KEGG ORTHOLOGY: K13273

ORTHOLOGY: K13273

Entry

K13273                      KO

Symbol

PMVK

Name

phosphomevalonate kinase [EC:2.7.4.2]

Pathway

map00900

Terpenoid backbone biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map04146

Peroxisome

Module

M00095

C5 isoprenoid biosynthesis, mevalonate pathway

Reaction

R03245

ATP:(R)-5-phosphomevalonate phosphotransferase

Disease

H01933

Porokeratosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K13273  PMVK; phosphomevalonate kinase
09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K13273  PMVK; phosphomevalonate kinase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.4  Phosphotransferases with a phosphate group as acceptor
    2.7.4.2  phosphomevalonate kinase
     K13273  PMVK; phosphomevalonate kinase

Other DBs

GO:

0004631

Genes

HSA:	10654(PMVK)

PTR:	457350(PMVK)

PPS:	100995977(PMVK)

GGO:	101137635(PMVK)

PON:	100455820(PMVK)

PPYG:

129018607(PMVK)

NLE:	100579889(PMVK)

HMH:	116469351(PMVK)

SSYN:

134734364(PMVK)

MCC:	717014(PMVK)

MCF:	102144963(PMVK)

MNI:	105497979(PMVK)

CSAB:

103223914(PMVK)

CATY:

105593502(PMVK)

PANU:

101000669(PMVK)

TGE:	112607334(PMVK)

MLEU:

105544822(PMVK)

RRO:	104663487(PMVK)

RBB:	108526810(PMVK)

TFN:	117075167(PMVK)

PTEH:

111543730(PMVK)

CANG:

105502012(PMVK)

CJC:	100387923(PMVK)

SBQ:	101032893(PMVK)

CIMI:

108292460(PMVK)

ANAN:

105733727(PMVK)

CSYR:

103249996(PMVK)

MMUR:

105873195(PMVK)

LCAT:

123634035(PMVK)

PCOQ:

105822002(PMVK)

OGA:	100967005(PMVK)

MMU:	68603(Pmvk)

MCAL:

110290832(Pmvk)

MPAH:

110320410(Pmvk)

RNO:	310645(Pmvk)

MCOC:

116093184(Pmvk)

ANU:	117706550(Pmvk)

ASYL:

127683094(Pmvk)

MUN:	110555632(Pmvk)

CGE:	100759992(Pmvk)

MAUA:

101825341(Pmvk)

PROB:

127232759(Pmvk)

PLEU:

114707935(Pmvk)

MORG:

121450783(Pmvk)

MFOT:

126486511

AAMP:

119801372(Pmvk)

NGI:	103751309(Pmvk)

HGL:	101720089(Pmvk)

CPOC:

100733721(Pmvk)

CCAN:

109688034(Pmvk)

DORD:

105984994(Pmvk)

DSP:	122109171(Pmvk)

PLOP:

125359880(Pmvk)

NCAR:

124978166

MMMA:

107135765 107156741(Pmvk)

ITI:	101961265(Pmvk)

OCU:

100345598

OPI:	101528646(PMVK)

TUP:	102483254(PMVK)

GVR:	103608168(PMVK) 103611053

CFA:	612251(PMVK)

CLUD:

112648960(PMVK)

VVP:	112918896(PMVK)

VLG:	121497889(PMVK)

NPO:	129508956(PMVK)

AML:	100470020(PMVK)

UMR:	103668387(PMVK)

UAH:	113245301(PMVK)

UAR:	123783458(PMVK)

ELK:

111138917

LLV:

125086358

MPUF:

101683949(PMVK)

MNP:	132025926(PMVK)

MLK:	131814363(PMVK)

NVS:	122918248(PMVK)

ORO:	101374602(PMVK)

EJU:	114198722(PMVK)

ZCA:	113933585(PMVK)

MLX:	118013860(PMVK)

NSU:	110573493(PMVK)

LWW:	102738854(PMVK)

FCA:	101096787(PMVK)

PYU:	121015658(PMVK)

PCOO:

112851747(PMVK)

PBG:	122476585(PMVK)

PVIV:

125155363(PMVK)

LRUF:

124521836

LGF:	123586719(PMVK)

PTG:	102949325(PMVK)

PPAD:

109256353(PMVK)

PUC:

125925734

PLEZ:

122212142(PMVK)

AJU:

106988381

HHV:	120244674(PMVK)

BTA:	513533(PMVK)

BOM:	102264771(PMVK)

BIU:	109553992(PMVK)

BBUB:

