KEGG ORTHOLOGY: K12501

ORTHOLOGY: K12501

Entry

K12501                      KO

Symbol

HST

Name

homogentisate solanesyltransferase [EC:2.5.1.117]

Pathway

map00130

Ubiquinone and other terpenoid-quinone biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01240

Biosynthesis of cofactors

Module

M00933

Plastoquinone biosynthesis, homogentisate + solanesyl-PP => plastoquinol

Reaction

R08782

all-trans-nonaprenyl-diphosphate:homogentisate nonaprenyltransferase (decarboxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K12501  HST; homogentisate solanesyltransferase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K12501  HST; homogentisate solanesyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.117  homogentisate solanesyltransferase
     K12501  HST; homogentisate solanesyltransferase
Prenyltransferases [BR:ko01006]
Compound prenylation
  HGA prenyltransferase
   K12501  HST; homogentisate solanesyltransferase

Other DBs

GO:

0010357

Genes

ATH:	AT3G11945(HST)

ALY:

9320940

CRB:

17893368

CSAT:

104745405 104764953 104776009

EUS:	EUTSA_v10020917mg

BRP:	103859421 103870296

BNA:	106353069 106401877 106415089 106452511

BOE:	106295456 106328784

RSZ:	108857256 108861640 130495167

THJ:

104799273

CPAP:

110811676

CIT:

102623177

CIC:	CICLE_v10011942mg

PVY:	116123782 116141098

MINC:

123217947

TCC:

18599202

GRA:

105799584

GHI:	107889470 107891223

GAB:

HSYR:

DZI:

EGR:

GMX:	106794098 732619(VTE2-2)

GSJ:	114368608 114391749

PVU:	PHAVU_007G263400g PHAVU_007G263600g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131628171 131631878

LJA:

130720185

ADU:

107488364

AIP:	107638265 107640277 107643163

AHF:	112740928 112749774 112749775 112801368

LANG:

109348270

PCIN:

129312483

QSA:	O6P43_005780

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103413543 103453758

MSYL:

126594281 126600879

ZJU:

107432279

CSAV:

115699217 115707809 115713148 115713205 115713215

CSV:	101215738 101215980

CMO:	103486726 103486727

BHJ:	120090397 120091489

MCHA:

111019344 111019365

CMAX:

111481663 111481664 111498286 111498673

CMOS:

111442127 111442432 111450149 111450175

CPEP:

111790845 111790846 111799849 111799850

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107817989 107825180

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110689168 110704797

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:	4343702(HPT2)

OBR:

OGL:

BDI:

ATS:

TDC:	119289099 119349253

TAES:

123065273 123142883 123182829

TUA:

LPER:

LRD:

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PDA:	103717661 120105149

EGU:

105046456

MUS:

103983014

ZOF:	121982551 121986455

DCT:

PEQ:

AOF:

NCOL:

ATR:

SMO:	SELMODRAFT_110629 SELMODRAFT_229530

PPP:

112292815

CRE:	CHLRE_06g283750v5

VCN:	VOLCADRAFT_78084

CSL:	COCSUDRAFT_15913

CVR:	CHLNCDRAFT_22974

APRO:

F751_1997

OLU:	OSTLU_32069

OTA:	OT_ostta06g01340

BPG:	Bathy05g01370

MIS:	MICPUN_108125

MPP:	MICPUCDRAFT_58789

CME:	CYME_CMS413C

GSL:	Gasu_34090

CCP:	CHC_T00000930001

PTI:	PHATRDRAFT_2738

FCY:	FRACYDRAFT_189402

TPS:	THAPSDRAFT_263902

EHX:	EMIHUDRAFT_115547 EMIHUDRAFT_95285

GTT:	GUITHDRAFT_157479

» show all

Reference

PMID:16989822

Authors

Sadre R, Gruber J, Frentzen M

Title

Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.

Journal

FEBS Lett 580:5357-62 (2006)
DOI:10.1016/j.febslet.2006.09.002

Reference

PMID:20400515

Authors

Sadre R, Frentzen M, Saeed M, Hawkes T

Title

Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis.

