Entry Name L-alanine---L-anticapsin ligase;
Class Ligases;BRITE hierarchy
Sysname L-alanine:L-anticapsin ligase (ADP-forming)
Reaction(IUBMB) ATP + L-alanine + L-anticapsin = ADP + phosphate + bacilysin [RN:
R11064 ]
Reaction(KEGG) Substrate Product Comment The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme requires Mg2+ or Mn2+ for activity, and has a broad substrate specificity in vitro [1].
History EC 6.3.2.49 created 2006 as EC 6.3.2.28, transferred 2015 to EC 6.3.2.49
Pathway ec00998 Biosynthesis of various antibiotics
ec01110 Biosynthesis of secondary metabolites
Orthology K13037 L-alanine-L-anticapsin ligase
Genes BAZ : BAMTA208_19085(bacD)
» show all Taxonomy Reference Authors Tabata K, Ikeda H, Hashimoto S
Title ywfE in Bacillus subtilis codes for a novel enzyme, L-amino acid ligase.
Journal Sequence Reference Authors Tsuda T, Suzuki T, Kojima S
Title Crystallization and preliminary X-ray diffraction analysis of Bacillus subtilis YwfE, an L-amino-acid ligase.
Journal Reference Authors Shomura Y, Hinokuchi E, Ikeda H, Senoo A, Takahashi Y, Saito J, Komori H, Shibata N, Yonetani Y, Higuchi Y
Title Structural and enzymatic characterization of BacD, an L-amino acid dipeptide ligase from Bacillus subtilis.
Journal Sequence Reference Authors Parker JB, Walsh CT
Title Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.
Journal Other DBs ExplorEnz - The Enzyme Database: 6.3.2.49
ExPASy - ENZYME nomenclature database: 6.3.2.49
LinkDB All DBs