102411625(PMVK)

BBIS:

104987427(PMVK)

CHX:	102172312(PMVK)

OAS:	101113026(PMVK)

BTAX:

128044696(PMVK)

CSUM:

138073175(PMVK)

ODA:	120855751(PMVK)

CCAD:

122432883(PMVK)

MREE:

136145070(PMVK)

OVR:	110149826(PMVK) 139030834

MBEZ:

129540944(PMVK)

SSC:	100152301(PMVK)

CFR:	102523720(PMVK)

CBAI:

105068177(PMVK)

CDK:	105089049(PMVK)

VPC:	102527794(PMVK)

BACU:

103017363(PMVK)

BMUS:

118886767(PMVK)

LVE:	103076280(PMVK)

OOR:	101277800(PMVK)

LALB:

132513168(PMVK)

DLE:	111167105(PMVK)

PCAD:

102993494(PMVK)

PSIU:

116762416(PMVK)

ECB:	100062963(PMVK)

EPZ:	103552868(PMVK)

EAI:	106828521(PMVK)

MYB:	102252484(PMVK)

MYD:	102759157(PMVK)

MMYO:

118673304(PMVK)

MLF:	102431912(PMVK)

MDT:	132221217(PMVK)

MYUM:

138995805(PMVK)

PKL:	118721455(PMVK)

EFUS:

103298916(PMVK)

MNA:	107543910(PMVK)

DRO:	112314326(PMVK)

SHON:

118990183(PMVK)

AJM:	119061800(PMVK)

PDIC:

114488909(PMVK)

PHAS:

123833449(PMVK)

MMF:	118637556(PMVK)

PPAM:

129062470(PMVK)

HAI:	109393437(PMVK)

RFQ:	117015395(PMVK)

PALE:

102895196(PMVK)

PGIG:

120592214(PMVK)

PVP:	105296382(PMVK)

RAY:	107504720 107505476(PMVK)

MJV:	108407287(PMVK)

TOD:	119235845(PMVK)

SARA:

101556297(PMVK)

SFUM:

130031868(PMVK)

SETR:

126020765(PMVK)

LAV:	100665338(PMVK)

TMU:

101359067

ETF:	101664504(PMVK)

DNM:	101427565(PMVK)

MDO:	100021196(PMVK)

GAS:	123245092(PMVK)

SHR:	100917077(PMVK)

AFZ:

127559848

PCW:	110212098(PMVK)

TVP:	118847653(PMVK)

PBRV:

138153679(PMVK)

OAA:	114807913(PMVK)

TACU:

119947331(PMVK)

GGA:	101747962(PMVK)

PCOC:

116237324(PMVK)

MGP:	104916279(PMVK)

CJO:	107324495(PMVK)

TPAI:

128078811(PMVK)

LMUT:

125685737(PMVK)

NMEL:

110391263(PMVK)

APLA:

101796838(PMVK)

ACYG:

125180269(PMVK)

CATA:

118258455(PMVK)

AFUL:

116499684(PMVK)

TGU:	100190393(PMVK)

LSR:	110471588(PMVK)

SCAN:

115484462(PMVK)

PMOA:

120498909(PMVK)

OTC:	121332180(PMVK)

PRUF:

121352180(PMVK)

ATRC:

139605382(PMVK)

GFR:	102039155(PMVK)

FAB:	101809157(PMVK)

OMA:	130263189(PMVK)

PHI:	102106340(PMVK)

PMAJ:

107214553(PMVK)

CCAE:

111922537(PMVK)

CBRC:

103611320(PMVK)

ACOE:

138098585(PMVK)

ZLE:	135457774(PMVK)

ACHL:

103805513(PMVK)

SVG:	106863392(PMVK)

MMEA:

130583225(PMVK)

CCIC:

134055299(PMVK)

FPG:	101920330(PMVK)

SHAB:

115602569(PMVK)

TALA:

104358109(PMVK)

ACHC:

115345781(PMVK)

AGEN:

126040697

HHAR:

128145855(PMVK)

PPUS:

135192771(PMVK)

AFOR:

103905532(PMVK)

CLV:	102087246(PMVK)

RTD:	128900881(PMVK)

NPD:	112955214(PMVK)

DNE:	112995803(PMVK)

AMJ:	109283975(PMVK)

CPOO:

109324786(PMVK)

GGN:	109293949(PMVK)

CMY:	119564200(PMVK)

CCAY:

125625939(PMVK)

DCC:	119847942(PMVK)

CPIC:

101930857(PMVK)

