KEGG   ORTHOLOGY: K13313
Entry
K13313                      KO                                     
Symbol
tylD, gerKI, mydI
Name
dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase [EC:1.1.1.364]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Module
M00794  dTDP-6-deoxy-D-allose biosynthesis
Reaction
R06438  dTDP-6-deoxy-alpha-D-allose:NAD+ oxidoreductase
R10573  dTDP-6-deoxy-alpha-D-allose:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13313  tylD, gerKI, mydI; dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.364  dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase
     K13313  tylD, gerKI, mydI; dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase
Genes
PQI: KH389_01255
FAP: GR316_01820
TMK: QGN29_03040
STRM: M444_29920
SCAL: I6J39_29640
SGK: PET44_28340
AMI: Amir_4843
NHY: JQS43_06885
RLO: GQ464_012990
AG: AAD12165(tylD) ABB52541(gerKI) BAC57025(mydI)
Reference
PMID:10220165 (tylD)
  Authors
Fouces R, Mellado E, Diez B, Barredo JL
  Title
The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region.
  Journal
Microbiology 145 ( Pt 4):855-68 (1999)
DOI:10.1099/13500872-145-4-855
  Sequence
[ag:AAD12165]
Reference
PMID:12583909 (mydI)
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS Microbiol Lett 218:135-41 (2003)
DOI:10.1111/j.1574-6968.2003.tb11509.x
  Sequence
[ag:BAC57025]
Reference
PMID:17053005 (gerKI)
  Authors
Thuy TT, Liou K, Oh TJ, Kim DH, Nam DH, Yoo JC, Sohng JK
  Title
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.
  Journal
Glycobiology 17:119-26 (2007)
DOI:10.1093/glycob/cwl060
  Sequence
[ag:ABB52541]
LinkDB

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