Journal

J Biol Chem 285:18191-8 (2010)
DOI:10.1074/jbc.M110.117929

Sequence

[ath:AT3G11945]

LinkDB

ENZYME: 2.5.1.117

Entry

EC 2.5.1.117                Enzyme

Name

homogentisate solanesyltransferase;
HST;
PDS2 (gene name)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

all-trans-nonaprenyl-diphosphate:homogentisate nonaprenyltransferase

Reaction(IUBMB)

all-trans-nonaprenyl diphosphate + homogentisate = diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2 [RN:R08782]

Reaction(KEGG)

R08782

Substrate

all-trans-nonaprenyl diphosphate [CPD:C04145];
homogentisate [CPD:C00544]

Product

diphosphate [CPD:C00013];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD:C17570];
CO2 [CPD:C00011]

Comment

Requires Mg2+ for activity. Part of the biosynthesis pathway of plastoquinol-9. The enzymes purified from the plant Arabidopsis thaliana and the alga Chlamydomonas reinhardtii are also active in vitro with unsaturated C10 to C20 prenyl diphosphates, producing main products that are not decarboxylated [2].

History

EC 2.5.1.117 created 2014

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K12501

homogentisate solanesyltransferase

Genes

ATH:	AT3G11945(HST)

ALY:

9320940

CRB:

17893368

CSAT:

104745405 104764953 104776009

EUS:	EUTSA_v10020917mg

BRP:	103859421 103870296

BNA:	106353069 106401877 106415089 106452511

BOE:	106295456 106328784

RSZ:	108857256 108861640 130495167

THJ:

104799273

CPAP:

110811676

CIT:

102623177

CIC:	CICLE_v10011942mg

PVY:	116123782 116141098

MINC:

123217947

TCC:

18599202

GRA:

105799584

GHI:	107889470 107891223

GAB:

108454348

HSYR:

120159828 120202024

DZI:

111311614

EGR:

104446383

GMX:	106794098 732619(VTE2-2)

GSJ:	114368608 114391749

PVU:	PHAVU_007G263400g PHAVU_007G263600g

VRA:

106772791

VAR:

108324919

VUN:

114189752

VUM:

124845334

CCAJ:

109815147

APRC:

113870943

MTR:

25483545

TPRA:

123906043

CAM:

101499831

PSAT:

127098289

VVO:	131628171 131631878

LJA:

130720185

ADU:

107488364

AIP:	107638265 107640277 107643163

AHF:	112740928 112749774 112749775 112801368

LANG:

109348270

PCIN:

129312483

QSA:	O6P43_005780

FVE:

101315076

RCN:

112191407

PPER:

18771788

PMUM:

103339596

PAVI:

110748815

PDUL:

117634837

MDM:	103413543 103453758

MSYL:

126594281 126600879

ZJU:

107432279

MNT:	112090276 112090288 112090338 112090624 112090625 112090629 112091786 112092455 112092457 112092653 112092669 112093398 112093399 112093962 21386351 21386352 21391268 21392968 21395652 21395653 21397213 21397216 21397218 21397221 21400881 21408641 21408642

CSAV:

115699217 115707809 115713148 115713205 115713215

CSV:	101215738 101215980

CMO:	103486726 103486727

BHJ:	120090397 120091489

MCHA:

111019344 111019365

CMAX:

111481663 111481664 111498286 111498673

CMOS:

111442127 111442432 111450149 111450175

CPEP:

111790845 111790846 111799849 111799850

RCU:

8258414

MEAN:

126677068

JCU:

105648962

HBR:

110649073

MESC:

110621278

POP:

7479502

PEU:

105141559

PALZ:

118043922

JRE:

109013473

CILL:

122279134

CAVE:

132192030 132192050

QSU:

111994066

QLO:

115953720

TWL:

120013938

VVI:

100264108

VRI:

117921155

SLY:

101261100

SPEN:

107014921

SOT:

102594989

SSTN:

125860216

SDUL:

129870495

CANN:

107863628

LBB:

132637052

NTA:	107817989 107825180

NSY:

104244646

NTO:

104097789

NAU:

109223328

INI:

