KEGG   ORTHOLOGY: K13392
Entry
K13392            Tight     KO                                     
Symbol
SALR
Name
salutaridine reductase (NADPH) [EC:1.1.1.248]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00944  Morphine biosynthesis, (S)-reticuline => morphine
Reaction
R04697  salutaridinol:NADP+ 7-oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13392  SALR; salutaridine reductase (NADPH)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.248  salutaridine reductase (NADPH)
     K13392  SALR; salutaridine reductase (NADPH)
Other DBs
GO: 0047037
Genes
PSOM: 113322262 113340174
AG: ABC47654(SALR)
Reference
PMID:16968522
  Authors
Ziegler J, Voigtlander S, Schmidt J, Kramell R, Miersch O, Ammer C, Gesell A, Kutchan TM
  Title
Comparative transcript and alkaloid profiling in Papaver species identifies a short chain dehydrogenase/reductase involved in morphine biosynthesis.
  Journal
Plant J 48:177-92 (2006)
DOI:10.1111/j.1365-313X.2006.02860.x
  Sequence
[ag:ABC47654]
Reference
PMID:17337529
  Authors
Geissler R, Brandt W, Ziegler J
  Title
Molecular modeling and site-directed mutagenesis reveal the benzylisoquinoline binding site of the short-chain dehydrogenase/reductase salutaridine reductase.
  Journal
Plant Physiol 143:1493-503 (2007)
DOI:10.1104/pp.106.095166
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