KEGG   ORTHOLOGY: K12554
Entry
K12554                      KO                                     
Symbol
murN
Name
alanine adding enzyme [EC:2.3.2.-]
Pathway
map00550  Peptidoglycan biosynthesis
map01100  Metabolic pathways
Reaction
R08780  L-alanyl-tRNA:undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine alanyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    K12554  murN; alanine adding enzyme
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01011 Peptidoglycan biosynthesis and degradation proteins
    K12554  murN; alanine adding enzyme
Peptidoglycan biosynthesis and degradation proteins [BR:ko01011]
 Precursor biosynthesis
  Amino acid ligase
   K12554  murN; alanine adding enzyme
Other DBs
COG: COG2348
Genes
SDO: SD1155_04360
SHA: SH1666(fmhC)
SHH: ShL2_01599(fmhA_2)
SLG: SLGD_01647
SLN: SLUG_16500(epr)
SWA: A284_11690
SPAS: STP1_1421
SHU: SHYC_08580
SSCH: LH95_09955
SSCZ: RN70_10715
SAGQ: EP23_01840
SKL: C7J89_00610 C7J89_01355
SFQ: C7J90_04585
SCAR: DWB96_13040
SSIM: SAMEA4384339_2322(femA_3)
SLLO: ISP08_12700
SFF: FOB90_09495
SSTE: SAMEA4384403_0183(femA_1)
MVT: I6J10_12385
MCL: MCCL_0128
MCAK: MCCS_02390(femA_1)
JEA: JEM45_01595
SBAC: BVH56_00945
LGR: LCGT_0582 LCGT_0583
LGV: LCGL_0601 LCGL_0602
LPK: LACPI_0938
LRN: CMV25_01210
LCAR: BHS00_06330
LPET: lgb_00584(femA) lgb_00585
LFO: LMK00_02870 LMK00_02875
SPY: SPy_0615(murN)
SPZ: M5005_Spy0510
SPYM: M1GAS476_1932(murN)
SPYA: A20_0552c(murN)
SPM: spyM18_0682(femA)
SPG: SpyM3_0434(murN)
SPS: SPs1421
SPH: MGAS10270_Spy0504
SPI: MGAS10750_Spy0529
SPJ: MGAS2096_Spy0522
SPK: MGAS9429_Spy0500
SPF: SpyM51353(murN)
SPA: M6_Spy0531
SPB: M28_Spy0489
STG: MGAS15252_0536(murN)
STX: MGAS1882_0533(murN)
SOZ: Spy49_0517c(murN)
STZ: SPYALAB49_000542
SPYH: L897_02750
SPN: SP_0616(fibB)
SPD: SPD_0536(fibB)
SPR: spr0541(murN)
SPW: SPCG_0576(murN)
SJJ: SPJ_0567
SNV: SPNINV200_05430(murN)
SPX: SPG_0559
SNT: SPT_0641
SND: MYY_0665
SPNN: T308_02905
SNE: SPN23F05550(murN)
SPV: SPH_0709
SNC: HMPREF0837_10905
SNM: SP70585_0677
SPP: SPP_0630
SNI: INV104_05140(murN)
SPNG: HMPREF1038_00637
SNB: SP670_0674
SNP: SPAP_0602
SNX: SPNOXC05620(murN)
SNU: SPNA45_01490(murN)
SPNE: SPN034156_16120(murN)
SPNU: SPN034183_05650(murN)
SPNM: SPN994038_05530(murN)
SPNO: SPN994039_05540(murN)
SAG: SAG0508(fibB) SAG1349
SAN: gbs0554 gbs1419
SAK: SAK_0658(fibB) SAK_1380
SGC: A964_0539(murN) A964_1263(murN)
SAGS: SaSA20_0493 SaSA20_1089
SAGL: GBS222_0485(fibB)
