2B3) 122433617(SH2B1)
SSC: 100154922(SH2B3) 100516788(SH2B1)
CFR: 102507870(SH2B1) 102523127(SH2B3)
CBAI: 105080700(SH2B3) 105082883(SH2B1)
CDK: 105102481(SH2B3) 105102782(SH2B1)
VPC: 102531377(SH2B3) 102533238(SH2B1)
BACU: 102998550(SH2B1) 103009464(SH2B3)
LVE: 103080846(SH2B1) 103085832(SH2B3)
OOR: 101284654(SH2B1) 101287918(SH2B3)
DLE: 111182196(SH2B1) 111186873(SH2B3)
PCAD: 102978790(SH2B3) 102981011(SH2B1)
PSIU: 116738962(SH2B3) 116740095(SH2B1)
ECB: 100057885(SH2B3) 100064371(SH2B1)
EPZ: 103554573(SH2B3) 103562736(SH2B1)
EAI: 106829101(SH2B1) 106842213(SH2B3)
MYB: 102240140(SH2B1) 102257437(SH2B3)
MYD: 102755008(SH2B3) 102759434(SH2B1)
MMYO: 118652867(SH2B1) 118657025 118678323(SH2B3)
MLF: 102432499(SH2B1) 102438656(SH2B3)
MNA: 107529568(SH2B3) 107541017(SH2B1)
PKL: 118704866(SH2B1) 118725461(SH2B3)
HAI: 109382249(SH2B3) 109385860(SH2B1)
DRO: 112304807(SH2B1) 112310463(SH2B3)
SHON: 118991099(SH2B3)
AJM: 119040444(SH2B3) 119045361(SH2B1)
PDIC: 114509693(SH2B3) 114511080(SH2B1)
PHAS: 123822979(SH2B3) 123825464(SH2B1)
MMF: 118640237(SH2B3) 118642287(SH2B1)
RFQ: 117017461(SH2B3) 117019582(SH2B1)
PALE: 102880921(SH2B3) 102885677(SH2B1)
PGIG: 120616103(SH2B3) 120620140(SH2B1)
PVP: 105289385(SH2B3) 105304580(SH2B1)
RAY: 107513254(SH2B3) 107515802(SH2B1)
MJV: 108385495(SH2B1) 108400539(SH2B3)
TOD: 119241791(SH2B1) 119244985(SH2B3)
SARA: 101549386(SH2B3) 101556732(SH2B1)
LAV: 100656348(SH2B3) 100676735(SH2B1)
MDO: 100014902(SH2B1) 100017994(SH2B3)
GAS: 123230686(SH2B1) 123255565
SHR: 100913226(SH2B1) 100919741(SH2B3)
PCW: 110196799(SH2B3) 110222058(SH2B1)
OAA: 100074705(SH2B3) 103166520(SH2B1)
GGA: 416876(SH2B3)
PCOC: 116228582(SH2B3)
MGP: 100547898(SH2B3)
CJO: 107321152(SH2B3)
NMEL: 110406647(SH2B3)
ACYG: 106031405(SH2B3)
AFUL: 116496152(SH2B3)
TGU: 100223819(SH2B3)
LSR: 110478167(SH2B3) 110483487
SCAN: 103818144(SH2B3)
PMOA: 120509715(SH2B3)
OTC: 121339025(SH2B3)
PRUF: 121365113(SH2B3)
GFR: 102042571(SH2B3)
FAB: 101807789(SH2B3)
PHI: 102102318(SH2B3)
PMAJ: 107211632(SH2B3)
CCAE: 111936715(SH2B3)
CCW: 120410849(SH2B3)
ETL: 114062689(SH2B3)
FPG: 101924617(SH2B3)
FCH: 102046699(SH2B3)
CLV: 102085187(SH2B3)
EGZ: 104122729(SH2B3)
NNI: 104019390(SH2B3)
TALA: 116965358(SH2B3)
ACHC: 115346373(SH2B3)
NPD: 112949396(SH2B3)
ASN: 102374776(SH2B3) 102382286(SH2B1)
AMJ: 102570853(SH2B1) 106739026(SH2B3)
CPOO: 109312658(SH2B3)
GGN: 109290567(SH2B3)
CMY: 102938314(SH2B3) 102945147(SH2B1)
CPIC: 101945736(SH2B1) 101954103(SH2B3)
CABI: 116822349(SH2B1) 116836706(SH2B3)
MRV: 120386112(SH2B3) 120404388(SH2B1)
ACS: 100564804(sh2b1) 100568136(sh2b3)
PVT: 110078507(SH2B1) 110083866(SH2B3)
SUND: 121916371(SH2B3) 121934251(SH2B1)
PBI: 103052881(SH2B1) 103054901(SH2B3)
PMUR: 107282509(SH2B1) 107286973(SH2B3) 107297019
TSR: 106551553 106555990(SH2B3)
PGUT: 117669145(SH2B1) 117672152(SH2B3)
VKO: 123028624(SH2B3) 123032215(SH2B1)
PMUA: 114581736(SH2B1) 114602739(SH2B3)
ZVI: 118087619(SH2B3) 118095134(SH2B1)
GJA: 107112144(SH2B3) 107122684(SH2B1)
STOW: 125442507(SH2B3) 125444493(SH2B1)
XLA: 108704216(sh2b1.S) 108704727(sh2b1.L) 108707168(sh2b3.S) 108716905(sh2b3.L)
XTR: 100101733(sh2b3) 101730577(sh2b1)
NPR: 108788537(SH2B3) 108796530(SH2B1)
RTEM: 120933251(SH2B3) 120943133(SH2B1)
BBUF: 120988572(SH2B3) 121007467(SH2B1)
