KEGG   ORTHOLOGY: K12712
Entry
K12712                      KO                                     
Symbol
novP, cloP, couP
Name
demethyldecarbamoylnovobiocin O-methyltransferase [EC:2.1.1.285]
Pathway
map00401  Novobiocin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06767  
R06771  S-adenosyl-L-methionine:demethyldecarbamoylnovobiocin 4''-O-methyltransferase
R06774  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12712  novP, cloP, couP; demethyldecarbamoylnovobiocin O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.285  demethyldecarbamoylnovobiocin O-methyltransferase
     K12712  novP, cloP, couP; demethyldecarbamoylnovobiocin O-methyltransferase
Genes
PFAK: KSS94_27025
SAOV: G3H79_01915
SFP: QUY26_02200
NGV: CDO52_02225
ACTU: Actkin_05240(mycF_2)
PMET: G4Y79_24100
AMOB: HG15A2_31330(novP)
AG: AAF67509(novP) AAG29794(couP) AAN65238(cloP)
Reference
  Authors
Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L
  Title
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.
  Journal
Antimicrob Agents Chemother 44:1214-22 (2000)
DOI:10.1128/AAC.44.5.1214-1222.2000
  Sequence
Reference
  Authors
Pojer F, Li SM, Heide L.
  Title
Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.
  Journal
Microbiology 148:3901-11 (2002)
DOI:10.1099/00221287-148-12-3901
  Sequence
Reference
  Authors
Freel Meyers CL, Oberthur M, Heide L, Kahne D, Walsh CT
  Title
Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN.
  Journal
Biochemistry 43:15022-36 (2004)
DOI:10.1021/bi048457z
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