109181711

ITR:

116006115

SIND:

105159639

OEU:

111391091

EGT:

105955266

SSPL:

121794363 121798679

SHIS:

125207417

APAN:

127254330

HAN:

110898146

ECAD:

122607555

LSV:

111905349

CCAV:

112521993

DCR:

108218311

CSIN:

114272823

RVL:

131318825

AEW:

130790844

BVG:

104906725

SOE:

110799402

CQI:	110689168 110704797

ATRI:

130825112

MOF:

131167854

NNU:

104597646

MING:

122061018

TSS:

122642920

PSOM:

113309639

OSA:	4343702(HPT2)

OBR:

102706213

OGL:

127780588

BDI:

100825292

ATS:

109781870

TDC:	119289099 119349253

TAES:

123065273 123142883 123182829

TUA:

125526948

LPER:

127324533

LRD:

124707218

SBI:

8055688

ZMA:

100280305

MFLO:

136542535 136550322

SITA:

101756828

SVS:

117844840

PVIR:

120661772 120692591

PHAI:

112879693

PDA:	103717661 120105149

EGU:

105046456

MUS:

103983014

ZOF:	121982551 121986455

DCT:

110095454

PEQ:

110023474

AOF:

109833364

NCOL:

116249599

ATR:

18448880

SMO:	SELMODRAFT_110629 SELMODRAFT_229530

PPP:

112292815

CRE:	CHLRE_06g283750v5

VCN:	VOLCADRAFT_78084

CSL:	COCSUDRAFT_15913

CVR:	CHLNCDRAFT_22974

APRO:

F751_1997

OLU:	OSTLU_32069

OTA:	OT_ostta06g01340

BPG:	Bathy05g01370

MIS:	MICPUN_108125

MPP:	MICPUCDRAFT_58789

CME:	CYME_CMS413C

GSL:	Gasu_34090

CCP:	CHC_T00000930001

PTI:	PHATRDRAFT_2738

FCY:	FRACYDRAFT_189402

TPS:	THAPSDRAFT_263902

EHX:	EMIHUDRAFT_115547 EMIHUDRAFT_95285

GTT:	GUITHDRAFT_157479

» show all

Reference

1 [PMID:16989822]

Authors

Sadre R, Gruber J, Frentzen M

Title

Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis.

Journal

FEBS Lett 580:5357-62 (2006)
DOI:10.1016/j.febslet.2006.09.002

Sequence

[cre:CHLRE_06g283750v5]

Reference

2 [PMID:20400515]

Authors

Sadre R, Frentzen M, Saeed M, Hawkes T

Title

Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis.

Journal

J Biol Chem 285:18191-8 (2010)
DOI:10.1074/jbc.M110.117929

Sequence

[cre:CHLRE_06g283750v5] [ath:AT3G11945]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.117

IUBMB Enzyme Nomenclature:

2.5.1.117

ExPASy - ENZYME nomenclature database:

2.5.1.117

BRENDA, the Enzyme Database:

2.5.1.117

LinkDB

REACTION: R08782

Entry

R08782                      Reaction

Name

all-trans-nonaprenyl-diphosphate:homogentisate nonaprenyltransferase (decarboxylating)

Definition

Homogentisate + all-trans-Nonaprenyl diphosphate <=> 2-Methyl-6-solanyl-1,4-benzoquinol + Diphosphate + CO2

Equation

C00544 + C04145 <=> C17570 + C00013 + C00011

Reaction class

RC01840

C00544_C17570

Enzyme

2.5.1.117

Pathway

rn00130

Ubiquinone and other terpenoid-quinone biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

rn01240

Biosynthesis of cofactors

Module

M00933

Plastoquinone biosynthesis, homogentisate + solanesyl-PP => plastoquinol

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.117
     R08782  Homogentisate + all-trans-Nonaprenyl diphosphate <=> 2-Methyl-6-solanyl-1,4-benzoquinol + Diphosphate + CO2

Orthology

K12501

homogentisate solanesyltransferase [EC:2.5.1.117]

Other DBs

RHEA:

37998

LinkDB

DBGET integrated database retrieval system