SAGM: BSA_14280 BSA_5960
SAGI: MSA_14700 MSA_6110
SAGR: SAIL_13990 SAIL_6250
SAGP: V193_02830
SAGC: DN94_02830
SAGT: GBSCOH1_0491 GBSCOH1_1210
SAGE: EN72_02925 EN72_07505
SAGG: EN73_03000 EN73_06635
SAGN: W903_0685 W903_1363
SAGJ: ID870_02900 ID870_06730
SMU: SMU_716(murN)
SMC: SmuNN2025_1281(murN)
SMUT: SMUGS5_03155
SMJ: SMULJ23_1282(murN)
SMUA: SMUFR_0624(murN)
STC: str0348(murO) str0596(murN)
STL: stu0348(murO) stu0596(murN)
STE: STER_0386 STER_0644
STN: STND_0596
STU: STH8232_0446 STH8232_0785(murN)
STW: Y1U_C0333 Y1U_C0572
STHE: T303_04145
STHS: AVT04_01930 AVT04_03155
SSA: SSA_0861(murN)
SSK: SSUD12_0368
SSUI: T15_0382
SGO: SGO_1624(murN)
SEZ: Sez_1320(murN)
SEQ: SZO_06480
SEZO: SeseC_01705
SEU: SEQ_1502
SUB: SUB0606(murN)
SDS: SDEG_0636
SDG: SDE12394_03420
SDA: GGS_0611(murN)
SDC: SDSE_0677(murN)
SDQ: SDSE167_0690
SGA: GALLO_1509 GALLO_1729
SGG: SGGBAA2069_c15310(murN) SGGBAA2069_c16880(murN1)
SGT: SGGB_1504(murN) SGGB_1716
SMB: smi_1583(fibB)
STB: SGPB_1405(murN) SGPB_1542
SCP: HMPREF0833_10856
SCF: Spaf_1437
SSR: SALIVB_1613(femB)
STF: Ssal_01687(murN)
STJ: SALIVA_0323(murO) SALIVA_0611(murN)
STRS: SSAL8618_03150
SSAH: HSISS4_00275(murO) HSISS4_00517(murN)
STD: SPPN_03245
SMN: SMA_1516 SMA_1639(femB)
SIF: Sinf_1330 Sinf_1467(fibB)
SIE: SCIM_0529
SIB: SIR_1112(murN)
SIU: SII_1133(murN)
SANG: SAIN_0585(murN) SAIN_1335
SANC: SANR_0597(murN) SANR_1557
SANS: DK43_07240
SCG: SCI_0622(murN)
SCON: SCRE_0602(murN)
SCOS: SCR2_0602(murN)
SOI: I872_02750
SIK: K710_1339
SIQ: DQ08_06200
SIO: DW64_06195
SIZ: SI82_06350
SLU: KE3_1459 KE3_1571
SIG: N596_04270
SIP: N597_06115
SPAT: A0O21_02755
STRA: ATM98_03935
SSOB: DK181_03425
SEQI: A6J79_05975
SKI: D7D50_06400
SPEI: EHW89_02745
SRAT: FY406_06915
SPLR: C0J00_06925 C0J00_07770
SVB: NCTC12167_00374(murO) NCTC12167_00631(murN)
SMEN: SAMEA4412692_0953(femA)
SFER: NCTC12278_01322(femA)
SCAI: NCTC12191_02001(murN)
SPSU: NCTC13786_01917(murN)
SCHJ: DDV21_008040
SPOC: NCTC10925_01240(murN)
SLAT: J4854_07440
SAUP: NCTC3168_01368(fibB)
SURN: NCTC13766_01448(murO) NCTC13766_01665(femB)
SACO: SAME_01701(femB) SAME_01879(femA)
SVF: NCTC3166_01380(fibB)
STOY: STYK_15250(murN)
SRUM: GPZ88_01520 GPZ88_02055
SACY: O6R09_06445 O6R09_07000
SMIE: NCTC11169_00545(murN_1)
SRUN: LPB404_07200
LROS: LROSL1_0108 LROSL1_0951 LROSL1_2143 LROSL1_2356
OOE: OEOE_0882 OEOE_1442
OEN: DSM07_01575 DSM07_03025
OSI: DLJ48_01405 DLJ48_02030
LME: LEUM_0327
