KEGG   ORTHOLOGY: K12698
Entry
K12698            Tight     KO                                     
Symbol
DAT
Name
deacetylvindoline O-acetyltransferase [EC:2.3.1.107]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Reaction
R03230  acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K12698  DAT; deacetylvindoline O-acetyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.107  deacetylvindoline O-acetyltransferase
     K12698  DAT; deacetylvindoline O-acetyltransferase
Other DBs
GO: 0047162
Genes
AG: AAC99311(DAT)
Reference
PMID:2350183
  Authors
Power R, Kurz WG, De Luca V
  Title
Purification and characterization of acetylcoenzyme A: deacetylvindoline 4-O-acetyltransferase from Catharanthus roseus.
  Journal
Arch Biochem Biophys 279:370-6 (1990)
DOI:10.1016/0003-9861(90)90504-R
Reference
PMID:9681034
  Authors
St-Pierre B, Laflamme P, Alarco AM, De Luca V
  Title
The terminal O-acetyltransferase involved in vindoline biosynthesis defines a new class of proteins responsible for coenzyme A-dependent acyl transfer.
  Journal
Plant J 14:703-13 (1998)
DOI:10.1046/j.1365-313x.1998.00174.x
  Sequence
[ag:AAC99311]
LinkDB

KEGG   ENZYME: 2.3.1.107
Entry
EC 2.3.1.107                Enzyme                                 
Name
deacetylvindoline O-acetyltransferase;
deacetylvindoline acetyltransferase;
DAT;
17-O-deacetylvindoline-17-O-acetyltransferase;
acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase;
acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase;
acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase;
acetylcoenzyme A:deacetylvindoline O-acetyltransferase;
17-O-deacetylvindoline O-acetyltransferase;
acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:deacetylvindoline 4-O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + deacetylvindoline = CoA + vindoline [RN:R03230]
Reaction(KEGG)
R03230
Substrate
acetyl-CoA [CPD:C00024];
deacetylvindoline [CPD:C01091]
Product
CoA [CPD:C00010];
vindoline [CPD:C01626]
Comment
Catalyses the final step in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle, Catharanthus roseus.
History
EC 2.3.1.107 created 1989, modified 2005
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12698  deacetylvindoline O-acetyltransferase
Reference
1  [PMID:24254076]
  Authors
Fahn W, Gundlach H, Deus-Neumann B, Stockigt J
  Title
Late enzymes of vindoline biosynthesis. Acetyl-CoA: 17-O-deacetylvindoline 17-O-acetyl-transferase.
  Journal
Plant Cell Rep 4:333-6 (1985)
DOI:10.1007/BF00269892
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.107
IUBMB Enzyme Nomenclature: 2.3.1.107
ExPASy - ENZYME nomenclature database: 2.3.1.107
BRENDA, the Enzyme Database: 2.3.1.107
CAS: 100630-41-9
LinkDB

KEGG   REACTION: R03230
Entry
R03230                      Reaction                               
Name
acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase
Definition
Acetyl-CoA + Deacetylvindoline <=> CoA + Vindoline
Equation
C00024 + C01091 <=> C00010 + C01626
Reaction class
RC00004  C00010_C00024
RC00055  C01091_C01626
Enzyme
2.3.1.107
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.107
     R03230  Acetyl-CoA + Deacetylvindoline <=> CoA + Vindoline
Orthology
K12698  deacetylvindoline O-acetyltransferase [EC:2.3.1.107]
Other DBs
RHEA: 24499
LinkDB

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