KEGG ORTHOLOGY: K12708

ORTHOLOGY: K12708

Entry

K12708            Tight     KO

Symbol

novR, cloR

Name

4-hydroxy-3-prenylphenylpyruvate oxygenase / 4-hydroxy-3-prenylbenzoate synthase [EC:1.13.11.83 1.13.12.23]

Pathway

map00401

Novobiocin biosynthesis

map01110

Biosynthesis of secondary metabolites

Reaction

R06758

3-(4-hydroxy-3-prenylphenyl)pyruvate:oxygen 1,2-oxidoreductase (4-hydroxy-3-prenylmandelate-forming)

R06759

4-hydroxy-3-prenylmandelate:oxygen oxidoreductase (4-hydroxy-3-prenylbenzoate forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12708  novR, cloR; 4-hydroxy-3-prenylphenylpyruvate oxygenase / 4-hydroxy-3-prenylbenzoate synthase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.83  4-hydroxy-3-prenylphenylpyruvate oxygenase
     K12708  novR, cloR; 4-hydroxy-3-prenylphenylpyruvate oxygenase / 4-hydroxy-3-prenylbenzoate synthase
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.23  4-hydroxy-3-prenylbenzoate synthase
     K12708  novR, cloR; 4-hydroxy-3-prenylphenylpyruvate oxygenase / 4-hydroxy-3-prenylbenzoate synthase

Other DBs

COG:

COG0235

Genes

NGV:	CDO52_02235

AG:	AAF67511(novR) AAN65240(cloR)

Reference

PMID:12777382

Authors

Pojer F, Kahlich R, Kammerer B, Li SM, Heide L.

Title

CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis.

Journal

J Biol Chem 278:30661-8 (2003)
DOI:10.1074/jbc.M303190200

Sequence

[ag:AAN65240]

LinkDB

ENZYME: 1.13.12.23

Entry

EC 1.13.12.23               Enzyme

Name

4-hydroxy-3-prenylbenzoate synthase;
CloR;
novR (gene name)

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

Sysname

4-hydroxy-3-prenylmandelate:oxygen oxidoreductase (4-hydroxy-3-prenylbenzoate forming)

Reaction(IUBMB)

4-hydroxy-3-prenylmandelate + O2 = 4-hydroxy-3-prenylbenzoate + CO2 + H2O [RN:R06759]

Reaction(KEGG)

R06759

Substrate

4-hydroxy-3-prenylmandelate [CPD:C12457];
O2 [CPD:C00007]

Product

4-hydroxy-3-prenylbenzoate [CPD:C12458];
CO2 [CPD:C00011];
H2O [CPD:C00001]

Comment

Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.11.83, 4-hydroxy-3-prenylphenylpyruvate oxygenase.

History

EC 1.13.12.23 created 2017

Pathway

ec00401

Novobiocin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K12708

4-hydroxy-3-prenylphenylpyruvate oxygenase / 4-hydroxy-3-prenylbenzoate synthase

Genes

NGV:	CDO52_02235

Reference

1 [PMID:12777382]

Authors

Pojer F, Kahlich R, Kammerer B, Li SM, Heide L.

Title

CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis.

Journal

J Biol Chem 278:30661-8 (2003)
DOI:10.1074/jbc.M303190200

Sequence

[ag:AAN65240]

Other DBs

ExplorEnz - The Enzyme Database:

1.13.12.23

IUBMB Enzyme Nomenclature:

1.13.12.23

ExPASy - ENZYME nomenclature database:

1.13.12.23

BRENDA, the Enzyme Database:

1.13.12.23

LinkDB

REACTION: R06759

Entry

R06759                      Reaction

Name

4-hydroxy-3-prenylmandelate:oxygen oxidoreductase (4-hydroxy-3-prenylbenzoate forming)

Definition

3-Dimethylallyl-4-hydroxymandelic acid + Oxygen <=> 3-Dimethylallyl-4-hydroxybenzoate + CO2 + H2O

Equation

C12457 + C00007 <=> C12458 + C00011 + C00001

Reaction class

RC01679

C12457_C12458

Enzyme

1.13.12.23

Pathway

rn00401

Novobiocin biosynthesis

rn01110

Biosynthesis of secondary metabolites

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.12  With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
    1.13.12.23
     R06759  3-Dimethylallyl-4-hydroxymandelic acid + Oxygen <=> 3-Dimethylallyl-4-hydroxybenzoate + CO2 + H2O

Orthology

K12708

4-hydroxy-3-prenylphenylpyruvate oxygenase / 4-hydroxy-3-prenylbenzoate synthase [EC:1.13.11.83 1.13.12.23]

Other DBs

RHEA:

52915

LinkDB

DBGET integrated database retrieval system