| Entry |
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| Name |
deacetylcephalosporin-C acetyltransferase;
acetyl-CoA:deacetylcephalosporin-C acetyltransferase;
DAC acetyltransferase;
cefG;
deacetylcephalosporin C acetyltransferase;
acetyl coenzyme A:DAC acetyltransferase;
acetyl-CoA:DAC acetyltransferase;
CPC acetylhydrolase;
acetyl-CoA:DAC O-acetyltransferase;
DAC-AT
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase
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| Reaction(IUBMB) |
acetyl-CoA + deacetylcephalosporin C = CoA + cephalosporin C [RN: R03064]
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| Reaction(KEGG) |
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| Substrate |
acetyl-CoA [CPD: C00024];
deacetylcephalosporin C [CPD: C03112]
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| Product |
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| Comment |
This enzyme catalyses the final step in the biosynthesis of cephalosporin C.
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| History |
EC 2.3.1.175 created 2005
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| Pathway |
| ec00311 | Penicillin and cephalosporin biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K12747 | deacetylcephalosporin-C acetyltransferase |
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| Reference |
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| Authors |
Matsuyama K, Matsumoto H, Matsuda A, Sugiura H, Komatsu K, Ichikawa S. |
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| Title |
Purification of acetyl coenzyme A: deacetylacephalosporin C O-acetyltransferase from Acremonium chrysogenum. |
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| Journal |
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| Reference |
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| Authors |
Gutierrez S, Velasco J, Fernandez FJ, Martin JF |
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| Title |
The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Matsuda A, Sugiura H, Matsuyama K, Matsumoto H, Ichikawa S, Komatsu K |
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| Title |
Cloning and disruption of the cefG gene encoding acetyl coenzyme A: deacetylcephalosporin C o-acetyltransferase from Acremonium chrysogenum. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Gutierrez S, Velasco J, Marcos AT, Fernandez FJ, Fierro F, Barredo JL, Diez B, Martin JF. |
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| Title |
Expression of the cefG gene is limiting for cephalosporin biosynthesis in Acremonium chrysogenum. |
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| Journal |
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| Reference |
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| Authors |
Velasco J, Gutierrez S, Campoy S, Martin JF. |
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| Title |
Molecular characterization of the Acremonium chrysogenum cefG gene product: the native deacetylcephalosporin C acetyltransferase is not processed into subunits. |
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| Journal |
Biochem J 337 ( Pt 3):379-85 (1999) |
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| Reference |
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| Authors |
Martin JF, Gutierrez S, Fernandez FJ, Velasco J, Fierro F, Marcos AT, Kosalkova K. |
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| Title |
Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.175 |
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| LinkDB |
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