TST:	117889083(PMVK)

CABI:

116830131(PMVK)

MRV:	120389992(PMVK)

ASAO:

132764089(PMVK)

PVT:	110081038(PMVK)

SUND:

121916084(PMVK)

PBI:	103061857(PMVK)

PMUR:

107296689(PMVK) 107302131

CTIG:

120317125(PMVK)

TSR:	106537468(PMVK)

PGUT:

117658877(PMVK)

APRI:

131186590(PMVK)

PTEX:

113446693(PMVK)

NSS:	113428379(PMVK)

VKO:	123032717(PMVK)

PMUA:

114586489(PMVK)

PRAF:

128404479(PMVK)

ZVI:	118076393(PMVK)

HCG:	128337684(PMVK)

GJA:	107117084(PMVK)

STOW:

125436527(PMVK)

EMC:	129330477(PMVK)

XLA:	734816(pmvk.L)

XTR:	116406889(pmvk)

NPR:	108795200(PMVK)

RTEM:

120920626(PMVK)

BBUF:

120994492(PMVK)

BGAR:

122932977(PMVK)

PWL:	138268583(PMVK)

MUO:	115458307(PMVK)

GSH:	117349921(PMVK)

DRE:	100003383(pmvk)

SRX:	107714427 107717898 107717899

SANH:

107661023 107697277

SGH:	107551729 107581753

CCAR:

109105653(pmvk) 109105854

CAUA:

113116493(pmvk)

CGIB:

127974552

PTET:

122360210(pmvk)

LROH:

127178696(pmvk)

OMC:	131521774(pmvk)

PPRM:

120476302(pmvk)

RKG:	130078242(pmvk)

MAMB:

125243302(pmvk)

CIDE:

127497294

CERY:

137024282(pmvk)

MASI:

127452552

TROS:

130557716(pmvk)

TDW:	130432699(pmvk)

MANU:

129447756(pmvk)

PDAB:

135720950 135760361

IPU:

108280390

IFU:	128623986(pmvk)

PHYP:

113543201(pmvk)

SMEO:

124402888(pmvk)

TFD:	113640269(pmvk)

TVC:	132839506(pmvk)

CGAR:

128513184(pmvk)

NGRA:

132871497(pmvk)

TRN:	134302738(pmvk)

AMEX:

103024664(pmvk)

CMAO:

118797341(pmvk)

EEE:	113584898(pmvk)

CHAR:

105896161(pmvk)

SPIL:

134082623(pmvk)

TRU:	101076038(pmvk)

TFS:	130532127(pmvk)

TNG:	GSTEN00011540G001

LCO:	104937305(pmvk)

TBEN:

117469467(pmvk)

PGEO:

117442600(pmvk)

GACU:

117557012(pmvk)

EMAC:

134862909(pmvk)

ELY:	117265785(pmvk)

EFO:	125893953(pmvk)

PLEP:

121964938(pmvk)

SLUC:

116058492(pmvk)

ECRA:

117940584(pmvk)

PFLV:

114557133(pmvk)

GAT:	120811162(pmvk)

PPUG:

119197562(pmvk)

AFB:	129109732(pmvk)

CLUM:

117745056(pmvk)

PSWI:

130213095(pmvk)

CANA:

137780923(pmvk)

CVE:

137887161

MSAM:

119884271 119892987

SCHU:

122881704(pmvk)

CUD:	121513839(pmvk)

SPUL:

138606731(pmvk)

LMIX:

132983230(pmvk)

ASTR:

137600965

MZE:	101478107(pmvk)

ONL:	100708938(pmvk)

OAU:	116334900(pmvk)

OLA:	101169184(pmvk)

OML:	112139354(pmvk)

CSAI:

133424879(pmvk)

XMA:	102236799(pmvk)

XCO:	114140195(pmvk)

XHE:	116717895(pmvk)

PRET:

103477450(pmvk)

PFOR:

103131142(pmvk)

PLAI:

106940011(pmvk)

PMEI:

106932707(pmvk)

GAF:	122830910(pmvk)

PPRL:

129351015 129355855

CVG:	107095271(pmvk)

CTUL:

119780908(pmvk)

GMU:	124865450(pmvk)

NFU:	107379240(pmvk)

KMR:	108228470(pmvk)

NWH:	119409766(pmvk)

AOCE:

111569478(pmvk)

EJA:

138214741

BFRE:

138633805(pmvk)

CSEM:

103388043(pmvk)

POV:	109644352(pmvk)

SSEN:

122775047(pmvk)

HHIP:

117776639(pmvk)

HSP:	118113439(pmvk)

PPLT:

128449205(pmvk)

SMAU:

118284562(pmvk)

LCF:

108884702

SDU:	111234086(pmvk)

SLAL:

111649953(pmvk) 111670549

XGL:	120784412(pmvk)

HCQ:	109512166(pmvk)

SSCV:

125974882(pmvk)

SBIA:

133513676(pmvk)

PEE:	133413228(pmvk)

PTAO:

133487424(pmvk)

BPEC:

110173784(pmvk)

MALB:

109970895(pmvk)

BSPL:

114842730(pmvk)

SJO:	128367060(pmvk)

SSCO:

133983128(pmvk)

SASA:

106580429(pmvk) 106605469

STRU:

115176604(pmvk) 115179734

OTW:	112228848(pmvk)

OMY:	110513733(pmvk)

OGO:	123997807 124005497(pmvk)

ONE:	115103280(pmvk)

OKI:	109908131(pmvk)

OKE:	118367552(pmvk)

OMM:	135520308(pmvk)

SALP:

111950284 111965035 112080250

SNH:

120031536

CCLU:

121570060 121572413

ELS:	105019172(pmvk)

SFM:	108925256(pmvk)

PKI:	111838427(pmvk)

AANG:

118223478(pmvk)

AROT:

135264660(pmvk)

CCOG:

133123298(pmvk)

LOC:	102691248(pmvk)

PSPA:

121306972(pmvk)

ARUT:

117395508 117965040

PSEX:

120538358(pmvk)

LCM:	102365471(PMVK)

PMRN:

116953566(PMVK)

LRJ:	133339811 133355222 133355223

BFO:

BBEL:

CIN:

SCLV:

SPU:	100890384 115922376

LPIC:

APLC:

ARUN:

AJC:

SKO:

PFLL:

DME:	Dmel_CG10268(Pmvk)

DER:

6549087

DSE:

6614721

DSI:	Dsimw501_GD21744(Dsim_GD21744)

DYA:	Dyak_GE12639

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17248

DAZ:

108611021

DNV:

115563204

DHE:

111600283

DVI:	6633928(Pmvk)

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135961829(Pmvk)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ015413

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

100885794(Mpk)

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139106695(Pmvk)

HST:

DQU:

CFO:

FEX:

PMEC:

138934793(Pmvk)

LHU:	105671076(Pmvk)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124222146(Pmvk)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138134983(Pmvk)

DPA:

109536581

ESIM:

136408871(Pmvk)

EFOR:

136349504(Pmvk)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

692835(Mpk)

BMAN:

114241058

MSEX:

115440108

DPL:	KGM_202532

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137923307(Pmvk)

PRAP:

PBX:

PNAP:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113503493 113506558

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

113364751 113387602 113388193

CCRN:

123297280

API:	100163413 100574505

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106678113(Pmvk)

NLU:

111060526

HVI:

124365837

MQU:

129003906

PHU:	Phum_PHUM349800

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_215326

DMK:	116921104 123471543

DPZ:

124335753

AFRA:

136040638

PJA:	122244105 122253184

PCHN:

125043229

PMOO:

119585289

HAME:

121860005 121860006

PCLA:

123768548(Pmvk)

PTRU:

123515923

ESN:

127003774

MNZ:

135209660

MRJ:	136855525(Pmvk)

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136984457(Pmvk)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F32D8.13(F32D8.13)

CBR:

CBG_27070

CRQ:	GCK72_016569

BMY:	BM_BM17214(Bm17214) BM_BM3767(Bm3767)

LOA:	LOAG_11811

TSP:

Tsp_06629

HRO:	HELRODRAFT_166571

LGI:	LOTGIDRAFT_179274

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HASI:

HCRA:

CRG:

CANU:

CVN:	111127753 111131711

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_072460

SHX:	MS3_00002105

OVI:	T265_15495

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130655013 130655014

RES:

135688327

TAD:	TRIADDRAFT_22239

AQU:	100636728 109580134

MBR:	MONBRDRAFT_27803

SRE:	PTSG_09211

ACAN:

ACA1_061550

AAF:	AURANDRAFT_7023

» show all

Reference

PMID:17902708

Authors

Herdendorf TJ, Miziorko HM

Title

Functional evaluation of conserved basic residues in human phosphomevalonate kinase.

Journal

Biochemistry 46:11780-8 (2007)
DOI:10.1021/bi701408t

Sequence

[hsa:10654]

LinkDB

DBGET integrated database retrieval system