BGAR: 122934961(SH2B3) 122944804(SH2B1)
DRE: 101884640(sh2b3) 558152(sh2b1)
PPRM: 120470149(sh2b3) 120490263(sh2b1)
MAMB: 125267284(sh2b3) 125278918(sh2b1)
PHYP: 113528148 113528211(sh2b1)
SMEO: 124380452(sh2b3) 124397291(sh2b1)
TFD: 113638095(sh2b1) 113656787(sh2b3)
AMEX: 103044007(sh2b3) 111192071(sh2b1)
EEE: 113569841(sh2b1) 113586788(sh2b3)
TRU: 101061983(sh2b1) 101062576(sh2b3)
LCO: 104935891(sh2b1)
CGOB: 115013940(sh2b3)
ELY: 117252638(sh2b3) 117268419(sh2b1)
PLEP: 121944016(sh2b3) 121956343(sh2b1)
SLUC: 116054047(sh2b3) 116060874(sh2b1)
ECRA: 117945554(sh2b3)
PFLV: 114556241(sh2b3) 114570291
GAT: 120828166(sh2b1) 120830782(sh2b3)
PPUG: 119220937(sh2b1) 119225665(sh2b3)
MSAM: 119891310(sh2b3) 119895336(sh2b1)
CUD: 121509585(sh2b3) 121529472(sh2b1)
ALAT: 119013911(sh2b1) 119019114(sh2b3)
MZE: 101469716(sh2b3) 101483387
ONL: 100698340(sh2b3) 100699816(sh2b1)
OAU: 116310502(sh2b3) 116318641(sh2b1)
OLA: 101160415(sh2b3) 101168212(sh2b1)
OML: 112139450(sh2b1) 112148726(sh2b3)
XMA: 102233963(sh2b1) 102234238(sh2b3)
XCO: 114154567(sh2b3) 114159415(sh2b1)
XHE: 116729791(sh2b3) 116734941(sh2b1)
PRET: 103469479(sh2b1) 103470099(sh2b3)
PFOR: 103141763(sh2b3) 103153099
PLAI: 106944941(sh2b3) 106961648
PMEI: 106906754 106923066(sh2b3)
GAF: 122821636(sh2b1) 122827453(sh2b3)
CVG: 107086307(sh2b3) 107096979(sh2b1)
CTUL: 119789972(sh2b1) 119798553(sh2b3)
NFU: 107372822 107394146(sh2b3)
KMR: 108228486(sh2b1) 108233769(sh2b3)
ALIM: 106533630(sh2b3) 106533907
NWH: 119413273(sh2b3) 119429811
AOCE: 111564708(sh2b3) 111571259
POV: 109636959(sh2b3) 109646143
SSEN: 122769475(sh2b3) 122784820(sh2b1)
HHIP: 117766008(sh2b1) 117768549(sh2b3)
HSP: 118114792(sh2b3) 118123471(sh2b1)
SDU: 111230793(sh2b3) 111238916(sh2b1)
SLAL: 111645154(sh2b3) 111652879
XGL: 120788237(sh2b1) 120804868(sh2b3)
HCQ: 109513824 109526724(sh2b3)
BPEC: 110167044(sh2b3) 110170328(sh2b1)
MALB: 109956564(sh2b3) 109967551(sh2b1)
BSPL: 114860577(sh2b1) 114861824(sh2b3)
OMY: 110525097(sh2b3) 110535686 110537914(sh2b1)
ELS: 105012812(sh2b1) 105014604(sh2b3)
SFM: 108934747(sh2b3) 108941541(sh2b1)
PKI: 111833753(sh2b1) 111850583(sh2b3)
AANG: 118212969 118216537(sh2b1) 118237517(sh2b3)
LOC: 102682340(sh2b3)
LCM: 102361027(SH2B1) 102361425(SH2B3)
CMK: 103184328(sh2b3)
RTP: 109911048(sh2b3)
BFO: 118425857
BBEL: 109465557
SPU: 592420
APLC: 110982231
SKO: 100374613
CPII: 120424398
BMOR: 101745173
BMAN: 114240473
DNX: 107165003
HHAL: 106691473
FCD: 110850954
HAZT: 108665646
DFR: 124497726
PCAN: 112561615
CRG: 105321569
MYI: 110447018
PMAX: 117332722
MMER: 123535372
OSN: 115224813
LAK: 106178064
EGL: EGR_03806
EPA: 110246350
ADF: 107339501
AMIL: 114955926
PDAM: 113681263
DGT: 114523573
XEN: 124434065
HMG: 100213002
AQU: 105316729
 » show all
Reference
  Authors
Nishi M, Werner ED, Oh BC, Frantz JD, Dhe-Paganon S, Hansen L, Lee J, Shoelson SE
  Title
Kinase activation through dimerization by human SH2-B.
  Journal
Mol Cell Biol 25:2607-21 (2005)
DOI:10.1128/MCB.25.7.2607-2621.2005
  Sequence
[hsa:25970]
Reference
  Authors
Wang X, Chen L, Maures TJ, Herrington J, Carter-Su C
  Title
SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells.
  Journal
J Biol Chem 279:133-41 (2004)
DOI:10.1074/jbc.M310040200
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