LMM: MI1_01380
LMK: LMES_0268
LCI: LCK_00234
LKI: LKI_04855
LEC: LGMK_07570
LCN: C270_06850
LGS: LEGAS_1646(murN)
LGE: C269_07870
LLF: BCR17_02945
LGC: A9176_01445
LSU: A6B45_01570
LPSE: FGL85_00435
WKO: WKK_01735
WCE: WS08_0909
WTR: KHQ32_05115
WCT: WS74_0975
WCI: WS105_0972
WCB: AO080_00850
WJO: FOL01_0258
WPA: CO680_07010
WSO: WSWS_00405(murN)
WHE: EFA59_01170 EFA59_05000
WDI: H9L19_01625
WVR: IE337_01970
WCO: G7084_03075
EFA: EF2150
EFL: EF62_2450
EFI: OG1RF_11691
EFD: EFD32_1741
EFS: EFS1_1750
EFN: DENG_02191(murN)
EFQ: DR75_987
ESS: ATZ33_13085
MPS: MPTP_0306 MPTP_0445
MPX: MPD5_1461
AUR: HMPREF9243_1543
AUN: AWM73_02215
ACG: AWM71_01515
ALOY: CJ190_002385
AMIT: DBT49_0002820
ATJ: DBT50_008535
GEG: LK443_09150
CLO: HMPREF0868_0292
EUU: ADJ67_01570
PCAT: Pcatena_03990(femA)
ARZ: AUT26_04335
ARX: ARZXY2_3017(murN)
ARTH: C3B78_03725
ARTY: AHiyo4_08550
PUE: FV140_05120
PNV: JMY29_04500
PAYJ: HMI59_16735
ACH: Achl_0886
APN: Asphe3_08070
PSUL: AU252_06300
PSNI: NIBR502771_00895
PSEY: GU243_20265
PDEL: JCQ34_03710
POK: SMD14_03975
RSA: RSal33209_0818
XYL: ET495_05715
BLO: BL0282 BL0284
BLJ: BLD_1027 BLD_1029
BLN: Blon_0413 Blon_0414 Blon_0415 Blon_1303
BLON: BLIJ_0421 BLIJ_0422 BLIJ_0423 BLIJ_1344
BLF: BLIF_0324 BLIF_0325 BLIF_0326
BLL: BLJ_0388 BLJ_0390
BLB: BBMN68_1043 BBMN68_1045
BLM: BLLJ_0331 BLLJ_0332 BLLJ_0333 BLLJ_0908
BLK: BLNIAS_02318 BLNIAS_02321
BLG: BIL_15400 BIL_15410
BLZ: BLGT_02150 BLGT_02160
BLX: GS08_02030 GS08_02040
BLA: BLA_0276
BLC: Balac_0288
BLT: Balat_0288
BBB: BIF_00564
BBC: BLC1_0278
BNM: BALAC2494_00838
BLV: BalV_0281
BLW: W7Y_0286
BLS: W91_0295
BANI: BL12_01450
BANL: BLAC_01460
BNI: BANAN_01510
BANM: EN10_01465
BKA: AH68_01315 AH68_01320
BKS: BBKW_0248
BCAT: BBCT_0212 BBCT_0213
BPSP: AH67_01500 AH67_01505
BPSC: BBPC_0240 BBPC_0241
BSCA: BBSC_2155 BBSC_2156
BCHO: BcFMB_03770 BcFMB_03775
BLEM: BL8807_02250 BL8807_02255
BEU: BE0216_09315 BE0216_09320 BE0216_09325
 » show all
Reference
PMID:18077448
  Authors
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
  Title
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
  Journal
J Biol Chem 283:6402-17 (2008)
DOI:10.1074/jbc.M708105200
Reference
PMID:10759563
  Authors
Filipe SR, Tomasz A
  Title
Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes.
  Journal
Proc Natl Acad Sci U S A 97:4891-6 (2000)
DOI:10.1073/pnas.080067697
  Sequence
[spr:spr0541]
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